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161. Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). (PubMed)

Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). Subcutaneous panniculitis-like T-cell lymphoma is an uncommon form of cutaneous lymphoma in the pediatric population. It is characterized histologically by subcutaneous infiltration of pleomorphic cytotoxic T cells, mimicking a lobular panniculitis. Although usually described as having an indolent clinical course, the condition may be complicated (...) by systemic involvement and hemophagocytic syndrome, resulting in a poorer prognosis. We present two pediatric patients with aggressive forms of subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome, and discuss the current literature.

2009 Journal of American Academy of Dermatology

162. Alpha-1 antitrypsin deficiency

known as Wegener's granulomatosis) and necrotising panniculitis are infrequent complications but can prompt diagnosis. Plasma AAT levels, protein phenotyping (called Pi-typing), and protein genotyping may be necessary for diagnosis. Rare alleles may require gene sequencing. Intravenous AAT augmentation therapy benefits some patients. Definition Alpha-1 antitrypsin (AAT) deficiency is an autosomal codominant genetic disorder (i.e., 1 allele is inherited from each parent and each allele is expressed

2018 BMJ Best Practice

163. British Association of Dermatologists and U.K. Curaneous Lymphoma Group (CLG) guidelines for the management of primary cutaneous lymphomas

clinical behaviour ? Primary cutaneous marginal zone B-cell lymphoma a ? Primary cutaneous follicle centre lymphoma ? Intermediate behaviour ? Primary cutaneous diffuse large B-cell lymphoma, leg type Cutaneous T-cell lymphoma ? Indolent clinical behaviour ? Mycosis fungoides (and variants) ? Primary cutaneous CD30 + lymphoproliferative disorder: anaplastic large cell lymphoma ? Primary cutaneous CD30 + lymphoproliferative disorder: lymphomatoid papulosis ? Subcutaneous panniculitis-like T-cell

2019 British Association of Dermatologists

164. Erythema nodosum

disease, auto-immune disease, malignancy, and pregnancy. They are also related to the ingestion of certain medications. Histopathology demonstrates a septal panniculitis without vasculitis. Miescher's radial granulomas are a diagnostical feature, but are not necessary for confirmation. Treatment consists of supportive care, including bed rest and leg elevation, as well as non-steroidal anti-inflammatory drugs (NSAIDs), potassium iodide, and intralesional or oral corticosteroids. Nodules may also (...) are associated with extravated blood, resulting in the appearance of purpura. These ecchymotic areas fade into variably pigmented patches before resolving. As new crops of nodules may form weeks after the initial presentation, lesions at varying stages of resolution may coexist. Microscopy of these lesions demonstrates a septal panniculitis without vasculitis. Bondi EE, Margolis DJ, Lazarus ZS. Panniculitis. In: Freedberg I, Eisen A, Wolff K, et al, eds. Fitzpatrick's dermatology in general medicine. 5th ed

2017 BMJ Best Practice

165. Scleroderma Morphea

of panniculitis. All differential diagnoses with respect to LS subtypes and stage of disease are summarized in Table 3. Specifics of juvenile localized scleroderma Whereas limited types of LS most commonly occur in adults, linear subtypes predominate in children. A study including 65 patients with juvenile LS revealed that linear subtypes may follow the lines of Blaschko. It was hypothesized that in linear LS, susceptible cells are present in a mosaic state and that exposure to some trigger factors finally (...) ) • Scleromyxedema • Chronic graft versus host disease • Nephrogenic systemic fibrosis, also known as nephrogenic fibrosing dermopathy • Porphyria cutanea tarda Linear localized scleroderma, “en coup de sabre” • Panniculitis • Lupus erythematosus profundus • Progressive lipodystrophy

2018 European Dermatology Forum

166. Primary Cutaneous Lymphomas: ESMO Clinical Practice Guidelines

studies (CT and/or FDG-PET scans) [5]. In PCLs with a predominantly subcutaneous presentation, such as subcutaneous panniculitis-like T cell lymphoma (SPTCL) and primary cutane- ous gamma/delta T cell lymphoma (PCGD-TCL), FDG-PET is essential to evaluate the extent of disease. In patients with typical lymphomatoid papulosis (LyP) or primary cutaneous CD4 þ small/medium T cell lymphoproliferative disorder (LPD), CT and FDG-PET scans are not required. Bone marrow biopsy and V C The Author(s) 2018 (...) disease with patches/?at plaques. In stage IB, Table 1. WHO-EORTC classi?cation for cutaneous lymphomas CutaneousTcelllymphoma Mycosis fungoides (MF) Variants of MF • Folliculotropic MF • Pagetoid reticulosis • Granulomatous slack skin Se ´zary syndrome Primary cutaneous CD30 þ lymphoproliferative disorders • Primary cutaneous anaplastic large cell lymphoma • Lymphomatoid papulosis Subcutaneous panniculitis-like T cell lymphoma Extranodal NK/T cell lymphoma, nasal-type Primary cutaneous peripheral T

2018 European Society for Medical Oncology

170. Lymphoma

? Lymphocyte rich ? Lymphocyte depleted Peripheral T-cell, unspecified Angioimmunoblastic (AITL. formerly AILD) Enteropathy associated T-cell Hepatosplenic T-cell Subcutaneous panniculitis-like Anaplastic large cell (CD30+) ALK+ Anaplastic large cell (CD30+) ALK- Extranodal NK/T-cell, nasal type Special Burkitt lymphoma Intermediate between DLBCL and BL Intermediate between DLBCL and Hodgkin lymphoma B lymphoblastic leukemia/lymphoma B prolymphocytic leukemia Lymphomas associated with HIV infection

2016 CPG Infobase

171. Calcific panniculitis in adult-onset dermatomyositis. (PubMed)

Calcific panniculitis in adult-onset dermatomyositis. Dermatomyositis (DM) is an idiopathic inflammatory myopathy associated with characteristic cutaneous features. Panniculitis is a rarely reported clinical finding in this condition. This report describes two cases of adult-onset DM complicated by severe calcific panniculitis. In both cases, the associated pain and loss of function seemed to be best managed on combination anti-malarial therapy with mepacrine and hydroxychloroquine.

2009 Clinical & Experimental Dermatology

172. A Case of Sweet's Panniculitis Associated with Spinal Metastasis from Prostate Cancer (PubMed)

A Case of Sweet's Panniculitis Associated with Spinal Metastasis from Prostate Cancer Sweet's panniculitis is a rare variant of Sweet's syndrome in which neutrophilic infiltrate can be found either in the subcutaneous fat or in both the dermis and the subcutaneous tissue. Due to the rarity of this entity, the association between Sweet's panniculitis and malignancies is inconclusive, but cases of Sweet's panniculitis have largely been associated with hematological malignancies. Herein, we (...) present a case of Sweet's panniculitis accompanied by bone metastasis from prostate cancer. Clinicians should be aware that Sweet's panniculitis may be associated with malignancies of solid organs.

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2010 Annals of dermatology

173. Eosinophilic Panniculitis and Insect Bite-Like Eruption in a Patient with Chronic Lymphocytic Leukaemia: A Spectrum of the Same Entity (PubMed)

Eosinophilic Panniculitis and Insect Bite-Like Eruption in a Patient with Chronic Lymphocytic Leukaemia: A Spectrum of the Same Entity Background. Eosinophilic dermatosis of hematologic disorders is a reactive process that may cause a variety of clinical manifestations. Methods. We report a patient who had outbreaks of skin lesions since the onset of chronic lymphocytic leukaemia. Results. The cutaneous eruptions began as eosinophilic panniculitis and after changed to insect bite-like lesions (...) . Conclusion. We think that eosinophilic panniculitis and insect bite-like lesions may be part of the spectrum of the same entity in patients with hematologic disorders.

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2010 Dermatology research and practice

174. Cellulitis - acute

in the subcutaneous tissues) that occurs as a result of excess accumulation of lymph due to inadequate drainage. Oedema with blisters. Panniculitis — inflammation of subcutaneous adipose tissue. Other conditions include: Drug reaction — characterized by itching and burning. There is usually a well-demarcated area of involvement and a history of similar reaction with prior exposure to the same drug. Necrotizing fasciitis — a destructive and rapidly progressive soft tissue infection that involves the deep

2019 NICE Clinical Knowledge Summaries

175. International Consolidated Venous Ulcer Guideline

resulting in fibrosing panniculitis of leg with severe, chronic venous insufficiency). A (Geyer et al., 2004; Navarro et al., 2002; Volikova et al., 2009) CVI= 1.000, High SOR A.2.b.v. Medial lower leg site, with slower healing in ulcers associated with VU location in posterior ankle or back of calf region. A (McGuckin et al., 2002; Pappas et al., 1997; Szewczyk et al., 2009; Yim et al., 2014), CVI= 0.762, High SOR Growth of hair indicates adequate arterial supply and likely VU healing outcome

2015 Association for the Advancement of Wound Care

176. Respreeza - human alpha1-proteinase inhibitor

-threatening, chronic pulmonary disease often becomes clinically apparent by the third to fourth decade of life, and usually progresses to severe respiratory insufficiency and premature death. The clinical manifestations may widely vary between patients, and are pulmonary emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by low serum levels of A1-PI, the main protease inhibitor (PI) in human serum. Type ZZ and SZ A1-PI deficiency are risk factors

2015 European Medicines Agency - EPARs

177. Istodax for Peripheral T-Cell Lymphoma

subtypes are PTCL Not Otherwise Specified (PTCL NOS), anaplastic large cell lymphoma (ALCL) and angioimmunoblastic T cell lymphoma (AITL). ALCL can be further subclassified based on the presence of ALK expression, which confers a superior prognosis. Other PTCL subtypes include hepatosplenic T-cell lymphoma, enteropathy-associated T-cell lymphoma, subcutaneous panniculitis-like T cell lymphoma, rare subtypes of primary cutaneous T cell lymphoma (not to be confused with mycosis fungoides), and extranodal

2015 Canadian Agency for Drugs and Technologies in Health - Rapid Review

179. Adult Non-Hodgkin Lymphoma Treatment (PDQ®): Health Professional Version

neoplasms Precursor T-cell neoplasm: precursor T-acute lymphoblastic leukemia/LBL. Peripheral T-cell and NK-cell neoplasms. T-cell CLL/prolymphocytic leukemia. T-cell granular lymphocytic leukemia. Mycosis fungoides (including Sézary syndrome). Peripheral T-cell lymphoma, not otherwise characterized. Hepatosplenic gamma/delta T-cell lymphoma. Subcutaneous panniculitis-like T-cell lymphoma. Angioimmunoblastic T-cell lymphoma. Extranodal T-/NK-cell lymphoma, nasal type. Enteropathy-type intestinal T-cell (...) -cell, diffuse large cell, immunoblastic, and T-cell rich large B-cell lymphoma). Distinguish: Mediastinal large B-cell lymphoma. Follicular large cell lymphoma (grade 3). Anaplastic large cell lymphoma (CD30-positive). Extranodal NK-/T-cell lymphoma, nasal type/aggressive NK-cell leukemia/blastic NK-cell lymphoma. Lymphomatoid granulomatosis (angiocentric pulmonary B-cell lymphoma). Angioimmunoblastic T-cell lymphoma. Peripheral T-cell lymphoma, unspecified. Subcutaneous panniculitis-like T-cell

2018 PDQ - NCI's Comprehensive Cancer Database

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