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Panniculitis

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561. Phase II, double-blinded, randomized study of enzastaurin plus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer. Full Text available with Trip Pro

) or overall survival (9.6 months in combination arm and 7.4 months in pemetrexed arm, p = 0.171). Drug-related serious adverse events included cerebrovascular accident, palpitations, and renal failure (n = 1, each) in combination arm and neutropenic sepsis, thrombocytopenia, and panniculitis (n = 1, each) in pemetrexed arm. Nonhematologic drug-related grade 3/4 toxicities were similar in both arms. Grade 3/4 hematologic toxicities were higher with the combination, specifically leukopenia (6.3% versus 0

2010 Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Controlled trial quality: uncertain

562. Cutaneous sclerosis: a previously undescribed manifestation of sclerosing mesenteritis. Full Text available with Trip Pro

Cutaneous sclerosis: a previously undescribed manifestation of sclerosing mesenteritis. Sclerosing mesenteritis is a rare disease of unknown etiology that is characterized by self-limited, nonspecific inflammation and fibrosis of the mesenteric adipose tissue. Histologic classification characterizes 3 main stages in the evolution of the fibroinflammatory process: mesenteric lipodystrophy (ML), mesenteric panniculitis (MP), and sclerosing (retractile) mesenteritis (SM).A 68-year-old woman

2010 Archives of Dermatology

563. Subcutaneous fat necrosis as a complication of whole-body cooling for birth asphyxia. Full Text available with Trip Pro

Subcutaneous fat necrosis as a complication of whole-body cooling for birth asphyxia. Subcutaneous fat necrosis (SCFN) of the newborn is a form of panniculitis that affects full-term neonates who often have suffered either birth asphyxia or hypothermia. The induction of hypothermia in newborns is becoming frequently used to reduce the neurologic sequelae associated with birth asphyxia. The risk of SCFN in neonates undergoing this therapy is unknown. Observation We describe a neonate who

2010 Archives of Dermatology

564. Lupus Mastitis: An Uncommon Complication of Systemic or Discoid Lupus. (Abstract)

Lupus Mastitis: An Uncommon Complication of Systemic or Discoid Lupus. Lupus mastitis is an uncommon presentation of lupus erythematosus profundus or lupus panniculitis, a rare variant of lupus erythematosus characterized by inflammation of the subcutaneous fat. Lupus mastitis can present as single or multiple subcutaneous or deep breast masses, often clinically mimicking malignancy. Although lupus mastitis is rare, with less than 25 cases reported, the histologic features are distinct (...) . Awareness of the entity and familiarity with the histologic features allow for accurate diagnosis and appropriate patient management. It most commonly affects women with a mean age at diagnosis of 40 years and an age range of 18 to 70 years. Typical histologic findings in lupus mastitis include a lymphocytic lobular panniculitis with plasma cells and hyaline fat necrosis. The lymphocytic infiltrate can be nodular, diffuse, periductal, and/or perilobular and germinal centers can frequently be identified

2010 American Journal of Surgical Pathology

565. Acute Fatal Fat Tissue Embolism After Autologous Fat Transfer in a Patient with Lupus Profundus. (Abstract)

, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom. Lucas Sebastian S Langrish Christopher J CJ Barlow Richard J RJ eng Case Reports Journal Article 2010 11 17 United States Dermatol Surg 9504371 1076-0512 IM Acute Disease Adipose Tissue transplantation Adult Cosmetic Techniques adverse effects Embolism, Fat etiology Face Fatal Outcome Female Humans Panniculitis, Lupus Erythematosus pathology surgery Transplantation, Autologous 2010 11 25 6 0 2010 11 26 6 0 2011 2 18 6 0

2010 Dermatologic Surgery

566. Bortezomib and Romidepsin in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Indolent B-cell Lymphoma, Peripheral T-cell Lymphoma or Cutaneous T-Cell Lymphoma

associated lymphoid tissue (MALT)]) Lymphoplasmacytic lymphoma PTCL, relapsed or refractory: Anaplastic large cell lymphoma, anaplastic lymphoma kinase (ALK)-positive Anaplastic large cell lymphoma, ALK-negative Angioimmunoblastic T-cell lymphoma Enteropathy-associated T-cell lymphoma Extranodal natural killer (NK)/T-cell lymphoma, nasal type Hepatosplenic T-cell lymphoma PTCL, not otherwise specified (NOS) Subcutaneous panniculitis-like T-cell lymphoma CTCL: * CTCL with subtypes of mycosis fungoides

2009 Clinical Trials

567. The Effectiveness of Alemtuzumab Given in Combination With CHOP and ESHAP in Patients Newly Diagnosed With Peripheral T-Cell Lymphoma (PTCL)

to 65 Years (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Patients must have a diagnosis of one of the following histologic types according to the WHO classification: Angioimmunoblastic T-cell lymphoma Extranodal NK/T-cell lymphoma, nasal type Enteropathy-type T-cell lymphoma Hepatosplenic gamma-delta T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Anaplastic large-cell lymphoma, T/null cell, primary systemic type

2009 Clinical Trials

568. Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma

Macroglobulinemia) CNS lymphoma Post transplant lymphoproliferative disorders Mycosis fungoides/Sezary syndrome Hodgkin Disease Primary effusion lymphoma Blastic natural killer (NK)-cell lymphoma Adult T-cell leukemia/lymphoma Extranodal NK/T-cell lymphoma, nasal type Enteropathy-type T-cell lymphoma Hepatosplenic T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Angioimmunoblastic T-cell lymphoma Anaplastic large cell lymphoma - primary cutaneous type For lymphoplasmacytic lymphoma patients

2009 Clinical Trials

569. Relationship between abdominal trauma or surgery and mesenteric panniculitis Full Text available with Trip Pro

Relationship between abdominal trauma or surgery and mesenteric panniculitis Mesenteric panniculitis is a rare disease characterized by chronic non-specific inflammation of mesenteric fat tissue. Several etiologic and/or associated factors have been reported in the literature so far. Although trauma or surgery is one of the potential etiologic factors for mesenteric panniculitis, to the best of our knowledge, no strong correlation has been shown in the literature until now.

2009 World journal of gastroenterology : WJG

570. An Interesting Case of Recurrent Small Bowel Obstruction Full Text available with Trip Pro

An Interesting Case of Recurrent Small Bowel Obstruction Sclerosing mesenteritis is associated with a spectrum of diseases which include mesenteric lipodystrophy and mesenteric panniculitis. This inflammatory and fibrosing disorder can affect the small and large bowel wall and mesenteric vessels by exerting a mass effect. The following case highlights the difficulties with diagnosing and managing this unusual disease. A 64-year-old man presented with acute central abdominal pain, radiating

2009 Case reports in gastroenterology

571. Calciphylaxis in chronic renal failure: An approach to risk factors Full Text available with Trip Pro

Calciphylaxis in chronic renal failure: An approach to risk factors We present a case of calcifying panniculitis due to calciphylaxis in a nontherapy compliance 65-year-old man suffering from chronic renal failure. Calciphylaxis, a life threatening condition, is characterized by high calcium x phosphate product, presence of calcium crystals in the skin and secondary hyperparathyroidism. The clinical presentation includes painful firm plaques, which could progress to nonhealing ulcers. A review

2009 Indian Journal of Nephrology

572. Calcific panniculitis in adult-onset dermatomyositis. (Abstract)

Calcific panniculitis in adult-onset dermatomyositis. Dermatomyositis (DM) is an idiopathic inflammatory myopathy associated with characteristic cutaneous features. Panniculitis is a rarely reported clinical finding in this condition. This report describes two cases of adult-onset DM complicated by severe calcific panniculitis. In both cases, the associated pain and loss of function seemed to be best managed on combination anti-malarial therapy with mepacrine and hydroxychloroquine.

2009 Clinical & Experimental Dermatology

573. Frequency, clinical features and prognosis of cutaneous manifestations in adult patients with reactive haemophagocytic syndrome. (Abstract)

patient had cytophagic histiocytic panniculitis. Histological features of maculopapular rash biopsies were usually nonspecific. The rate of in-hospital death was not significantly associated with cutaneous involvement.A generalized, nonpruriginous, transient, maculopapular rash is frequently observed in patients with RHS. Although nonspecific, awareness of this cutaneous involvement may assist physicians in the initial diagnosis of RHS.

2009 British Journal of Dermatology

574. Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: clinical and immunological study of 270 patients. (Abstract)

of photosensitivity (P < 0.001), panniculitis (P = 0.009) and SLE (P = 0.003) than localized DLE. In patients with SCLE and those with CCLE, photosensitivity, arthralgias, arthritis, nephropathy and xerophthalmia were associated with SLE. In patients with SCLE, significant correlations existed between clinical and immunological data. Conclusions In our series, differences in the expression of CCLE and SCLE were found with respect to the distribution and type of lesions, systemic features and immunological

2009 British Journal of Dermatology

575. Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). (Abstract)

Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). Subcutaneous panniculitis-like T-cell lymphoma is an uncommon form of cutaneous lymphoma in the pediatric population. It is characterized histologically by subcutaneous infiltration of pleomorphic cytotoxic T cells, mimicking a lobular panniculitis. Although usually described as having an indolent clinical course, the condition may be complicated (...) by systemic involvement and hemophagocytic syndrome, resulting in a poorer prognosis. We present two pediatric patients with aggressive forms of subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome, and discuss the current literature.

2009 Journal of American Academy of Dermatology

576. Silicone breast implant rupture presenting as bilateral leg nodules. (Abstract)

subcutaneous nodules on the medial aspect of the shins and ankles. Her medical history was notable for bilateral breast augmentation with silicone implants 30 years before presentation. Although there were no signs or symptoms on breast examination, ultrasonography and magnetic resonance imaging confirmed that both implants had ruptured. Histological examination of a punch biopsy from a nodule on the shin found lobular granulomatous panniculitis. An excisional biopsy of the lesion was analysed by scanning

2009 Clinical & Experimental Dermatology

577. Drug-induced skin pathology. Full Text available with Trip Pro

Drug-induced skin pathology. Drug-induced cutaneous rashes, whether confined to the skin or part of a systemic disease, are characterised by a spectrum of inflammatory disease patterns that include perivascular dermatitis, nodular and diffuse dermatitis, vesiculobullous lesions, pustular eruptions, sclerodermoid reactions, vasculitis, folliculitis/perifolliculitis and panniculitis. While a single drug can elicit a range of reaction patterns, no reaction pattern is specific for a particular drug

2009 Journal of Clinical Pathology

578. EN (erythema nodosum)

EN (erythema nodosum) EN (erythema nodosum) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search EN (erythema nodosum) Erythema nodosum is a panniculitis - an inflammation of the fat, seen principally in adult females. The female to male ratio is five to one but in children the ratio is 1:1 The disease can be seen at any age with a peak incidence between the ages of 20 and 30 years (1). The manifestation is with red nodules

2010 GP Notebook

579. erythema nodosum

erythema nodosum erythema nodosum - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search erythema nodosum Erythema nodosum is a panniculitis - an inflammation of the fat, seen principally in adult females. The female to male ratio is five to one but in children the ratio is 1:1 The disease can be seen at any age with a peak incidence between the ages of 20 and 30 years (1). The manifestation is with red nodules - in the literal

2010 GP Notebook

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