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Panniculitis

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181. Chilblains

minutes of cold exposure lasting up to 1 hour. Frostbite Superficial frostbite (skin and subcutis) presents with erythema and initial pain followed by a sense of warmth — affected skin becomes waxy and white. Deep frostbite (extends to subcutaneous tissues and may involve nerves, major vessels, muscle and bone) can result in joint immobility and paralysis. Cold panniculitis Panniculitis (inflammation of the subcutaneous fat) caused by cold exposure. Infants are particularly susceptible to cold (...) panniculitis but it may also occur in adults, typically obese females. Livedo reticularis Mottled, cyanotic discolouration of the skin with a characteristic network pattern — accentuated by cold. Vascular or neuropathic conditions Peripheral vascular disease, diabetes mellitus (diabetic foot), and vasculitis may present with skin changes similar to chilblains. Granuloma annulare Typically presents as annular indurated papules and/or plaques on the extremities which slowly enlarge before eventually

2018 NICE Clinical Knowledge Summaries

182. Compression stockings as an effective treatment for erythema nodosum: Case series Full Text available with Trip Pro

Compression stockings as an effective treatment for erythema nodosum: Case series Erythema nodosum (EN) is a septal panniculitis that is characterized clinically by tender, erythematous, subcutaneous nodules that are predominately localized on the pretibial lower legs. EN affects women more than men and can be idiopathic or secondary to another disease process such as infection or an immune response. Treatment options for erythema nodosum are suboptimal and often involve significant side

2017 International journal of women's dermatology

183. Inflammatory skin disorders and self-esteem Full Text available with Trip Pro

inflammatory conditions panniculitis quality of life self-esteemmental healthinflammatory skinpsoriasisatopic dermatitiseczema 2017 09 01 2017 09 25 2018 6 7 6 0 2018 6 7 6 0 2018 6 7 6 1 epublish 29872672 10.1016/j.ijwd.2017.09.006 S2352-6475(17)30079-5 PMC5986113 JAMA Dermatol. 2015 Jul;151(7):743-52 25738422 J Pediatr. 2016 Feb;169:284-90.e5 26616249 J Cutan Med Surg. 2010 Nov-Dec;14(6):285-90 21084021 Arch Dermatol. 2005 Jan;141(1):19-26 15655138 J Invest Dermatol. 2017 Jan;137(1):26-30 27616422

2017 International journal of women's dermatology

184. Cutaneous Lupus Erythematosus (CLE), Treatment

erythematosus, CLE). Based on clinical features, histological changes, and serological abnormalities, four CLE subtypes can be defined: (i) acute CLE (ACLE), (ii) subacute CLE (SCLE), (iii) chronic CLE (CCLE), including discoid LE (DLE), chilblain LE (CHLE), and LE panniculitis (LEP), and (iv) intermittent CLE (ICLE), synonymously LE tumidus (LET). To date, no drugs have been licensed for the treatment of CLE, although several therapeutic agents are approved for SLE, including the novel monoclonal antibody

2016 European Dermatology Forum

187. Suspected inflammatory rheumatic diseases in patients presenting with skin rashes. (Abstract)

-inflammatory syndromes, transient macular purpura of vasculitis in Sjögren's syndrome, Behçet's disease, or RA, Raynaud's phenomenon in SSc and mixed connective tissue disease, erythema nodosum or other panniculitis in RA, Behçet's disease and SLE, pustular eruptions in Behçet's disease, psoriasis, and hereditary auto-inflammatory syndromes. After reviewing in detail the cutaneous manifestations of the most frequent inflammatory rheumatic diseases, we describe a topographic and morphological approach

2019 Best practice & research. Clinical rheumatology

188. Early onset granulomatous arthritis, uveitis and skin rash: characterisation of skin involvement in Blau syndrome. (Abstract)

diagnosis (p=0.003) and reduces the diagnostic delay (p=0.048). Early skin lesions had a homogeneous, stereotypical clinical presentation, namely non-confluent erythematous or pigmented millimetric papules in 13/14(93%) patients. In contrast, skin lesions occurring during later disease stages had a more heterogeneous clinical presentation, including ichthyosiform dermatosis, panniculitis, livedoid lesions and vasculitis. Whatever their time of occurrence and the clinical aspect, all biopsied showed

2019 Journal of the European Academy of Dermatology and Venereology

189. Erdheim-Chester Disease: Expanding the spectrum of cutaneous manifestations. (Abstract)

common finding being subcutaneous nodules (n=5). A single patient presented with granuloma annulare-like lesions. Another patient with mixed ECD and Langerhans cell histiocytosis presented with lightly scaling, pink-red macules. In three patients, skin lesions were the first manifestation of the disease. Most patients presented with bone/extremity pain, weight loss and other constitutional symptoms at the time of diagnosis. BRAF-V600E mutation was not found in patients with panniculitis-like (...) and granuloma annulare-like lesions.The most common presentation in ECD is periorbital XLL. Other presentations include non-facial cutaneous xanthomas, panniculitis-like lesions, and granuloma annulare-like lesions. Associated symptoms at presentation include bone/extremity pain and weight loss. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

190. Investigating the presence of neutrophil extracellular traps in cutaneous lesions of different subtypes of lupus erythematosus. (Abstract)

with subacute cutaneous lupus or SCLE, 11 with acute cutaneous SLE, 7 with lupus panniculitis and 2 with chilblains). Immunofluorescence was performed on formalin-fixed paraffin-embedded skin biopsies using antibodies against neutrophilic granules (elastase, myeloperoxidase, PR-3 proteins and citrullinated histone 3). Dihydroethidium staining was performed to detect reactive oxygen species (ROS), known inducers of NETs. NETs were detected in the different subtypes of cutaneous lupus as well as in cutaneous (...) lesions of SLE. The amounts of neutrophils producing NETs were significantly higher in lupus panniculitis (49%), acute cutaneous SLE (41%) and DLE (32%), in comparison with SCLE (5%) and chilblains (0%). This suggests that NETs might be associated with more tissue damage and scarring. ROS were observed in the different cutaneous subtypes of lupus independent of NETs.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2019 Experimental Dermatology

191. Acquired Lipodystrophy Associated with Nivolumab in a Patient with Advanced Renal Cell Carcinoma. (Abstract)

1.5 units/kg/day insulin. Subcutaneous biopsy of medial surface of the arm revealed chronic lobular panniculitis. Despite nivolumab's possible involvement in the onset of lipodystrophy, the maintenance of nivolumab therapy was justified by the observed reduction in the progression of the cancer, combined with the lack of an alternative chemotherapy. The therapy was withdrawn after eight months of treatment because of grade 3 hepatitis.Anti-PD1 therapy has great potential. Early recognition

2019 Journal of Clinical Endocrinology and Metabolism

193. Belinostat (Beleodaq)

-negative • Angioimmunoblastic T-cell lymphoma (AITL) • Enteropathy-associated T-cell lymphoma • Extranodal natural killer (NK)/T-cell lymphoma, nasal type • Hepatosplenic T-cell lymphoma • Peripheral T-cell lymphoma, not otherwise specified (NOS) • Subcutaneous panniculitis-like T-cell lymphoma Diagnosis of PTCL was to be based on biopsy specimens characterized by positivity in the malignant cell population of at least 3 of the following T-cell markers: ßF1, CD2, CD3, CD4, CD5, CD7, CD8, and negativity (...) panniculitis-like T-cell lymphoma were TIA-1, granzyme B and Perforin. It was acknowledged that no marker has absolute lineage specificity, and that immunophenotypic studies were to be performed with panels of monoclonal antibodies. Final diagnoses containing caveats such as “suspicious of” or “presumably” were to be considered inadequate for a patient to be enrolled in the trial. 2. Pathology material was to be available at the site for each patient before enrollment to be sent to the Sponsor (or designee

2013 FDA - Drug Approval Package

194. Istodax - romidepsin

2.3 3.0 Adult T cell leukaemia/lymphoma 1.0 2.0 Subcutaneous panniculitis-like T-cell lymphoma 0.5 1.3 Of the approximately 65,000 new cases of non-Hodgkin’s lymphoma (NHL) diagnosed in the US each year, with a similar incidence reported in the EU, PTCLs comprise between 5% and 10% of the cases (Armitage and Weisenburger, 1998; Jemal et al, 2007; Groves et al, 2000). These T-cell neoplasms account for approximately 10% to 15% of all lymphoid neoplasms (Armitage, 2006; Jaffe et al, 2001

2013 European Medicines Agency - EPARs

195. Venous eczema and lipodermatosclerosis

of the lower legs. Acute lipodermatosclerosis (sclerosing panniculitis) is characterized by painful inflammation above the ankles, which may be mistaken for cellulitis or phlebitis. Chronic lipodermatosclerosis may follow an acute episode or develop gradually. It is characterized by painful, hardened, tight, red or brown skin, which if circumferentially affecting the ankle area may eventually result in the leg having an 'inverted champagne bottle' or 'bowling pin' appearance. Atrophie blanche (star-shaped

2017 NICE Clinical Knowledge Summaries

196. Folotyn - pralatrexate

peripheral T/NK-cell lymphoma – unspecified ? Subcutaneous panniculitis T-cell lymphoma ? Transformed mycosis fungoides 2. Patient had documented PD after at least 1 prior treatment. Patients may not have received an experimental drug or biologic as their only prior therapy. Patient must have had clear PD after the last treatment received. Patient had at least 1 biopsy from initial diagnosis or in the relapsed setting to confirm the diagnosis of PTCL. 3. ECOG performance status = 2. 4. At least 18 years

2012 European Medicines Agency - EPARs

197. Phase II of Lenalidomide After Salvage Therapy in R/R Non-Hodgkin T-cell Lymphoma

diagnosed based on WHO classification: Peripheral T-cell lymphoma, not otherwise specified Angioimmunoblastic T-cell lymphoma Anaplastic large cell lymphoma, ALK-/+ Enteropathy-associated T-cell lymphoma Monomorphic epitheliotropic intestinal T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Cutaneous T-cell lymphoma including mycosis fungoides and sezary syndrome Relapse or progression after one or more previous therapies. Partial response or more to a salvage therapy and at least 4 cycles

2018 Clinical Trials

198. Chidamide Combined With CHOPE Regimen for Peripheral T-cell Lymphoma Patients

for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histopathology / cytology diagnosed as peripheral T cell lymphoma (PTCL) according to WHO 2016 classification criteria(NK/T cell lymphoma and ALK positive anaplastic large cell lymphoma excluded)including:Peripheral T-cell lymphoma, NOS,Angioimmunoblastic T-cell lymphoma,Anaplastic large-cell lymphoma, ALK negative,Enteropathy-associated T-cell lymphoma,Hepatosplenic T-cell lymphoma,Subcutaneous panniculitis T-cell lymphoma

2018 Clinical Trials

199. A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers

suspicion of skin cancer (e.g. BCC, SCC, sarcoma), which was not ruled out by biopsy, Patients with skin disorders unrelated to the wound that are presented adjacent to the wound, Patients suffering from chronic skin disorders (Idiopathic Pruritus, Psoriasis, Panniculitis, Pyoderma Gangrenosum, etc.) that might deteriorate as a result of local trauma or debridement, Wound has sinus tracts or tunnels extending under healthy tissue (following debridement "un-roofing"- if relevant), or penetrating

2018 Clinical Trials

200. Pembrolizumab and Pralatrexate in Treating Participants With Relapsed or Refractory Peripheral T-Cell Lymphomas

phenotype Follicular T-cell lymphoma Indolent T-cell lymphoproliferative disorder of the gastrointestinal (GI) tract Extranodal NK-/T-cell lymphoma Enteropathy-associated T cell lymphoma Monomorphic epitheliotropic intestinal T-cell lymphoma Hepatosplenic T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Transformed mycosis fungoides Patients must have failed at least one prior regimen, including: Recurrence of disease after a documented complete response (CR). Progression of disease after

2018 Clinical Trials

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