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Parietal Lobe

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121. Disrupted anatomic white matter network in left mesial temporal lobe epilepsy. (PubMed)

Disrupted anatomic white matter network in left mesial temporal lobe epilepsy. Brain imaging studies have shown widespread structural abnormalities in patients with temporal lobe epilepsy (TLE) within and beyond the affected temporal lobe, suggesting an altered network. Graph theoretical analysis based on white matter tractography has provided a new perspective to evaluate the connectivity of the brain. The alterations in the topologic properties of a whole brain white matter network (...) mTLE exhibited concurrent decreases of global and local efficiencies and widespread reduction of regional efficiency in ipsilateral temporal, bilateral frontal, and bilateral parietal areas. Communication hubs, such as the left precuneus, were also altered in patients with mTLE compared to controls.Our results demonstrate white matter network disruption in patients with left mTLE, supporting the notion that mTLE is a systemic brain disorder.Wiley Periodicals, Inc. © 2014 International League

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2014 Epilepsia

122. The extratemporal lobe epilepsies in the epilepsy monitoring unit (PubMed)

The extratemporal lobe epilepsies in the epilepsy monitoring unit Extratemporal lobe epilepsies (ETLE) are characterized by the epileptogenic foci outside the temporal lobe. They have a wide spectrum of semiological presentation depending upon the site of origin. They can arise from frontal, parietal, occipital lobes and from hypothalamic hamartoma. We discuss in this review the semiology of different types of ETLE encountered in the epilepsy monitoring unit.

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2014 Annals of Indian Academy of Neurology

123. Frontal Lobe Syndromes (Diagnosis)

with frontal lobe dysfunction. Working memory involves a complex circuit that involves many brain regions, including the dorsolateral frontal cortex, thalamus, and parts of the temporal and parietal cortices. Working memory is defined as memory for a limited amount of information (such as a telephone number) that needs to be kept in consciousness for a few seconds (until the number is dialed) and then may be lost forever. Most patients are able to hold 6 or 7 digits in working memory. Patients with frontal (...) Frontal Lobe Syndromes (Diagnosis) Frontal Lobe Syndromes: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEzNTg2Ni1vdmVydmlldw== processing > Frontal Lobe Syndromes

2014 eMedicine.com

124. Frontal and Temporal Lobe Dementia (Diagnosis)

also showed hypometabolism in the left frontal lobe and, occasionally, a lesser degree of hypometabolism in the right hemisphere. These patterns of cortical involvement have been confirmed in many subsequent studies. The pattern of frontal and/or temporal involvement is distinct from that of Alzheimer disease, in which both parietal lobes tend to show the earliest hypometabolism. New ligands used to bind to amyloid protein deposits (eg, Pittsburgh Compound B, or the recently approved florbetapir (...) Frontal and Temporal Lobe Dementia (Diagnosis) Frontotemporal Dementia and Frontotemporal Lobar Degeneration: Overview, Etiology, Genetic Distribution and Variation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

125. Frontal Lobe Syndromes (Overview)

with frontal lobe dysfunction. Working memory involves a complex circuit that involves many brain regions, including the dorsolateral frontal cortex, thalamus, and parts of the temporal and parietal cortices. Working memory is defined as memory for a limited amount of information (such as a telephone number) that needs to be kept in consciousness for a few seconds (until the number is dialed) and then may be lost forever. Most patients are able to hold 6 or 7 digits in working memory. Patients with frontal (...) Frontal Lobe Syndromes (Overview) Frontal Lobe Syndromes: Background, Pathophysiology, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEzNTg2Ni1vdmVydmlldw== processing > Frontal Lobe Syndromes

2014 eMedicine.com

126. Frontal and Temporal Lobe Dementia (Overview)

also showed hypometabolism in the left frontal lobe and, occasionally, a lesser degree of hypometabolism in the right hemisphere. These patterns of cortical involvement have been confirmed in many subsequent studies. The pattern of frontal and/or temporal involvement is distinct from that of Alzheimer disease, in which both parietal lobes tend to show the earliest hypometabolism. New ligands used to bind to amyloid protein deposits (eg, Pittsburgh Compound B, or the recently approved florbetapir (...) Frontal and Temporal Lobe Dementia (Overview) Frontotemporal Dementia and Frontotemporal Lobar Degeneration: Overview, Etiology, Genetic Distribution and Variation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

127. Frontal and Temporal Lobe Dementia (Treatment)

also showed hypometabolism in the left frontal lobe and, occasionally, a lesser degree of hypometabolism in the right hemisphere. These patterns of cortical involvement have been confirmed in many subsequent studies. The pattern of frontal and/or temporal involvement is distinct from that of Alzheimer disease, in which both parietal lobes tend to show the earliest hypometabolism. New ligands used to bind to amyloid protein deposits (eg, Pittsburgh Compound B, or the recently approved florbetapir (...) Frontal and Temporal Lobe Dementia (Treatment) Frontotemporal Dementia and Frontotemporal Lobar Degeneration: Overview, Etiology, Genetic Distribution and Variation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

128. Frontal and Temporal Lobe Dementia (Follow-up)

also showed hypometabolism in the left frontal lobe and, occasionally, a lesser degree of hypometabolism in the right hemisphere. These patterns of cortical involvement have been confirmed in many subsequent studies. The pattern of frontal and/or temporal involvement is distinct from that of Alzheimer disease, in which both parietal lobes tend to show the earliest hypometabolism. New ligands used to bind to amyloid protein deposits (eg, Pittsburgh Compound B, or the recently approved florbetapir (...) Frontal and Temporal Lobe Dementia (Follow-up) Frontotemporal Dementia and Frontotemporal Lobar Degeneration: Overview, Etiology, Genetic Distribution and Variation Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache

2014 eMedicine.com

129. Right parietal cortex and calculation processing: intraoperative functional mapping of multiplication and addition in patients affected by a brain tumor. (PubMed)

Right parietal cortex and calculation processing: intraoperative functional mapping of multiplication and addition in patients affected by a brain tumor. The role of parietal areas in number processing is well known. The significance of intraoperative functional mapping of these areas has been only partially explored, however, and only a few discordant data are available in the surgical literature with regard to the right parietal lobe. The purpose of this study was to evaluate the clinical (...) impact of simple calculation in cortical electrostimulation of right-handed patients affected by a right parietal brain tumor.Calculation mapping in awake surgery was performed in 3 right-handed patients affected by high-grade gliomas located in the right parietal lobe. Preoperatively, none of the patients presented with calculation deficits. In all 3 cases, after sensorimotor and language mapping, cortical and intraparietal sulcus areas involved in single-digit multiplication and addition

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2013 Journal of Neurosurgery

130. Task-Dependent Interaction between Parietal and Contralateral Primary Motor Cortex during Explicit versus Implicit Motor Imagery (PubMed)

Task-Dependent Interaction between Parietal and Contralateral Primary Motor Cortex during Explicit versus Implicit Motor Imagery Both mental rotation (MR) and motor imagery (MI) involve an internalization of movement within motor and parietal cortex. Transcranial magnetic stimulation (TMS) techniques allow for a task-dependent investigation of the interhemispheric interaction between these areas. We used image-guided dual-coil TMS to investigate interactions between right inferior parietal lobe

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2012 PloS one

131. Towards an understanding of parietal mnemonic processes: some conceptual guideposts (PubMed)

Towards an understanding of parietal mnemonic processes: some conceptual guideposts The posterior parietal lobes have been implicated in a range of episodic memory retrieval tasks, but the nature of parietal contributions to remembering remains unclear. In an attempt to identify fruitful avenues of further research, several heuristic questions about parietal mnemonic activations are considered in light of recent empirical findings: Do such parietal activations reflect memory processes (...) , or their contents? Do they precede, follow, or co-occur with retrieval? What can we learn from their pattern of lateralization? Do they index access to episodic representations, or the feeling of remembering? Are parietal activations graded by memory strength, quantity of retrieved information, or the type of retrieval? How do memory-related activations map onto functional parcellation of parietal lobes suggested by other cognitive phenomena? Consideration of these questions can promote understanding

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2012 Frontiers in integrative neuroscience

132. Parietal Contributions to Visual Working Memory Depend on Task Difficulty (PubMed)

capacity and WM task demands. We discuss these findings in terms of alternative WM strategies employed by low and high WM capacity individuals. We speculate that low WM capacity individuals do not recruit the posterior parietal lobe for WM tasks as efficiently as high WM capacity individuals. Consequently, tDCS provides greater benefit to individuals with high WM capacity. (...) Parietal Contributions to Visual Working Memory Depend on Task Difficulty The nature of parietal contributions to working memory (WM) remain poorly understood but of considerable interest. We previously reported that posterior parietal damage selectively impaired WM probed by recognition (Berryhill and Olson, 2008a). Recent studies provided support using a neuromodulatory technique, transcranial direct current stimulation (tDCS) applied to the right parietal cortex (P4). These studies confirmed

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2012 Frontiers in Psychiatry

133. High frequency rTMS over the left parietal lobule increases non-word reading accuracy. (PubMed)

High frequency rTMS over the left parietal lobule increases non-word reading accuracy. Increasing evidence in the literature supports the usefulness of Transcranial Magnetic Stimulation (TMS) in studying reading processes. Two brain regions are primarily involved in phonological decoding: the left superior temporal gyrus (STG), which is associated with the auditory representation of spoken words, and the left inferior parietal lobe (IPL), which operates in phonological computation. This study

2012 Neuropsychologia

134. Clinical evidence of parietal cortex dysfunction and correlation with extent of allodynia in CRPS type 1. (PubMed)

Clinical evidence of parietal cortex dysfunction and correlation with extent of allodynia in CRPS type 1. Unusual symptoms such as digit misidentification and neglect-like phenomena have been reported in complex regional pain syndrome (CRPS), which we hypothesized could be explained by parietal lobe dysfunction.Twenty-two patients with chronic CRPS attending an in-patient rehabilitation programme underwent standard neurological examination followed by clinical assessment of parietal lobe (...) function and detailed sensory testing.Fifteen (68%) patients had evidence of parietal lobe dysfunction. Six (27%) subjects failed six or more test categories and demonstrated new clinical signs consistent with their parietal testing impairments, which were impacting significantly on activities of daily living. A higher incidence was noted in subjects with >1 limb involvement, CRPS affecting the dominant side and in left-handed subjects. Eighteen patients (82%) had mechanical allodynia covering 3-57.5

2012 European Journal of Pain

135. Alteration of global workspace during loss of consciousness: A study of parietal seizures. (PubMed)

Alteration of global workspace during loss of consciousness: A study of parietal seizures. Loss of consciousness (LOC) in epileptic seizures has a strongly negative impact on quality of life. Recently, we showed that LOC occurring during temporal lobe seizures was correlated with a nonlinear increase of neural synchrony in associative--and particularly parietal--cortices. Whether these mechanisms might be observed in other types of seizures is unknown. This study aimed at investigating (...) the relationship between changes in synchrony and degree of LOC during parietal lobe epilepsy (PLE), a form of epilepsy in which seizures directly involve the parietal associative cortices.Ten patients undergoing stereoelectroencephalography (SEEG) during presurgical evaluation of PLE were studied. The LOC intensity was scored using the Conscious Seizure Scale (CSS). For each studied seizure (n = 29), interdependencies between signals recorded from six brain regions were estimated as a function of time

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2012 Epilepsia

136. Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia. (PubMed)

-middle temporal gyri (P < 0.05, cluster correction). WM volume was significantly increased in ASz children relative to TD children in a cluster encompassing the left inferior parietal lobe, occipital lobe, and superior temporal gyrus. Post-hoc analyses indicated that these abnormalities were not limited to ASz children who self-reported auditory hallucinations on questionnaire. Our findings suggest that children aged 9-12 years who present multiple ASz are characterized by abnormalities of GM and WM (...) Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia. Distributed abnormalities of gray matter (GM) and white matter (WM) volume characterize individuals experiencing their first episode of schizophrenia. Regions of abnormality are present already, albeit less extensively, during the prodromal phase of illness. This study aimed to determine whether putatively at-risk children, aged 9-12 years, who present multiple antecedents

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2013 Schizophrenia bulletin

137. Viral and paraneoplastic encephalitis in a patient with liver transplant with unilateral temporoparietal lobe abnormalities: a diagnostic challenge (PubMed)

Viral and paraneoplastic encephalitis in a patient with liver transplant with unilateral temporoparietal lobe abnormalities: a diagnostic challenge We report a patient who recently had a liver transplant presented with increasing confusion and intermittent hallucinations. MRI of the brain revealed diffuse left temporal and parietal lobe swelling with cortical diffusion restriction suggestive of possible infectious aetiology, although stroke was also possible given the presence of left posterior

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2013 BMJ case reports

138. Presurgical connectome and postsurgical seizure control in temporal lobe epilepsy. (PubMed)

thalamocortical regions, with a pathologic increase in ipsilateral medial temporal lobe, insular, and frontal connectivity. Among patients, those not seizure-free exhibited a higher connectivity between structures in 1) the ipsilateral medial and lateral temporal lobe, 2) the ipsilateral medial temporal and parietal lobe, and 3) the contralateral temporal pole and parietal lobe. Patients not seizure-free also exhibited lower small-worldness in the subnetwork within the ipsilateral temporal lobe, with higher (...) Presurgical connectome and postsurgical seizure control in temporal lobe epilepsy. The objective of this study was to evaluate whether patients with surgically refractory medial temporal lobe epilepsy (MTLE) exhibit a distinct pattern of structural network organization involving the temporal lobes and extratemporal regions.We retrospectively studied 18 healthy controls and 20 patients with medication refractory unilateral MTLE who underwent anterior temporal lobectomy for treatment of seizures

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2013 Neurology

139. Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy. (PubMed)

Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy. The purpose of the present study was to identify abnormal areas of regional synchronization in patients with mesial temporal lobe epilepsy and hippocampus sclerosis (mTLE-HS) compared to healthy controls, by applying a relatively novel method, the Regional Homogeneity (ReHo) method to resting state fMRI (RS-fMRI) data.Eyes closed RS-fMRI data were acquired from 10 mTLE-HS patients (four right (...) structures, whereas decreased ReHo was observed mainly in default mode network (DMN) (including precuneus and posterior cingulate gyrus, bilateral inferior lateral parietal, and mesial prefrontal cortex) and cerebellum in patients relative to the control group.This study identified that ReHo pattern in mTLE-HS patients was altered compared to healthy controls. We consider decreased ReHo in DMN to be responsible for wide functional impairments in cognitive processes. We propose that the increased ReHo

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2013 Epilepsia

140. Disrupted segregation of working memory networks in temporal lobe epilepsy (PubMed)

left) and 30 healthy controls underwent working memory functional MRI (fMRI) and Diffusion Tensor Imaging (DTI). Six seed regions were identified for FC analysis; 4 within a task-positive network (left and right middle frontal gyri and superior parietal lobes), and 2 within a task-negative network (left and right hippocampi). FC maps were created by extracting the time-series of the fMRI signal in each region in each subject and were used as regressors of interest for additional GLM fMRI analyses (...) . Structural connectivity (SC) corresponding to areas to which the left and right hippocampi were connected was determined using tractography, and a mean FA for each hippocampal SC map was calculated. Both left and right HS groups showed atypical FC between task-positive and task-negative networks compared to controls. This was characterised by co-activation of the task-positive superior parietal lobe ipsilateral to the typically task-negative sclerosed hippocampus. Correlational analysis revealed stronger

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2013 NeuroImage : Clinical

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