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582. European Guidelines for Photodermatoses - Photoaggravated Disorders

+ Discoid lupus Vacuolar degeneration thickening PV PAD +/- 20% positive 20% ana/Ro positive Lupus profundus normal PV PAD panniculitis negative Positive or negative Positive or negative Rowell’s Vacuolar change- necrosis of epidermis PV negative May be + Ro & ANA may be positive SLE variable Variable variable positive positive Table 2 Level of evidence Type of evidence 1 ++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well-conducted meta-analyses

2005 European Dermatology Forum

583. Guidelines for the management of primary cutaneous T-cell lympohomas

. When disease is restricted to the skin radio- therapy may be indicated, but systemic dissemination is likely and most patients will require some form of multiagent chemotherapy, although responses are likely to be poor. Primary cutaneous extranodal NK-like/ T-cell lymphomas (nasal type) have a poor prognosis. 2 Primary subcutaneous panniculitis-like T-cell lymphomas are rare but also have a poor prognosis with a high incidence of systemic involve- ment and haemophagocytosis either at diagnosis

2003 British Association of Dermatologists

584. Narrative review: diseases that masquerade as infectious cellulitis. (Abstract)

, familial Mediterranean fever, and foreign-body reactions. Diseases that uncommonly masquerade as infectious cellulitis include urticaria, lymphedema, lupus erythematosus, sarcoidosis, lymphoma, leukemia, Paget disease, and panniculitis. Clinicians should do an initial diagnostic work-up directed by the findings from a detailed history and complete physical examination. In many cases, skin biopsy is the only tool that helps identify the correct diagnosis. Special tests may also be needed.

2005 Annals of Internal Medicine

585. Alpha-1 antitrypsin deficiency

panniculitis. ORPHA:60 Classification level: Disorder Synonym(s): - Prevalence: 1-5 / 10 000 Inheritance: Autosomal recessive Age of onset: All ages ICD-10: E88.0 OMIM: UMLS: C0221757 C3501835 MeSH: C531610 D019896 GARD: MedDRA: 10001806 Detailed information Article for general public Professionals Summary information Emergency guidelines Review article Guidance for genetic testing Clinical genetics review Additional information Further information on this disease Health care resources for this disease

2005 Orphanet

586. Cutaneous lymphoma

T-cell lymphoma), forms with a poor prognosis (Sezary syndrome and peripheral T-cell lymphoma) and forms with a variable prognosis (pleomorphic small/medium-sized T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, cutaneous T/NK cell lymphomas (referred to as nasal-type lesions), epidermotropic CD8+ T-cell lymphomas and the TCRgamma-delta phenotype). The group of cutaneous B-cell lymphomas includes marginal zone B-cell lymphomas and primary cutaneous follicular lymphomas (both

2005 Orphanet

587. Lupus erythematosus, cutaneous

, tinea corporis, erythema anulare centrifugum, granuloma annulare, erythema gyratum repens, psoriasis. DLE: sarcoidosis, tuberculosis, leprosy, classic mycosis fungoides, cutaneous pseudolymphoma, granuloma faciale, nummular eczema, psoriasis, squamous and basal cell carcinoma, rosacea, lichen planus. ChLE: frostbites. LEP: subcutaneous panniculitis-like T-cell lymphoma, erythema nodosum. LET: Jessner lymphocytic infiltration of the skin, polymorphous light eruption, reticular erythematosus mucinosis

2005 Orphanet

588. A case of Weber-Christian disease with collapsing glomerulopathy. (Abstract)

A case of Weber-Christian disease with collapsing glomerulopathy. We report a case of Weber-Christian disease confirmed by skin biopsy in a patient who presented with collapsing glomerulopathy and lipophagic interstitial nephritis. On renal biopsy, glomerular visceral epithelial cells, tubular cells, and interstitial macrophages were loaded with inclusions that were morphologically consistent with oxidized lipoproteins, suggesting that lipids derived from the panniculitis may have

2006 American Journal of Kidney Diseases

589. Other formulations and future considerations for apomorphine for subcutaneous injection therapy. (Abstract)

at a rate of 4 mg/h is well tolerated, and has been postulated to be equivalent to approximately 600 mg levodopa/day. This therapy is associated with skin complications, particularly nodule formation, and focal panniculitis is seen in more than 50% of subjects. Optimal dosages for intranasal apomorphine range from 2 to 5 mg per inhalation with benefit seen at 7.5 minutes and duration of effect of 45 to 55 minutes. Side effects included nasal irritation, vestibulitis, dyskinesias, yawning, and nausea

2004 Neurology

590. Diabetic (lymphocytic) mastopathy with exuberant lymphohistiocytic and granulomatous response: a case report with review of the literature. (Abstract)

. This process had infiltrative, ill-defined edges and involved the subcutaneous tissues. The overlying epidermis was normal. The final diagnosis was diabetic mastopathy with an exuberant lymphohistiocytic response. The differential diagnosis included Rosai-Dorfman disease, inflammatory myofibroblastic tumor, granulomatous mastitis, sclerosing lipogranulomatous response/sclerosing lipogranuloma, lupus panniculitis, and rheumatoid nodules. Immunohistochemical studies and flow cytometry confirmed

2006 American Journal of Surgical Pathology

591. Subcutaneous, blastic natural killer (NK), NK/T-cell, and other cytotoxic lymphomas of the skin: a morphologic, immunophenotypic, and molecular study of 50 patients. (Abstract)

of the skin. Clinical, morphologic, phenotypical, and genetic features and data on Epstein-Barr virus association allowed us to classify our cases according to the following 7 categories: a) subcutaneous "panniculitis-like" T-cell lymphoma (SPTCL): 10 cases (estimated 5-year survival: 80%); b) blastic NK-cell lymphoma: 12 cases (estimated 5-year survival: 0%); c) nasal-type extranodal NK/T-cell lymphoma: 5 patients (estimated 5-year survival: 0%); d) epidermotropic CD8+ T-cell lymphoma: 5 cases (estimated

2004 American Journal of Surgical Pathology

592. Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy. Full Text available with Trip Pro

by immunohistochemistry. Using cultured human preadipocytes and adipocytes, we elucidated a possible mechanism leading to adipocyte loss in this patient.Analysis of adipose tissue samples of the patient with acquired lipodystrophy obtained from skin areas affected by panniculitis suggested that loss of adipocytes was mediated by CD95-induced apoptosis. Regression of adipose tissue was accompanied by lymphohistiocytic infiltration/inflammation and increased serum levels of inflammatory cytokines interferon-gamma

2006 Journal of Clinical Endocrinology and Metabolism

593. CXCR3-mediated recruitment of cytotoxic lymphocytes in lupus erythematosus profundus. (Abstract)

CXCR3-mediated recruitment of cytotoxic lymphocytes in lupus erythematosus profundus. Lupus erythematosus profundus (LEP) is a rare variant lupus erythematosus with unclear etiology characterized by lobular panniculitis. Recently, we observed a case of LEP involving the lower right eyelid. Our immunohistological analyses of lesional skin biopsies revealed a type I IFN signature in the context of cytotoxic lobular panniculitis.Since type I IFNs have been shown to be involved in other cutaneous (...) was characterized using monoclonal antibodies specific for CD3, CD4, CD8, CD20, CD68, and CD123. Subsequently, we analyzed the expression the type I IFN Marker MxA, the cytotoxic molecules granzyme B and Tia1, the chemokine receptor CXCR3 and its ligand, the interferon inducible protein IP10/CXCL10.LEP skin lesions were characterized by a lobular panniculitis, dominated by cytotoxic CXCR3(+) lymphocytes. Strong MxA expression indicated extensive type I IFN production within the fat lobules. Numerous

2007 Journal of American Academy of Dermatology

594. Lupus erythematosus profundus in black South Africans. (Abstract)

Lupus erythematosus profundus in black South Africans. Lupus erythematosus profundus (lupus panniculitis) is a rare variant of lupus erythematosus with predominant involvement of the subcutaneous tissue. There are only a few reported series of patients with this condition; none in individuals of African ancestry. The aim of the study was to evaluate clinical, histopathological and laboratory findings in black South African patients with lupus profundus.Ten prospectively observed patients were

2006 International Journal of Dermatology

595. Peripheral T-cell lymphoma presenting as lipoatrophy and nodules. (Abstract)

Peripheral T-cell lymphoma presenting as lipoatrophy and nodules. Cutaneous lymphomas have many morphologic forms and clinical features. Lymphoma presents rarely with a constellation of nodules, panniculitis, and localized lipoatrophy. The histopathologic similarities of lymphoma and connective tissue disease panniculitis may create a diagnostic challenge.We retrospectively reviewed the case of a 47-year-old man who presented 15 years earlier with recurrent fevers, fatigue, tender subcutaneous (...) nodules, and facial, trunk, and extremity lipoatrophy.Initial biopsy of a cutaneous nodule showed lymphohistiocytic panniculitis without atypical inflammatory cells. Serologic tests showed negative connective tissue serologies, yet the initial clinical impression was most consistent with lupus panniculitis. Initially, the patient was treated with oral prednisone; later, steroid-sparing agents were used with modest improvement evidenced by resolution of his systemic symptoms and stabilization

2006 International Journal of Dermatology

596. Lipomembranous changes and calcification associated with systemic lupus erythematosus. (Abstract)

, and panniculitis associated with dermatomyositis, but rarely associated with SLE. We speculate that ischaemic changes due to the vascular disturbance of the lower legs may have induced lipomembranous changes and calcification in the subcutaneous tissues in the present case.

2007 Clinical & Experimental Dermatology

597. The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. (Abstract)

consensus agreement compared with the original WHO and EORTC classifications. In cutaneous T-cell lymphomas, these include folliculotropic mycosis fungoides, defining features of Sézary syndrome, primary cutaneous CD30+ lymphoproliferative disorders (primary cutaneous anaplastic large cell lymphoma, lymphomatoid papulosis and borderline lesions) and subcutaneous panniculitis-like T-cell lymphoma. Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma, primary cutaneous aggressive

2005 British Journal of Dermatology

598. Rare complication of Q fever vaccination. (Abstract)

Rare complication of Q fever vaccination. A 32-year-old woman with a past history of malignant melanoma presented with a lump in the upper left arm that was excised. Histological examination revealed a granulomatous dermatitis and panniculitis that proved to be a rare reaction to Q fever vaccination.

2005 Australasian Journal of Dermatology

599. Three cases of lymphomatoid papulosis with a CD56+ immunophenotype. (Abstract)

expressed cytotoxic granules (T-cell intracellular antigen-1+ and granzyme B+) and were CD8+ and CD56+. Expression of CD56 is associated with a poor prognosis in subcutaneous panniculitis-like T-cell lymphoma and blastic natural killer cell lymphoma. However, the two cases of CD56+ LyP previously reported and the 3 cases in this series all appear to be pursuing an indolent course with no evidence of systemic disease.

2006 Journal of American Academy of Dermatology

600. Primary cutaneous T-cell lymphoma occurring after organ transplantation. (Abstract)

the literature relating to posttransplant primary CTCL. Of the 23 cases of posttransplant primary CTCL, 5 patients had erythrodermic disease, and 8 had primary cutaneous anaplastic large cell lymphoma. In addition, there are two cases of mycosis fungoides, one case of subcutaneous panniculitis-like T-cell lymphoma, one case of CD30+ lymphomatoid papulosis, and 6 cases of peripheral T-cell lymphoma, of which 3 were CD30+ large cell lymphomas. Seventeen cases had renal transplants and the majority received

2006 Journal of American Academy of Dermatology

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