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Panniculitis

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21. Relapsed subcutaneous panniculitis-like T cell lymphoma evaluated by FDG PET/CT: A clinical case report. (PubMed)

Relapsed subcutaneous panniculitis-like T cell lymphoma evaluated by FDG PET/CT: A clinical case report. Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare primary cutaneous T cell lymphomas expressing α/β T cell receptors that preferentially involves subcutis, and few reports have investigated the diagnosis of suspicious relapsed SPTCL using F-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT).A 15-year-old woman complaining of a growing

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2018 Medicine

22. Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome. (PubMed)

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome. Subcutaneous panniculitis-like T cell lymphoma (SPTCL), a non-Hodgkin lymphoma, can be associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune activation that adversely affects survival1,2. T cell immunoglobulin mucin 3 (TIM-3) is a modulator of immune responses expressed on subgroups of T and innate immune cells. We

2018 Nature Genetics

23. Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. (PubMed)

Alpha-1 antitrypsin deficiency panniculitis: clinical and pathologic characteristics of 10 cases. Alpha-1 antitrypsin deficiency (AATD) may be associated with liver and lung disease and rarely causes panniculitis.We evaluated the clinicopathologic and laboratory findings of AATD panniculitis in 10 patients.We conducted a retrospective review of all cases of AATD panniculitis at Mayo Clinic, Rochester, MN, from 1989 to 2016.Ten patients with AATD panniculitis were included. Seven of ten were (...) women. Clinical lesions were most commonly nodular (100%), erythematous (90%), ulcerated (90%), and painful (90%) subcutaneous nodules and plaques. Extracutaneous associations were rare. PiZZ phenotype was most commonly identified (50%). Histopathologically, lobular panniculitis (80%) with associated septal involvement (60%) and a predominant neutrophilic infiltrate (100%) were most common. Treatments varied; dapsone and alpha-1 proteinase inhibitor infusions were each used in five (50%) patients

2018 International Journal of Dermatology

24. Cold Panniculitis After Ice Therapy for Supraventricular Tachycardia. (PubMed)

Cold Panniculitis After Ice Therapy for Supraventricular Tachycardia. A late preterm infant presenting with supraventricular tachycardia (SVT) was admitted to the pediatric intensive care unit because of poor systolic function seen on echocardiogram. The hospitalization was complicated by multiple breakthrough episodes of SVT requiring ice placed on the face during each repeat episode. The infant was later diagnosed as having cold panniculitis secondary to the application of ice to the face (...) on multiple occasions. In children who are hemodynamically stable during SVT episodes, ice is used as first-line treatment. It is important to be aware of how often ice is being applied to the face and the duration of time to limit complications such as cold panniculitis.

2018 Pediatric Emergency Care

25. Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. (PubMed)

Lupus erythematosus panniculitis in a 10-year-old female child with severe systemic lupus erythematosus: A case report. Lupus erythematosus panniculitis (LEP) is a rare subset of lupus erythematosus. The incidence of LEP in systemic lupus erythematosus (SLE) ranges from 2% to 5%. In the previous literature, most LEP patients were women aged from 20 to 60 years, while pediatric cases were rare, all of whom appeared on their own without SLE.A rare LEP in a 10-year-old female child with severe SLE

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2018 Medicine

26. Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. (PubMed)

Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. We report on 4 children who presented with aseptic panniculitis associated with inherited immunodeficiency. Three patients had a B-cell immunodeficiency resulting from mutations in the TRNT1 and NF-κb2 genes (no mutation was found in the third patient), and 1 had a T-cell deficiency (mutation in the LCK gene). Panniculitis occurred before the age of 2 years in the 4 patients and preceded the onset (...) of recurrent infections because of immunodeficiency in 2. It presented either as nodules, which resolved spontaneously within 1 to 2 weeks (3 patients), or chronic ulcerative lesions (1 patient) associated with unexplained fever and elevated acute phase reactants, without evidence of infection or high-titer autoantibodies. Febrile nodules relapsed in 2 patients, and recurrent attacks of unexplained fever (without relapse of panniculitis) occurred in the third. Skin biopsy revealed predominantly lympho

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2018 Pediatrics

27. Chronic pancreatitis with multiple pseudocysts and pancreatic panniculitis: A case report. (PubMed)

Chronic pancreatitis with multiple pseudocysts and pancreatic panniculitis: A case report. Pancreatic pseudocyst can present single or multiple, inside or outside the pancreas. Pancreatic panniculitis is a rare skin lesion in pancreatic disease patients. The purpose of this study is to report a case of chronic pancreatitis coexisting with multiple pseudocysts and pancreatic panniculitis.A 46-year-old man with chronic pancreatitis presented multiple small cystic lesions inside the head (...) of the pancreas and two large cystic lesions adjacent to the tail of the pancreas. The patient also developed subcutaneous nodules involving upper and lower limbs, hands, and lower abdomen bilaterally.The patient was diagnosed with pancreatic pseudocyst and pancreatic panniculitis resulted from chronic pancreatitis.Bile duct stent and pancreatic duct stent placement was performed endoscopicly.Panniculitis faded three weeks later and the pancreatic pseudocysts disappeared six weeks later.Clinicians should

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2018 Medicine

28. Pancreatic panniculitis: A case series from a tertiary university hospital in Spain. (PubMed)

Pancreatic panniculitis: A case series from a tertiary university hospital in Spain. Pancreatic panniculitis is a rare type that only occurs in 2-3% of all patients with pancreatic diseases. It is usually described in association with benign pancreatic disease and less commonly in association with pancreatic carcinoma. We describe a case of pancreatic panniculitis as the first manifestation of underlying ampullary adenocarcinoma and a new case of pancreatitis, panniculitis and polyarthritis (...) (PPP-Syndrome). Pancreatic panniculitis may be the cutaneous manifestation of pancreatic allograft rejection after simultaneous pancreas-kidney transplantation.© 2018 The Australasian College of Dermatologists.

2018 Australasian Journal of Dermatology

29. Mesenteric Panniculitis-First Case Series After Bariatric Surgery. (PubMed)

Mesenteric Panniculitis-First Case Series After Bariatric Surgery. Mesenteric panniculitis is an uncommon pathology, of poorly understood etiology, characterized by progressive inflammation and fibrosis of the small bowel mesentery. This disease has been reported usually after other abdominal surgeries. We present two cases of young male patients who underwent laparoscopic sleeve gastrectomy and developed abdominal symptoms within 45-60 days of surgery. Both were investigated for known post (...) -bariatric complications. While first patient presented (5 months later) at an irreversible stage and died within 8-9 months of primary surgery, in second patient, the disease process could be reversed through early intervention, diagnosis, treatment, and compliance. Mesenteric panniculitis is a rapidly progressive entity, which can be adequately treated by early identification and long-term immune-suppressive therapy.

2018 Obesity Surgery

30. Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. (PubMed)

Pancreatic panniculitis: the "bright" side of the moon in solid cancer patients. Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3-3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood (...) , but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes. Histopathology shows subcutaneous lobular fat necrosis with anuclear adipocytes (called ghost cells) surrounded by a mixed inflammatory infiltrate. Focal calcification may also be seen. The treatment is directed to the underlying disorder, which may result in regression of skin lesions.We present two cases of pancreatic panniculitis with similar clinical, laboratory

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2018 BMC Gastroenterology

31. Disseminated extrapulmonary Legionella pneumophila infection presenting with panniculitis: case report and literature review. (PubMed)

Disseminated extrapulmonary Legionella pneumophila infection presenting with panniculitis: case report and literature review. Legionellosis is a well-known cause of pneumonia. Primary cutaneous and subcutaneous infection caused by Legionella pneumophila is rare and the diagnosis is challenging.A 38-year-old Thai woman with systemic lupus erythematosus and myasthenia gravis treated with prednisolone and azathioprine presented to our hospital with low-grade fever, diarrhea, and indurated skin (...) lesions on both thighs. Initial examination showed plaques on both inner thighs. Magnetic resonance imaging showed myositis and swelling of the skin and subcutaneous tissue. Diagnosis of panniculitis due to L. pneumophila was carried out by histopathology, Gram stain, and 16S rRNA gene sequencing method of tissue biopsy from multiple sites on both thighs. Myocarditis was diagnosed by echocardiography. The final diagnosis was disseminated extrapulmonary legionellosis. Treatment comprised intravenous

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2018 BMC Infectious Diseases

32. Distinctive lupus panniculitis of scalp with linear alopecia along Blaschko's lines: a review of the literature. (PubMed)

Distinctive lupus panniculitis of scalp with linear alopecia along Blaschko's lines: a review of the literature. Lupus panniculitis of the scalp (LPS) is a rare and distinctive clinical feature of lupus erythematosus panniculitis (LEP) with linear alopecia along Blaschko's lines. In this study, we investigated clinical features and treatments of LPS by literature review of articles in the English language from PubMed and SCOPUS databases up to April 2018. The following key words, "lupus (...) panniculitis, "lupus erythematosus panniculitis", "lupus profundus", "head", and "scalp", were used. Twenty cases of LPS were identified (mean age = 26.4 [10-53] years, female: male ratio = 1:1, mean disease duration = 86.89 [8-336] weeks). The most commonly affected areas of scalp included parietal (70%), frontal (45%), temporal (40%), occipital (30%), and vertex (10%), along 70% of Blaschko's lines with morphologic lesions linear, annular, arch-shaped, and ulcer. Besides, ANA (60%) was in particular

2018 International Journal of Dermatology

33. Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients. (PubMed)

Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma of mature cytotoxic T cells. Initially, patients with SPTCL were treated with doxorubicin-based polychemotherapy.To analyze clinical, biologic, immunophenotypical, molecular, imaging, treatment, and outcome data reflecting the current state of knowledge.A retrospective (...) multicenter study of 16 patients with SPTCL that was diagnosed between 1996 and 2016.The female-to-male ratio was 1.7. The median age at diagnosis was 46.5 years. Patients presented with multiple nodular or plaque-like lesions preferentially affecting the legs and/or trunk. Histopathology typically showed a lobular panniculitis with individual adipocytes surrounded by atypical lymphocytes, usually with a CD3+, CD4-, CD8+, CD56-, TIA1 cytotoxic granule associated RNA binding protein 1-positive phenotype

2018 Journal of American Academy of Dermatology

34. Dermatomyositis panniculitis: A clinico-pathologic and immunohistochemical study of 18 cases. (PubMed)

Dermatomyositis panniculitis: A clinico-pathologic and immunohistochemical study of 18 cases. Panniculitis occurring in dermatomyositis is uncommon, with only a few cases described in the literature, most of them as case reports.This report describes the clinicopathological and immunohistochemical findings in a series of 18 patients with panniculitis associated with dermatomyositis.In each patient, we collected the clinical data of the cutaneous lesions as well as the characteristic clinical (...) and laboratory findings. A series of histopathologic findings was recorded in the biopsy of each patient. A panel of antibodies was used in some cases to investigate the immunophenotype of the infiltrate. Data of treatment and follow-up were also collected.Of the 18 patients, 13 were female and 5 were male, ranging in age from 13 to 74 years (median, 46.4 years). In addition to panniculitis, all patients presented pathognomonic cutaneous findings of DM and reported proximal muscle weakness prior

2018 Journal of the European Academy of Dermatology and Venereology

35. Atypical lymphocytic lobular panniculitis: an overlap condition with features of subcutaneous panniculitis-like T-cell lymphoma and lupus profundus (PubMed)

Atypical lymphocytic lobular panniculitis: an overlap condition with features of subcutaneous panniculitis-like T-cell lymphoma and lupus profundus 27807018 2017 02 23 2018 11 13 1757-790X 2016 2016 Nov 02 BMJ case reports BMJ Case Rep Atypical lymphocytic lobular panniculitis: an overlap condition with features of subcutaneous panniculitis-like T-cell lymphoma and lupus profundus. bcr2016215335 10.1136/bcr-2016-215335 He Alice A http://orcid.org/0000-0002-1938-0619 Department of Dermatology (...) Antirheumatic Agents 4QWG6N8QKH Hydroxychloroquine Subcutaneous panniculitis-like T-cell lymphoma IM Antirheumatic Agents therapeutic use Biopsy Diagnosis, Differential Female Humans Hydroxychloroquine therapeutic use Lymphoma, T-Cell diagnosis drug therapy pathology Middle Aged Necrosis Panniculitis diagnosis drug therapy pathology Panniculitis, Lupus Erythematosus diagnosis drug therapy pathology Polymerase Chain Reaction Upper Extremity Conflicts of Interest: None declared. 2016 11 4 6 0 2017 2 24 6 0

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2016 BMJ case reports

36. Subcutaneous Panniculitis-Like T Cell Lymphoma Mimicking Early-Onset Nodular Panniculitis (PubMed)

Subcutaneous Panniculitis-Like T Cell Lymphoma Mimicking Early-Onset Nodular Panniculitis Subcutaneous panniculitis-like T cell lymphoma is a very uncommon subtype of cutaneous T cell lymphoma. The manifestations of this rare disease are atypical at onset, and may mimic some rheumatic or dermatologic diseases, which causes the delay of diagnosis and treatment.We report a 24-year-old man suffering from intermittent fever and skin nodules on the left anterior chest wall, who was initially (...) misdiagnosed with nodular panniculitis and finally diagnosed with subcutaneous panniculitis-like T cell lymphoma through repeat examination of biopsy of the skin nodule. Positron emission tomography revealed extracutaneous adipose tissue involvement. Subsequently, hemophagocytic syndrome occurred while under a conventional dose of glucocorticoid, but remission was induced by treatment with cyclosporine A and high doses of dexamethasone.In order to avoid the delay diagnosis and inappropriate treatment

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2016 The American journal of case reports

37. Useful Parameters for Distinguishing Subcutaneous Panniculitis-like T-Cell Lymphoma From Lupus Erythematosus Panniculitis. (PubMed)

Useful Parameters for Distinguishing Subcutaneous Panniculitis-like T-Cell Lymphoma From Lupus Erythematosus Panniculitis. Some cases of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and lupus erythematosus panniculitis (LEP) demonstrate clinical and histopathologic overlap, raising the possibility that they represent opposite ends of a disease spectrum. SPTCL, however, is typically associated with greater morbidity and risk for hemophagocytic lymphohistiocytosis (HLH); therefore

2016 American Journal of Surgical Pathology

38. An Unexpected Etiology of Pancreatic Panniculitis: A Case Report (PubMed)

An Unexpected Etiology of Pancreatic Panniculitis: A Case Report Pancreatic panniculitis is a rare cause of subcutaneous fat necrosis secondary to elevated serum levels of pancreatic enzymes. It is most often associated with pancreatic acinar cell carcinoma, but has also been seen in patients with pancreatitis.We present a case of a 64 year old Caucasian man without symptoms of pancreatitis who presents with pancreatic panniculitis manifesting in multiple subcutaneous ulcerating nodules (...) of the bilateral lower extremities, discovered to have a previously unreported etiology for this condition. He had no evidence of pancreatitis or malignancy, but instead a pancreatic-portal fistula resulting in panniculitis.Peripancreatic vascular lesions must also be considered in the differential diagnosis of pancreatic panniculitis. The diagnosis, pathology, and treatment of pancreatic panniculitis are reviewed herein.

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2017 Journal of Pancreatic Cancer

39. Pancreatitis, panniculitis and polyarthritis (PPP-) syndrome caused by post-pancreatitis pseudocyst with mesenteric fistula. Diagnosis and successful surgical treatment. Case report and review of literature (PubMed)

Pancreatitis, panniculitis and polyarthritis (PPP-) syndrome caused by post-pancreatitis pseudocyst with mesenteric fistula. Diagnosis and successful surgical treatment. Case report and review of literature Pancreatitis, panniculitis and polyarthritis syndrome is a very rare extra-pancreatic complication of pancreatic diseases.While in most cases this syndrome is caused by acute or chronic pancreatitis, we report a case of a 62-year-old man presenting with extensive intraosseous fat necrosis (...) , polyarthritis and panniculitis caused by a post-pancreatitis pseudocyst with a fistula to the superior mesenteric vein and extremely high blood levels of lipase. This became symptomatic 2.5 years after an episode of acute pancreatitis and as in most cases abdominal symptoms were absent. Treatment by surgical resection of the pancreatic head with the pseudocyst and mesenteric fistula led to complete remission of all symptoms.A review of the literature revealed that all publications are limited to case

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2017 International journal of surgery case reports

40. Lupus erythematosus panniculitis resistant to standard treatment, complicated with macrophage activation syndrome (PubMed)

Lupus erythematosus panniculitis resistant to standard treatment, complicated with macrophage activation syndrome 28670262 2018 11 13 1642-395X 34 3 2017 Jun Postepy dermatologii i alergologii Postepy Dermatol Alergol Lupus erythematosus panniculitis resistant to standard treatment, complicated with macrophage activation syndrome. 281-283 10.5114/ada.2017.67852 Juczynska Katarzyna K Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland. Wozniacka Anna A Department

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2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

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