How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

203 results for

Paraneoplastic Pemphigus

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. Pemphigus (PubMed)

Pemphigus Pemphigus is a group of IgG-mediated autoimmune diseases of stratified squamous epithelia, such as the skin and oral mucosa, in which acantholysis (the loss of cell adhesion) causes blisters and erosions. Pemphigus has three major subtypes: pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. IgG autoantibodies are characteristically raised against desmoglein 1 and desmoglein 3, which are cell-cell adhesion molecules found in desmosomes. The sites of blister formation (...) can be physiologically explained by the anti-desmoglein autoantibody profile and tissue-specific expression pattern of desmoglein isoforms. The pathophysiological roles of T cells and B cells have been characterized in mouse models of pemphigus and patients, revealing insights into the mechanisms of autoimmunity. Diagnosis is based on clinical manifestations and confirmed with histological and immunochemical testing. The current first-line treatment is systemic corticosteroids and adjuvant

Full Text available with Trip Pro

2017 Nature reviews. Disease primers

62. Paraneoplastic Autoimmune Multi-organ Syndrome: Association with Retroperitoneal Kaposi's Sarcoma. (PubMed)

Cozzani Emanuele E Rongioletti Franco F De Col Elena E Pastorino Carlotta C Murialdo Giovanni G Parodi Aurora A eng Case Reports Journal Article Research Support, Non-U.S. Gov't Sweden Acta Derm Venereol 0370310 0001-5555 0 Steroids IM Aged Antineoplastic Combined Chemotherapy Protocols therapeutic use Autoimmune Diseases diagnosis drug therapy etiology Fatal Outcome Humans Male Paraneoplastic Syndromes diagnosis drug therapy etiology Pemphigus diagnosis drug therapy etiology Retroperitoneal Neoplasms (...) Paraneoplastic Autoimmune Multi-organ Syndrome: Association with Retroperitoneal Kaposi's Sarcoma. 26072713 2016 12 13 2016 12 30 1651-2057 96 2 2016 Feb Acta dermato-venereologica Acta Derm. Venereol. Paraneoplastic Autoimmune Multi-organ Syndrome: Association with Retroperitoneal Kaposi's Sarcoma. 261-2 10.2340/00015555-2169 Ghigliotti Giovanni G Department of Dermatology, IRCCS AOU San Martino-IST, DISSAL, Sezione di Dermatologia, University of Genoa, 16100 Genoa, Italy. Di Zenzo Giovanni G

Full Text available with Trip Pro

2015 Acta Dermato-Venereologica

63. Wound Dressings for Pemphigus and Pemphigoid

Inclusion Criteria: Diagnosis of pemphigus vulgaris, pemphigus foliaceus , pemphigus vegetans, paraneoplastic pemphigus or bullous pemphigoid At least four areas of active disease in the trunk or limbs of 8 x 8 cm characterized by denudation, ulceration, scabs or blisters. Capable of being evaluated weekly either as outpatient or hospitalized Actively treated with immunosuppressive or immunomodulatory drugs for pemphigus or pemphigoid control Willing to sign an informed consent Exclusion Criteria (...) Wound Dressings for Pemphigus and Pemphigoid Wound Dressings for Pemphigus and Pemphigoid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Wound Dressings for Pemphigus and Pemphigoid The safety

2015 Clinical Trials

64. A Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Rituximab Versus MMF in Patients With Pemphigus Vulgaris

study participation Able to comply with the study protocol, in the investigator's judgment Exclusion Criteria: Diagnosis of pemphigus foliaceus or evidence of paraneoplastic pemphigus or other non-PV autoimmune blistering disease History of a severe allergic or anaphylactic reaction to humanized or murine monoclonal antibodies, or known hypersensitivity to any component of rituximab Known hypersensitivity or contraindication to MMF, mycophenolic acid, polysorbate, or oral corticosteroids Lack (...) A Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Rituximab Versus MMF in Patients With Pemphigus Vulgaris A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You

2015 Clinical Trials

65. Anti-desmocollin autoantibodies in non-classical pemphigus. (PubMed)

) of human Dsc1-3 in mammalian cells and examined sera of various types of pemphigus, including 79 paraneoplastic pemphigus (PNP) sera, by novel enzyme-linked immunosorbent assays (ELISAs) using the RPs. We also performed ELISAs of Dsc baculoproteins and used the complementary DNA (cDNA) transfection method, and compared the results with those of mammalian ELISAs.Through mammalian ELISAs, IgG autoantibodies to Dsc1, Dsc2 and Dsc3 were detected in 16.5%, 36.7% and 59.5% of PNP sera, respectively (...) Anti-desmocollin autoantibodies in non-classical pemphigus. Despite the established pathogenic role of anti-desmoglein (Dsg) antibodies in classical pemphigus, the significance of autoantibodies to another desmosomal cadherin, desmocollin (Dsc) is at present unknown. No consistent immunoassay for immunoglobulin (Ig) G autoantibodies to Dscs has been developed.The aim of this study was to develop reliable assays to detect anti-Dsc autoantibodies.We expressed soluble recombinant proteins (RPs

2015 British Journal of Dermatology

66. Paraneoplastic Syndromes (Overview)

to individual, prognosis may vary greatly. For example, disseminated intravascular coagulation indicates a poor prognosis, whereas hypertrophic osteoarthropathy is one of the few paraneoplastic syndromes that may indicate a more favorable prognosis. Some paraneoplastic disorders may resolve spontaneously. Death may result from the underlying cancer or from an irreversible system impairment, usually or kidney failure. In a review of patients with paraneoplastic pemphigus, infection was a major cause of death (...) . . . Leger S, Picard D, Ingen-Housz-Oro S, Arnault JP, Aubin F, et al. Prognostic factors of paraneoplastic pemphigus. Arch Dermatol . 2012 Oct. 148(10):1165-72. . Kawasoe T, Yamamoto Y, Okumura Y, et al. A case report of paraneoplastic neurological syndrome associated with occult breast cancer. Breast Cancer . 2006. 13(2):202-4. . Noorani A, Sadiq Z, Minakaran N, et al. Paraneoplastic cerebellar degeneration as a presentation of breast cancer - a case report and review of the literature. Int Semin Surg

2014 eMedicine.com

67. Paraneoplastic Syndromes (Treatment)

in patients without paraneoplastic syndromes (ie, surgery, radiation, or chemotherapy, alone or in combination). The second therapeutic option, in patients with clearly identifiable antibodies in their serum, is immunosuppression. This may be accomplished with intravenous immunoglobulins, [ , ] steroids or other immunosuppressive drugs, [ ] or plasma exchange. Some patients with paraneoplastic pemphigus [ , , , ] seem to derive some benefit from rituximab, but further studies are necessary to confirm (...) . Prognostic factors of paraneoplastic pemphigus. Arch Dermatol . 2012 Oct. 148(10):1165-72. . Kawasoe T, Yamamoto Y, Okumura Y, et al. A case report of paraneoplastic neurological syndrome associated with occult breast cancer. Breast Cancer . 2006. 13(2):202-4. . Noorani A, Sadiq Z, Minakaran N, et al. Paraneoplastic cerebellar degeneration as a presentation of breast cancer - a case report and review of the literature. Int Semin Surg Oncol . 2008 Apr 21. 5:8. . Hagler KT, Lynch JW Jr. Paraneoplastic

2014 eMedicine.com

68. Paraneoplastic Diseases (Treatment)

Paraneoplastic Diseases (Treatment) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NTExMy1vdmVydmlldw== processing > Dermatologic Manifestations of Paraneoplastic Syndromes Updated: Dec 22, 2017 Author: Mary V Kaldas, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Paraneoplastic Syndromes Overview Overview More than a quarter century ago, Curth proposed the following criteria to define a paraneoplastic syndrome: The malignancy and syndrome must appear at the same time, and their clinical courses should not significantly

2014 eMedicine.com

69. Paraneoplastic Diseases (Overview)

Paraneoplastic Diseases (Overview) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NTExMy1vdmVydmlldw== processing > Dermatologic Manifestations of Paraneoplastic Syndromes Updated: Dec 22, 2017 Author: Mary V Kaldas, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Paraneoplastic Syndromes Overview Overview More than a quarter century ago, Curth proposed the following criteria to define a paraneoplastic syndrome: The malignancy and syndrome must appear at the same time, and their clinical courses should not significantly

2014 eMedicine.com

70. Paraneoplastic Syndromes (Follow-up)

in patients without paraneoplastic syndromes (ie, surgery, radiation, or chemotherapy, alone or in combination). The second therapeutic option, in patients with clearly identifiable antibodies in their serum, is immunosuppression. This may be accomplished with intravenous immunoglobulins, [ , ] steroids or other immunosuppressive drugs, [ ] or plasma exchange. Some patients with paraneoplastic pemphigus [ , , , ] seem to derive some benefit from rituximab, but further studies are necessary to confirm (...) . Prognostic factors of paraneoplastic pemphigus. Arch Dermatol . 2012 Oct. 148(10):1165-72. . Kawasoe T, Yamamoto Y, Okumura Y, et al. A case report of paraneoplastic neurological syndrome associated with occult breast cancer. Breast Cancer . 2006. 13(2):202-4. . Noorani A, Sadiq Z, Minakaran N, et al. Paraneoplastic cerebellar degeneration as a presentation of breast cancer - a case report and review of the literature. Int Semin Surg Oncol . 2008 Apr 21. 5:8. . Hagler KT, Lynch JW Jr. Paraneoplastic

2014 eMedicine.com

71. Paraneoplastic Diseases (Follow-up)

Paraneoplastic Diseases (Follow-up) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NTExMy1vdmVydmlldw== processing > Dermatologic Manifestations of Paraneoplastic Syndromes Updated: Dec 22, 2017 Author: Mary V Kaldas, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Paraneoplastic Syndromes Overview Overview More than a quarter century ago, Curth proposed the following criteria to define a paraneoplastic syndrome: The malignancy and syndrome must appear at the same time, and their clinical courses should not significantly

2014 eMedicine.com

72. Paraneoplastic Syndromes (Diagnosis)

to individual, prognosis may vary greatly. For example, disseminated intravascular coagulation indicates a poor prognosis, whereas hypertrophic osteoarthropathy is one of the few paraneoplastic syndromes that may indicate a more favorable prognosis. Some paraneoplastic disorders may resolve spontaneously. Death may result from the underlying cancer or from an irreversible system impairment, usually or kidney failure. In a review of patients with paraneoplastic pemphigus, infection was a major cause of death (...) . . . Leger S, Picard D, Ingen-Housz-Oro S, Arnault JP, Aubin F, et al. Prognostic factors of paraneoplastic pemphigus. Arch Dermatol . 2012 Oct. 148(10):1165-72. . Kawasoe T, Yamamoto Y, Okumura Y, et al. A case report of paraneoplastic neurological syndrome associated with occult breast cancer. Breast Cancer . 2006. 13(2):202-4. . Noorani A, Sadiq Z, Minakaran N, et al. Paraneoplastic cerebellar degeneration as a presentation of breast cancer - a case report and review of the literature. Int Semin Surg

2014 eMedicine.com

73. Paraneoplastic Diseases (Diagnosis)

Paraneoplastic Diseases (Diagnosis) Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NTExMy1vdmVydmlldw== processing > Dermatologic Manifestations of Paraneoplastic Syndromes Updated: Dec 22, 2017 Author: Mary V Kaldas, MD; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Paraneoplastic Syndromes Overview Overview More than a quarter century ago, Curth proposed the following criteria to define a paraneoplastic syndrome: The malignancy and syndrome must appear at the same time, and their clinical courses should not significantly

2014 eMedicine.com

74. Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University. (PubMed)

in four cases, and cetapril, thiopronine and captopril in one patient each), and a nonthiol drug, sulfasalazine, in one patient. By ELISAs and/or IB analyses, nine patients reacted only with desmoglein 1 (Dsg1), four reacted with Dsg1 and Dsg3, and four showed no specific reactivity. By IB of normal human epidermal extracts, in addition to positive reactivity with Dsg1, four patients with no detectable malignancy showed paraneoplastic pemphigus-like reactivity with the 210-kDa envoplakin and the 190 (...) Clinical and immunological profiles in 17 Japanese patients with drug-induced pemphigus studied at Kurume University. Drug-induced pemphigus (DIP) shows clinical, histopathological and immunological features of pemphigus. However, little is known about immunological profiles in DIP.To characterize clinical and immunological profiles in patients with DIP.We studied 17 Japanese patients with DIP who were treated at Kurume University Hospital or who consulted from other hospitals between 1997

2014 British Journal of Dermatology

75. Pemphigus Vulgaris (Overview)

of the Pathogenesis of Pemphigus and Pemphigoid Meeting in Munich, September 2016. J Invest Dermatol . 2017 Jun. 137 (6):1199-1203. . Mentink LF, de Jong MC, Kloosterhuis GJ, Zuiderveen J, Jonkman MF, Pas HH. Coexistence of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. Br J Dermatol . 2007 Apr. 156(4):635-41. . Bhol K, Mohimen A, Ahmed AR. Correlation of subclasses of IgG with disease activity in pemphigus vulgaris. Dermatology . 1994. 189 Suppl 1 (...) Pemphigus Vulgaris (Overview) Pemphigus Vulgaris: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NDE4Ny1vdmVydmlldw== processing > Pemphigus Vulgaris Updated

2014 eMedicine.com

76. Pemphigus Foliaceus (Overview)

), endemic pemphigus foliaceus, endemic pemphigus foliaceus with antigenic reactivity characteristic of paraneoplastic pemphigus (but with no neoplasm), immunoglobulin A (IgA) pemphigus foliaceus, and drug-induced pemphigus foliaceus. See ; ; ; and for more information. Senear and Usher originally described PE in 1926 as an unusual type of pemphigus with features of lupus erythematosus. PE (also known as Senear-Usher syndrome) is best viewed as a localized form of pemphigus foliaceus. Chorzelski et al (...) but occurs in an endemic fashion. [ , ] It also may have autoantibodies to optic nerve sheath envelope cell junctions, the clinical significance of which is unknown. [ ] Heterogeneous antigenic reactivity was observed as in paraneoplastic pemphigus but with no evidence of association with neoplasia. This endemic pemphigus disease in El Bagre had immunologic features similar to pemphigus foliaceus or erythematosus. Chorzelski et al in 1999 [ ] described paraneoplastic pemphigus with cutaneous

2014 eMedicine.com

77. Pemphigus Erythematosus (Overview)

, Cohen JJ, Kerdel FA. Immunoablative high-dose cyclophosphamide without stem cell rescue in pemphigus foliaceus. Int J Dermatol . 2002 Jun. 41(6):340-4. . Hayag MV, Cohen JA, Kerdel FA. Immunoablative high-dose cyclophosphamide without stem cell rescue in a patient with pemphigus vulgaris. J Am Acad Dermatol . 2000 Dec. 43(6):1065-9. . Nousari HC, Brodsky RA, Jones RJ, Grever MR, Anhalt GJ. Immunoablative high-dose cyclophosphamide without stem cell rescue in paraneoplastic pemphigus: report (...) , Gogstetter DS, Scott G, Gaspari AA. Minocycline-induced hyperpigmentation in patients with pemphigus and pemphigoid. Arch Dermatol . 2000 Sep. 136(9):1133-8. . Borradori L, Lombardi T, Samson J, Girardet C, Saurat JH, Hugli A. Anti-CD20 monoclonal antibody (rituximab) for refractory erosive stomatitis secondary to CD20(+) follicular lymphoma-associated paraneoplastic pemphigus. Arch Dermatol . 2001 Mar. 137(3):269-72. . Goebeler M, Herzog S, Brocker EB, Zillikens D. Rapid response of treatment-resistant

2014 eMedicine.com

78. Pemphigus Herpetiformis (Overview)

-negative pemphigus herpetiformis. J Am Acad Dermatol . 2010 Jul. 63 (1):e8-10. . Prado R, Brice SL, Fukuda S, Hashimoto T, Fujita M. Paraneoplastic pemphigus herpetiformis with IgG antibodies to desmoglein 3 and without mucosal lesions. Arch Dermatol . 2011 Jan. 147 (1):67-71. . Ohyama B, Nishifuji K, Chan PT, Kawaguchi A, Yamashita T, Ishii N, et al. Epitope spreading is rarely found in pemphigus vulgaris by large-scale longitudinal study using desmoglein 2-based swapped molecules. J Invest Dermatol (...) of onset at 6 years. Dermatol Online J . 2011 Jun 15. 17(6):10. . Schoch JJ, Boull CL, Camilleri MJ, Tollefson MM, Hook KP, Polcari IC. Transplacental Transmission of Pemphigus Herpetiformis in the Setting of Maternal Lymphoma. Pediatr Dermatol . 2015 Nov-Dec. 32 (6):e234-7. . Kubota Y, Yoshino Y, Mizoguchi M. A case of herpetiform pemphigus associated with lung cancer. J Dermatol . 1994 Aug. 21(8):609-11. . Palleschi GM, Giomi B. Herpetiformis pemphigus and lung carcinoma: a case of paraneoplastic

2014 eMedicine.com

79. Pemphigus, IgA (Treatment)

, Maehara Lde S, Enokihara MM. Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus. An Bras Dermatol . 2014 Jan-Feb. 89 (1):96-106. . Howell SM, Bessinger GT, Altman CE, Belnap CM. Rapid response of IgA pemphigus of the subcorneal pustular dermatosis subtype to treatment with adalimumab and mycophenolate mofetil. J Am Acad Dermatol . 2005 Sep. 53(3):541-3. . Gruss C, Zillikens D, Hashimoto T, et al. Rapid response of IgA pemphigus (...) Pemphigus, IgA (Treatment) IgA Pemphigus Treatment & Management: Medical Care, Activity, Complications Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2Mzc3Ni10cmVhdG1lbnQ= processing > IgA Pemphigus Treatment

2014 eMedicine.com

80. Pemphigus Vulgaris (Treatment)

of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. Br J Dermatol . 2007 Apr. 156(4):635-41. . Bhol K, Mohimen A, Ahmed AR. Correlation of subclasses of IgG with disease activity in pemphigus vulgaris. Dermatology . 1994. 189 Suppl 1:85-9. . Wilson CL, Wojnarowska F, Dean D, Pasricha JS. IgG subclasses in pemphigus in Indian and UK populations. Clin Exp Dermatol . 1993 May. 18(3):226-30. . Fitzpatrick RE, Newcomer VD. The correlation (...) Pemphigus Vulgaris (Treatment) Pemphigus Vulgaris Treatment & Management: Medical Care, Consultations, Diet Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA2NDE4Ny10cmVhdG1lbnQ= processing > Pemphigus Vulgaris

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>