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Parietal Lobe

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201. Magnetic resonance imaging measures of brain atrophy from the EXPEDITION3 trial in mild Alzheimer's disease. Full Text available with Trip Pro

centrally by tensor-based morphometry with a standard FreeSurfer brain parcellation. Prespecified volumetric measures, including whole brain and ventricles, along with anatomically localized regions in the temporal, parietal, and frontal lobes were evaluated in those participants.Group-mean differences in brain atrophy rates were directionally consistent across a number of brain regions but small in magnitude (1.3-6.9% slowing) and not statistically significant when corrected for multiple comparisons

2019 Alzheimer's & dementia (New York, N. Y.) Controlled trial quality: uncertain

202. Neuroimaging Findings in US Government Personnel With Possible Exposure to Directional Phenomena in Havana, Cuba. Full Text available with Trip Pro

significantly greater ventral diencephalon and cerebellar gray matter volumes and significantly smaller frontal, occipital, and parietal lobe white matter volumes; significantly lower mean diffusivity in the inferior vermis of the cerebellum (patients: 7.71 × 10-4 mm2/s; controls: 8.98 × 10-4 mm2/s; difference, -1.27 × 10-4 [95% CI, -1.93 × 10-4 to -6.17 × 10-5] mm2/s; P < .001); and significantly lower mean functional connectivity in the auditory subnetwork (patients: 0.45; controls: 0.61; difference

2019 JAMA

203. Akynzeo (netupitant / palonosetron)

. Gall bladder: microscopic signs of phospholipidosis NOAEL: 200 mg/kg B-167720 (non-GLP) Dog/ beagle 1/sex/group 3, 10, 30, 30, 60, 100 and 150; escalating dose design Oral 150 mg/kg None Slight or moderate parietal cell necrosis in the glandular stomach. Minimal vacuolated macrophage infiltration in lymphoid tissues and lungs indicates minimal phospholipidosis. Four single dose studies in mice, rats and dogs. The major toxicity findings included death, microscopic changes in multiple organs (...) and this was agreed by the CHMP. Administration of netupitant to rabbits during the period of organogenesis was shown to increase the incidence of some foetal malformations: limb and paw positional anomalies, minimal/partial fusion of sternebrae, and agenesis of accessory lung lobe. The NOAEL for embryo-fetal development is 3 mg/kg/day. Taking into account the teratogen effect of netupitant in rabbit without a safety margin, a contraindication of AKYNZEO during pregnancy with a contraception measure for women

2015 European Medicines Agency - EPARs

204. The Utility of Positron Emission Tomography in Epilepsy

only 30% to 50% of patients undergoing extratemporal resection achieve seizure freedom (51). The results of the present study suggest that localization is greater in patients with temporal lobe epilepsy, who are more likely to benefit from surgical treatment than in patients with extratemporal lobe epilepsy. It appears that the heterogeneous clinical features of extratemporal (i.e., frontal, insular, occipital, and parietal) epilepsy make accurate localization more difficult. This is a critical (...) evaluation of refractory temporal lobe epilepsy: Comparison of MR imaging, PET and ictal SPECT in localization of the epileptogenic substrate. Egypt J Radiol Nucl Med. 2013 September;44(3):641-9. 5. Kim DW, Lee SK, Yun CH, Kim KK, Lee DS, Chung CK, et al. Parietal lobe epilepsy: the semiology, yield of diagnostic workup, and surgical outcome. Epilepsia. 2004 June;45(6):641-9. 6. Kim YK, Lee DS, Lee SK, Chung CK, Chung JK, Lee MC. 18F-FDG PET in localization of frontal lobe epilepsy: comparison of visual

2015 Cancer Care Ontario

205. Alpha desynchronization during simple working memory unmasks pathological aging in cognitively healthy individuals. Full Text available with Trip Pro

-back WM testing, the behavioral performance was similar between the two groups, however, qEEG notably differentiated CH-PATs from CH-NATs on the simple, 0-back testing: Alpha ERD decreased from baseline only in the parietal region in CH-NATs, while it decreased in all brain regions in CH-PATs. Alpha SE did not change in CH-NATs, but was increased from baseline in the CH-PATs in frontal and left lateral regions (p<0.01), and was higher in the frontal region (p<0.01) of CH-PATs compared to CH-NATs (...) . The alpha ERD and SE analyses suggest there is frontal lobe dysfunction during WM processing in the CH-PAT stage. Additional power and correlations with behavioral performance were also explored. This study provide pilot information to further evaluate whether this biomarker has clinical significance.

2019 PLoS ONE

206. Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia. Full Text available with Trip Pro

-semantic processes rely on partially distinct neural substrates: a dorsal (occipito-parietal) and a ventral (occipito-temporal) route, respectively. Here, we investigated the spatiotemporal features of orthography-to-phonology mapping, capitalizing on the time resolution of magnetoencephalography and the unique clinical model offered by patients with semantic variant of primary progressive aphasia (svPPA). Behaviourally, patients with svPPA manifest marked lexico-semantic impairments including (...) difficulties in reading words with exceptional orthographic to phonological correspondence (irregular words). Moreover, they present with focal neurodegeneration in the anterior temporal lobe, affecting primarily the ventral, occipito-temporal, lexical route. Therefore, this clinical population allows for testing of specific hypotheses on the neural implementation of the dual-route model for reading, such as whether damage to one route can be compensated by over-reliance on the other. To this end, we

2020 Brain

207. Sex effects on brain structure in de novo Parkinson's disease: a multimodal neuroimaging study. (Abstract)

matched for disease duration and severity, males demonstrated generally greater brain atrophy and disrupted connectivity. Males with Parkinson's disease had significantly greater tissue loss than females in 11 cortical regions including bilateral frontal and left insular lobe, right postcentral gyrus, left inferior temporal and cingulate gyrus and left thalamus, while females had greater atrophy in six cortical regions, including regions in the left frontal lobe, right parietal lobe, left insular

2020 Brain

208. Neuronal pentraxin 2: a synapse-derived CSF biomarker in genetic frontotemporal dementia. Full Text available with Trip Pro

(median 643 pg/mL, IQR (301-872)) than presymptomatic carriers (1003 pg/mL (624-1358), p<0.001) and non-carriers (990 pg/mL (597-1373), p<0.001) (corrected for age). Similar results were found for NPTX1 and NPTXR. Among mutation carriers, NPTX2 concentration correlated with several clinical disease severity measures, NfL and grey matter volume of the frontal, temporal and parietal lobes, insula and whole brain. NPTX2 predicted subsequent decline in phonemic verbal fluency and Clinical Dementia Rating

2020 Neurosurgery and Psychiatry

209. Abnormal information flow in postpartum depression: A resting-state functional magnetic resonance imaging study. (Abstract)

analyses were performed to evaluate the relationship of the information flow characteristics with clinical scales. A predictive model for the mental state of the patients with PPD was established using SVR based on information flow characteristics.The information flow patterns in the amygdala, cingulum gyrus, insula, hippocampus, frontal lobe, parietal lobe, and occipital lobe changed significantly in the patients with PPD. The preferred information flow direction between the amygdala and the temporal (...) and frontal lobes significantly correlated with clinical scales. Prediction analysis shows that the information flow patterns can be used to assess depression in patients with PPD.This exploratory study has a small sample size with no longitudinal research.The change in information flow pattern in the amygdala may play an important role in the neuropathological mechanism of PPD and may provide promising markers for clinical evaluation.Copyright © 2020 Elsevier B.V. All rights reserved.

2020 Journal of Affective Disorders

210. Two-week rTMS-induced neuroimaging changes measured with fMRI in depression. (Abstract)

increased FCD in the right dorsal anterior cingulate cortex and OFC and decreased FCD in the right inferior parietal lobe and in the CEN. After rTMS, patients showed increased ALFF in the left dorsolateral prefrontal cortex (DLPFC)and superior frontal gyrus, FCD in the right dorsal anterior cingulate cortex, superior temporal gyrus and CEN, as well as decreased FCD in the bilateral lingual gyrus than pre-rTMS . These rTMS induced neuroimaging changes did not significantly correlated with clinical

2020 Journal of Affective Disorders

211. Structural and functional brain abnormalities in HIV disease revealed by multimodal MRI fusion: association with cognitive function. (Abstract)

lobe; and functional connectivity in fronto-parietal and visual processing regions. Component loadings for fractional anisotropy also correlated with immunosuppression.These results suggest that co-alterations in brain structure and function can distinguish people with and without HIV and may drive cognitive impairment. As MRI becomes more commonplace in HIV care, multimodal fusion may provide neural biomarkers to support diagnosis and treatment of cognitive impairment.© The Author(s) 2020 (...) ), using global cognitive functioning as the reference.Compared to controls, participants with HIV had lower global cognitive functioning. One joint component was both group discriminating and correlated with cognitive function. This component included the following covarying regions: fractional anisotropy in the corpus callosum, short and long association fiber tracts, and corticopontine fibers; gray matter volume in thalamus, prefrontal cortex, precuneus, posterior parietal regions, and occipital

2020 Clinical Infectious Diseases

213. Gray Matter Regions Associated With Functional Mobility in Community-Dwelling Older Adults. (Abstract)

the mobility measures and neuroimaging measures were conducted using whole brain and regional and tract-specific measures. This was followed by linear regression models relating the mobility measures to regions or tracts identified in the correlation analysis, and adjusting for age, sex, and body mass index.Significant associations were found between higher GMV in multiple regions, primarily the parietal and temporal lobes, and better performance in gait speed, DGI, and FSST. After adjusting for personal (...) factors, greater parahippocampus GMV was independently associated with greater gait speed. Greater inferior parietal lobe, supramarginal gyrus, and superior temporal gyrus GMVs were associated with gait function. Greater postcentral gyrus, parahippocampus, and superior temporal gyrus GMVs were associated with faster FSST performance. The WMHV and FA were not significantly correlated with the mobility measures.Gray matter regions associated with higher performance in mobility measures serving gait

2020 Journal of the American Geriatrics Society

214. Exposure to food in anorexia nervosa and brain correlates of food-related anxiety: findings from a pilot study. (Abstract)

treatment, patients (compared to HC), show increased activity in the dorsolateral prefrontal cortex, decreased activity in the superior parietal lobe and no differences in the ACC. The level of activation of the insula (pre-treatment) predicted the degree of post-treatment reduction in self-reported food anxiety in AN. Changes in food-related anxiety were also associated with changes in neural activation in a cluster located in the middle temporal gyrus/lateral parietal cortex.The primary limitations

2020 Journal of Affective Disorders

215. Impaired social learning predicts reduced real-life motivation in individuals with depression: A computational fMRI study. Full Text available with Trip Pro

to engage in real-life social activities and demonstrated elevated uncertainty about social outcomes in the task. Moreover, HD subjects displayed altered encoding of social reward predictions in the insula, temporal lobe and parietal lobe. Interestingly, across all subjects, higher task uncertainty and reduced parietal prediction encoding were associated with decreased motivation to engage in real-life social activities.The size of the included sample was relatively small. The results should thus

2020 Journal of Affective Disorders

216. Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers. (Abstract)

, including 54 symptomatic C9orf72 carriers (72.2% behavioral variant FTD), 83 asymptomatic carriers, and 249 controls (age range = 18-86 years). Symptomatic carriers showed fairly symmetric reduction in CTh/CSA in most of the frontal lobes, in addition to large temporoparietal areas. Presymptomatic subjects had reduced CTh/CSA in more restricted areas of the medial frontoparietal lobes, in addition to scattered lateral frontal, parietal, and temporal areas. These differences were explained by faster

2020 Annals of Neurology

217. Synaptic Loss in Primary Tauopathies Revealed by [<sup>11</sup> C]UCB-J Positron Emission Tomography. Full Text available with Trip Pro

, temporal, parietal, and occipital lobes, cingulate, hippocampus, insula, amygdala, and subcortical structures in both PSP and CBD patients compared to controls (P < 0.01), with median reductions up to 50%, consistent with postmortem data. Reductions of 20% to 30% were widespread even in areas of the brain with minimal atrophy. There was a negative correlation between global [11 C]UCB-J binding and the PSP and CBD rating scales (R = -0.61, P < 0.002; R = -0.72, P < 0.001, respectively) and a positive

2020 Movement Disorders

218. Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease. (Abstract)

groups.At baseline, compared with Parkinson's disease with stable normal cognition cases, Parkinson's disease with conversion to mild cognitive impairment patients showed cortical atrophy of the parietal and occipital lobes, similar to Parkinson's disease with stable mild cognitive impairment and Parkinson's disease with conversion to dementia patients. The latter groups (ie, patients with cognitive impairment from the study entry) showed additional involvement of the frontotemporal cortices (...) patients showing specific cortical thinning accumulation in the medial and superior frontal gyri, inferior temporal, precuneus, posterior cingulum, and supramarginal gyri bilaterally; and Parkinson's disease with stable normal cognition patients showing cortical thinning progression, mainly in the occipital and parietal regions bilaterally.Cortical thinning progression is more prominent in the initial stages of PD cognitive decline. The involvement of frontotemporoparietal regions, the hippocampus

2020 Movement Disorders

219. Motor Cerebellar Connectivity and Future Development of Freezing of Gait in De Novo Parkinson's Disease. (Abstract)

. Connectivity between lobule VI and the right superior parietal lobule, right fusiform gyrus, and left inferior temporal gyrus; between lobule VIIb and the right superior parietal lobule, right hippocampus, and right middle temporal gyrus; and between lobule VIIIb and the bilateral fusiform gyri, right middle occipital gyrus, and bilateral parietal lobes was inversely proportional to freezing of gait latency. The freezing of gait latency-related cortical functional connectivity from the motor cerebellum

2020 Movement Disorders

220. A parcellation-based model of the auditory network. (Abstract)

of the auditory network: areas 44 and 8C, auditory area 1, 4, and 5, frontal operculum area 4, the lateral belt, medial belt and parabelt, parietal area F centromedian, perisylvian language area, retroinsular cortex, supplementary and cingulate eye field and the temporoparietal junction area 1. These regions showed consistent interconnections between adjacent parcellations. The frontal aslant tract was found to connect areas within the frontal lobe, while the arcuate fasciculus was found to connect (...) the frontal and temporal lobe, and subcortical U-fibers were found to connect parcellations within the temporal area. Further studies may refine this model with the ultimate goal of clinical application.Copyright © 2020. Published by Elsevier B.V.

2020 Hearing Research

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