How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

2,840 results for

Parietal Lobe

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Low Functional Robustness in Mesial Temporal Lobe Epilepsy Full Text available with Trip Pro

Low Functional Robustness in Mesial Temporal Lobe Epilepsy Brain functional topology was investigated in patients with mesial temporal lobe epilepsy (mTLE) by means of graph theory measures in two differentially defined graphs. Measures of segregation, integration, and centrality were compared between subjects with mTLE and healthy controls (HC).Eleven subjects with mTLE (age 36.5±10.9years) and 15 age-matched HC (age 36.8±14.0years) participated in this study. Both anatomically (...) of patients presented lower global segregation than HC while showing higher global but lower local integration. They also failed to engage regions that comprise the default-mode network (DMN) as hubs such as bilateral medial frontal regions, PCC/precuneus complex, and right inferior parietal lobule, which were present in controls. Furthermore, the cerebellum in subjects with mTLE seemed to be playing a major role in the integration of their functional networks, which was evident through the engagement

2016 Epilepsy research

82. Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy Full Text available with Trip Pro

Abnormal UP/DOWN Membrane Potential Dynamics Coupled with the Neocortical Slow Oscillation in Dentate Granule Cells during the Latent Phase of Temporal Lobe Epilepsy The dentate gyrus, a major entry point to the hippocampus, gates (or filters) incoming information from the cortex. During sleep or anesthesia, the slow-wave oscillation (SWO) orchestrates hippocampus-neocortex communication, which is important for memory formation. The dentate gate is altered in temporal lobe epilepsy (TLE) early (...) during epileptogenesis, which favors the propagation of pathological activities. Yet, whether the gating of physiological SWO by dentate granule cells (DGCs) is altered in TLE has remained unexplored. We combined intracellular recordings of membrane potential (V m) of DGCs and local field potential recordings of the SWO in parietal cortex in anesthetized rats early during epileptogenesis [post-status epilepticus (SE) rats]. As expected, in control rats, the V m of DGCs weakly and rarely oscillated

2016 eNeuro

83. The Anterolateral Limit of the Occipital Lobe: An Anatomical and Imaging Study Full Text available with Trip Pro

The Anterolateral Limit of the Occipital Lobe: An Anatomical and Imaging Study Objectives The boundaries of the temporal lobe, the parietal lobe, and the anterior portion of the occipital lobe (OL) are poorly defined. Lesions in these areas can be difficult to localize. Therefore, we studied the anterolateral limit of the OL to identify reliable anatomical landmarks. Design In 10 formalin-fixed cadaveric heads, the boundaries of the OL and relative anatomical landmarks were studied. Main

2016 Journal of neurological surgery. Part B, Skull base

84. Alteration of the Intra- and Cross- Hemisphere Posterior Default Mode Network in Frontal Lobe Glioma Patients Full Text available with Trip Pro

Alteration of the Intra- and Cross- Hemisphere Posterior Default Mode Network in Frontal Lobe Glioma Patients Patients with frontal lobe gliomas often experience neurocognitive dysfunctions before surgery, which affects the default mode network (DMN) to different degrees. This study quantitatively analyzed this effect from the perspective of cerebral hemispheric functional connectivity (FC). We collected resting-state fMRI data from 20 frontal lobe glioma patients before treatment and 20 (...) healthy controls. All of the patients and controls were right-handed. After pre-processing the images, FC maps were built from the seed defined in the left or right posterior cingulate cortex (PCC) to the target regions determined in the left or right temporal-parietal junction (TPJ), respectively. The intra- and cross-group statistical calculations of FC strength were compared. The conclusions were as follows: (1) the intra-hemisphere FC strength values between the PCC and TPJ on the left and right

2016 Scientific reports

85. Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy Full Text available with Trip Pro

Resting state functional network disruptions in a kainic acid model of temporal lobe epilepsy We studied the graph topological properties of brain networks derived from resting-state functional magnetic resonance imaging in a kainic acid induced model of temporal lobe epilepsy (TLE) in rats. Functional connectivity was determined by temporal correlation of the resting-state Blood Oxygen Level Dependent (BOLD) signals between two brain regions during 1.5% and 2% isoflurane, and analyzed (...) and temporal association cortex, and posterior parietal cortex. The TLE model manifested a higher clustering coefficient, increased global and local efficiency, and increased small-worldness as compared to controls, despite having a similar characteristic path length. These results suggest extensive disruptions in the functional brain networks, which may be the basis of altered cognitive, emotional and psychiatric symptoms in TLE.

2016 NeuroImage : Clinical

86. Altered local spontaneous activity in frontal lobe epilepsy: a resting‐state functional magnetic resonance imaging study Full Text available with Trip Pro

Altered local spontaneous activity in frontal lobe epilepsy: a resting‐state functional magnetic resonance imaging study The purpose of this study was to investigate the local spatiotemporal consistency of spontaneous brain activity in patients with frontal lobe epilepsy (FLE).Eyes closed resting-state functional magnetic resonance imaging (fMRI) data were collected from 19 FLE patients and 19 age- and gender-matched healthy controls. A novel measure, named FOur-dimensional (spatiotemporal (...) the frontal and parietal cortices, as well as the basal ganglia. The decreased FOCA was located in the temporal cortex, posterior default model regions, and cerebellum. In addition, the FOCA measure was linked to the duration of epilepsy in basal ganglia.Our study suggested that alterations of local spontaneous activity in frontoparietal cortex and basal ganglia was associated with the pathophysiology of FLE; and the abnormality in frontal and default model regions might account for the potential

2016 Brain and behavior

87. Insights into Intrinsic Brain Networks based on Graph Theory and PET in right- compared to left-sided Temporal Lobe Epilepsy Full Text available with Trip Pro

connectivity, inferred from inter-regional [(18)F]FDG PET uptake correlations, in right-sided (RTLE; n = 30) and left-sided TLE (LTLE; n = 32) with healthy controls (HC; n = 31) using graph theory based network analysis. Comparing LTLE and RTLE and patient groups separately to HC, we observed higher lobar connectivity weights in RTLE compared to LTLE for connections of the temporal and the parietal lobe of the contralateral hemisphere (CH). Moreover, especially in RTLE compared to LTLE higher local (...) Insights into Intrinsic Brain Networks based on Graph Theory and PET in right- compared to left-sided Temporal Lobe Epilepsy The human brain exhibits marked hemispheric differences, though it is not fully understood to what extent lateralization of the epileptic focus is relevant. Preoperative [(18)F]FDG-PET depicts lateralization of seizure focus in patients with temporal lobe epilepsy and reveals dysfunctional metabolic brain connectivity. The aim of the present study was to compare metabolic

2016 Scientific reports

88. Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy Full Text available with Trip Pro

Altered Anterior-Posterior Connectivity Through the Arcuate Fasciculus in Temporal Lobe Epilepsy How the interactions between cortices through a specific white matter pathway change during cognitive processing in patients with epilepsy remains unclear. Here, we used surface-based structural connectivity analysis to examine the change in structural connectivity with Broca's area/the right Broca's homologue in the lateral temporal and inferior parietal cortices through the arcuate fasciculus (AF (...) ) in 17 patients with left temporal lobe epilepsy (TLE) compared with 17 healthy controls. Then, we investigated its functional relevance to the changes in task-related responses and task-modulated functional connectivity with Broca's area/the right Broca's homologue during a semantic classification task of a single word. The structural connectivity through the AF pathway and task-modulated functional connectivity with Broca's area decreased in the left midtemporal cortex. Furthermore, task-related

2016 Human brain mapping

89. The superficial white matter in temporal lobe epilepsy: a key link between structural and functional network disruptions. Full Text available with Trip Pro

The superficial white matter in temporal lobe epilepsy: a key link between structural and functional network disruptions. Drug-resistant temporal lobe epilepsy is increasingly recognized as a system-level disorder affecting the structure and function of large-scale grey matter networks. While diffusion magnetic resonance imaging studies have demonstrated deep fibre tract alterations, the superficial white matter immediately below the cortex has so far been neglected despite its proximity (...) to neocortical regions and key role in maintaining cortico-cortical connectivity. Using multi-modal 3 T magnetic resonance imaging, we mapped the topography of superficial white matter diffusion alterations in 61 consecutive temporal lobe epilepsy patients relative to 38 healthy controls and studied the relationship to large-scale structural as well as functional networks. Our approach continuously sampled mean diffusivity and fractional anisotropy along surfaces running 2 mm below the cortex. Multivariate

2016 Brain

90. Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy. Full Text available with Trip Pro

in ipsilateral insula and occipital lobe, contralateral motor area, and bilateral temporal and frontal lobes. TLE-NL had GM progression in ipsilateral hypothalamus and parietal lobe, contralateral cerebellum, and bilateral temporal lobe. Controls did not show changes in GM volume between MRIs.Diffuse extrahippocampal GM atrophy is present in seizure-free patients with TLE-HS. In addition, there is progressive GM atrophy in patients with and without HS. These results demonstrate that not only ongoing seizures (...) Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy. To investigate the presence and progression of gray matter (GM) reduction in seizure-free patients with temporal lobe epilepsy (TLE).We enrolled 39 consecutive TLE patients, seizure-free for at least 2 years--20 with magnetic resonance imaging (MRI) signs of hippocampal sclerosis (TLE-HS), 19 with normal MRI (TLE-NL), and 74 healthy controls. For longitudinal analysis, we included individuals who had

2016 Epilepsia

91. The Role of Right Inferior Parietal Cortex in Auditory Spatial Attention: A Repetitive Transcranial Magnetic Stimulation Study Full Text available with Trip Pro

the first time window. The asymmetric effect of attended location on gradients in the third time window may relate to neglect of the left hemispace after right parietal injury. Together, these results highlight the role of the right inferior parietal cortex in modulating frontal lobe attention network activity. (...) The Role of Right Inferior Parietal Cortex in Auditory Spatial Attention: A Repetitive Transcranial Magnetic Stimulation Study Behavioral studies support the concept of an auditory spatial attention gradient by demonstrating that attentional benefits progressively diminish as distance increases from an attended location. Damage to the right inferior parietal cortex can induce a rightward attention bias, which implicates this region in the construction of attention gradients. This study used

2015 PloS one

92. Refuting the hypothesis that a unilateral human parietal lesion abolishes saccade corollary discharge. Full Text available with Trip Pro

Refuting the hypothesis that a unilateral human parietal lesion abolishes saccade corollary discharge. This paper questions the prominent role that the parietal lobe is thought to play in the processing of corollary discharges for saccadic eye movements. A corollary discharge copies the motor neurons' signal and sends it to brain areas involved in monitoring eye trajectories. The classic double-step saccade task has been used extensively to study these mechanisms: two targets (T1 and T2 (...) ) are quickly (40-150 ms) flashed sequentially in the periphery. After the extinction of the fixation point, subjects are to make two saccades (S1 and S2), in the dark, to the remembered locations of the targets in the order they appeared. The success of S2 requires a corollary discharge encoding S1's vector. Patients with a parietal lobe lesion, particularly on the right, are impaired at generating an accurate S2 when S1 is directed contralesionally, but not ipsilesionally, thought due to an impaired

2015 Brain

93. Fusion and Fission of Cognitive Functions in the Human Parietal Cortex Full Text available with Trip Pro

Fusion and Fission of Cognitive Functions in the Human Parietal Cortex How is higher cognitive function organized in the human parietal cortex? A century of neuropsychology and 30 years of functional neuroimaging has implicated the parietal lobe in many different verbal and nonverbal cognitive domains. There is little clarity, however, on how these functions are organized, that is, where do these functions coalesce (implying a shared, underpinning neurocomputation) and where do they divide (...) (indicating different underlying neural functions). Until now, there has been no multi-domain synthesis in order to reveal where there is fusion or fission of functions in the parietal cortex. This aim was achieved through a large-scale activation likelihood estimation (ALE) analysis of 386 studies (3952 activation peaks) covering 8 cognitive domains. A tripartite, domain-general neuroanatomical division and 5 principles of cognitive organization were established, and these are discussed with respect

2014 Cerebral Cortex (New York, NY)

94. Decreased γ-Aminobutyric Acid Levels in the Parietal Region of Patients With Alzheimer’s disease Full Text available with Trip Pro

Decreased γ-Aminobutyric Acid Levels in the Parietal Region of Patients With Alzheimer’s disease To determine whether there are in vivo differences of γ-aminobutyric acid (GABA) levels in frontal and parietal regions of Alzheimer's disease (AD) patients, compared with healthy controls using magnetic resonance spectroscopy ((1) H-MRS).Fifteen AD patients and fifteen age- and gender-matched healthy controls underwent (1) H-MRS of the frontal and parietal lobes using the "MEGA-Point Resolved (...) GABA+/Cr and MMSE scores was also analyzed.Significant lower GABA+/Cr ratios were found in the parietal region of AD patients compared with controls (P = 0.041). In AD patients, no significant correlations between GABA+/Cr and MMSE scores were found in either the frontal (r = -0.164; P = 0.558) or parietal regions (r = 0.025; P = 0.929).Decreased GABA+/Cr levels were present in the parietal region of patients with AD in vivo, suggesting that abnormalities of the GABAergic system may be present

2014 Journal of magnetic resonance imaging : JMRI

95. Parcellation of left parietal tool representations by functional connectivity Full Text available with Trip Pro

. A third cluster in the superior parietal lobe expressed privileged functional connectivity with dorsal occipital cortex. Control analyses using Monte Carlo style permutation tests demonstrated that the clustering solutions were outside the range of what would be observed based on chance 'lumpiness' in random data, or mere anatomical proximity. Finally, hierarchical clustering analyses were used to formally relate the resulting parcellation scheme of left parietal tool representations to previous work (...) Parcellation of left parietal tool representations by functional connectivity Manipulating a tool according to its function requires the integration of visual, conceptual, and motor information, a process subserved in part by left parietal cortex. How these different types of information are integrated and how their integration is reflected in neural responses in the parietal lobule remains an open question. Here, participants viewed images of tools and animals during functional magnetic

2014 Neuropsychologia

96. Epileptic kinetopsia localizes to superior parietal lobule and intraparietal sulcus Full Text available with Trip Pro

, Queen Square, London, UK. Wehner Tim T From the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. Diehl Beate B From the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. b.diehl@ucl.ac.uk. eng Case Reports Journal Article 2014 07 16 United States Neurology 0401060 0028-3878 AIM IM Adult Brain Neoplasms complications diagnosis physiopathology Electroencephalography methods Female Humans Neural Pathways physiopathology Parietal Lobe physiopathology (...) Epileptic kinetopsia localizes to superior parietal lobule and intraparietal sulcus 25031283 2014 12 22 2018 11 13 1526-632X 83 8 2014 Aug 19 Neurology Neurology Epileptic kinetopsia localizes to superior parietal lobule and intraparietal sulcus. 768-70 10.1212/WNL.0000000000000709 Perumal Madhusoothanan Bhagavathi MB From the National Hospital for Neurology and Neurosurgery, Queen Square, London, UK. Chinnasami Suganthi S From the National Hospital for Neurology and Neurosurgery, Queen Square

2014 Neurology

97. Fronto-parietal connectivity changes following noxious stimulation during anesthesia Full Text available with Trip Pro

Fronto-parietal connectivity changes following noxious stimulation during anesthesia The aim of our study was to assess the changes in the fronto-parietal connectivity estimated by the cross approximate entropy (XAppEn) during noxious stimulation while under chloral hydrate anaesthesia, in rats.A group of 11 Wistar rats chronically implanted with Ni-Cr electrodes, which were placed on the dura mater of the right hemisphere (over the olfactory cortex, the frontal and the parietal lobes), were (...) used in the present study. Noxious stimuli of a mechanical and thermal nature were applied on the left hindpaw during chloral hydrate anesthesia. The anesthetic depth was estimated through median frequency computation, which in that instance was of 2-3 Hz. Fronto-parietal functional cortical connectivity was assessed by using XAppEn.After data processing and analysis we observed an increase of fronto-parietal functional connectivity during mechanical and thermal noxious stimulation. In addition

2014 Journal of medicine and life

98. Commonalities for numerical and continuous quantity skills at temporo-parietal junction. Full Text available with Trip Pro

of numerical and continuous quantity processing in the right TPJ; in contrast, individual differences in number proficiency were associated with gray matter volume in number-specific cortical regions in the right parietal lobe. Together, our new converging evidence of selective numerical impairment and of number-specific brain areas at least partially distinct from common magnitude areas suggests that the human brain is equipped with different ways of quantifying the outside world. (...) Commonalities for numerical and continuous quantity skills at temporo-parietal junction. How do our abilities to process number and other continuous quantities such as time and space relate to each other? Recent evidence suggests that these abilities share common magnitude processing and neural resources, although other findings also highlight the role of dimension-specific processes. To further characterize the relation between number, time, and space, we first examined them in a population

2014 Journal of cognitive neuroscience

99. Functional connectivity changes between parietal and prefrontal cortices in primary insomnia patients: evidence from resting-state fMRI Full Text available with Trip Pro

of cortical pathways by measuring local and regional correlations in blood oxygen level dependent (BOLD) signs independent of specific task demands.We compared the R-fMRI activity patterns of 15 healthy controls to 15 primary insomnia patients (all 30 participants were right-handed) using a 3.0 T MRI scanner. The SPM8 and REST1.7 software packages were used for preprocessing and analysis. Activity was expressed relative to the superior parietal lobe (SPL, the seed region) to reveal differences (...) , while connectivity was weaker between the SPL and right superior frontal gyrus (dorsolateral prefrontal cortex).Primary insomnia appears to alter the functional connectivity between the parietal and frontal lobes, cortical structures critical for spatial and verbal working memory.

2014 European Journal Of Medical Research

100. Increased suicide attempts in young depressed patients with abnormal temporal-parietal-limbic gray matter volume. (Abstract)

in depressive patients.Compared with controls, patients without suicide history showed significant decreased gray matter volume in the left insula lobe [-35 18 9], whereas patients with suicide history showed significantly decreased gray matter volume in the right middle temporal gyrus [60 -53 -8] and increased gray matter volume in the right parietal lobe [39 -39 60]. Compared with the non-suicidal depressed patient group, the suicidal group showed significant decreased gray matter volume in left limbic (...) Increased suicide attempts in young depressed patients with abnormal temporal-parietal-limbic gray matter volume. Suicide is a major cause of death throughout the world. Approximately 60% of all suicides have a history of depression. Previous studies of structural brain imaging have shown that suicide is often associated with abnormal fronto-limbic networks. However, the mechanism underlying suicide in depression remains poorly understood.Twenty sex- and age-matched suicidal unipolar patients

2014 Journal of Affective Disorders

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>