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Pediatric Auditory Screening

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21. Initial Results of a Safety and Feasibility Study of Auditory Brainstem Implantation in Congenitally Deaf Children. (Full text)

Initial Results of a Safety and Feasibility Study of Auditory Brainstem Implantation in Congenitally Deaf Children. To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency.Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period.Tertiary children's hospital and university-based pediatric speech/language/hearing center.ABI implantation (...) and postsurgical programming.The primary outcome measure is the number and type of adverse events during ABI surgery and postsurgical follow-up, including behavioral mapping of the device. The secondary outcome measure is access to and early integration of sound.To date, nine children are enrolled. Five children have successfully undergone ABI surgery and postoperative behavioral programming. Three children were screen failures, and one child is currently undergoing candidacy evaluation. Expected adverse

2016 Otology and Neurotology PubMed

22. Safety and Tolerability Study of VTS-270 in Pediatric Participants With Niemann-Pick Type C (NPC) Disease

and running) that only measures skills to 36 months. The raw score is reported for each subscale domain. The potential score ranges are as follows: Visual Reception: 33 items, score range=0-50, Fine Motor: 30 items, score range= 0-49, Receptive Language: 33 items, score range= 0-48, Expressive Language: 28 items, score range= 0-50. A higher raw score indicates more advanced abilities in that section. Change From Baseline in Auditory Brainstem Response (ABR) Assessed Using Standard Clinical Pediatric Score (...) (hearing threshold). Other parameters of interest include amplitude (the number of neurons firing), latency (the speed of transmission), interpeak latency (the time between peaks), and interaural latency (the difference in wave V latency between ears). The interpeak latency I-V interval (or central transmission time) is considered the most reliable index of brainstem function. Auditory brainstem response assessments were based on standard clinical pediatric score criteria: mild hearing loss: 21-40

2018 Clinical Trials

23. Identification of Pure-Tone Audiologic Thresholds for Pediatric Cochlear Implant Candidacy: A Systematic Review. (PubMed)

candidacy criterion for pediatric cochlear implantation using 4 domains of speech and language development as independent outcome measures (speech production, speech perception, receptive language, and auditory performance).PubMed and Embase databases were searched up to June 28, 2017, to identify studies comparing speech and language development between children who were profoundly deaf using cochlear implants and children with severe hearing loss using hearing aids, because no studies are available (...) Identification of Pure-Tone Audiologic Thresholds for Pediatric Cochlear Implant Candidacy: A Systematic Review. Although current guidelines recommend cochlear implantation only for children with profound hearing impairment (HI) (>90 decibel [dB] hearing level [HL]), studies show that children with severe hearing impairment (>70-90 dB HL) could also benefit from cochlear implantation.To perform a systematic review to identify audiologic thresholds (in dB HL) that could serve as an audiologic

2018 JAMA otolaryngology-- head & neck surgery

24. The follow-up results of newborn hearing screening of Gaziosmanpasa Taksim Research and Training Hospital (Full text)

The follow-up results of newborn hearing screening of Gaziosmanpasa Taksim Research and Training Hospital This study aimed to present the results of newborns who were referred to advanced audiology centers after newborn hearing screening, and to determine concordance of our results with the American Academy of Pediatrics guidelines about the ages of hearing loss, aid fitting, and cochlear implantation.A total of 7502 newborns were screened in Gaziosmanpaşa Taksim Research and Training Hospital (...) between March 2014 and June 2016 using the transient otoacustic emissions test as the first two steps and automated auditory brainstem response test for the third step. Newborns who had risk factors were screened using the automated auditory brainstem response only. Newborns who failed the screening tests were referred to advanced audiology centers.Of the 7502 newborns, 6736 (90%) completed the screening. The ratio of hearing loss was 0.08%. Six of 62 newborns who failed auditory brainstem response

2018 Turkish Archives of Pediatrics/Türk Pediatri Arşivi PubMed

25. Auditory processing disorder (APD)

) Auditory Signal Processing in Hearing-Impaired Listeners. 1st International Symposium on Auditory and Audiological Research (ISAAR 2007). Denmark, Centertryk A/S, pp. 281-290. Moore D.R., Ferguson M.A., Edmondson-Jones A.M., Ratib S., Riley A. 2010. The nature of auditory processing disorder in children. Pediatr, 126, e382-e390. Musiek F.E., Bellis T.J., Chermak G.D. 2005. Nonmodularity of the CANS: Implications for (central) auditory processing disorder. Am J Audiol, 14, 128-138. Rosen S., Cohen M (...) ., Vanniasegaram I. 2010. Auditory and cognitive abilities of children suspected of auditory processing disorder (APD). Int J Pediatr Otorhinolaryngol, 74, 594-600. Schmithorst VJ, Holland SK, Plante E. 2011 Diffusion tensor imaging reveals white matter microstructure correlations with auditory processing ability. Ear Hear, 32, 156-67. Sharma M., Purdy S.C, Kelly A.S. 2009. Comorbidity of auditory processing, language, and reading disorders. J Speech Lang Hear Res, 52, 706-22. Watson C.S., Kidd G.R. 2009

2011 British Society of Audiology

26. The economics of screening infants at risk of hearing impairment: an international analysis

and the results were reported adequately. The methods were not well reported and so it is difficult to assess the authors' conclusions. Type of economic evaluation Cost-effectiveness analysis Study objective To estimate the cost-effectiveness of different screening strategies for detecting hearing impairment in infants. Interventions The study made two unique comparisons. Universal screening with transient evoked otoacoustic emissions (TEOAE) or automated auditory brainstem response (AABR) was compared (...) : The methodology was appropriate and the results were reported adequately. The methods were not well reported and so it was difficult to assess the authors' conclusions. Bibliographic details Burke MJ, Shenton RC, Taylor MJ. The economics of screening infants at risk of hearing impairment: an international analysis. International Journal of Pediatric Otorhinolaryngology 2012; 76(2): 212-218 PubMedID DOI Original Paper URL Indexing Status Subject indexing assigned by NLM MeSH Cohort Studies; Cost-Benefit

2012 NHS Economic Evaluation Database.

27. Newborn Screening for Krabbe Leukodystrophy: A Review of the Clinical and Cost Effectiveness and Guidelines

average $U.S.1,475 per infant screened positive for Krabbe disease. These cost included DNA analysis for both parents and the infant, a confirmatory enzyme test for the infant, venipuncture, and a consultation by a metabolic specialist. Additional evaluation costs for infants with a positive confirmatory test were estimated average $U.S.2,669. These costs included hospital admission, a neurology consult, a nerve conduction study, a brainstem auditory evokes response study, and an MRI with and without (...) spots for newborn screening. Clin Chem. 2004 Oct;50(10):1785-96. 7. Li Y, Brockmann K, Turecek F, Scott CR, Gelb MH. Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: application to newborn screening for Krabbe disease. Clin Chem. 2004 Mar;50(3):638-40. 8. Duffner PK, Caggana M, Orsini JJ, Wenger DA, Patterson MC, Crosley CJ, et al. Newborn screening for Krabbe disease: the New York State model. Pediatr Neurol. 2009 Apr;40(4):245-52. 9. National Newborn Screening

2012 Canadian Agency for Drugs and Technologies in Health - Rapid Review

28. Long-Term Variability of Distortion-Product Otoacoustic Emissions in Infants and Children and Its Relation to Pediatric Ototoxicity Monitoring. (PubMed)

Long-Term Variability of Distortion-Product Otoacoustic Emissions in Infants and Children and Its Relation to Pediatric Ototoxicity Monitoring. Distortion-product otoacoustic emissions (DPOAEs) provide a rapid, noninvasive measure of outer hair cell damage associated with chemotherapy and are a key component of pediatric ototoxicity monitoring. Serial monitoring of DPOAE levels in reference to baseline measures is one method for detecting ototoxic damage. Interpreting DPOAE findings (...) in this context requires that test-retest differences be considered in relation to normal variability, data which are lacking in children. This study sought to (1) characterize normal test-retest variability in DPOAE level over the long time periods reflective of pediatric chemotherapy regimens for a variety of childhood ages and f2 primary frequencies using common clinical instrumentation and stimulus parameters; (2) develop level-shift reference intervals; and (3) account for any age-related change in DPOAE

2017 Ear and hearing

29. Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis

auditory assessments up to 24 weeks [ Time Frame: Baseline up to approximately 24 weeks ] Auditory assessments will be performed at screening, EOT and as needed basis: comprehensive audiometry threshold examination, speech recognition. The data will be summarized using the Safety set. Clinically significant abnormalities will be reported as adverse events. Absolute change for ALT(alanine aminotransferase) up to 24 weeks [ Time Frame: Baseline up to approximately 24 weeks ] To assess the overall safety (...) Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis Safety Study of Crushed Deferasirox Film Coated Tablets in Pediatric Patients With Transfusional Hemosiderosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2017 Clinical Trials

30. A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD)

A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD) A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved (...) Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Safety, Pharmacokinetic, Single Ascending Dose Study of Tesevatinib in Pediatric Subjects With Autosomal Recessive Polycystic Kidney Disease (ARPKD) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical

2017 Clinical Trials

31. Targeting regional pediatric congenital hearing loss using a spatial scan statistic. (Full text)

Targeting regional pediatric congenital hearing loss using a spatial scan statistic. Congenital hearing loss is a common problem, and timely identification and intervention are paramount for language development. Patients from rural regions may have many barriers to timely diagnosis and intervention. The purpose of this study was to examine the spatial and hospital-based distribution of failed infant hearing screening testing and pediatric congenital hearing loss throughout Kentucky.Data (...) significant (p < 0.05) high-rate clusters with failed newborn hearing screenings in Kentucky, including two in the Appalachian region. Hospitals using two-stage otoacoustic emission testing demonstrated higher rates of failed screening (p = 0.009) than those using two-stage automated auditory brainstem response testing. A significant cluster of high rate of PCHL was observed in Western Kentucky. Five of the 54 birthing hospitals were found to have higher relative risk of PCHL, and two of those hospitals

2017 Ear and hearing PubMed

32. Management of Pediatric Cervical Spine and Spinal Cord Injuries (Full text)

Management of Pediatric Cervical Spine and Spinal Cord Injuries We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Management of Pediatric Cervical Spine and Spinal Cord Injuries | Neurosurgery | Oxford Academic Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation (...) Article navigation March 2013 Article Contents Article Navigation Management of Pediatric Cervical Spine and Spinal Cord Injuries Curtis J. Rozzelle, MD *Division of Neurological Surgery, Children's Hospital of Alabama University of Alabama at Birmingham, Birmingham Alabama Search for other works by this author on: Bizhan Aarabi, MD, FRCSC ‡Department of Neurosurgery, University of Maryland, Baltimore, Maryland Search for other works by this author on: Sanjay S. Dhall, MD §Department of Neurosurgery

2013 Congress of Neurological Surgeons PubMed

33. Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study. (Full text)

Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study. Hearing loss rates in infants admitted to neonatal intensive care units (NICU) run at 2-15%, compared to 0.3% in full-term births. The etiology of this difference remains poorly understood. We examined whether the level of ambient sound and/or cumulative gentamicin (an aminoglycoside) exposure affect NICU hearing screening results, as either exposure can cause (...) acquired, permanent hearing loss. We hypothesized that higher levels of ambient sound in the NICU, and/or gentamicin dosing, increase the risk of referral on the distortion product otoacoustic emission (DPOAE) assessments and/or automated auditory brainstem response (AABR) screens.This was a prospective pilot outcomes study of 82 infants (<37 weeks gestational age) admitted to the NICU at Oregon Health & Science University. An ER-200D sound pressure level dosimeter was used to collect daily sound

2017 International Journal of Pediatric Otorhinolaryngology PubMed

34. SELECTIVE DEVELOPMENTAL ALTERATIONS IN THE HIV-1 TRANSGENIC RAT: OPPORTUNITIES FOR DIAGNOSIS OF PEDIATRIC HIV-1 (Full text)

SELECTIVE DEVELOPMENTAL ALTERATIONS IN THE HIV-1 TRANSGENIC RAT: OPPORTUNITIES FOR DIAGNOSIS OF PEDIATRIC HIV-1 Since the advent of combination antiretroviral therapy (cART), pediatric HIV-1 (PHIV) has evolved from a fatal disease to a chronic disease as children perinatally infected with HIV-1 survive into adulthood. The HIV-1 transgenic (Tg) rat, which expresses 7 of the 9 HIV-1 genes constitutively throughout development, was used to model the early development of chronic neurological (...) of the forebrain cholinergic inhibitory system. Alterations in the development of PPI and perceptual sharpening were observed in both auditory and visual PPI as indexed by a relative insensitivity to the dimension of time (msec for ISI; days of age for perceptual sharpening) as a function of the HIV-1 transgene. Presence of the HIV-1 transgene was diagnosed with 97.1 % accuracy using auditory and visual PPI measurements from PD 17 and 21. Early selective developmental alterations observed in the HIV-1 Tg rats

2016 Journal of neurovirology PubMed

35. Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America

(Guthrie's test) Cranial ultrasound Screening test for hearing capabilities by auditory evoked potentials Fundus of the eye or retinal image capture by RetCam®. Follow-up from Day 4 to 2 years: - Clinical examination focusing on neuropsychomotor development at the 2nd, 4th, 9th, 18th and 24th month. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 2220 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Études (...) Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America Zika Virus Infection's Neonatal and Pediatric Consequences in French Department of America - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2016 Clinical Trials

36. Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis

Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Trial on Safety and Efficacy of Velmanase Alfa Treatment in Pediatric Patients With Alpha-Mannosidosis (rhLaman-08) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02998879 Recruitment Status : Active, not recruiting First Posted : December 21, 2016 Last

2016 Clinical Trials

37. Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review. (Full text)

Patient-Reported Measures of Hearing Loss and Tinnitus in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review. We identified studies that described use of any patient-reported outcome scale for hearing loss or tinnitus among children and adolescents and young adults (AYAs) with cancer or hematopoietic stem cell transplantation (HSCT) recipients.In this systematic review, we performed electronic searches of OvidSP MEDLINE, EMBASE, and PsycINFO to August 2015. We (...) included studies if they used any patient-reported scale of hearing loss or tinnitus among children and AYAs with cancer or HSCT recipients. Only English language publications were included. Two reviewers identified studies and abstracted data.There were 953 studies screened; 6 met eligibility criteria. All studies administered hearing patient-reported outcomes only once, after therapy completion. None of the studies described the psychometric properties of the hearing-specific component. Three

2016 Journal of speech, language, and hearing research : JSLHR PubMed

38. Children with ANSD fitted with hearing aids applying the AAA Pediatric Amplification Guideline: Current Practice and Outcomes (Full text)

Children with ANSD fitted with hearing aids applying the AAA Pediatric Amplification Guideline: Current Practice and Outcomes Up to 15% of children with permanent hearing loss (HL) have auditory neuropathy spectrum disorder (ANSD), which involves normal outer hair cell function and disordered afferent neural activity in the auditory nerve or brainstem. Given the varying presentations of ANSD in children, there is a need for more evidence-based research on appropriate clinical interventions (...) for this population.This study compared the speech production, speech perception, and language outcomes of children with ANSD, who are hard of hearing, to children with similar degrees of mild-to-moderately severe sensorineural hearing loss (SNHL), all of whom were fitted with bilateral hearing aids (HAs) based on the American Academy of Audiology pediatric amplification guidelines.Speech perception and communication outcomes data were gathered in a prospective accelerated longitudinal design, with entry

2016 Journal of the American Academy of Audiology PubMed

39. A Systematic Review to Define the Speech and Language Benefit of Early (<12 Months) Pediatric Cochlear Implantation. (Full text)

A Systematic Review to Define the Speech and Language Benefit of Early (<12 Months) Pediatric Cochlear Implantation. This review aimed to evaluate the additional benefit of pediatric cochlear implantation before 12 months of age considering improved speech and language development and auditory performance.We conducted a search in PubMed, EMBASE and CINAHL databases and included studies comparing groups with different ages at implantation and assessing speech perception and speech production (...) balanced kindergarten combined with consonant-nucleus-consonant) but not on Glendonald auditory screening procedure scores. Implantation before 12 months resulted in better speech production (diagnostic evaluation of articulation and phonology and infant-toddler meaningful auditory integration scale), auditory performance (Categories of Auditory Performance-II score) and receptive language scores (2 out of 5; Preschool Language Scale combined with oral and written language skills and Peabody Picture

2016 Audiology & Neuro-Otology PubMed

40. Genetic Screening of Anderson-Fabry Disease in Probands Referred From Multispecialty Clinics. (PubMed)

is 0.62%, with diagnosis confirmation in 0.12%.This study sought to expand screening from these settings to include ophthalmology, dermatology, gastroenterology, internal medicine, pediatrics, and medical genetics to increase diagnostic yield and comprehensively evaluate organ involvement in AFD patients.In a 10-year prospective multidisciplinary, multicenter study, we expanded clinical, genetic, and biochemical screening to consecutive patients enrolled from all aforementioned clinical settings. We (...) Genetic Screening of Anderson-Fabry Disease in Probands Referred From Multispecialty Clinics. Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants

2016 Journal of the American College of Cardiology

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