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Parietal Lobe

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81. Temporal Lobe

border shared with the occipital lobe. Definition (CHV) the lower lateral lobe of either cerebral hemisphere Definition (CHV) the lower lateral lobe of either cerebral hemisphere Definition (CHV) the lower lateral lobe of either cerebral hemisphere Definition (CHV) the lower lateral lobe of either cerebral hemisphere Definition (NCI_CDISC) Lower lateral part of the cerebral hemisphere. (MSH2001) Definition (NCI) One of the cerebral lobes. It is located inferior to the frontal and parietal lobes (...) Temporal Lobe Temporal Lobe Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Temporal Lobe Temporal Lobe Aka: Temporal Lobe , Temporal

2018 FP Notebook

82. Frontal Lobe

window. Related Studies (from Trip Database) Ontology: frontal lobe (C0016733) Definition (FMA) Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border. Definition (NCI) The part of the brain located anterior to the parietal lobes at the front of each cerebral hemisphere. Definition (NCI_CDISC) The part of the brain located anterior to the parietal lobes (...) Frontal Lobe Frontal Lobe Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Frontal Lobe Frontal Lobe Aka: Frontal Lobe , Cerebral

2018 FP Notebook

83. Behaviorally Relevant Abstract Object Identity Representation in the Human Parietal Cortex Full Text available with Trip Pro

. Unlike previous studies, we also failed to observe identity representations in posterior ventral and lateral visual object-processing regions, likely due to the greater amount of identity abstraction demanded by our stimulus manipulation here. Our MRI slice coverage precluded us from examining identity representation in anterior temporal lobe, a likely region for the computing of identity information in the ventral region. Overall, we show that human parietal cortex, part of the dorsal visual (...) Behaviorally Relevant Abstract Object Identity Representation in the Human Parietal Cortex The representation of object identity is fundamental to human vision. Using fMRI and multivoxel pattern analysis, here we report the representation of highly abstract object identity information in human parietal cortex. Specifically, in superior intraparietal sulcus (IPS), a region previously shown to track visual short-term memory capacity, we found object identity representations for famous faces

2016 The Journal of Neuroscience

84. How Do Visual and Parietal Cortex Contribute to Visual Short-Term Memory? Full Text available with Trip Pro

, California 92093. Sprague Thomas C TC 0000-0001-9530-2463 Neurosciences Graduate Program, University of California, San Diego, La Jolla, California 92093; Department of Psychology, New York University, New York, New York 10003. eng Journal Article Comment 2016 05 03 United States eNeuro 101647362 2373-2822 IM Nat Neurosci. 2016 Jan;19(1):150-7 26595654 Attention physiology Brain Mapping methods Female Humans Male Memory, Short-Term physiology Occipital Lobe physiology Parietal Lobe physiology Psychomotor (...) How Do Visual and Parietal Cortex Contribute to Visual Short-Term Memory? 27294194 2016 07 20 2018 12 02 2373-2822 3 2 2016 Mar-Apr eNeuro eNeuro How Do Visual and Parietal Cortex Contribute to Visual Short-Term Memory? 10.1523/ENEURO.0041-16.2016 ENEURO.0041-16.2016 Ester Edward F EF 0000-0002-1372-8768 Department of Psychology, University of California, San Diego , La Jolla, California 92093. Rademaker Rosanne L RL Department of Psychology, University of California, San Diego , La Jolla

2016 eNeuro

85. Global Visual Motion Sensitivity: Associations with Parietal Area and Children’s Mathematical Cognition Full Text available with Trip Pro

with individual differences in children's brain development, in a group of typically developing 5- to 12-year-olds. Good performance was associated with a relative increase in parietal lobe surface area, most strongly around the intraparietal sulcus and decrease in occipital area. In line with the involvement of intraparietal sulcus, areas in visuospatial and numerical cognition, we also found that global motion performance was correlated with tests of visuomotor integration and numerical skills. Individual (...) Global Visual Motion Sensitivity: Associations with Parietal Area and Children’s Mathematical Cognition Sensitivity to global visual motion has been proposed as a signature of brain development, related to the dorsal rather than ventral cortical stream. Thresholds for global motion have been found to be elevated more than for global static form in many developmental disorders, leading to the idea of "dorsal stream vulnerability." Here we explore the association of global motion thresholds

2016 Journal of cognitive neuroscience

86. The Role of Right Inferior Parietal Cortex in Auditory Spatial Attention: A Repetitive Transcranial Magnetic Stimulation Study Full Text available with Trip Pro

the first time window. The asymmetric effect of attended location on gradients in the third time window may relate to neglect of the left hemispace after right parietal injury. Together, these results highlight the role of the right inferior parietal cortex in modulating frontal lobe attention network activity. (...) The Role of Right Inferior Parietal Cortex in Auditory Spatial Attention: A Repetitive Transcranial Magnetic Stimulation Study Behavioral studies support the concept of an auditory spatial attention gradient by demonstrating that attentional benefits progressively diminish as distance increases from an attended location. Damage to the right inferior parietal cortex can induce a rightward attention bias, which implicates this region in the construction of attention gradients. This study used

2015 PloS one

87. Refuting the hypothesis that a unilateral human parietal lesion abolishes saccade corollary discharge. Full Text available with Trip Pro

Refuting the hypothesis that a unilateral human parietal lesion abolishes saccade corollary discharge. This paper questions the prominent role that the parietal lobe is thought to play in the processing of corollary discharges for saccadic eye movements. A corollary discharge copies the motor neurons' signal and sends it to brain areas involved in monitoring eye trajectories. The classic double-step saccade task has been used extensively to study these mechanisms: two targets (T1 and T2 (...) ) are quickly (40-150 ms) flashed sequentially in the periphery. After the extinction of the fixation point, subjects are to make two saccades (S1 and S2), in the dark, to the remembered locations of the targets in the order they appeared. The success of S2 requires a corollary discharge encoding S1's vector. Patients with a parietal lobe lesion, particularly on the right, are impaired at generating an accurate S2 when S1 is directed contralesionally, but not ipsilesionally, thought due to an impaired

2015 Brain

88. Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy. Full Text available with Trip Pro

in ipsilateral insula and occipital lobe, contralateral motor area, and bilateral temporal and frontal lobes. TLE-NL had GM progression in ipsilateral hypothalamus and parietal lobe, contralateral cerebellum, and bilateral temporal lobe. Controls did not show changes in GM volume between MRIs.Diffuse extrahippocampal GM atrophy is present in seizure-free patients with TLE-HS. In addition, there is progressive GM atrophy in patients with and without HS. These results demonstrate that not only ongoing seizures (...) Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy. To investigate the presence and progression of gray matter (GM) reduction in seizure-free patients with temporal lobe epilepsy (TLE).We enrolled 39 consecutive TLE patients, seizure-free for at least 2 years--20 with magnetic resonance imaging (MRI) signs of hippocampal sclerosis (TLE-HS), 19 with normal MRI (TLE-NL), and 74 healthy controls. For longitudinal analysis, we included individuals who had

2016 Epilepsia

89. The Anterolateral Limit of the Occipital Lobe: An Anatomical and Imaging Study Full Text available with Trip Pro

The Anterolateral Limit of the Occipital Lobe: An Anatomical and Imaging Study Objectives The boundaries of the temporal lobe, the parietal lobe, and the anterior portion of the occipital lobe (OL) are poorly defined. Lesions in these areas can be difficult to localize. Therefore, we studied the anterolateral limit of the OL to identify reliable anatomical landmarks. Design In 10 formalin-fixed cadaveric heads, the boundaries of the OL and relative anatomical landmarks were studied. Main

2016 Journal of neurological surgery. Part B, Skull base

90. Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy Full Text available with Trip Pro

Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy The dentate gyrus, a major entry point to the hippocampus, gates (or filters) incoming information from the cortex. During sleep or anesthesia, the slow-wave oscillation (SWO) orchestrates hippocampus-neocortex communication, which is important for memory formation. The dentate gate is altered in temporal lobe epilepsy (TLE) early (...) during epileptogenesis, which favors the propagation of pathological activities. Yet, whether the gating of physiological SWO by dentate granule cells (DGCs) is altered in TLE has remained unexplored. We combined intracellular recordings of membrane potential (V m) of DGCs and local field potential recordings of the SWO in parietal cortex in anesthetized rats early during epileptogenesis [post-status epilepticus (SE) rats]. As expected, in control rats, the V m of DGCs weakly and rarely oscillated

2016 eNeuro

91. Alteration of the Intra- and Cross- Hemisphere Posterior Default Mode Network in Frontal Lobe Glioma Patients Full Text available with Trip Pro

Alteration of the Intra- and Cross- Hemisphere Posterior Default Mode Network in Frontal Lobe Glioma Patients Patients with frontal lobe gliomas often experience neurocognitive dysfunctions before surgery, which affects the default mode network (DMN) to different degrees. This study quantitatively analyzed this effect from the perspective of cerebral hemispheric functional connectivity (FC). We collected resting-state fMRI data from 20 frontal lobe glioma patients before treatment and 20 (...) healthy controls. All of the patients and controls were right-handed. After pre-processing the images, FC maps were built from the seed defined in the left or right posterior cingulate cortex (PCC) to the target regions determined in the left or right temporal-parietal junction (TPJ), respectively. The intra- and cross-group statistical calculations of FC strength were compared. The conclusions were as follows: (1) the intra-hemisphere FC strength values between the PCC and TPJ on the left and right

2016 Scientific reports

92. Altered local spontaneous activity in frontal lobe epilepsy: a resting‐state functional magnetic resonance imaging study Full Text available with Trip Pro

Altered local spontaneous activity in frontal lobe epilepsy: a resting‐state functional magnetic resonance imaging study The purpose of this study was to investigate the local spatiotemporal consistency of spontaneous brain activity in patients with frontal lobe epilepsy (FLE).Eyes closed resting-state functional magnetic resonance imaging (fMRI) data were collected from 19 FLE patients and 19 age- and gender-matched healthy controls. A novel measure, named FOur-dimensional (spatiotemporal (...) the frontal and parietal cortices, as well as the basal ganglia. The decreased FOCA was located in the temporal cortex, posterior default model regions, and cerebellum. In addition, the FOCA measure was linked to the duration of epilepsy in basal ganglia.Our study suggested that alterations of local spontaneous activity in frontoparietal cortex and basal ganglia was associated with the pathophysiology of FLE; and the abnormality in frontal and default model regions might account for the potential

2016 Brain and behavior

93. Insights into Intrinsic Brain Networks based on Graph Theory and PET in right- compared to left-sided Temporal Lobe Epilepsy Full Text available with Trip Pro

connectivity, inferred from inter-regional [(18)F]FDG PET uptake correlations, in right-sided (RTLE; n = 30) and left-sided TLE (LTLE; n = 32) with healthy controls (HC; n = 31) using graph theory based network analysis. Comparing LTLE and RTLE and patient groups separately to HC, we observed higher lobar connectivity weights in RTLE compared to LTLE for connections of the temporal and the parietal lobe of the contralateral hemisphere (CH). Moreover, especially in RTLE compared to LTLE higher local (...) Insights into Intrinsic Brain Networks based on Graph Theory and PET in right- compared to left-sided Temporal Lobe Epilepsy The human brain exhibits marked hemispheric differences, though it is not fully understood to what extent lateralization of the epileptic focus is relevant. Preoperative [(18)F]FDG-PET depicts lateralization of seizure focus in patients with temporal lobe epilepsy and reveals dysfunctional metabolic brain connectivity. The aim of the present study was to compare metabolic

2016 Scientific reports

94. Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy Full Text available with Trip Pro

Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed (...) and temporal association cortex, and posterior parietal cortex. The TLE model manifested a higher clustering coefficient, increased global and local efficiency, and increased small-worldness as compared to controls, despite having a similar characteristic path length. These results suggest extensive disruptions in the functional brain networks, which may be the basis of altered cognitive, emotional and psychiatric symptoms in TLE.

2016 NeuroImage : Clinical

95. Low Functional Robustness in Mesial Temporal Lobe Epilepsy Full Text available with Trip Pro

Low Functional Robustness in Mesial Temporal Lobe Epilepsy Brain functional topology was investigated in patients with mesial temporal lobe epilepsy (mTLE) by means of graph theory measures in two differentially defined graphs. Measures of segregation, integration, and centrality were compared between subjects with mTLE and healthy controls (HC).Eleven subjects with mTLE (age 36.5±10.9years) and 15 age-matched HC (age 36.8±14.0years) participated in this study. Both anatomically (...) of patients presented lower global segregation than HC while showing higher global but lower local integration. They also failed to engage regions that comprise the default-mode network (DMN) as hubs such as bilateral medial frontal regions, PCC/precuneus complex, and right inferior parietal lobule, which were present in controls. Furthermore, the cerebellum in subjects with mTLE seemed to be playing a major role in the integration of their functional networks, which was evident through the engagement

2016 Epilepsy research

96. Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy Full Text available with Trip Pro

Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy It is estimated that 30%-40% of epilepsy patients are refractory to therapy and animal models are useful for the identification of more efficacious therapeutic agents. Various well-characterized syndrome-specific models are needed to assess their relevance to human seizure disorders and their validity for testing potential therapies. The corneal kindled mouse model of temporal lobe epilepsy (TLE) allows (...) posterior parietal cortex at 2 time points in each of these TLE models. Corneal kindled mice were observed to have astrogliosis, but not microgliosis or neuron cell death. In contrast, TMEV-injected mice had astrogliosis, microgliosis, neuron death, and astrocyte and microglial proliferation. Our results suggest that these 2 animal models might be appropriate for evaluation of distinct therapies for TLE. © 2016 American Association of Neuropathologists, Inc. All rights reserved.

2016 Journal of neuropathology and experimental neurology

97. Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy Full Text available with Trip Pro

Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca's area/the right Broca's homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF (...) ) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca's area/the right Broca's homologue during a semantic classification task of a single word. The structural connectivity through the AF pathway and task-modulated functional connectivity with Broca's area decreased in the left midtemporal cortex. Furthermore, task-related

2016 Human brain mapping

98. Clinical Reasoning: Seizures from the neglected lobe Full Text available with Trip Pro

Female Humans Parietal Lobe pathology Seizures diagnosis physiopathology 2016 3 9 6 0 2016 3 10 6 0 2016 7 29 6 0 ppublish 26952306 WNL.0000000000002447 10.1212/WNL.0000000000002447 PMC4782116 PM R. 2012 Dec;4(12):928-35 23122896 Acta Neuropathol. 2010 Sep;120(3):359-67 20607544 Eur J Radiol. 2013 Nov;82(11):1964-72 23787273 J Int Neuropsychol Soc. 2000 Sep;6(6):731-3 11011519 Arch Neurol. 1992 Mar;49(3):246-51 1536626 J Cogn Neurosci. 2001 Jul 1;13(5):698-710 11506665 Semin Ophthalmol. 2006 Oct-Dec (...) Clinical Reasoning: Seizures from the neglected lobe 26952306 2016 07 28 2018 11 13 1526-632X 86 10 2016 Mar 08 Neurology Neurology Clinical Reasoning: Seizures from the neglected lobe. e97-e100 10.1212/WNL.0000000000002447 Muhlhofer Wolfgang W From the Department of Neurology (W.M., B.P., N.S.), University of California San Francisco; and Palo Alto University (G.L.), CA. wolfgang.muhlhofer@ucsf.edu. Paul Brianna B From the Department of Neurology (W.M., B.P., N.S.), University of California

2016 Neurology

99. The superficial white matter in temporal lobe epilepsy: a key link between structural and functional network disruptions. Full Text available with Trip Pro

The superficial white matter in temporal lobe epilepsy: a key link between structural and functional network disruptions. Drug-resistant temporal lobe epilepsy is increasingly recognized as a system-level disorder affecting the structure and function of large-scale grey matter networks. While diffusion magnetic resonance imaging studies have demonstrated deep fibre tract alterations, the superficial white matter immediately below the cortex has so far been neglected despite its proximity (...) to neocortical regions and key role in maintaining cortico-cortical connectivity. Using multi-modal 3 T magnetic resonance imaging, we mapped the topography of superficial white matter diffusion alterations in 61 consecutive temporal lobe epilepsy patients relative to 38 healthy controls and studied the relationship to large-scale structural as well as functional networks. Our approach continuously sampled mean diffusivity and fractional anisotropy along surfaces running 2 mm below the cortex. Multivariate

2016 Brain

100. Connectome Reorganization Associated With Surgical Outcome in Temporal Lobe Epilepsy. Full Text available with Trip Pro

Connectome Reorganization Associated With Surgical Outcome in Temporal Lobe Epilepsy. To identify the distinct pattern of anatomical network reorganization in surgically refractory mesial temporal lobe epilepsy (MTLE) patients using a longitudinal design. We collected longitudinal diffusion-weighted images of 19 MTLE patients before and after anterior temporal lobectomy. Patients were classified as seizure-free (SF) or nonseizure-free (NSF) at least 1 year after surgery. We constructed whole (...) before surgery and then converge after surgery, suggesting that surgery remodeled these structures into a similar status. Conversly, contralateral amygdala-planum-temporale and thalamic-parietal tracts showed higher connectivity strength in NSF than in SF patients after surgery, indicating maladaptive neuroplastic responses to surgery in NSF patients. Our findings suggest that surgical outcomes are associated not only with the preoperative pattern of anatomical connectivity, but also with connectome

2015 Medicine

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