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Panniculitis

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681. Alpha-1-antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy. (Abstract)

Alpha-1-antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy. Alpha-1-antitrypsin is the principal serum protease inhibitor. In addition to the well-recognized association with early-onset emphysema and cirrhosis, alpha-1-antitrypsin deficiency may be associated with panniculitis. The treatment of this type of panniculitis presents a significant challenge. Previous attempts using immunosuppressive, anti-inflammatory, and cytotoxic drugs have shown variable (...) results.To report a case of alpha-1-antitrypsin deficiency-associated panniculitis treated with plasma exchange therapy.A 23-year-old patient developed painful red nodules on her thighs and buttocks with spontaneous ulceration and discharge of oily fluid. A skin biopsy specimen showed septal and lobular panniculitis. The serum alpha-1-antitrypsin level was 22 mg/dL. She was treated with plasma exchange therapy.Treatment of this patient with plasma exchange therapy led to the control of the cutaneous

2004 International Journal of Dermatology

682. Sclerodermic linear lupus panniculitis: report of two cases. (Abstract)

Sclerodermic linear lupus panniculitis: report of two cases. Lupus erythematosus panniculitis is a rare disease characterized by deep subcutaneous nodules, most commonly localized on the upper limbs and face. Unique clinical presentations, such as linear configuration or 'overlap' forms between lupus erythematosus panniculitis and localized scleroderma have been reported. We present here the clinical characteristics, course and laboratory findings of 2 patients having linear lupus erythematosus (...) panniculitis with localized scleroderma-like changes. The 2 patients (of the 14 patients with lupus erythematosus panniculitis seen by us since 1990) were females with a young age at the onset of disease (median, 25 years). In 1 case, evolution into systemic lupus erythematosus with severe renal involvement occurred whereas the other patient, who had a spontaneous abortion and exhibited anticardiolipin antibodies, should be followed and screened for the emergence of antiphospholipid syndrome. Thus

2005 Dermatology

683. Pseudosclerodermatous panniculitis after irradiation and bronchiolitis obliterans organizing pneumonia: simultaneous onset suggesting a common origin. (Abstract)

Pseudosclerodermatous panniculitis after irradiation and bronchiolitis obliterans organizing pneumonia: simultaneous onset suggesting a common origin. Due to the technical evolution of radiation therapy of breast carcinoma, new manifestations occur as side effects. Newly described unexpected cutaneous events are morphea of the breast and pseudosclerodermatous panniculitis after irradiation (PPAI). They appear as specific consequences of megavoltage radiation. Radiotherapy-induced bronchiolitis

2004 Dermatology

684. Factitious panniculitis masquerading as pyoderma gangrenosum. (Abstract)

Factitious panniculitis masquerading as pyoderma gangrenosum. We report a case of factitious panniculitis masquerading as florid pyoderma gangrenosum in a 35-year-old woman. At presentation, she had tender, ecchymotic plaques over the lower trunk and limbs, and several biopsies showed active lobular panniculitis. However, the extensive ulceration that ensued was clinically persuasive for pyoderma gangrenosum. We elected to treat the inflammatory element symptomatically with a range of topical (...) the diagnosis to have been factitious panniculitis on the basis of strong circumstantial evidence and the disparity between the histological and clinical features.

2005 Clinical & Experimental Dermatology

685. Q fever: a new cause of 'doughnut' granulomatous lobular panniculitis. (Abstract)

Q fever: a new cause of 'doughnut' granulomatous lobular panniculitis. Q fever is an uncommon zoonotic rickettsial disease with no exanthem or specific cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69-year-old Spanish woman with chronic myelogenous leukaemia developed fever and two subcutaneous nodules. The patient complained of extreme pain. Biopsy revealed a granulomatous lobular panniculitis with a characteristic 'fibrin ring' or 'doughnut' appearance (...) : fibrin and inflammatory cells arranged around a central clear space. Changes of membranous lipodystrophy were also found. Q fever serological studies were positive. Our patient had panniculitis with singular histopathological features. These histopathological changes have been described in liver and bone marrow of patients with Q fever. To the best of our knowledge, this cutaneous involvement due to Q fever has not previously been described in the literature.

2004 British Journal of Dermatology

686. Whipple's disease presenting with symmetrical panniculitis. (Abstract)

Whipple's disease presenting with symmetrical panniculitis. Specific cutaneous involvement in Whipple's disease is extremely rare. The condition usually runs a chronic course, with symptoms preceding diagnosis by years or even decades. We report a 44-year-old man who presented with a rapid onset of progressive, extensive, symmetrical plaques of panniculitis affecting the inner thighs and forearms. He had accompanying large joint arthritis and was profoundly anaemic. Biopsy of the subcutis (...) revealed a florid septal panniculitis with infiltration of the septa by foamy macrophages containing intracellular granules that stained strongly with periodic acid-Schiff reagent. A similar but more intense infiltrate was seen in the small bowel lamina propria, and a diagnosis of Whipple's disease was made. Symmetrical panniculitis has not previously been reported as a manifestation of Whipple's disease.

2004 British Journal of Dermatology

687. Unusual case of subcutaneous panniculitis-like T-cell lymphoma. (Abstract)

Unusual case of subcutaneous panniculitis-like T-cell lymphoma. An unusual case of subcutaneous panniculitis-like T-cell lymphoma is presented involving multiple organ systems, which eventually culminated in rapid demise from the haemophagocytic syndrome, after an initial protracted course. A 44-year-old man presented in April 2001 with bronchiolitis obliterans organising pneumonia that initially responded well to corticosteroids. However, the condition relapsed on attempted prednisone (...) withdrawal in January 2002 and the patient was noted to have developed truncal subcutaneous nodules. Initial skin biopsy revealed lobular panniculitis, with negative microbiological culture. In July 2002, mononeuritis multiplex was diagnosed after the patient presented with paresthesiae and was treated with pulse cyclophosphamide therapy. By November 2002 there was ulceration of the subcutaneous nodules. Repeat skin biopsy revealed subcutaneous panniculitis-like T-cell lymphoma. The clinical

2004 Australasian Journal of Dermatology

688. Panniculitis due to non-tuberculous mycobacteria in two immunocompromised patients. Full Text available with Trip Pro

Panniculitis due to non-tuberculous mycobacteria in two immunocompromised patients. Inflammation of subcutaneous tissue (panniculitis) may occur in association with tuberculosis, but so far only three cases of non-tuberculous mycobacteria-related lobular panniculitis have been reported. We describe two new cases with marked cellular immunity failure due to hypercorticism. Clinical presentation did not differ significantly from lobular panniculitis of other aetiologies. Histological samples (...) displayed signs of lobular panniculitis and clues for mycobacteria infection with granulomatous lesions and presence of numerous acid-fast bacilli on special staining. Both patients responded quickly to a combination of macrolides, ethambutol and fluoroquinolones. However, like in other infections with tuberculous or non-tuberculous mycobacteria, long-term treatment (at least 6 months) was necessary to prevent relapses.

2004 Acta Dermato-Venereologica

689. Anetodermic lupus panniculitis and antiphospholipid antibodies: report of three cases. Full Text available with Trip Pro

Anetodermic lupus panniculitis and antiphospholipid antibodies: report of three cases. Anetoderma is a rare cutaneous disease characterized by a loss of normal elastic tissue that is presented clinically as localized areas of wrinkled or flaccid skin. This form may be associated with several immunological abnormalities, most notably lupus erythematosus and antiphospholipid antibodies with or without clinical manifestations of the antiphospholipid syndrome. A retrospective study was conducted (...) with the aim of summarizing the clinical characteristics, course and laboratory findings in three women with anetoderma-associated lupus erythematosus panniculitis, an unusual variant of cutaneous lupus erythematosus. The 3 patients (of the 12 patients with lupus erythematosus panniculitis seen by us since 1990) were all at a young age at onset of panniculitis (median, 22 years). None of the patients developed severe systemic involvement up to 9 years (median, 5 years) from onset of the disease. The most

2004 Acta Dermato-Venereologica

690. Sclerosing panniculitis is associated with pulmonary hypertension in systemic sclerosis. (Abstract)

Sclerosing panniculitis is associated with pulmonary hypertension in systemic sclerosis. There have been no reports of patients with sclerosing panniculitis and systemic sclerosis (SSc).To evaluate the incidence of sclerosing panniculitis in patients with SSc, and to investigate the clinical features of such cases.In total, 128 patients with SSc treated at our clinic were investigated retrospectively.SSc patients with sclerosing panniculitis had pulmonary hypertension (PH), especially isolated (...) PH, at a significantly higher incidence than those without. Among the SSc patients with PH, those with sclerosing panniculitis had pulmonary infarctions at a higher incidence than those without.Our results suggest that thrombosis caused by venous hypertension of the leg may be the main cause of PH in patients with SSc and sclerosing panniculitis. Sclerosing panniculitis may be a useful marker of PH in patients with SSc.

2005 British Journal of Dermatology

691. Calcifying panniculitis following subcutaneous injections of nadroparin-calcium in a patient with osteomalacia. Full Text available with Trip Pro

Calcifying panniculitis following subcutaneous injections of nadroparin-calcium in a patient with osteomalacia. Calcifying panniculitis is a rare form of calcinosis cutis belonging to the spectrum of calciphylaxis that has almost invariably been described in patients with severe renal disturbances. We report a patient with osteomalacia without chronic renal failure, who developed calcifying panniculitis following subcutaneous administration of nadroparin-calcium. Light microscopy studies (...) of biopsy specimens revealed multiple foci of microcalcification within the adipose lobules, in the interadipocyte spaces, in connective tissue septa and in the media of small arteries in the subcutis. The patient had an elevated level of intact parathyroid hormone, whereas the calcium-phosphorus product was normal. The lesions slowly resolved upon discontinuation of nadroparin. We conclude that calcifying panniculitis is a rare complication associated with the subcutaneous administration of nadroparin

2005 British Journal of Dermatology

692. Connective tissue panniculitis in a child with vitiligo and Hashimoto's thyroiditis. (Abstract)

Connective tissue panniculitis in a child with vitiligo and Hashimoto's thyroiditis. SUMMARY A 9-year-old girl presented with a 6-month history of inflamed tender nodules in the pretibial area. These eventually healed leaving depressed areas of atrophy and loss of subcutaneous tissue. Histology showed a predominantly lymphocytic lobular panniculitis, consistent with connective tissue panniculitis. Investigations revealed an elevated thyroid stimulating hormone, elevated thyroid antiperoxidase (...) antibody and a weakly positive antinuclear antibody (titre 1 in 40). She was commenced on hydroxychloroquine 300 mg daily, which resulted in resolution of the panniculitis. She developed focal vitiligo on the thighs. This gradually improved with 0.1% mometasone furoate ointment. The hydroxychloroquine dose was tapered to 200 mg daily after 12 months, then to 100 mg daily after 18 months therapy. Her thyroid autoantibody levels continued to rise and the hydroxychloroquine was increased again to 300 mg

2006 Australasian Journal of Dermatology

693. A case of Rothmann-Makai panniculitis successfully treated with tetracycline. (Abstract)

A case of Rothmann-Makai panniculitis successfully treated with tetracycline. Rothmann-Makai syndrome (lipogranulomatosis subcutanea) is a rare variant of Weber-Christian disease, but lacks visceral involvements and systemic manifestations. We herein report the case of a 56-year-old Chinese woman with this disorder who complained of subcutaneous tender nodules over her extremities, trunk, and face of 2 years' duration. She was firstly treated with 300 mg of oral roxythromycin for 8 weeks

2006 Clinical & Experimental Dermatology

694. Pancreatic panniculitis associated with allograft pancreatitis and rejection in a simultaneous pancreas-kidney transplant recipient. (Abstract)

Pancreatic panniculitis associated with allograft pancreatitis and rejection in a simultaneous pancreas-kidney transplant recipient. Pancreatic panniculitis is an uncommon condition that can occur in association with pancreatic disease. We present a case of pancreatic panniculitis in a female pancreas-kidney transplant recipient 5 months post-transplant. The patient was on standard immunosuppressive medications and had acute rejection of her renal allograft. The diagnosis of allograft (...) pancreatitis and rejection presenting with pancreatic panniculitis was supported clinically, histopathologically and by laboratory and imaging data. This is the fourth case of pancreatic panniculitis occurring in a transplant recipient and the first in a simultaneous pancreas-kidney transplant recipient. It is also the first case associated with allograft rejection. Clinicians should be aware that pancreatic panniculitis may be a manifestation of underlying allograft pancreatic disease.

2006 American Journal of Transplantation

695. Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS). Full Text available with Trip Pro

Small vessel vasculitis and relapsing panniculitis in tumour necrosis factor receptor associated periodic syndrome (TRAPS). A 66 year old female patient had relapsing fever and non-suppurative panniculitis suggestive of enigmatic "Weber-Christian disease" (WCD). Antineutrophil cytoplasmic antibodies with specificity for human leucocyte elastase (HLE-ANCA) were detected. A biopsy showed small vessel vasculitis and panniculitis. A 53 year old man had recurrent episodes of abdominal pain (...) , erythematous rash, and myalgia. Fever attacks had stopped a few years ago. A biopsy showed panniculitis and fasciitis. In both patients mutations (R92Q, T50M) of the tumour necrosis factor receptor super family (TNFRSF) 1A gene were disclosed. Mutations of the TNFRSF 1A gene are the cause of tumour necrosis factor receptor associated periodic syndrome (TRAPS). Both patients responded favourably to treatment with the human soluble p75 TNF alpha receptor fusion protein etanercept (2 x 25 mg subcutaneously

2004 Annals of the Rheumatic Diseases

696. Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis. (Abstract)

Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis. Cytophagic histiocytic panniculitis (CHP) is a rare, usually fatal disease of childhood; it typically presents with daily high spiking fevers and severe panniculitis. Hemophagocytosis from macrophage activation during a cytokine storm can result in pancytopenia and disseminated intravascular coagulopathy. We describe a 14-year-old girl with long-standing CHP who

2006 Journal of Rheumatology

697. Active chronic hepatitis and febrile panniculitis. Full Text available with Trip Pro

Active chronic hepatitis and febrile panniculitis. Two patients with autoimmune hepatitis B negative chronic hepatitis and febrile panniculitis are described. On each occasion the panniculitis responded to increasing the doses of prednisolone.

1989 Gut

698. Liquefying panniculitis associated with acinous carcinoma of the pancreas responding to octreotide. Full Text available with Trip Pro

Liquefying panniculitis associated with acinous carcinoma of the pancreas responding to octreotide. 8046712 1994 09 01 2018 11 13 0141-0768 87 6 1994 Jun Journal of the Royal Society of Medicine J R Soc Med Liquefying panniculitis associated with acinous carcinoma of the pancreas responding to octreotide. 361-2 Hudson-Peacock M J MJ Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne. Regnard C F CF Farr P M PM eng Case Reports Journal Article England J R Soc Med 7802879 (...) 0141-0768 IM Adenocarcinoma complications pathology Aged Female Humans Liver Neoplasms pathology secondary Pancreatic Neoplasms complications pathology Panniculitis etiology pathology Skin pathology 1994 6 1 1994 6 1 0 1 1994 6 1 0 0 ppublish 8046712 PMC1294571 Arch Dermatol. 1975 Apr;111(4):506-10 1122153 J Rheumatol. 1975 Mar;2(1):15-20 1185731 Drugs. 1989 Nov;38(5):658-702 2689136 Cutis. 1978 Jun;21(6):763-8 207490 J Am Acad Dermatol. 1986 Feb;14(2 Pt 2):331-4 3950133 Am J Dig Dis. 1976 Nov;21

1994 Journal of the Royal Society of Medicine

699. Panniculitis mimicking Degos' papulosis. Full Text available with Trip Pro

Panniculitis mimicking Degos' papulosis. 6864710 1983 08 11 2018 11 13 0141-0768 76 5 1983 May Journal of the Royal Society of Medicine J R Soc Med Panniculitis mimicking Degos' papulosis. 428-9 Monk B E BE Pembroke A C AC eng Case Reports Journal Article England J R Soc Med 7802879 0141-0768 IM Diagnosis, Differential Female Humans Infant Panniculitis, Nodular Nonsuppurative diagnosis pathology Skin pathology Skin Diseases diagnosis pathology Syndrome 1983 5 1 1983 5 1 0 1 1983 5 1 0 0

1983 Journal of the Royal Society of Medicine

700. Pustular panniculitis in rheumatoid arthritis. Full Text available with Trip Pro

Pustular panniculitis in rheumatoid arthritis. 2041012 1991 07 05 2018 11 13 0141-0768 84 5 1991 May Journal of the Royal Society of Medicine J R Soc Med Pustular panniculitis in rheumatoid arthritis. 307-8 Anstey A A Department of Dermatology, Wycombe General Hospital, Bucks. Wilkinson J D JD Wojnarowska F F Kirk A A Gowers L L eng Case Reports Journal Article England J R Soc Med 7802879 0141-0768 IM Arthritis, Rheumatoid complications pathology Biopsy Female Humans Middle Aged Panniculitis

1991 Journal of the Royal Society of Medicine

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