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Pathergy

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41. Behçet's disease departs the ‘Silk Road’: a case report and brief review of literature with geographical comparison Full Text available with Trip Pro

showed findings typically seen in Western patients with BD, which include intestinal manifestations, cardiac involvement, and lack of pathergy reaction and ocular changes. Our investigation demonstrates that the clinical manifestations common to this disorder vary among geographic and ethnic populations. Commonly used criteria for the diagnosis of BD may not be sensitive for some populations, such as Western BD, potentially leading to underdiagnoses and mismanagement. Recognition and select inclusion

2016 Journal of community hospital internal medicine perspectives

42. Successful treatment of Behçet’s uveitis with Tocilizumab Full Text available with Trip Pro

Successful treatment of Behçet’s uveitis with Tocilizumab A 33-year-old man with history of lymphoma was misdiagnosed as multiple sclerosis (MS) 18 months previously, developed intermediate uveitis, unresponsive to interferon, and corticosteroids. A diagnosis of Behçet's disease (BD) was made on the basis of recurrent orogenital ulceration, erythema nodosum, and a positive pathergy test. The patient was started on Tocilizumab and experienced an improvement in visual acuity and intraocular

2016 Saudi Journal of Ophthalmology

43. Severe Bilateral Lower Extremity Pyoderma Gangrenosum Full Text available with Trip Pro

of Surgery, University of South Florida Morsani College of Medicine, Tampa. Payne Wyatt G WG C.W. Bill Young Bay Pines VA Medical Center, Bay Pines, Fla. eng Case Reports 2016 11 21 United States Eplasty 101316107 1937-5719 TNF-α inhibitors lower extremities pathergy pyoderma gangrenosum wound 2016 12 17 6 0 2016 12 17 6 0 2016 12 17 6 1 epublish 27980702 PMC5120372 Wounds. 2009 Apr;21(4):89-94 25903230 Am J Clin Dermatol. 2012 Jun 1;13(3):191-211 22356259 Br J Dermatol. 2015 Jun;172(6):1487-97 25350484

2016 Eplasty

44. Postoperative Pyoderma Gangrenosum: A Clinical Review of Published Cases. Full Text available with Trip Pro

Postoperative Pyoderma Gangrenosum: A Clinical Review of Published Cases. Postoperative pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by PG at surgical incisions. It is often misdiagnosed as wound infection, and pathergy may complicate wound debridement. From September 1, 2013, through November 30, 2013, a literature search was conducted of articles published from January 1, 1978, through December 31, 2012. We referenced PubMed, MEDLINE, and Mayo Clinic Libraries using

2016 Mayo Clinic Proceedings

45. Pyoderma gangrenosum during pregnancy - treatment options revisited. (Abstract)

for the health of the mother and the unborn.In pregnant females, it is particularly important to diagnose PG and control disease activity due to the risk of pathergy and wound healing deficiencies during delivery and post-partum. A limited number of treatment options are available to date, which require a precise risk-benefit evaluation.© 2016 European Academy of Dermatology and Venereology.

2016 Journal of the European Academy of Dermatology and Venereology

46. Ulcus vulvae acutum — A case of genital ulcers in adolescent girl Full Text available with Trip Pro

, inflammatory, traumatic, and neoplastic causes. We describe a case of adolescent female with an episode of ulcus vulvae acutum associated with infectious mononucleosis. The diagnosis was supported by the clinical symptoms, elevated circulating levels of liver enzymes, positive EBV serology, cervical and inguinal lymphadenomegaly, and hepatosplenomegaly. The patient presented a history of aphthous stomatitis. Negative Pathergy test and the absence of any other related symptoms allowed us to exclude

2015 Case Reports in Women's Health

47. Behçet's disease in black skin. A retrospective study of 50 cases in Dakar. Full Text available with Trip Pro

women. Two patients had a positive family history of Behçet's disease. The oral and genital aphthous lesions were present in 100% of patients. The pathergy test was positive in 16 patients (32%). Following skin conditions were observed: pseudofolliculitis in 15 patients (30%), acneiform papules in 6 patients (12%), erythema nodosum in 4 patients (8%) and leg ulcers in one patient. Ocular involvement was reported in 22 patients (44%) and joint involvement in 20 patients (40%). Neurological

2015 Journal of dermatological case reports

48. Use of Becaplermin for nondiabetic ulcers: pyoderma gangrenosum and calciphylaxis Full Text available with Trip Pro

gangrenosum (PG), a neutrophilic dermatosis. We also report that topical collagenase worsened PG ulcers, consistent with pathergy. Becaplermin can be used to help treat ulcers resulting from calciphylaxis and PG. These encouraging results lend support for the utilization of becaplermin in the treatment of nondiabetic chronic ulcers of various etiologies. © 2015 Wiley Periodicals, Inc.

2015 Dermatologic therapy

49. Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran Full Text available with Trip Pro

correlations do not survive Bonferroni correction, while carriers of the rs76546355 risk allele predominate in BD cases with genital ulcers, positive pathergy test and positive BD family history (2.31 × 10(-4) ≤ P ≤ 1.59 × 10(-3)).We found that the HLA-B*51 allele and the rs76546355/rs116799036 MHC SNP are independent genetic risk factors for BD in Iranian, and that positivity for the rs76546355/rs116799036 risk allele, but not for B*51, does correlate with specific demographic characteristics or clinical

2015 Arthritis research & therapy

50. Interleukin-10 gene polymorphisms are associated with Behcet’s disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population Full Text available with Trip Pro

with extraocular findings, including genital ulcers, skin lesions, and a positive pathergy test. No difference was found among the mRNA expressions of IL-10 in the peripheral blood mononuclear cells (PBMCs) of controls with different genotypes of rs1800871 after stimulation of lipopolysaccharide (LPS) or anti-CD3/CD28 antibodies.The findings showed that IL-10 is a risk gene for BD but not for VKH syndrome.

2015 Molecular vision

52. An unusual case of bilateral Pyoderma Gangrenosum with Achilles tendon rupture. (Abstract)

after the left ankle developed a foul-smelling discharging wound. Repeat debridement led to worsening of the condition (pathergy). Intraoperative tissue cultures and microscopy showed no evidence of fungi, bacteria or mycobacteria. Histology showed granulation, inflammatory infiltrate, abscess formation and focal necrotizing vasculitis. Dermatology opinion confirmed PG. Awareness of the diagnosis of PG, and early involvement of dermatology, in a rapidly progressing wound is essential to avoid (...) delayed treatment and prevent worsening through pathergy. © 2014 British Association of Dermatologists.

2014 British Journal of Dermatology

53. Sweet's syndrome following surgery: Cutaneous trauma as a possible aetiological co-factor in neutrophilic dermatoses. (Abstract)

with the development of Sweet's syndrome and resolution was obtained after the initiation of dapsone. We propose that surgery may produce an acute inflammatory response in a similar manner to pathergy reactions, which play an aetiological role in other neutrophilic dermatoses, such as pyoderma gangrenosum. We conclude that there may be greater overlap between these neutrophilic dermatoses than previously appreciated. © 2014 The Australasian College of Dermatologists.

2014 Australasian Journal of Dermatology

54. Behcet Disease (Follow-up)

Spontaneous arterial aneurysm formation Thrombotic obstruction in large-caliber vessels Cardiac involvement Proper timing for surgical treatment is important. Delayed wound healing or inflammation at operative sites may be related to pathergy. Previous Next: Consultations Consultation with the following specialists may be necessary: Dermatologist - For evaluation of mucocutaneous lesions (ie, oral ulcer, genital ulcer, skin lesions) Ophthalmologist - For evaluation of eye involvement Rheumatologist (...) thrombomodulin and pathergy test in Behcet disease. Ann Rheum Dis . 2008 Jun. 67(6):892-3. . Espinosa G, Font J, Tàssies D, Vidaller A, Deulofeu R, López-Soto A, et al. Vascular involvement in Behçet's disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med . 2002 Jan. 112(1):37-43. . Usküdar O, Erdem A, Demiroglu H, Dikmenoglu N. Decreased erythrocyte deformability in Behçet's disease. Clin Hemorheol Microcirc . 2005. 33(2):89-94. . Akar S, Ozcan MA, Ates H, Gürler

2014 eMedicine.com

55. Pyoderma Gangrenosum (Diagnosis)

diseases, diabetes, and trauma. In a process termed pathergy, new ulcerations may occur after trauma or injury to the skin in 30% of patients who already have pyoderma gangrenosum. (See , , and .) Patients with pyoderma gangrenosum may have involvement of other organ systems that manifests as sterile neutrophilic infiltrates. Culture-negative pulmonary infiltrates are the most common extracutaneous manifestation. [ , ] Other organs systems that may be involved include the heart, the central nervous (...) fail. These patients pose a difficult clinical problem that requires frequent follow-up and long-term care. Some patients demonstrate pathergy, or the development of pyoderma gangrenosum–like lesions at the site of skin trauma; in such instances, protection of the skin from trauma may prevent a recurrence of the disease. Pathergy may create problems with wound healing, especially after surgical procedures (eg, breast reconstruction). [ , ] Death from pyoderma gangrenosum is rare, but it may occur

2014 eMedicine.com

56. Pyoderma Gangrenosum (Overview)

diseases, diabetes, and trauma. In a process termed pathergy, new ulcerations may occur after trauma or injury to the skin in 30% of patients who already have pyoderma gangrenosum. (See , , and .) Patients with pyoderma gangrenosum may have involvement of other organ systems that manifests as sterile neutrophilic infiltrates. Culture-negative pulmonary infiltrates are the most common extracutaneous manifestation. [ , ] Other organs systems that may be involved include the heart, the central nervous (...) fail. These patients pose a difficult clinical problem that requires frequent follow-up and long-term care. Some patients demonstrate pathergy, or the development of pyoderma gangrenosum–like lesions at the site of skin trauma; in such instances, protection of the skin from trauma may prevent a recurrence of the disease. Pathergy may create problems with wound healing, especially after surgical procedures (eg, breast reconstruction). [ , ] Death from pyoderma gangrenosum is rare, but it may occur

2014 eMedicine.com

57. Subcorneal Pustular Dermatosis (Overview)

in association with rheumatoid arthritis. Br J Dermatol . 1995 Feb. 132(2):313-5. . Lin RY, Schwartz RA, Lambert WC. Subcorneal pustular dermatosis with polyarthritis. Cutis . 1986 Feb. 37(2):123-4, 126. . Delaporte E, Colombel JF, Nguyen-Mailfer C, Piette F, Cortot A, Bergoend H. Subcorneal pustular dermatosis in a patient with Crohn's disease. Acta Derm Venereol . 1992 Aug. 72 (4):301-2. . García-Salces I, Baldellou R, Hörndler C, Zubiri ML. Subcorneal pustular dermatosis with pathergy phenomenon

2014 eMedicine.com

58. Behcet Disease (Treatment)

Spontaneous arterial aneurysm formation Thrombotic obstruction in large-caliber vessels Cardiac involvement Proper timing for surgical treatment is important. Delayed wound healing or inflammation at operative sites may be related to pathergy. Previous Next: Consultations Consultation with the following specialists may be necessary: Dermatologist - For evaluation of mucocutaneous lesions (ie, oral ulcer, genital ulcer, skin lesions) Ophthalmologist - For evaluation of eye involvement Rheumatologist (...) thrombomodulin and pathergy test in Behcet disease. Ann Rheum Dis . 2008 Jun. 67(6):892-3. . Espinosa G, Font J, Tàssies D, Vidaller A, Deulofeu R, López-Soto A, et al. Vascular involvement in Behçet's disease: relation with thrombophilic factors, coagulation activation, and thrombomodulin. Am J Med . 2002 Jan. 112(1):37-43. . Usküdar O, Erdem A, Demiroglu H, Dikmenoglu N. Decreased erythrocyte deformability in Behçet's disease. Clin Hemorheol Microcirc . 2005. 33(2):89-94. . Akar S, Ozcan MA, Ates H, Gürler

2014 eMedicine.com

59. Pyoderma Gangrenosum (Treatment)

conditions. Surgery Surgery should be avoided, if possible, because of the pathergic phenomenon that may occur with surgical manipulation or grafting, resulting in wound enlargement. [ ] Pathergy is seen in about 30% of cases. In some patients, grafting has resulted in the development of pyoderma gangrenosum at the harvest site. In cases in which surgery is required, the best plan, if possible, is to have the patient on therapy, and active disease under control, in order to prevent pathergy. Some

2014 eMedicine.com

60. Subcorneal Pustular Dermatosis (Treatment)

, Schwartz RA, Lambert WC. Subcorneal pustular dermatosis with polyarthritis. Cutis . 1986 Feb. 37(2):123-4, 126. . Delaporte E, Colombel JF, Nguyen-Mailfer C, Piette F, Cortot A, Bergoend H. Subcorneal pustular dermatosis in a patient with Crohn's disease. Acta Derm Venereol . 1992 Aug. 72 (4):301-2. . García-Salces I, Baldellou R, Hörndler C, Zubiri ML. Subcorneal pustular dermatosis with pathergy phenomenon in a patient with Crohn's disease. J Eur Acad Dermatol Venereol . 2009 Mar. 23 (3):349-50

2014 eMedicine.com

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