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21. Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease. (PubMed)

in patients with ocular BD (p=1.94×10-5, pc=8.34×10-4, OR=0.466). Stratification according to gender showed that rs7234029 was significantly associated with BD in men. A stratified analysis according to the main clinical features showed that rs7234029 was significantly associated with genital ulcers, skin lesions and a positive pathergy test. No association could be detected between BD and CD122 gene polymorphisms. Functional studies showed that rs7234029 GG genotype carriers had a higher PNPT2 mRNA

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2018 British Journal of Ophthalmology

22. The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum. (PubMed)

(17.7) years. Pathergy was recorded in 100 patients (28.1%). A total of 238 patients (66.9%) had associated medical comorbidities: inflammatory bowel disease in 146 patients (41.0%); inflammatory arthritis in 73 patients (20.5%); solid organ malignant neoplasms in 23 patients (6.5%); hematologic malignant neoplasms in 21 patients (5.9%); and hematologic disorders, specifically monoclonal gammopathy of undetermined significance, myelodysplastic syndrome, and polycythemia vera in 17 patients (4.8 (...) %). When stratified by age, pathergy was more common in patients 65 years or older (36.3% vs 24.3%; P = .02). Inflammatory bowel disease was the only medical comorbidity that was more common in patients younger than 65 years (47.7% vs 26.6%; P < .001), while a number of medical comorbidities were more common in those 65 years or older, including rheumatoid arthritis (13.3% vs 6.2%; P = .03), ankylosing spondylitis (1.8% vs 0%; P = .04), solid organ malignant neoplasms (13.3% vs 3.3%; P < .001

2018 JAMA dermatology (Chicago, Ill.)

23. Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. (PubMed)

Appropriateness Method. The criteria were validated against peer-reviewed established cases of pyoderma gangrenosum and mimickers using k-fold cross-validation with methods of multiple imputation.Delphi exercise yielded 1 major criterion-biopsy of ulcer edge demonstrating neutrophilic infiltrate-and 8 minor criteria: (1) exclusion of infection; (2) pathergy; (3) history of inflammatory bowel disease or inflammatory arthritis; (4) history of papule, pustule, or vesicle ulcerating within 4 days of appearing; (5

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2018 JAMA dermatology (Chicago, Ill.)

24. Cutaneous Pyoderma Gangrenosum of the Hand (PubMed)

immunosuppression pathergy surgical debridement 2018 3 1 6 0 2018 3 1 6 0 2018 3 1 6 1 epublish 29487673 PMC5799722 BMJ. 2006 Jul 22;333(7560):181-4 16858047 Int J Dermatol. 2004 Nov;43(11):790-800 15533059 J Am Acad Dermatol. 2010 Apr;62(4):646-54 20227580 J Cutan Pathol. 1986 Oct;13(5):323-30 3537032 BMJ. 2017 Mar 21;356:j1462 28325754 Medicine (Baltimore). 2000 Jan;79(1):37-46 10670408 Am J Gastroenterol. 2003 Aug;98(8):1821-6 12907338 Am J Clin Dermatol. 2017 Jun;18(3):355-372 28224502

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2018 Eplasty

25. Skin Grafting in Pyoderma Gangrenosum (PubMed)

101316107 1937-5719 adalimumab allograft chronic wounds pathergy pyoderma gangrenosum 2018 6 14 6 0 2018 6 14 6 0 2018 6 14 6 1 epublish 29896322 PMC5981776 J Am Acad Dermatol. 2016 Apr;74(4):760-5 26979359 J Dtsch Dermatol Ges. 2017 Jan;15(1):34-40 28140549 Med Clin (Barc). 2017 Sep 20;149(6):256-260 28629662 Hautarzt. 2017 Aug;68(8):625-631 28577055 Acta Derm Venereol. 2015 May;95(5):525-31 25387526 Clin Rev Allergy Immunol. 2018 Feb;54(1):114-130 28688013 Wound Repair Regen. 2003 Mar;11 Suppl 1:S1-28

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2018 Eplasty

26. Behçet’s Disease: Pulmonary Aneurysm Resolution with Oral Therapy and HLA B72 Allele Association (PubMed)

and a positive pathergy test, the patient was diagnosed with Behçet's disease. Oral pharmacological treatment began with corticosteroids, cyclophosphamide, and anticoagulant suspension. The HLA B72 allele was identified in the patient and her two sisters, demonstrating the familial characteristic of the disease and the presence of this allele in a female patient with Behçet's disease. After 12 months of treatment, the clinical condition completely resolved.© 2018 Marshfield Clinic.

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2018 Clinical medicine & research

27. Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum

, corticosensitivity of lesions, pathergie phenomenon, painful lesions). Demographic data, clinical appearance of the lesions, cardiovascular and metabolic comorbidities, other associated pathologies, histological findings of the ulcer biopsy and biological results to describe the population and associated pathologies or comorbidities to PG Condition or disease Intervention/treatment Pyoderma Gangrenosum Other: pathology associated Detailed Description: Pyoderma gangrenosum (PG) is a rare disease. She is often (...) clinical appearance with ulceration well limited and purulent or pustule hutches, exclusion of differential diagnoses) and at least 2 minor criteria (among compatible histological aspect, classically compatible associated pathologies, corticosensitivity of lesions, pathergie phenomenon, painful lesions). Demographic data, clinical appearance of the lesions, cardiovascular and metabolic comorbidities, other associated pathologies, histological findings of the ulcer biopsy and biological results

2018 Clinical Trials

28. Two cases of maggot debridement therapy in pyoderma gangrenosum (PubMed)

Arash A Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. eng Case Reports 2018 11 10 United States JAAD Case Rep 101665210 2352-5126 MDT, maggot debridement therapy PG, pyoderma gangrenosum debridement maggot debridement therapy pathergy pyoderma gangrenosum wound 2018 11 21 6 0 2018 11 21 6 0 2018 11 21 6 1 epublish 30456277 10.1016/j.jdcr.2018.07.016 S2352-5126(18)30197-8 PMC6232634 Arch Dermatol. 2012 Apr;148(4):432-8 22184720 J Wound Care. 2013 Sep;22(9):462-9

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2018 JAAD Case Reports

29. A pyoderma gangrenous-like cutaneous leishmaniasis in a Libyan woman with rheumatoid arthritis: a case report (PubMed)

woman with rheumatoid arthritis on low dose steroids with pyoderma gangrenosum-like skin lesions and positive pathergy. Slit-smear was positive for Leishmania amastigotes and histopathological examination confirmed the diagnosis of cutaneous leishmaniasis. The lesions healed completely by parenteral sodium stibogluconate (Pentostam) 600 mg daily.We report for the first time, a rare and unusual presentation of pyoderma gangrenosum like-cutaneous leishmaniasis in a patient with rheumatoid arthritis

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2018 BMC research notes

30. Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). (PubMed)

examination revealed left abduction limitation and right-sided hypoesthesia. Kernig and Brudzinski signs were absent, and pathergy test results were negative. Laboratory evaluation revealed normal complete and differential blood counts, normal serum chemistry, and normal immune function. Analysis of her serum was negative for antiaquaporin 4 antibody, rheumatism antibody profile, and paraneoplastic profile. Serum analysis was also negative for human immunodeficiency virus type 1 and 2 RNA, hepatitis B

2018 Radiology

31. Underlying Systemic Diseases in Pyoderma Gangrenosum: A Systematic Review and Meta-Analysis. (PubMed)

disease (17.6%; 95% confidence interval 13.0-22.7), followed by arthritis (12.8%; 95% confidence interval 9.2-16.9), hematological malignancies (8.9%; 95% confidence interval 6.5-11.6), and solid malignancies (7.4%; 95% confidence interval 5.8-9.1). In 16.3% (95% confidence interval 7.7-27.1) of cases, the onset of pyoderma gangrenosum was attributed to the pathergy phenomenon.More than half of patients with pyoderma gangrenosum present with a relevant underlying disease. Inflammatory bowel disease

2018 American journal of clinical dermatology

32. Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. (PubMed)

Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions. A newly described entity, necrotizing Sweet syndrome, is a severe and locally aggressive dermatological condition that clinically and histopathologically resembles a necrotizing soft tissue infection. It is characterized by pathergy, a nonspecific inflammatory response

2017 Journal of Hand Surgery - American

33. Behçet's disease with multiple splenic abscesses in a child (PubMed)

, he had recurrent stomatitis. A colonoscopy showed multiple well-demarcated ulcerations throughout the colon, and abdominal computed tomography showed multiple splenic abscesses. Pathergy and HLA-B51 tests were positive. Investigations did not reveal any infectious organisms in the aspirate obtained via ultrasound-guided fine needle aspiration. After steroid treatment, all symptoms and multiple aseptic splenic abscesses resolved. However, oral ulcers, genital ulcers, and abdominal pain recurred

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2017 Intestinal research

34. Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child (PubMed)

Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child Behçet's disease (BD) is a multisystem disorder of unknown aetiology, characterized by recurrent oral ulcers, genital ulcers, uveitis, skin lesions, and pathergy. Gastrointestinal disease outside the oral cavity is well recognized and usually takes the form of small intestinal ulcers, with the most significant lesions frequently occurring in the ileocaecal region. Symptoms usually include nausea, vomiting, colicky

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2017 Case Reports in Radiology

35. Pyoderma Gangrenosum: A Rare Cause of Cutaneous Ulceration and One Easily Misdiagnosed (PubMed)

of the underlying infection. PG in children is more likely to have an atypical distribution involving the head and neck (26.6%) or buttocks (15%). An interesting feature in this case is the presence of pathergy, a term used to describe the induction or exacerbation of PG at sites of iatrogenic or incidental trauma. It is seen in 31% of patients with PG.

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2016 Case reports in pediatrics

36. Thrombose de la veine dorsale profonde de la verge revelant une maladie de Behcet (PubMed)

, the etiological investigation revealed Behcet's disease whose diagnosis was based on the association of a major criteria, such as oral aphthous ulcers with 3 minor criteria such as: genital aphthous ulcers, ocular involvement, and a positive skin pathergy test within 24h. The patient underwent etiological treatment with good clinical evolution and preservation of erectile function.

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2016 The Pan African medical journal

37. Blastomycosis-Like Pyoderma- A Rare Case Report (PubMed)

. Investigations revealed anaemia with hypochromasia, neutrophilic leucocytosis, hypo-proteinemia and hypo-albuminemia with reversal of A/G ratio. Pathergy test was negative. Pus on Gram's stain showed plenty of pus cells, and negative for AFB and fungal stain. On culture of pus grew Coagulase negative staphylococcus species. Biopsy showed acanthosis of epidermis with moderate lymphocytic infiltrates in dermis and focally a few neutrophils and histiocytes. Patient fulfilled the criteria for diagnosis

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2016 Journal of clinical and diagnostic research : JCDR

38. Genetic Variation in the REL Gene Increases Risk of Behcet’s Disease in a Chinese Han Population but That of PRKCQ Does Not (PubMed)

rs842647 polymorphism was associated with BD patients with skin lesions. No significant association of the other five SNPs between BD patients with other extra-ocular findings, including genital ulcer, arthritis, and positive pathergy test results was found. The REL rs842647 polymorphism may be a susceptibility factor for BD pathogenesis and skin lesions, which indicate that c-Rel may be involved in the pathogenesis and skin lesions of BD through the NF-κB pathway.

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2016 PloS one

39. Pyoderma gangrenosum induced by episiotomy (PubMed)

Pyoderma gangrenosum induced by episiotomy We present a patient who developed genital ulceration within hours following episiotomy procedure during a normal vaginal delivery. This was initially treated by the gynaecology and medical team as cellulitis with no improvement. A diagnosis of pyoderma gangrenosum (PG) was made by the dermatology team 12 days later. On further investigation, she was found to be hepatitis C positive. We report this case to highlight the phenomenon of pathergy

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2016 BMJ case reports

40. Behçet's disease departs the ‘Silk Road’: a case report and brief review of literature with geographical comparison (PubMed)

showed findings typically seen in Western patients with BD, which include intestinal manifestations, cardiac involvement, and lack of pathergy reaction and ocular changes. Our investigation demonstrates that the clinical manifestations common to this disorder vary among geographic and ethnic populations. Commonly used criteria for the diagnosis of BD may not be sensitive for some populations, such as Western BD, potentially leading to underdiagnoses and mismanagement. Recognition and select inclusion

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2016 Journal of community hospital internal medicine perspectives

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