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621. Study of Pralatrexate & Gemcitabine With B12 & Folic Acid to Treat Relapsed/Refractory Lymphoproliferative Malignancies

, Inc: Lymphoproliferative malignancies Lymphoma Hodgkin's lymphoma (HL) Non-Hodgkin's lymphoma (NHL) PTCL T/NK-cell leukemia/lymphoma T-cell lymphoma/leukemia (HTLV 1+) Angioimmunoblastic T-cell lymphoma Blastic NK lymphoma Anaplastic large cell lymphoma T/NK-cell lymphoma Enteropathy-type intestinal lymphoma Hepatosplenic T-cell lymphoma Extranodal peripheral T/NK-cell lymphoma Subcutaneous panniculitis T-cell lymphoma Transformed mycosis fungoides PDX Pralatrexate Gemcitabine Gemzar Vitamin B12

2007 Clinical Trials

622. The Effectiveness of Alemtuzumab Combination With CHOP to Treat Patients Newly Diagnosed With PTCL

Subcutaneous panniculitis-like T-cell lymphoma Anaplastic large-cell lymphoma,T/null cell,primary systemic type Peripheral T-cell lymphoma,not otherwise characterized Newly diagnosed,age 15-65 years. Complete work up for baseline evaluation and measurement (Appendix B) Patient's free written inform consent. Exclusion Criteria: Patients with a known hypersensitivity to murine proteins or to any component of alemtuzumab. Patients who have received prior antilymphoma treatment with chemotherapy

2007 Clinical Trials

623. A Trial of Romidepsin for Progressive or Relapsed Peripheral T-cell Lymphoma

not otherwise specified, angioimmunoblastic T-cell lymphoma, extranodal natural killer (NK)/T-cell lymphoma nasal type, enteropathy- type T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, cutaneous γδ T-cell lymphoma (excludes mycosis fungoides or Sezary syndrome), transformed mycosis fungoides, hepatosplenic T-cell lymphoma, anaplastic large cell lymphoma (ALCL; anaplastic lymphoma kinase [ALK]-1 negative), or patients with ALK 1 expressing ALCL (ALK-1 positive) who have relapsed disease

2007 Clinical Trials

624. Chronic diarrhoea with thickening of the colonic wall Full Text available with Trip Pro

, Sigmoid pathology Diarrhea etiology pathology Female Humans Panniculitis, Peritoneal complications pathology 2006 12 19 9 0 2007 2 3 9 0 2006 12 19 9 0 ppublish 17172587 56/1/94 10.1136/gut.2006.093096 PMC1856648

2007 Gut

625. A Clinical Case Study: Sclerosing Mesenteritis Presenting as Chylous Ascites Full Text available with Trip Pro

A Clinical Case Study: Sclerosing Mesenteritis Presenting as Chylous Ascites 18382700 2008 05 14 2018 11 13 1934-1997 10 2 2008 Feb 07 Medscape journal of medicine Medscape J Med A clinical case study: sclerosing mesenteritis presenting as chylous ascites. 30 Arora Manish M Dubin Ethan E eng Case Reports Letter Review 2008 02 07 United States Medscape J Med 101462763 1934-1997 IM Aged, 80 and over Chylous Ascites diagnosis Diagnosis, Differential Humans Male Panniculitis, Peritoneal diagnosis

2008 The Medscape Journal of Medicine

626. CD56+ hematological neoplasms presenting in the skin: a retrospective analysis of 23 new cases and 130 cases from the literature. Full Text available with Trip Pro

)/T-cell lymphomas, 63 blastic NK-cell lymphomas, 14 cutaneous CD30+ lymphoproliferations, 10 cases of myeloid leukemia, six cases of subcutaneous panniculitis-like T-cell lymphoma (SCPLTCL) and seven peripheral T-cell lymphomas, unspecified.In general, these CD56+ hematological neoplasms had a poor prognosis, with only 27% of patients alive after a median follow-up of 12 months. The median survival was 13 months. Nasal and nasal-type NK/T-cell lymphomas and CD56+ SCPLTCL had the worst prognosis

2004 Annals of oncology : official journal of the European Society for Medical Oncology / ESMO

627. Vasculitis in erythema induratum of Bazin: a histopathologic study of 101 biopsy specimens from 86 patients. (Abstract)

Vasculitis in erythema induratum of Bazin: a histopathologic study of 101 biopsy specimens from 86 patients. Erythema induratum of Bazin is a mostly lobular panniculitis. There is considerable controversy in the literature about whether or not vasculitis is a histopathologic requirement to establish the diagnosis of erythema induratum of Bazin. Even accepting vasculitis as a histopathologic criterion, there is no agreement about the nature and size of the involved vessels.The main goal of our (...) study was to investigate whether or not vasculitis was present in a large series of cases of erythema induratum of Bazin and, when vasculitis was found, to determine the nature and localization of the involved vessels.We studied 101 skin biopsy specimens from 86 patients with clinicopathologic diagnosis of erythema induratum of Bazin. Histopathologic criteria required in each case to be included in this study were: (1) a mostly lobular panniculitis with necrotic adipocytes at the center of the fat

2008 Journal of American Academy of Dermatology

628. Histopathological evolution of a cutaneous myxofibrosarcoma. (Abstract)

Histopathological evolution of a cutaneous myxofibrosarcoma. A 54-year-old woman presented with a 6-month history of a tender and swollen plaque appearing as a panniculitis affecting the left pretibial area. The initial histopathology revealed dermal and subcutaneous inflammation with interstitial histiocytes and mucinosis suggestive of either granuloma annulare or necrobiosis lipoidica. Over the subsequent 6 months the plaque grew progressively, despite treatment with topical corticosteroids (...) under occlusion. Distal to the plaque reduced sensation developed in the limb. Biopsies of the nodular areas now revealed a dense dermal infiltrate of atypical spindle cells within a prominent myxoid stroma and a pleomorphic multinucleated epithelioid cell component. These features were those of an intermediate grade myxofibrosarcoma. This soft-tissue sarcoma may initially masquerade clinically as a panniculitis and a granulomatous process on biopsy as in our patient, leading to a delay in surgical

2008 Australasian Journal of Dermatology

629. Neutrophilic dermatoses with acute myeloid leukemia associated with an increase of serum colony-stimulating factor. Full Text available with Trip Pro

Neutrophilic dermatoses with acute myeloid leukemia associated with an increase of serum colony-stimulating factor. We report a case of acute myeloid leukemia with folliculitis, Sweet's syndrome, and neutrophilic panniculitis after remission induction chemotherapy for acute myeloid leukemia. The level of endogenous granulocyte colony-stimulating factor was closely associated with disease activity.

2008 Journal of American Academy of Dermatology

630. Erythema induratum in a Kenyan child. (Abstract)

, consolidation and/or cavitation suggestive of tuberculosis. Sputum and gastric washings were negative for acid-fast bacilli. Histology on a skin biopsy showed a granulomatous panniculitis with no histological evidence of Mycobacterium tuberculosis, consistent with erythema induratum. In view of her constitutional symptoms, chronic non-productive cough and positive Mantoux test, she was diagnosed with pulmonary tuberculosis despite the non-specific chest X-ray and negative bacteriology. Anti-tuberculous

2008 Australasian Journal of Dermatology

631. Subcutaneous Sarcoidosis Masquerading as Cellulitis. (Abstract)

improvement. A skin biopsy showed granulomatous panniculitis but confirmation of the diagnosis of systemic sarcoidosis was based on the characteristic chest roentgenogram, the high CD4/CD8 ratio of T lymphocytes in bronchoalveolar lavage, and the typical 'panda' and 'lambda' signs on the (67)Ga scan. Such cases with atypical clinical presentation cause some difficulty in reaching the diagnosis but a skin biopsy as well as typical imaging and laboratory signs are usually important to establish

2008 Dermatology

632. Tissue-toxic effects of phosphatidylcholine/deoxycholate after subcutaneous injection for fat dissolution in rats and a human volunteer. (Abstract)

formation, and necrotic changes of the walls of small blood vessels. Histologic sections of subcutaneous tissue from the human volunteer showed dose-dependent panniculitis, fat cysts, and vessel necrosis. DC (2.5%), tested for comparison in the rat, exerted membrane and histologic effects similar to those of PC/DC. Solvent controls caused negligible alterations.Injection lipolysis with PC/DC causes tissue fibrosis and necrosis of adipose and vascular tissues in rat and man, making the long-term safety

2008 Dermatologic Surgery

633. Towards understanding the pathology of erythema nodosum leprosum. (Abstract)

analysis of studies on the pathology of ENL. Our main findings are as follows. ENL is characterised by an inflammatory infiltrate of neutrophils with vasculitis and/or panniculitis. There is deposition of immune complexes and complement together with Mycobacterium leprae antigens in the skin. Changes in serum levels of Igs indicate a transient, localised immune response. The major T-cell subtype in ENL is the CD4 cell, in contrast to lepromatous leprosy where CD8 cells predominate. The cytokines

2008 Transactions of the Royal Society of Tropical Medicine & Hygiene

634. Alpha1-antitrypsin deficiency: incidence and implications. (Abstract)

in nonsmokers. Ten to twenty percent of affected neonates develop significant liver disease. Panniculitis, a rare skin complication of AAT deficiency, is characterized by acute inflammatory infiltrate and fat necrosis. While we concentrate on the pulmonary aspect of AAT deficiency, we have included discussion of liver disease and panniculitis. Critical care and advanced practice nurses will benefit from gaining a better understanding of the causes, pathophysiology, diagnosis, and treatment of this disorder.

2005 Dimensions of critical care nursing

635. Erythema nodosum as an early sign of Crohn's disease. (Abstract)

Erythema nodosum as an early sign of Crohn's disease. Erythema nodosum is the most common form of septal panniculitis and the most frequent skin manifestation associated with inflammatory bowel disease. Since the development of erythema nodosum is closely related with a variety of disorders and conditions, it can serve as an important early sign of systemic disease. We report on a 25-year-old woman with Crohn's disease following a long history of recurrent erythema nodosum.

2007 International Journal of Dermatology

636. A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome Full Text available with Trip Pro

A Case of Erythema Nodosum and Serositis Associated with Myelodysplastic Syndrome Myelodysplastic syndrome (MDS) is a heterogenous group of stem cell disorders usually characterized by progressive refractory cytopenias, which could progress to acute myeloid leukemia. MDS may be associated with a wide spectrum of skin lesions, including neoplastic cell infiltration, Sweet's syndrome, pyoderma gangrenosum, erythema elevatum diutinum, vasculitis, and panniculitis. However, erythema nodosum

2005 The Korean journal of internal medicine

637. Non-anaplastic peripheral T-cell lymphoma in childhood and adolescence: A Children’s Oncology Group Study Full Text available with Trip Pro

with PTCL whose tumor cells did not express CD30 and/or ALK, as determined by immunohistochemistry, between 1992 and 2000 on one of two treatment protocols for localized NHL (POG 9219) or advanced stage large cell lymphoma (POG 9315). All cases were centrally reviewed.The median age was 12.6 (range 0.7-16.9)-9 male and 11 female. Histological subtypes in the WHO Classification included PTCL, unspecified (12), extra-nodal NK/T-cell lymphoma of nasal type (4), subcutaneous panniculitis-like T cell

2008 Pediatric blood & cancer

638. Lipoma

is not usually required if MRI is available. Differential diagnosis - these may be differentiated by the punctum in their surface and also by their site in the dermis, attached to the surface. Subcutaneous tumours. Nodular fasciitis. Liposarcoma. Metastatic disease. . Nodular subcutaneous fat necrosis. Weber-Christian panniculitis (recurring inflammation in the fat layer of the skin). Vasculitic nodules. Rheumatic nodules. . Infections - eg, onchocerciasis. Haematoma. Management They can be left alone

2008 Mentor

639. Erythema Induratum (Bazin's Disease)

to describe chronic inflammatory nodules of the legs that showed histopathological changes similar to those of erythema induratum, but without an association with TB. The vasculitis is of the larger vessels with panniculitis - an inflammation involving subcutaneous fat and occasionally muscle, with or without vasculitis. Erythema induratum and nodular vasculitis had been seen as the same disease for many years but nodular vasculitis is now considered to be a multifactorial syndrome of lobular panniculitis (...) second. Erythema induratum often remains undiagnosed or misdiagnosed because it can masquerade as other types of chronic nodules of the lower extremities. Differential diagnosis Cold panniculitis. . . . . . Lupus panniculitis. Investigations FBC and ESR. CXR. If a Mantoux test is performed it should be at a 1:10,000 dilution, as the response can be very marked. Unlike nodular vasculitis, erythema induratum is seen as a tuberculous disease and a strongly positive Mantoux response is regarded

2008 Mentor

640. Gnathostomiasis

, larvae invade the gastric wall and cause eosinophilia and various symptoms. Clinical features include: General: mild malaise, fever, urticaria, anorexia, nausea, vomiting, diarrhoea and epigastric pain. Skin: most commonly migratory, nodular panniculitis, [ ] soft tissue eruptions, boils and nodules in one or several areas. Pulmonary: cough, chest pain, dyspnoea or haemoptysis. Patient may cough up worm. Genitourinary: haematuria, urinary retention. Ophthalmological: decreased visual acuity

2008 Mentor

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