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21. The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum. Full Text available with Trip Pro

(17.7) years. Pathergy was recorded in 100 patients (28.1%). A total of 238 patients (66.9%) had associated medical comorbidities: inflammatory bowel disease in 146 patients (41.0%); inflammatory arthritis in 73 patients (20.5%); solid organ malignant neoplasms in 23 patients (6.5%); hematologic malignant neoplasms in 21 patients (5.9%); and hematologic disorders, specifically monoclonal gammopathy of undetermined significance, myelodysplastic syndrome, and polycythemia vera in 17 patients (4.8 (...) %). When stratified by age, pathergy was more common in patients 65 years or older (36.3% vs 24.3%; P = .02). Inflammatory bowel disease was the only medical comorbidity that was more common in patients younger than 65 years (47.7% vs 26.6%; P < .001), while a number of medical comorbidities were more common in those 65 years or older, including rheumatoid arthritis (13.3% vs 6.2%; P = .03), ankylosing spondylitis (1.8% vs 0%; P = .04), solid organ malignant neoplasms (13.3% vs 3.3%; P < .001

2018 JAMA dermatology (Chicago, Ill.)

22. Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts. (Abstract)

Appropriateness Method. The criteria were validated against peer-reviewed established cases of pyoderma gangrenosum and mimickers using k-fold cross-validation with methods of multiple imputation.Delphi exercise yielded 1 major criterion-biopsy of ulcer edge demonstrating neutrophilic infiltrate-and 8 minor criteria: (1) exclusion of infection; (2) pathergy; (3) history of inflammatory bowel disease or inflammatory arthritis; (4) history of papule, pustule, or vesicle ulcerating within 4 days of appearing; (5

2018 JAMA dermatology (Chicago, Ill.)

23. Successful mesenchymal stem cell treatment of leg ulcers complicated by Behcet disease: A case report and literature review. Full Text available with Trip Pro

, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking.Based upon the patient's clinical feature and positive pathergy test , BD was confirmed.Conventional immunosuppressive therapy and anti-tumor necrosis factor inhibitors, adalimumab and etanercept, had no demonstrable clinical effect. Mesenchymal stem cell (MSC) injection combined with low-dose prednisone and thalidomide, however, completely ameliorated the ulcers on one leg, significantly

2018 Medicine

24. Case 259: Primary Central Nervous System Lymphomatoid Granulomatosis Mimicking Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS). Full Text available with Trip Pro

examination revealed left abduction limitation and right-sided hypoesthesia. Kernig and Brudzinski signs were absent, and pathergy test results were negative. Laboratory evaluation revealed normal complete and differential blood counts, normal serum chemistry, and normal immune function. Analysis of her serum was negative for antiaquaporin 4 antibody, rheumatism antibody profile, and paraneoplastic profile. Serum analysis was also negative for human immunodeficiency virus type 1 and 2 RNA, hepatitis B

2018 Radiology

25. Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease. Full Text available with Trip Pro

in patients with ocular BD (p=1.94×10-5, pc=8.34×10-4, OR=0.466). Stratification according to gender showed that rs7234029 was significantly associated with BD in men. A stratified analysis according to the main clinical features showed that rs7234029 was significantly associated with genital ulcers, skin lesions and a positive pathergy test. No association could be detected between BD and CD122 gene polymorphisms. Functional studies showed that rs7234029 GG genotype carriers had a higher PNPT2 mRNA

2018 British Journal of Ophthalmology

26. Study on the Clinical Features, Comorbidities and Pathologies Associated With Pyoderma Gangrenosum

, corticosensitivity of lesions, pathergie phenomenon, painful lesions). Demographic data, clinical appearance of the lesions, cardiovascular and metabolic comorbidities, other associated pathologies, histological findings of the ulcer biopsy and biological results to describe the population and associated pathologies or comorbidities to PG Condition or disease Intervention/treatment Pyoderma Gangrenosum Other: pathology associated Detailed Description: Pyoderma gangrenosum (PG) is a rare disease. She is often (...) clinical appearance with ulceration well limited and purulent or pustule hutches, exclusion of differential diagnoses) and at least 2 minor criteria (among compatible histological aspect, classically compatible associated pathologies, corticosensitivity of lesions, pathergie phenomenon, painful lesions). Demographic data, clinical appearance of the lesions, cardiovascular and metabolic comorbidities, other associated pathologies, histological findings of the ulcer biopsy and biological results

2018 Clinical Trials

27. Cutaneous Pyoderma Gangrenosum of the Hand Full Text available with Trip Pro

immunosuppression pathergy surgical debridement 2018 3 1 6 0 2018 3 1 6 0 2018 3 1 6 1 epublish 29487673 PMC5799722 BMJ. 2006 Jul 22;333(7560):181-4 16858047 Int J Dermatol. 2004 Nov;43(11):790-800 15533059 J Am Acad Dermatol. 2010 Apr;62(4):646-54 20227580 J Cutan Pathol. 1986 Oct;13(5):323-30 3537032 BMJ. 2017 Mar 21;356:j1462 28325754 Medicine (Baltimore). 2000 Jan;79(1):37-46 10670408 Am J Gastroenterol. 2003 Aug;98(8):1821-6 12907338 Am J Clin Dermatol. 2017 Jun;18(3):355-372 28224502

2018 Eplasty

28. Two cases of maggot debridement therapy in pyoderma gangrenosum Full Text available with Trip Pro

Arash A Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts. eng Case Reports 2018 11 10 United States JAAD Case Rep 101665210 2352-5126 MDT, maggot debridement therapy PG, pyoderma gangrenosum debridement maggot debridement therapy pathergy pyoderma gangrenosum wound 2018 11 21 6 0 2018 11 21 6 0 2018 11 21 6 1 epublish 30456277 10.1016/j.jdcr.2018.07.016 S2352-5126(18)30197-8 PMC6232634 Arch Dermatol. 2012 Apr;148(4):432-8 22184720 J Wound Care. 2013 Sep;22(9):462-9

2018 JAAD Case Reports

29. Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. (Abstract)

Necrotizing Sweet Syndrome of the Upper Extremity After Elective Hand Surgery. Sweet syndrome, or acute febrile neutrophilic dermatosis, is a systemic disease process mainly characterized by hyperpyrexia and skin lesions. A newly described entity, necrotizing Sweet syndrome, is a severe and locally aggressive dermatological condition that clinically and histopathologically resembles a necrotizing soft tissue infection. It is characterized by pathergy, a nonspecific inflammatory response

2017 Journal of Hand Surgery - American

30. Do clinical findings of Behçet’s disease vary by gender?: A single-center experience from 329 patients Full Text available with Trip Pro

on the clinical features and gender distribution of BD. The aim of the present study was to determine the clinical characteristics of BD and the presence of a relation with gender and to investigate the correlation of our results with the current literature.We retrospectively reviewed 329 patient files. The demographic features of the patients, their symptoms and findings of BD, the results of pathergy tests, the presence of any individuals in the family with BD, and HLA-B51 antigen positivity were

2016 European journal of rheumatology

31. Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child Full Text available with Trip Pro

Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child Behçet's disease (BD) is a multisystem disorder of unknown aetiology, characterized by recurrent oral ulcers, genital ulcers, uveitis, skin lesions, and pathergy. Gastrointestinal disease outside the oral cavity is well recognized and usually takes the form of small intestinal ulcers, with the most significant lesions frequently occurring in the ileocaecal region. Symptoms usually include nausea, vomiting, colicky

2017 Case Reports in Radiology

32. Behçet's disease with multiple splenic abscesses in a child Full Text available with Trip Pro

, he had recurrent stomatitis. A colonoscopy showed multiple well-demarcated ulcerations throughout the colon, and abdominal computed tomography showed multiple splenic abscesses. Pathergy and HLA-B51 tests were positive. Investigations did not reveal any infectious organisms in the aspirate obtained via ultrasound-guided fine needle aspiration. After steroid treatment, all symptoms and multiple aseptic splenic abscesses resolved. However, oral ulcers, genital ulcers, and abdominal pain recurred

2017 Intestinal research

33. Pyoderma Gangrenosum

Aka: Pyoderma Gangrenosum , Pathergy II. Epidemiology Rare III. Pathophysiology ic dermatosis Also occurs in Behcet Disease and s release elastase and other enzymes that result in skin breakdown IV. Symptoms Painful s and ulcers that form on the legs, buttocks, and face in response to minor V. Signs Lesion characteristics Initial Hemorrhagic, red or painful, tender Next Lesion ulcerates Ulcer has irregular, raised, undermined border and advances peripherally Ulcer base with exudate (...) that is pustular and hemorrhagic Necrotic eschar may form Next Ulcer heals with thin, atrophic scar Distribution (in order of most common to least common) Legs Buttocks Face Pathergy See ing and ulceration in response to minor Also seen with Behcet Disease VI. Associated Conditions (e.g. , ) (e.g. , ) Hepatitis VII. Differential Diagnosis See VIII. References Fitzpatrick (1992) Color Atlas and Synopsis of Clinical Dermatology Jhun and DeClerck in Herbert (2015) EM:Rap 15(8): 19-20 Images: Related links

2018 FP Notebook

34. Thrombose de la veine dorsale profonde de la verge revelant une maladie de Behcet Full Text available with Trip Pro

, the etiological investigation revealed Behcet's disease whose diagnosis was based on the association of a major criteria, such as oral aphthous ulcers with 3 minor criteria such as: genital aphthous ulcers, ocular involvement, and a positive skin pathergy test within 24h. The patient underwent etiological treatment with good clinical evolution and preservation of erectile function.

2016 The Pan African medical journal

35. Pyoderma Gangrenosum: A Rare Cause of Cutaneous Ulceration and One Easily Misdiagnosed Full Text available with Trip Pro

of the underlying infection. PG in children is more likely to have an atypical distribution involving the head and neck (26.6%) or buttocks (15%). An interesting feature in this case is the presence of pathergy, a term used to describe the induction or exacerbation of PG at sites of iatrogenic or incidental trauma. It is seen in 31% of patients with PG.

2016 Case reports in pediatrics

36. Investigation of Behçet’s Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey Full Text available with Trip Pro

hospital, and the Pathergy Test and eye examinations were performed.The annual prevalence of RAS was determined as 10.84%. The annual prevalence was determined to be higher in women than in men (p=0.000). It was observed that the prevalence was at the peak level in the 3(rd) decade, and then decreased proportionally in the following decades (p=0.000). It was also observed that the aphtha recurrence decreased in the following decades (p=0.048). The Behçet's prevalence was found to be 0.60

2016 Balkan medical journal

37. Blastomycosis-Like Pyoderma- A Rare Case Report Full Text available with Trip Pro

. Investigations revealed anaemia with hypochromasia, neutrophilic leucocytosis, hypo-proteinemia and hypo-albuminemia with reversal of A/G ratio. Pathergy test was negative. Pus on Gram's stain showed plenty of pus cells, and negative for AFB and fungal stain. On culture of pus grew Coagulase negative staphylococcus species. Biopsy showed acanthosis of epidermis with moderate lymphocytic infiltrates in dermis and focally a few neutrophils and histiocytes. Patient fulfilled the criteria for diagnosis

2016 Journal of clinical and diagnostic research : JCDR

38. Successful Treatment of Pyoderma Gangrenosum after Augmentation Mastopexy Using Vacuum Therapy Full Text available with Trip Pro

Successful Treatment of Pyoderma Gangrenosum after Augmentation Mastopexy Using Vacuum Therapy Pyoderma gangrenosum (PG) is a rare, severe, destructive neutrophilic dermatosis characterized by a progressive, necrotizing process after skin injury. Its cause is still unknown, and diagnosis represents a challenge when ulcers are seen after surgery. Bacterial infection is not found in the wounds. Patients exhibit "pathergy" with the appearance of new lesions after local trauma such as surgical

2016 Plastic and Reconstructive Surgery Global Open

39. Genetic Variation in the REL Gene Increases Risk of Behcet’s Disease in a Chinese Han Population but That of PRKCQ Does Not Full Text available with Trip Pro

rs842647 polymorphism was associated with BD patients with skin lesions. No significant association of the other five SNPs between BD patients with other extra-ocular findings, including genital ulcer, arthritis, and positive pathergy test results was found. The REL rs842647 polymorphism may be a susceptibility factor for BD pathogenesis and skin lesions, which indicate that c-Rel may be involved in the pathogenesis and skin lesions of BD through the NF-κB pathway.

2016 PloS one

40. Pyoderma gangrenosum induced by episiotomy Full Text available with Trip Pro

Pyoderma gangrenosum induced by episiotomy We present a patient who developed genital ulceration within hours following episiotomy procedure during a normal vaginal delivery. This was initially treated by the gynaecology and medical team as cellulitis with no improvement. A diagnosis of pyoderma gangrenosum (PG) was made by the dermatology team 12 days later. On further investigation, she was found to be hepatitis C positive. We report this case to highlight the phenomenon of pathergy

2016 BMJ case reports

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