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541. Expression of interleukin-17 is correlated with interferon-α expression in cutaneous lesions of lupus erythematosus. (Abstract)

with the pathogenesis of LE.Skin tissue samples from 33 cases, including chronic discoid LE (n = 24), acute (A)CLE (n = 4), subacute CLE (n = 1) and lupus panniculitis (n = 4) were collected for immunohistochemistry. Expression of IL-6, IL-17A, IFN-α, IFN-γ, myxovirus protein (Mx)A and transforming growth factor (TGF)-β was assessed in these samples.All LE specimens had staining for IL-6 and TGF-β in the infiltrated inflammatory cells. IL-17A staining was seen in 84.8% of specimens, and IFN-α or MxA was seen (...) in 93.9%. TGF-β expression in ACLE was significantly greater than that in both chronic cutaneous (CC)LE and in lupus panniculitis (P = 0.02 for both). Expression of IL-17A was positively associated with expression of IFN-α and MxA (Spearman's ρ = 0.56 and 0.39, respectively). In addition, the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) correlated positively with expression of IFN-α and MxA (ρ = 0.40 for both), whereas there was no correlation with IL-17A expression.Two major

2011 Clinical & Experimental Dermatology

542. Lipodystrophies: Genetic and Acquired Body Fat Disorders. Full Text available with Trip Pro

are mainly autoimmune in origin and display complement abnormalities. Localized lipodystrophies occur due to drug or vaccine injections, pressure, panniculitis, and other unknown reasons. The current management includes cosmetic surgery and early identification and treatment of metabolic and other complications with diet, exercise, hypoglycemic drugs, and lipid-lowering agents.

2011 Journal of Clinical Endocrinology and Metabolism

543. Mutations in PSMB8 cause CANDLE syndrome with evidence of genetic and phenotypic heterogeneity. Full Text available with Trip Pro

, unlike in other autoinflammatory disorders.CANDLE syndrome is caused by mutations in PSMB8, a gene recently reported to cause "JMP" syndrome (joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced childhood-onset lipodystrophy) in adults. We extend the clinical and pathogenic description of this novel autoinflammatory syndrome, thereby expanding the clinical and genetic disease spectrum of PSMB8-associated disorders. IFN may be a key mediator of the inflammatory response

2011 Arthritis and Rheumatism

544. Protocol To Evaluate Patient Measurements After Ultrasonic Treatment

bruising disorder, anticoagulative / thromboembolic condition , hemorrhagic (bleeding) status or use of anti coagulants. Tissue ischemia in the area to be treated. Suffering from concurrent conditions such as liver or kidney disorders, Hypertension or abnormally high blood pressure. High cholesterol and/or diabetes. Active collagen vascular disease (e.g. fibromyalgia, panniculitis, lupus etc.). Epilepsy. Tuberculosis. Auxiliary electric organs (such as pacemakers), metal or myoelectric prosthesis

2011 Clinical Trials

545. A Phase 3 Trial of E7777 in Combination With CHOP Compared With CHOP Alone for the First-Line Treatment of Peripheral T-cell Lymphoma

lymphoma/leukemia, extranodal NK/TCL nasal type, enteropathy-associated TCL, hepatosplenic TCL, subcutaneous panniculitis-like TCL, and cutaneous T-cell lymphoma (CTCL) including mycosis fungoides and Sezary syndrome. Known central nervous system (CNS) involvement with lymphoma. Prior chemotherapy, immunotherapy, denileukin diftitox, or investigational agent(s) for this lymphoma, with the exception that a single cycle of CHOP (or CHOP-based therapy) is allowed if the last dose of CHOP (or CHOP-based

2011 Clinical Trials

546. Clinical Evaluation of the SNaP Wound Care System in Promoting Healing in Chronic Wounds

a thick eschar that persists after wound debridement. Patient has an HbA1C >12%. Patient has ulcers due to inflammatory conditions such as pyoderma gangrenosum, rheumatoid arthritis, vasculitis, cryoglobulinaemia, necrobiosis lipoidica, panniculitis, lupus erythematosus, scleroderma, or calcinosis. Patient has untreated osteomyelitis. Patient has any other condition that, in the opinion of the investigator, makes the patient inappropriate to take part in this study. Patient is allergic to the wound

2011 Clinical Trials

547. Alpha 1-antitrypsin deficiency

patients. Patients are usually labeled as having COPD without an underlying cause. It is estimated that about 1% of all COPD patients actually have an A1AT deficiency. Thus, testing should be performed for all patients with COPD, asthma with irreversible airflow obstruction, unexplained , or necrotizing panniculitis. [ ] The initial test performed is serum A1AT level. A low level of A1AT confirms the diagnosis and further assessment with A1AT protein phenotyping and A1AT genotyping should be carried

2012 Wikipedia

548. List of cutaneous conditions

, pressure-induced alopecia) (barber's itch, folliculitis barbae traumatica, razor bumps, scarring pseudofolliculitis of the beard, shave bumps) (alopecia cicatrisata) (pterygium inversus unguis, ventral pterygium) (dorsal pterygium) (brachyonychia, nail en raquette , racquet thumb) (idiopathic palmoplantar hidradenitis, idiopathic plantar hidradenitis, painful plantar erythema, palmoplantar eccrine hidradenitis, plantar panniculitis) (temporal alopecia, temporal triangular alopecia) (bamboo hair (...) ) (sandpapered nails, trachyonychia) ( cheveux incoiffable , pili trianguli et canaliculi, spun-glass hair) (woolly hair nevus) Conditions of the subcutaneous fat [ ] See also: Conditions of the are those affecting the layer of that lies between the and underlying . (Lawrence syndrome, Lawrence–Seip syndrome) (Dercum's disease) (alpha1-protease deficiency panniculitis, alpha1-proteinase deficiency panniculitis) (acquired partial lipodystrophy, cephalothoracic lipodystrophy, progressive lipodystrophy) (benign

2012 Wikipedia

549. Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome

Posted: June 16, 2016 Last Verified: June 2016 Keywords provided by University Hospital, Grenoble: adipose tissue obese patients inflammation oxidative stress sleep apnea syndrome Additional relevant MeSH terms: Layout table for MeSH terms Syndrome Inflammation Apnea Sleep Apnea Syndromes Panniculitis Steatitis Disease Pathologic Processes Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders

2010 Clinical Trials

550. T-Cell Project: Prospective Collection of Data in Patients With Peripheral T-Cell Lymphoma

and biological information. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 2000 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Prospective Collection of Data in Pts With Peripheral T-Cell Lymphoma: PTCL,NOS;AITL; Extranodal NK/T-cell;Enteropathy-type; Hepatosplenic γ-δ; Subcutaneous Panniculitis-like; ALCL,Primary Systemic Type. By the Intl. T-Cell Lymphoma Project Study Start Date : September 2006 Estimated (...) lymphoma; Hepatosplenic T-cell lymphoma; Peripheral gamma-delta T-cell lymphoma; Subcutaneous panniculitis-like T-cell lymphoma; Unclassifiable peripheral T-cell Lymphoma Unclassifiable NK-cell lymphoma Age over 18 Tissue biopsies adequate for diagnosis and classification and available for centralized review Clinical data including baseline information on disease localization and laboratory parameters at staging, features of treatment adopted and assurance of follow-up updating for at least 5 years

2010 Clinical Trials

551. Comprehensive Oncology Measures for Peripheral T-cell Lymphoma Treatment Registry

with Peripheral T-cell Lymphoma (PTCL): Aggressive natural killer (NK)-cell leukemia Adult T-cell lymphoma/leukemia (human T-cell leukemia virus [HTLV] 1+) Angioimmunoblastic T-cell lymphoma Anaplastic large cell lymphoma (ALCL), primary systemic type (ALK+, ALK-) PTCL, not otherwise specified (NOS) T/NK-cell lymphoma, nasal type Enteropathy-type intestinal lymphoma Hepatosplenic T-cell lymphoma Subcutaneous panniculitis T-cell lymphoma Transformed mycosis fungoides (at diagnosis of transformation) T-cell

2010 Clinical Trials

552. Clinical Evaluation of the SNaP Wound Care System

-related cellulitis Patients with thick eschar at wound base post debridement Patients with wounds located in an area not amenable to forming an air- tight seal Ulcers due to inflammatory conditions such as pyodermagangrenosum, rheumatoid arthritis, vasculitis, cryoglobulinemia, necrobiosislipoidicadiabeticorum, lupus or pancreatic panniculitis, cryofibrinogenemia, calcinosis cutis, scleroderma, Raynaud's syndrome Patient has untreated osteomyelitis Patient is allergic to wound care products Patient

2010 Clinical Trials

553. Bortezomib and Azacitidine in Treating Patients With Relapsed or Refractory T-Cell Lymphoma

belonging to one of the following WHO entities: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS); Mycosis Fungoides and Sezary Syndrome (MF-SS); Angioimmunoblastic T-cell lymphoma (AITL); CD30-positive Anaplastic Large Cell Lymphoma (ALCL), systemic; T/NK-cell lymphoma, extranodal, nasal and nasal type; Hepatosplenic T-cell lymphoma, gamma/delta or alpha/beta; Enteropathy-associated T-cell lymphoma (EATL); Adult T-cell Leukemia/Lymphoma (ATLL); Subcutaneous panniculitis-like T-cell

2010 Clinical Trials

554. Protocol To Evaluate Patient Measurements After Ultrasonic Treatment

-up period, or has completed all other study-required follow-up less than 30 days before enrolment in this study. Keloid scars, hypertrophic scars or a history of abnormal healing. Thrombophlebitis. Bleeding or bruising disorders (e.g. idiopathic thrombocytopenic purpura, anticoagulated patients). Tissue ischemia in the area to be treated. Hypertension or abnormally high blood pressure. High cholesterol. Active collagen vascular disease (e.g. fibromyalgia, panniculitis, lupus etc.). Diabetes

2010 Clinical Trials

555. Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

lymphoma; subcutaneous panniculitis-like T-cell lymphoma; angioimmunoblastic T-cell lymphoma; anaplastic large cell lymphoma - primary cutaneous type For lymphoplasmacytic lymphoma patients without measurable lymphadenopathy, measurable disease can be defined by both of the following criteria: bone marrow lymphoplasmacytosis with > 10% lymphoplasmacytic cells or aggregates, sheets, lymphocytes, plasma cells, or lymphoplasmacytic cells on bone marrow biopsy and quantitative IgM monoclonal protein

2010 Clinical Trials

556. Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

fungoides/Sezary syndrome; Hodgkin Disease; Primary effusion lymphoma; Adult T-cell leukemia/lymphoma; Extranodal NK/T-cell lymphoma, nasal type; Enteropathy-type T-cell lymphoma; Hepatosplenic T-cell lymphoma; Subcutaneous panniculitis-like T-cell lymphoma; Angioimmunoblastic T-cell lymphoma; Anaplastic large cell lymphoma-primary cutaneous type; and Blastic plasmacytoid dendritic cell neoplasm Measurable disease by CT or MRI or PET/CT: Must have at least one lesion that has a single diameter of >= 2

2010 Clinical Trials

557. Prospective Study of Functional and Quality of Life Outcomes in Panniculectomy Patients

Panniculitis Procedure: panniculectomy Not Applicable Detailed Description: This is a prospective trial to determine what if any functional and quality of life benefits are achieved with a panniculectomy. Patients will be evaluated preoperatively and postoperatively with specific interventions aimed at describing their functional status. These interventions will include: echocardiogram, pulmonary function testing, arterial blood gas, functional capacity evaluation by physical therapy, and a quality of life (...) , 2018 Last Verified: August 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Keywords provided by Wake Forest University Health Sciences ( Wake Forest University ): panniculitis panniculectomy Additional relevant MeSH terms: Layout table for MeSH terms Panniculitis Connective Tissue Diseases Skin Diseases

2010 Clinical Trials

558. Neutrophilic dermatoses in a patient with collagenous colitis Full Text available with Trip Pro

Neutrophilic dermatoses in a patient with collagenous colitis We report the case of a 75-year old woman with collagenous colitis who presented with erythematous and edematous plaques on the periorbital and eyelid regions, accompanied by oral ulcers. Histopathology showed a dermal neutrophilic infiltrate plus mild septal and lobular panniculitis with lymphocytes, neutrophils and eosinophils. Five years earlier she had presented a flare of papules and vesicles on the trunk, together with oral (...) ulcers; a skin biopsy revealed a neutrophilic dermal infiltrate and Sweet's syndrome was diagnosed. Both the neutrophilic panniculitis and the Sweet's syndrome were accompanied by fever, malaise and diarrhea. Cutaneous and intestinal symptoms disappeared with corticoid therapy. The two types of neutrophilic dermatoses that appeared in periods of colitis activity suggest that intestinal and cutaneous manifestations may be related.

2010 Dermatology Reports

559. The Differential Imaging Features of Fat-Containing Tumors in the Peritoneal Cavity and Retroperitoneum: the Radiologic-Pathologic Correlation Full Text available with Trip Pro

, until the lesions become large or symptomatic. The third group tumors (i.e., mesenteric panniculitis and pseudolipoma of Glisson's capsule) require medical treatment or no treatment at all. Identifying factors such as whether the fat is macroscopic or microscopic within the lesion, the origin of the lesions, and the presence of combined calcification is important for narrowing the differential diagnosis. The development and wide-spread use of modern imaging modalities make identification

2010 Korean Journal of Radiology

560. Clinical Pearls in Dermatology Full Text available with Trip Pro

Labialis diagnosis Humans Male Middle Aged Panniculitis diagnosis Pyoderma Gangrenosum diagnosis Scabies diagnosis Skin Diseases diagnosis therapy 2010 9 3 6 0 2010 9 3 6 0 2010 9 29 6 0 ppublish 20810795 S0025-6196(11)60215-2 10.4065/mcp.2010.0305 PMC2931620 Arch Dermatol. 2000 Mar;136(3):330-6 10724194 J Am Acad Dermatol. 2002 Feb;46(2):187-92 11807428 Mayo Clin Proc. 2003 Feb;78(2):174-94 12583529 Curr Opin Infect Dis. 2010 Apr;23(2):111-8 20075729 Int J Dermatol. 2004 Nov;43(11):790-800 15533059 J

2010 Mayo Clinic Proceedings

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