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Pathergy

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121. 'Sticky' neutrophils, pathergic arthritis, and response to heparin in pyoderma gangrenosum complicating ulcerative colitis. (PubMed)

'Sticky' neutrophils, pathergic arthritis, and response to heparin in pyoderma gangrenosum complicating ulcerative colitis. Pyoderma gangrenosum is strongly associated with inflammatory bowel disease and exhibits pathergy, occurring at sites of previous minor trauma. A patient is presented with a 21 year history of extensive ulcerative colitis, who developed pyoderma gangrenosum and arthralgia while receiving high dose corticosteroids for active ulcerative colitis. The arthralgia exhibited (...) pathergy affecting particularly the left temporomandibular joint, which was stressed by an asymmetric bite, and the left elbow, which had been fractured many years previously. This prompted the hypothesis that neutrophils in this condition may be marginated, as a result of increased stickiness of either the neutrophil or the vascular endothelium. The introduction of heparin therapy was associated with rapid resolution of the arthralgia, pyoderma gangrenosum, and ulcerative colitis.

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1995 Gut

122. A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients. (PubMed)

% and the most common location was the trunk, whereas in the control group the frequency was 89% and the most common location was the face. In acne and non-acne patients, the frequency was 100% and 86.1% respectively. The total mean number, and mean numbers of PPL on the location of trunk, upper and lower extremities, and genitalia were higher in patients with BD than in controls. When the PPL in BD patients with a positive pathergy test was compared with that in patients with a negative pathergy test

1998 International journal of dermatology

123. Dapsone in Behçet's disease: a double-blind, placebo-controlled, cross-over study. (PubMed)

100 mg daily or placebo for three months in a double-blind manner. After three months, patients were crossed over and followed for a further three months. Patients were followed up in each visit by assessing the number, size, duration and frequency of oral and genital ulcers, other cutaneous manifestations, and systemic manifestations of the disease. A pathergy test was done on each visit. Laboratory investigations included hemoglobin concentration, white blood cell count, ESR, and C-reactive (...) protein. In dapsone-treated patients, there were significant reductions in the oral and genital ulcer parameters as well as the incidence of other cutanous and systemic manifestations. In the placebo-treated group, there were no significant changes in these parameters. The pathergy test result as well as those of other laboratory tests were all decreased in the dapsone-treated group. Although this study was a small scale study, it shows that dapsone was effective in treatment of mucocutaneous

2002 The Journal of dermatology

124. Prevalence of Behçet's disease in an Arab community in Israel (PubMed)

lasting more than seven days) during the previous year were invited for an extensive interview and examination by a rheumatologist or a paediatrician.A total of 4876 subjects were included in this survey, of whom six (one male, five female) were diagnosed as having BD. Of these six, two were siblings (a brother and a sister). Five had skin lesions, four had visual involvement, and all had genital ulcers and joint symptoms; one in two patients had a positive pathergy test. Five of the six carried HLA

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2002 Annals of the Rheumatic Diseases

125. Response to intradermal injection of monosodium urate crystals in Behçet's syndrome. (PubMed)

Response to intradermal injection of monosodium urate crystals in Behçet's syndrome. The cutaneous response to intradermal injection of monosodium urate crystals was investigated in 97 patients with Behçet's syndrome in Turkey and 14 in the United Kingdom, and in 82 healthy and 88 diseased controls. Urate crystals produced an increased erythematous response in patients compared with controls in both countries. This response was different from that of the pathergy test performed at the same

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1991 Annals of the Rheumatic Diseases

126. Behçet's disease in Iraqi patients. (PubMed)

, mainly the knees and ankles. The pathergy test was positive in 37 of 52 patients with BD, and negative in all 120 healthy controls and in 20 healthy volunteers who possessed the HLA-B51 antigen. HLA-B51 was present in 32 of 52 (62%) patients with BD compared with 51 of 175 (29%) unrelated normal controls. Both the pathergy and HLA-B51 tests were negative in four of 52 patients with BD. Behçet's disease is not uncommon in Iraq. Practising physicians, dermatologists, and ophthalmologists must be more

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1986 Annals of the Rheumatic Diseases

127. Pathergy in non-Hodgkin lymphoma (PubMed)

Pathergy in non-Hodgkin lymphoma 12612114 2003 04 10 2018 11 13 0141-0768 96 3 2003 Mar Journal of the Royal Society of Medicine J R Soc Med Pathergy in non-Hodgkin lymphoma. 127-9 Burney Ikram A IA Department of Medicine, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan. ikram.burney@aku.edu Moatter Tariq T Siddiqui Tariq T Yaqoob Nausheen N eng Case Reports Journal Article England J R Soc Med 7802879 0141-0768 IM Adult Biopsy Bone and Bones pathology Diagnosis

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2003 Journal of the Royal Society of Medicine

128. Pathergy reaction in different body areas in Behçet's disease. (PubMed)

Pathergy reaction in different body areas in Behçet's disease. Behçet's disease (BD) is a chronic inflammatory multisystemic disorder characterized mainly by vasculitis. Although the pathergy reaction (PR) has been accepted as one of the major criteria in this disease, there is a lack of a standardized method to measure PR. The aim of this study was to evaluate results of PR in different body areas and the effect on the positive rate of PR of application of numerous needle pricks. The pathergy

2007 Clinical & Experimental Dermatology

129. Pathergy in atypical eosinophilic pustular folliculitis. (PubMed)

Pathergy in atypical eosinophilic pustular folliculitis. A 15-year-old, unmarried female presented to our dermatology department for an intensely pruritic skin rash that had appeared abruptly 3 days earlier. She had a remarkable medical history for a case of allergic rhinitis and several attacks of asthma in her early childhood. The condition waxed and waned initially but had improved in recent years. Physical examination revealed several erythematous plaques, papules studded with scattered (...) , a diagnosis of eosinophilic pustular folliculitis with pathergy was made. Systemic prednisolone 30 mg in divided doses was given. After 1 week of systemic corticosteroid therapy, the patient's condition was significantly improved and the patient was subsequently discharged. Two months later she had a relapse, upon which corticosteroid therapy was commenced leading to lesional resolution. The foci of eosinophilic folliculitis healed with areas of hyperpigmentation with variable scarring.

2005 International Journal of Dermatology

130. Pathergy (PubMed)

Pathergy 17452660 2007 05 10 2018 11 13 1488-2329 176 9 2007 Apr 24 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Pathergy. 1275-6 Madan Vishal V The Dermatology Centre, Hope Hospital, Salford, United Kingdom. Lear John J eng Case Reports Journal Article Canada CMAJ 9711805 0820-3946 AIM IM Adult Behcet Syndrome diagnosis Diagnosis, Differential Erythema diagnosis Humans Male Skin Diseases, Vesiculobullous diagnosis 2007 4 25 9 0 2007 5 11 9 0

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2007 CMAJ : Canadian Medical Association Journal

131. Usefulness of HLA determination and pathergy test in the diagnosis of uveitis in Turkey. (PubMed)

Usefulness of HLA determination and pathergy test in the diagnosis of uveitis in Turkey. 6976795 1982 04 20 2018 11 13 0007-1161 65 11 1981 Nov The British journal of ophthalmology Br J Ophthalmol Usefulness of HLA determination and pathergy test in the diagnosis of uveitis in Turkey. 798-9 Ozyazgan Y Y Pazarli H H Yazici H H Yurdakul S S Tüzün Y Y Altaç M M Ulkü B B Müftüoğlu A A eng Journal Article England Br J Ophthalmol 0421041 0007-1161 0 HLA Antigens 0 HLA-B27 Antigen IM Adolescent Adult

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1981 The British journal of ophthalmology

132. The pathergy test and Behçet's syndrome in Britain. (PubMed)

The pathergy test and Behçet's syndrome in Britain. Skin hypersensitivity to needle puncture (pathergy test) together with a positive HLA B5 antigen has been reported as a diagnostic test for Behçet's syndrome (BS) in Turkish patients. We have studied the pathergy test by 2 methods in 7 healthy volunteers who have the HLA B5(Bw 51 split) antigen and 19 patients with BS. The test was negative in all the normal volunteers and only one of the 19 patients with BS had a positive test by one (...) of the 2 methods. Cluster analysis of our patients and those reported from Turkey showed no difference in their clinical features. The positivity of the pathergy test, and hence its diagnostic usefulness, seem to differ between Britain and Turkey, and we conclude that this difference is not related to the possession of the HLA B5 (Bw 51 split) antigen.

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1984 Annals of the Rheumatic Diseases

133. A comparative study of the pathergy reaction among Turkish and British patients with Behçet's disease. (PubMed)

A comparative study of the pathergy reaction among Turkish and British patients with Behçet's disease. Forty-eight Turkish and 12 British patients along with 24 Turkish and 7 British healthy controls were assessed for the presence of the pathergy phenomenon. A photographic method with 'blind' reading was utilised. The pathergy phenomenon was present only among the Turkish patients.

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1984 Annals of the Rheumatic Diseases

134. Effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome. (PubMed)

Effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome. To assess the effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome.The pathergy phenomenon was assessed in 183 patients with Behçet's syndrome in a single blind study at 48 hours after a needle prick of the forearm skin, cleaned in the conventional way with alcohol, with 10% povidine iodine, with 100% chlorhexidine, and with a 4% aqueous solution of chlorhexidine.The (...) surgical cleaning of the forearm with povidone iodine before the application of the needle prick reduced the prevalence of the pathergy reaction to 27% from 48% in the conventionally (by alcohol swab) cleaned forearm. Cleaning the forearm with 100% chlorhexidine reduced the prevalence of the pathergy to 36% from 59% in the conventionally cleaned forearm. No significant changes were observed with a 4% aqueous solution of chlorhexidine.Surgical cleaning of the skin with disinfectants of various

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1993 Annals of the Rheumatic Diseases

135. Comparative study of the skin pathergy test with blunt and sharp needles in Behçet's disease: confirmed specificity but decreased sensitivity with sharp needles. (PubMed)

Comparative study of the skin pathergy test with blunt and sharp needles in Behçet's disease: confirmed specificity but decreased sensitivity with sharp needles. To compare the specificity and sensitivity of the skin pathergy test performed with blunt and sharp needles in patients with Behçet's disease.The skin pathergy test was performed using the simultaneous four needle prick method with blunt and sharp, thick and thin needles in 92 patients with Behçet's disease, 64 healthy controls (...) , and 128 patients without Behçet's disease. The test was evaluated at 48 hours.No positive skin pathergy test was found in healthy controls and patients without Behçet's disease. The frequency and intensity of the positive skin pathergy test with blunt needles were significantly higher than those with sharp needles.This study reconfirmed the specificity of a positive skin pathergy test for Behçet's disease using blunt and sharp needles and showed a decreased sensitivity and intensity of the reaction

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1993 Annals of the Rheumatic Diseases

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