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Peliosis Hepatitis

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1. Liver lesions detected in a hepatitis B core total antibody-positive patient masquerading as hepatocellular carcinoma: a rare case of peliosis hepatis and a review of the literature (PubMed)

Liver lesions detected in a hepatitis B core total antibody-positive patient masquerading as hepatocellular carcinoma: a rare case of peliosis hepatis and a review of the literature Peliosis Hepatis (PH) is a rare vascular disorder of the liver, characterized by the presence of cystic blood-filled cavities distributed throughout the hepatic parenchyma. The pathogenesis of PH remains controversial. The preoperative diagnosis of PH is difficult, due to the non-specific imaging characteristics (...) of PH and almost all cases are diagnosed on histology post resection. This study presents a case of PH masquerading as hepatocellular carcinoma (HCC). The patient is a 45-year old Chinese lady, who presented with transaminitis. She was found to be hepatitis B virus core total antibody-positive with an alpha-fetoprotein (AFP) of 29.4 ng/ml. Triphasic liver computed tomography showed several arterial hypervascular lesions and hypoenhancing lesions on the venous phase, particularly in the segments 6/7

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2017 Annals of Hepato-Biliary-Pancreatic Surgery

2. Peliosis Hepatis Complicating Pregnancy: A Rare Entity (PubMed)

Peliosis Hepatis Complicating Pregnancy: A Rare Entity Peliosis hepatis (PH) is a rare, benign condition of the liver characterized by the presence of blood-filled lacunar spaces in the parenchyma. It usually has a chronic presentation and is a rare cause of portal hypertension reported in adult patients. Its etiology is diverse and ranges from infectious agents to tumors to toxic substances and anabolic steroids; however, the cause remains unclear in 25-50% of patients. Similarly (...) , the symptomatology and imaging findings are diverse. Biopsy is the definitive test to diagnose the condition. Herein, we present a case of a young female presenting in her seventh month of gestational amenorrhea with signs of portal hypertension and subsequently diagnosed to have PH. She was managed conservatively and delivered her baby normally. Later, she presented with spontaneous bacterial peritonitis and hepatic encephalopathy and developed hepatorenal syndrome. She later succumbed to her illness

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2017 Journal of translational internal medicine

3. Peliosis Hepatitis

Peliosis Hepatitis Peliosis Hepatitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Peliosis Hepatitis Peliosis Hepatitis Aka (...) : Peliosis Hepatitis , Bacillary Peliosis Hepatitis , Bacillary Peliosis II. Pathophysiology Infected cystic blood filled spaces in hepatic lobules Complication of caused by (or B. quintana) Occurs in ( <100 cells/mm3) or other immunocompromised patients III. Symptoms Weight loss IV. Management Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Peliosis Hepatitis." Click on the image (or right click) to open the source website in a new

2018 FP Notebook

4. A Fatal Case of Intra-Abdominal Hemorrhage Following Diagnostic Blind Percutaneous Liver Biopsy in a Patient With Peliosis Hepatis (PubMed)

A Fatal Case of Intra-Abdominal Hemorrhage Following Diagnostic Blind Percutaneous Liver Biopsy in a Patient With Peliosis Hepatis Peliosis hepatis (PH) is a rare vascular condition of the liver characterized by the presence of cystic blood filled cavities distributed randomly throughout the liver parenchyma. We describe a case of a 42-year-old previously healthy male patient, airlifted to us in a state of hemorrhagic shock after undergoing percutaneous diagnostic liver biopsy for lesions seen (...) on CT scan. Repeat CT scan with IV contrast on presentation in our hospital showed intraperitoneal bleeding. Hepatic angiography failed to identify any specific bleeding source. A diagnostic laparoscopy was performed and approximate 9 L of hemoperitoneum was evacuated. The postoperative course was complicated with rapid hemodynamic deterioration, associated with acute hepatic failure progressively leading to multiorgan failure and death in spite of aggressive intensive care support. We suggest

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2017 Gastroenterology research

5. Peliosis Hepatis Mimicking Malignant Hypervascular Tumors. (PubMed)

and investigated the clinicopathological features underlying this condition.Detailed herein is a case of peliosis hepatis on the basis of our findings. Our patient illustrated a lethal instance which mimicked a malignancy although it is usually an indolent finding.Peliosis hepatis should always be borne in mind as a differential diagnosis of atypical hypervascular hepatic lesion, especially in patients with clinical conditions described in the text. (...) Peliosis Hepatis Mimicking Malignant Hypervascular Tumors. Peliosis hepatis is an uncommon vascular condition characterized by multiple, randomly distributed, blood-filled, and cyst-like cavities throughout the liver. The unique clinical nature consisting of an asymptomatic, benign, and incidental finding sometimes conceals itself even until autopsy. However, the exact pathomechanism remains as yet unproven.We encountered the patient with multiple hypervascular masses in the whole liver

2016 Journal of Gastrointestinal Surgery

6. Peliosis hepatis in a child with myotubular myopathy: Successful treatment using hepatic artery embolization. (PubMed)

Peliosis hepatis in a child with myotubular myopathy: Successful treatment using hepatic artery embolization. Peliosis hepatis (PH) is a rare condition characterized by multiple blood-filled spaces within the hepatic parenchyma that can lead to fatal hemorrhage. There is no consensus on the best treatment algorithm for PH, and therapy is directed at removing the potential causative agent with operative intervention when necessary. Here we present the first known case of PH in a child (...) with myotubular myopathy who was successfully treated with angiography and hepatic artery embolization as a first line therapy, without the need for operative intervention. Awareness of this condition and the available treatment modalities may lead to favorable outcomes in future cases. © 2013.

2013 Journal of Pediatric Surgery

7. Peliosis hepatitis

Peliosis hepatitis Peliosis Hepatitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Peliosis Hepatitis Peliosis Hepatitis Aka (...) : Peliosis Hepatitis , Bacillary Peliosis Hepatitis , Bacillary Peliosis II. Pathophysiology Infected cystic blood filled spaces in hepatic lobules Complication of caused by (or B. quintana) Occurs in ( <100 cells/mm3) or other immunocompromised patients III. Symptoms Weight loss IV. Management Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Peliosis Hepatitis." Click on the image (or right click) to open the source website in a new

2015 FP Notebook

8. Peliosis hepatis: Personal experience and literature review (PubMed)

Peliosis hepatis: Personal experience and literature review Peliosis hepatis (PH) is a disease characterized by multiple and small, blood-filled cysts within the parenchymatous organs. PH is a very rare disease, more common in adults, and when it affects the liver, it comes to the surgeon's attention only in an extremely urgent situation after the lesion's rupture with the resulting hemoperitoneum. This report describes the case of a 29-year-old woman affected by recurring abdominal pain (...) . Computed tomography scans showed a hepatic lesion formed by multiple hypodense areas, which showed an early acquisition of the contrast during the arterial phase. Furthermore, it remained isodense with the remaining parenchyma during the late venous phase. We decided on performing a liver resection of segment VII while avoiding a biopsy for safety reasons. The histopathologic examination confirmed the diagnosis of focal PH. PH should always be considered in the differential diagnosis of hepatic lesions

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2015 World Journal of Gastroenterology

9. Peliosis hepatis presenting with massive hepatomegaly in a patient with idiopathic thrombocytopenic purpura (PubMed)

Peliosis hepatis presenting with massive hepatomegaly in a patient with idiopathic thrombocytopenic purpura Peliosis hepatis is a rare condition that can cause hepatic hemorrhage, rupture, and ultimately liver failure. Several authors have reported that peliosis hepatis develops in association with chronic wasting disease or prolonged use of anabolic steroids or oral contraceptives. In this report we describe a case in which discontinuation of steroid therapy improved the condition of a patient (...) with peliosis hepatis. Our patient was a 64-year-old woman with a history of long-term steroid treatment for idiopathic thrombocytopenic purpura . Her symptoms included abdominal pain and weight loss; the only finding of a physical examination was hepatomegaly. We performed computed tomography (CT) and magnetic resonance imaging (MRI) of the liver and a liver biopsy. Based on these findings plus clinical observations, she was diagnosed with peliosis hepatis and her steroid treatment was terminated

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2015 Clinical and molecular hepatology

10. Atypical Hepatocellular Neoplasm With Peliosis in Cirrhotic Liver Versus Hepatocellular Carcinoma: A Diagnostic Trap. (PubMed)

Atypical Hepatocellular Neoplasm With Peliosis in Cirrhotic Liver Versus Hepatocellular Carcinoma: A Diagnostic Trap. Atypical hepatocellular neoplasm (AHN) is an adenoma-like hepatic tumor that even occurs in noncirrhotic liver of males (any age) or females ≥ 50 years old, or associates focal atypical features. In this article, 2 unusual cases diagnosed in elderly cirrhotic patients, unrelated to steroids, are presented. The first case was incidentally diagnosed in an 83-year-old female (...) . During laparoscopic surgery for cholecystectomy, hemoperitoneum was installed and laparotomy was necessary to remove a 70-mm nodular encapsulated hepatic tumor that was microscopically composed by hepatocyte-like cells with clear cytoplasm, arranged in 1- to 2-cell-thick plates and intermingled with areas of peliosis, negative for alpha fetoprotein (αFP), p53, and keratin 7, with low Ki67 index and intact reticulin framework. The second case was incidentally diagnosed at ultrasound examination

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2015 Medicine

11. Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees

Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees Copyright © ESPGHAL and NASPGHAN. All rights reserved. Hepatic Issues and Complications Associated With Inflammatory Bowel Disease: A Clinical Report From the NASPGHAN Inflammatory Bowel Disease and Hepatology Committees Lawrence J. Saubermann, y Mark Deneau, z Richard A. Falcone, § Karen F. Murray, jj Sabina Ali, Rohit Kohli (...) of the disease process, related to medication toxicity, or the result of an underlying primary hepatic disorder unrelated to IBD. This latter possibility is beyond the scope of this review article, but does need to be considered in anyone with elevated liver function tests. This review is provided as a clinical summary of some of the major hepatic issues that may occur in patients with IBD. KeyWords: autoimmune hepatitis, Crohn disease, hepatitis, in?ammatory bowel disease, primary sclerosing cholangitis

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

12. Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience (PubMed)

transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepatic peliosis, and hepatocellular plate atrophy (HPA).We identified 88 patients with non-obstructive SD. Inflammatory conditions (32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic (76%). Majority (78%) had localized SD to Zone III. Medication-related SD had higher (...) Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns.Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver

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2018 World journal of hepatology

13. Peliosis hepatis in recipients of renal transplants. (PubMed)

Peliosis hepatis in recipients of renal transplants. Peliosis hepatis, an uncommon liver lesion characterised by blood-filled cavities bordered by hepatocytic plates, was found in 12 patients three to 17 months after renal transplantation. Hepatomegaly and portal hypertension were present in five of the six patients with major peliosis hepatis, and were absent in the other six with minor hepatic lesions. Alterations of centrilobular vein walls in some of these patients suggest that peliosis

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1978 Gut

14. Peliosis Hepatis after Administration of Fluoxymesterone (PubMed)

Peliosis Hepatis after Administration of Fluoxymesterone 13756172 1998 11 01 2018 11 30 0008-4409 83 1960 Oct 15 Canadian Medical Association journal Can Med Assoc J Peliosis hepatis after administration of fluoxymesterone. 860-2 KINTZEN W W SILNY J J eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Androgens 9JU12S4YFY Fluoxymesterone OM Androgens toxicity Fluoxymesterone Hepatitis etiology Hepatitis A Humans Peliosis Hepatis ANDROGENS/toxicology HEPATITIS/etiology 1960 10 15

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1960 Canadian Medical Association Journal

15. Peliosis Hepatis

Peliosis Hepatis Peliosis Hepatis - Hepatic and Biliary Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / OTHER TOPICS IN THIS CHAPTER Test your knowledge Hepatic Fibrosis Which (...) cell lining, accompanied by dilated hepatic sinusoids. The cause is probably damage to the sinusoidal lining cells. Peliosis hepatis is associated with use of hormones (eg, anabolic steroids, oral contraceptives, glucocorticoids), tamoxifen , vinyl chloride, vitamin A, and, particularly in kidney transplant recipients, azathioprine . Peliosis hepatis is usually asymptomatic, but occasionally cysts rupture, resulting in hemorrhage and sometimes causing death. Some patients develop overt liver

2013 Merck Manual (19th Edition)

16. Spontaneous hepatic haemorrhage: a review of pathogenesis, aetiology and treatment (PubMed)

. Other causes are benign hepatic lesions (hemangioma, adenoma, focal nodular hyperplasia, nodular regenerative hyperplasia, biliary cystadenoma and angiomyelolipoma), malignant hepatic tumours (angiosarcoma, haemangioendothelioma, hepatoblastoma and rhabdoid sarcoma), peliosis hepatis, amyloid, systemic lupus erythematosis, polyarteritis nodosa, HELLP syndrome and acute fatty liver of pregnancy. Treatment practice emphasizes arterial embolization to obtain haemostasis with a hepatectomy reserved (...) Spontaneous hepatic haemorrhage: a review of pathogenesis, aetiology and treatment A spontaneous hepatic haemorrhage (SHH) is a rare condition that presents acutely to both hepatobiliary and general surgeons. Management of the condition is challenging because of the emergent presentation requiring immediate intervention, the presence of underlying chronic liver disease and the multiple potential underlying aetiological conditions.A literature search on a spontaneous hepatic haemorrhage

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2015 HPB : the official journal of the International Hepato Pancreato Biliary Association

17. Hepatic Adenoma

Hepatic Adenoma Hepatic Adenoma Imaging: Overview, Radiography, Computed Tomography Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzY5MTA0LW92ZXJ2aWV3 processing > Hepatic Adenoma Imaging Updated: Apr 08, 2016 (...) Author: Karen Kodsi Garfield, MD; Chief Editor: John Karani, MBBS, FRCR Share Email Print Feedback Close Sections Sections Hepatic Adenoma Imaging Overview Overview Hepatic adenoma is a rare, benign tumor of the liver. [ , , , ] Two types of hepatic adenoma have been identified, including tumors of bile duct origin and tumors of liver cell origin. Hepatic adenomas of bile duct origin are usually smaller than 1 cm and are not of clinical interest; typically, they are found incidentally on postmortem

2014 eMedicine Radiology

18. Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology. (PubMed)

Development of hepatic angiosarcoma in man induced by vinyl chloride, thorotrast, and arsenic. Comparison with cases of unknown etiology. Examples of human angiosarcoma following exposure to vinyl chloride, Thorotrast, or arsenic (medicinal and industrial) and cases, including children, of unknown etiology were studied to establish diagnostic criteria and to study their evolution. The uniform evolution suggests an environmental factor also in the cases of unknown etiology, which may (...) of the various sinusoidal cells proceeds to an overgrowth of angiosarcoma cells, presumably derived from endothelial cells. In early stages they are usually in contact with hepatocytes (intralobular growth). A trabecular arrangement results from loosening of the lobular plate arrangement by dilatation of sinusoids, leading to primary peliosis. With disappearance of the hepatocytes, various growth patterns develop, terminating in nodular, solid angiosarcoma composed of either spindle-shaped or polyhedral

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1978 The American journal of pathology

19. Suspected Liver Metastases

in 16.8% of patients, in which the majority of lesions (30.4%) were FNH. Other lesions such as perfusion abnormalities, post-therapy effects, and hepatic cysts made up most of the remaining new lesions. Vascular injury in the form of sinusoidal obstructive syndrome is responsible for causing some focal lesions, such as nodular regenerative hyperplasia and peliosis. This is most commonly seen after myeloablative chemotherapy prior to bone marrow transplant or with oxaliplatin-based chemotherapy (...) response to chemotherapeutic regimens. The incidence of liver metastases at the time of initial presentation of a malignancy correlates with tumor type, location, degree of differentiation, and the T and N stage of the primary tumor. Some tumors, such as colon, pancreatic cancer, lung, gastric cancer, and neuroendocrine tumors, are more predisposed to develop liver metastasis. The pathways of spread to the liver are through the portal vein, the hepatic artery, and lymphatic spread. Liver metastasis can

2016 American College of Radiology

20. Stivarga (regorafenib hydrate)

- proportionally. The C max and AUC 0-24 on Day 26 were lower than those on Day 1. The applicant explained that the lower values may be caused by hepatic drug-metabolizing enzymes induced by the repeated doses, which are involved in metabolism of regorafenib, but the definite causes 20 remain unknown [Note by PMDA: 13- and 52-week repeat-dose studies did not show such significant decrease in exposure of regorafenib as observed in the 4-week repeat-dose study]. PK parameters of regorafenib (male and female dogs

2013 Pharmaceuticals and Medical Devices Agency, Japan

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