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Panniculitis

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681. Whipple's disease presenting with symmetrical panniculitis. (Abstract)

Whipple's disease presenting with symmetrical panniculitis. Specific cutaneous involvement in Whipple's disease is extremely rare. The condition usually runs a chronic course, with symptoms preceding diagnosis by years or even decades. We report a 44-year-old man who presented with a rapid onset of progressive, extensive, symmetrical plaques of panniculitis affecting the inner thighs and forearms. He had accompanying large joint arthritis and was profoundly anaemic. Biopsy of the subcutis (...) revealed a florid septal panniculitis with infiltration of the septa by foamy macrophages containing intracellular granules that stained strongly with periodic acid-Schiff reagent. A similar but more intense infiltrate was seen in the small bowel lamina propria, and a diagnosis of Whipple's disease was made. Symmetrical panniculitis has not previously been reported as a manifestation of Whipple's disease.

2004 British Journal of Dermatology

682. Unusual case of subcutaneous panniculitis-like T-cell lymphoma. (Abstract)

Unusual case of subcutaneous panniculitis-like T-cell lymphoma. An unusual case of subcutaneous panniculitis-like T-cell lymphoma is presented involving multiple organ systems, which eventually culminated in rapid demise from the haemophagocytic syndrome, after an initial protracted course. A 44-year-old man presented in April 2001 with bronchiolitis obliterans organising pneumonia that initially responded well to corticosteroids. However, the condition relapsed on attempted prednisone (...) withdrawal in January 2002 and the patient was noted to have developed truncal subcutaneous nodules. Initial skin biopsy revealed lobular panniculitis, with negative microbiological culture. In July 2002, mononeuritis multiplex was diagnosed after the patient presented with paresthesiae and was treated with pulse cyclophosphamide therapy. By November 2002 there was ulceration of the subcutaneous nodules. Repeat skin biopsy revealed subcutaneous panniculitis-like T-cell lymphoma. The clinical

2004 Australasian Journal of Dermatology

683. Panniculitis due to non-tuberculous mycobacteria in two immunocompromised patients. Full Text available with Trip Pro

Panniculitis due to non-tuberculous mycobacteria in two immunocompromised patients. Inflammation of subcutaneous tissue (panniculitis) may occur in association with tuberculosis, but so far only three cases of non-tuberculous mycobacteria-related lobular panniculitis have been reported. We describe two new cases with marked cellular immunity failure due to hypercorticism. Clinical presentation did not differ significantly from lobular panniculitis of other aetiologies. Histological samples (...) displayed signs of lobular panniculitis and clues for mycobacteria infection with granulomatous lesions and presence of numerous acid-fast bacilli on special staining. Both patients responded quickly to a combination of macrolides, ethambutol and fluoroquinolones. However, like in other infections with tuberculous or non-tuberculous mycobacteria, long-term treatment (at least 6 months) was necessary to prevent relapses.

2004 Acta Dermato-Venereologica

684. Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis. (Abstract)

Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis. Topical capsaicin is well known to reduce nociceptive pain and neurogenic inflammation by depleting substance P. Its fibrinolytic and antithrombotic effects are less well known. We report two cases of acute lipodermatosclerosis which did not respond to several conventional treatment regimens and one case of acute lobular panniculitis in a pregnant woman with venous insufficiency, who were successfully

2005 Journal of Dermatological Treatment

685. Localized panniculitis secondary to subcutaneous glatiramer acetate injections for the treatment of multiple sclerosis: a clinicopathologic and immunohistochemical study. (Abstract)

Localized panniculitis secondary to subcutaneous glatiramer acetate injections for the treatment of multiple sclerosis: a clinicopathologic and immunohistochemical study. Glatiramer acetate has been shown to be effective in reducing the relapse and improving the disability of patients with multiple sclerosis. The most common adverse effects at the injection sites include pain, inflammation, and induration that spontaneously disappear within hours or a few days.We sought to characterize (...) the histopathologic findings of localized panniculitis induced by glatiramer acetate at the injection sites.Seven patients receiving daily glatiramer acetate injections for treatment of multiple sclerosis developed localized panniculitis at the injection sites. The lesions were histopathologically and immunohistochemically studied.The lesions consisted of a mostly lobular panniculitis, with lipophagic granuloma, namely histiocytes engulfing the lipids from necrotic adipocytes. In many areas, scattered neutrophils

2006 Journal of American Academy of Dermatology

686. Autosomal recessive plasma cell panniculitis with morphea-like clinical manifestation. (Abstract)

Autosomal recessive plasma cell panniculitis with morphea-like clinical manifestation. Two siblings had hyperpigmented indurations over the inner aspects of both thighs extending to the lower abdomen. Skin biopsy showed plasma cell panniculitis favoring a diagnosis of morphea profundus. Family history of consanguinity was present, but both parents were unaffected. To our knowledge this is the first report of autosomal recessive plasma cell panniculitis with the clinical manifestations

2006 Journal of American Academy of Dermatology

687. Neutrophilic panniculitis. (Abstract)

Neutrophilic panniculitis. Neutrophilic (lobular) panniculitis (NP) is a very rare condition that belongs to the group of neutrophilic dermatoses. We report the case of a patient with NP and review the relevant literature. NP appears as a subcutaneous nodular eruption. Histology shows a lobular neutrophilic infiltrate. NP must be differentiated from other types of panniculitis, and also from the subcutaneous septal involvement that may occur in some cases of Sweet's syndrome and from erythema

2004 Journal of American Academy of Dermatology

688. Alpha-1-antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy. (Abstract)

Alpha-1-antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy. Alpha-1-antitrypsin is the principal serum protease inhibitor. In addition to the well-recognized association with early-onset emphysema and cirrhosis, alpha-1-antitrypsin deficiency may be associated with panniculitis. The treatment of this type of panniculitis presents a significant challenge. Previous attempts using immunosuppressive, anti-inflammatory, and cytotoxic drugs have shown variable (...) results.To report a case of alpha-1-antitrypsin deficiency-associated panniculitis treated with plasma exchange therapy.A 23-year-old patient developed painful red nodules on her thighs and buttocks with spontaneous ulceration and discharge of oily fluid. A skin biopsy specimen showed septal and lobular panniculitis. The serum alpha-1-antitrypsin level was 22 mg/dL. She was treated with plasma exchange therapy.Treatment of this patient with plasma exchange therapy led to the control of the cutaneous

2004 International Journal of Dermatology

689. Two cases of factitial panniculitis induced by electroacupuncture. (Abstract)

Two cases of factitial panniculitis induced by electroacupuncture. Factitial panniculitis can be produced by mechanical, physical, or chemical means. It often causes an unusual clinical and histological feature that defies diagnosis until self-inoculation or mechanical trauma is suspected and proved. Acupuncture has been used in East Asia for centuries as a method of treatment for various conditions, especially for pain relief, and is known to be a relatively safe system. The needles are often (...) manipulated by hand once they are placed at the acupuncture points. Electroacupuncture, the application of pulsating electrical current to acupuncture needles, was developed in China as an extension of hand manipulation, and produces continuous and stronger stimulation; however, although this may provide more effective treatment, it may also provoke more mechanical trauma. We report two cases of factitial panniculitis in two young women, who presented with multiple subcutaneous nodules along

2008 Clinical & Experimental Dermatology

690. Pancreatic panniculitis and carcinoma of the pancreas. (Abstract)

Pancreatic panniculitis and carcinoma of the pancreas. Pancreatic panniculitis is a rare complication of carcinoma of the pancreas, most often accompanying the rare acinar cystadenocarcinoma. It presents with painful erythematous subcutaneous nodules typically located on the leg. We present a case of a 79-year-old man with neuroendocrine carcinoma of the pancreas and liver metastasis, who developed painful subcutaneous nodules on his shins. Laboratory values included a raised lipase level

2008 Clinical & Experimental Dermatology

691. Subcutaneous Panniculitis-like T-cell Lymphoma: A Clinicopathologic, Immunophenotypic, and Molecular Study of 22 Asian Cases According to WHO-EORTC Classification. (Abstract)

Subcutaneous Panniculitis-like T-cell Lymphoma: A Clinicopathologic, Immunophenotypic, and Molecular Study of 22 Asian Cases According to WHO-EORTC Classification. Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is defined as a rare cytotoxic alpha/beta T-cell lymphoma characterized by primary involvement of subcutaneous tissue mimicking panniculitis and a predominant CD3+/CD4-/CD8+ phenotype in 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO

2008 American Journal of Surgical Pathology

692. Nephrogenic systemic fibrosis with septal panniculitis mimicking erythema nodosum. (Abstract)

Nephrogenic systemic fibrosis with septal panniculitis mimicking erythema nodosum. Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy is an idiopathic fibrosing disorder recently described in patients with renal disease. The typical histology in nephrogenic systemic fibrosis consists of haphazardly arranged dermal collagen bundles with clefting, collagenous change which extends into the subcutaneous septa, mucin deposition, fibroblast proliferation, and increased elastic fibers

2008 Journal of American Academy of Dermatology

693. Infantile onset panniculitis with uveitis and systemic granulomatosis: a new clinicopathologic entity. Full Text available with Trip Pro

Infantile onset panniculitis with uveitis and systemic granulomatosis: a new clinicopathologic entity. We report on 4 children with infantile-onset lobular panniculitis, high fever, uveitis, and systemic granulomatous inflammation, recruited through the International Registry of Pediatric Granulomatous Arthritis. Neither CARD15 nor CIAS1 mutations were found. Despite immunosuppressive therapy, disease course was progressive. Response to anti-tumor necrosis factor monoclonal antibody in 3

2007 Journal of Pediatrics

694. Neutrophilic panniculitis in infancy: a cutaneous manifestation of juvenile rheumatoid arthritis. (Abstract)

Neutrophilic panniculitis in infancy: a cutaneous manifestation of juvenile rheumatoid arthritis. Neutrophilic panniculitis is rare and is classified as a panniculitic member of the neutrophilic dermatoses spectrum. In affected patients, an underlying systemic disease, such as myelodysplasia, is often present. We describe an infant with juvenile rheumatoid arthritis who developed neutrophilic panniculitis. Neutrophilic panniculitis clinically mimics other panniculitides and biopsy specimen can

2007 Journal of American Academy of Dermatology

695. Clinicopathological Characterization and Genomic Aberrations in Subcutaneous Panniculitis-Like T-Cell Lymphoma. Full Text available with Trip Pro

Clinicopathological Characterization and Genomic Aberrations in Subcutaneous Panniculitis-Like T-Cell Lymphoma. Subcutaneous panniculitis-like T-cell lymphomas (SPTLs) represent a rare, difficult-to-diagnose, and poorly characterized subtype of cutaneous T-cell lymphomas (CTCLs) affecting younger people more than the other CTCL forms. We performed a thorough clinical, immunohistological, and molecular analysis of nine Finnish SPTL patients. Specifically, we performed single-cell comparative

2008 Journal of Investigative Dermatology

696. Panniculitis and lipoatrophy after subcutaneous injection of interferon β‐1b in a patient with multiple sclerosis Full Text available with Trip Pro

Panniculitis and lipoatrophy after subcutaneous injection of interferon β‐1b in a patient with multiple sclerosis 16782776 2006 12 04 2018 11 13 1468-330X 77 12 2006 Dec Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Panniculitis and lipoatrophy after subcutaneous injection of interferon beta-1b in a patient with multiple sclerosis. 1382-3 O'Sullivan S S SS Cronin E M EM Sweeney B J BJ Bourke J F JF Fitzgibbon J J eng Case Reports Letter 2006 06 16 (...) England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 0 Adjuvants, Immunologic 0 Recombinant Proteins 145155-23-3 Interferon beta-1b 77238-31-4 Interferon-beta IM Adipose Tissue pathology Adjuvants, Immunologic adverse effects therapeutic use Adult Atrophy chemically induced Humans Interferon beta-1b Interferon-beta adverse effects therapeutic use Male Multiple Sclerosis drug therapy Panniculitis chemically induced Recombinant Proteins 2006 6 20 9 0 2006 12 9 9 0 2006 6 20 9 0 ppublish 16782776

2006 Journal of neurology, neurosurgery, and psychiatry

697. An Unusual Presentation of Mesenteric Panniculitis Full Text available with Trip Pro

An Unusual Presentation of Mesenteric Panniculitis 19061011 2009 08 21 2018 11 13 1980-5322 63 6 2008 Dec Clinics (Sao Paulo, Brazil) Clinics (Sao Paulo) An unusual presentation of mesenteric panniculitis. 843-4 S1807-59322008000600023 Ferrari Teresa Cristina A TC Couto Carolina M CM Vilaça Tatiane S TS Xavier Marcelo A P MA Faria Luciana C LC eng Case Reports Letter Brazil Clinics (Sao Paulo) 101244734 1807-5932 0 Anti-Inflammatory Agents VB0R961HZT Prednisone IM Adult Anti-Inflammatory Agents (...) therapeutic use Humans Male Panniculitis, Peritoneal diagnosis drug therapy pathology Prednisone therapeutic use 2008 12 9 9 0 2009 8 22 9 0 2008 12 9 9 0 ppublish 19061011 S1807-59322008000600023 PMC2664289 Radiographics. 2003 Nov-Dec;23(6):1561-7 14615565 Gastroenterology. 1980 Aug;79(2):352-6 7399242 Am J Surg Pathol. 1989 Jun;13(6):513-21 2658633 Clin Gastroenterol Hepatol. 2007 May;5(5):589-96; quiz 523-4 17478346 Ann Chir. 2006 Feb;131(2):85-90 16242659 Rev Med Interne. 2007 May;28(5):289-95

2008 Clinics (Sao Paulo, Brazil)

698. Cytophagic histiocytic panniculitis with fatal haemophagocytic lymphohistiocytosis in a paediatric patient with perforin gene mutation Full Text available with Trip Pro

Cytophagic histiocytic panniculitis with fatal haemophagocytic lymphohistiocytosis in a paediatric patient with perforin gene mutation 17601962 2008 06 06 2018 11 13 0021-9746 60 10 2007 Oct Journal of clinical pathology J. Clin. Pathol. Cytophagic histiocytic panniculitis with fatal haemophagocytic lymphohistiocytosis in a paediatric patient with perforin gene mutation. 1168-9 Chen Rong-Long RL Division of Paediatric Hematology/Oncology, Cancer Centre, Chi-Mei Medical Centre, Liou Ying Campus (...) , Tainan, Taiwan. Hsu Yung-Hsiang YH Ueda Ikuyo I Imashuku Shinsaku S Takeuchi Kengo K Tu Benjamin Pang-hsien BP Chuang Shih-Sung SS eng Case Reports Journal Article 2007 06 29 England J Clin Pathol 0376601 0021-9746 126465-35-8 Perforin AIM IM Base Sequence Child Fatal Outcome Female Humans Lymphohistiocytosis, Hemophagocytic genetics pathology Molecular Sequence Data Panniculitis genetics pathology Perforin genetics Point Mutation 2007 7 3 9 0 2008 6 7 9 0 2007 7 3 9 0 ppublish 17601962 jcp

2007 Journal of Clinical Pathology

699. A pilot study of thalidomide for patients with symptomatic mesenteric panniculitis. (Abstract)

A pilot study of thalidomide for patients with symptomatic mesenteric panniculitis. Mesenteric panniculitis is a rare condition with no standard therapy.To assess the safety and efficacy of thalidomide for the treatment of patients with symptomatic mesenteric panniculitis using a newly established clinical disease activity index (Mesenteric Panniculitis Subjective Assessment Score).In an open-label pilot study, five patients with symptomatic mesenteric panniculitis received oral thalidomide (...) , 200 mg nightly, for 12 weeks. The primary end-point was a reduction in the Mesenteric Panniculitis Subjective Assessment Score by > or = 20% at 12 weeks or complete remission (absence of symptoms).Four (80%) of the five patients responded. The median Mesenteric Panniculitis Subjective Assessment Score at baseline was 39 and at week 12 was 25 (average decrease of 44%). One patient achieved complete remission by week 4, which was sustained. At 12 weeks, three (75%) patients experienced a global

2002 Alimentary Pharmacology & Therapeutics

700. Panniculitis and lipodystrophy. (Abstract)

Panniculitis and lipodystrophy. Panniculitis and lipodystrophy are rare disorders of subcutaneous tissue. Recently the incidence of lipodystrophy has been increasing secondary to its appearance in patients with HIV. In this population, the lipodystrophy appears to be a direct consequence of drug therapy. A review of the available literature regarding pathogenesis and treatment options is discussed. The diagnosis of panniculitis has been hampered by problems. The recent literature has

2002 Current Opinion in Rheumatology

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