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181. Calcific panniculitis in adult-onset dermatomyositis. (PubMed)

Calcific panniculitis in adult-onset dermatomyositis. Dermatomyositis (DM) is an idiopathic inflammatory myopathy associated with characteristic cutaneous features. Panniculitis is a rarely reported clinical finding in this condition. This report describes two cases of adult-onset DM complicated by severe calcific panniculitis. In both cases, the associated pain and loss of function seemed to be best managed on combination anti-malarial therapy with mepacrine and hydroxychloroquine.

2009 Clinical & Experimental Dermatology

182. Acquired Lipodystrophy Associated with Nivolumab in a Patient with Advanced Renal Cell Carcinoma. (PubMed)

1.5 units/kg/day insulin. Subcutaneous biopsy of medial surface of the arm revealed chronic lobular panniculitis. Despite nivolumab's possible involvement in the onset of lipodystrophy, the maintenance of nivolumab therapy was justified by the observed reduction in the progression of the cancer, combined with the lack of an alternative chemotherapy. The therapy was withdrawn after eight months of treatment because of grade 3 hepatitis.Anti-PD1 therapy has great potential. Early recognition

2019 Journal of Clinical Endocrinology and Metabolism

183. Erdheim-Chester Disease: Expanding the spectrum of cutaneous manifestations. (PubMed)

common finding being subcutaneous nodules (n=5). A single patient presented with granuloma annulare-like lesions. Another patient with mixed ECD and Langerhans cell histiocytosis presented with lightly scaling, pink-red macules. In three patients, skin lesions were the first manifestation of the disease. Most patients presented with bone/extremity pain, weight loss and other constitutional symptoms at the time of diagnosis. BRAF-V600E mutation was not found in patients with panniculitis-like (...) and granuloma annulare-like lesions.The most common presentation in ECD is periorbital XLL. Other presentations include non-facial cutaneous xanthomas, panniculitis-like lesions, and granuloma annulare-like lesions. Associated symptoms at presentation include bone/extremity pain and weight loss. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.

2019 British Journal of Dermatology

184. Early onset granulomatous arthritis, uveitis and skin rash: characterisation of skin involvement in Blau syndrome. (PubMed)

diagnosis (p=0.003) and reduces the diagnostic delay (p=0.048). Early skin lesions had a homogeneous, stereotypical clinical presentation, namely non-confluent erythematous or pigmented millimetric papules in 13/14(93%) patients. In contrast, skin lesions occurring during later disease stages had a more heterogeneous clinical presentation, including ichthyosiform dermatosis, panniculitis, livedoid lesions and vasculitis. Whatever their time of occurrence and the clinical aspect, all biopsied showed

2019 Journal of the European Academy of Dermatology and Venereology

185. Suspected inflammatory rheumatic diseases in patients presenting with skin rashes. (PubMed)

-inflammatory syndromes, transient macular purpura of vasculitis in Sjögren's syndrome, Behçet's disease, or RA, Raynaud's phenomenon in SSc and mixed connective tissue disease, erythema nodosum or other panniculitis in RA, Behçet's disease and SLE, pustular eruptions in Behçet's disease, psoriasis, and hereditary auto-inflammatory syndromes. After reviewing in detail the cutaneous manifestations of the most frequent inflammatory rheumatic diseases, we describe a topographic and morphological approach

2019 Best practice & research. Clinical rheumatology

186. Investigating the presence of neutrophil extracellular traps in cutaneous lesions of different subtypes of lupus erythematosus. (PubMed)

with subacute cutaneous lupus or SCLE, 11 with acute cutaneous SLE, 7 with lupus panniculitis and 2 with chilblains). Immunofluorescence was performed on formalin-fixed paraffin-embedded skin biopsies using antibodies against neutrophilic granules (elastase, myeloperoxidase, PR-3 proteins and citrullinated histone 3). Dihydroethidium staining was performed to detect reactive oxygen species (ROS), known inducers of NETs. NETs were detected in the different subtypes of cutaneous lupus as well as in cutaneous (...) lesions of SLE. The amounts of neutrophils producing NETs were significantly higher in lupus panniculitis (49%), acute cutaneous SLE (41%) and DLE (32%), in comparison with SCLE (5%) and chilblains (0%). This suggests that NETs might be associated with more tissue damage and scarring. ROS were observed in the different cutaneous subtypes of lupus independent of NETs.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

2019 Experimental Dermatology

187. Cutaneous CD8+ Cytotoxic T-Cell Lymphoma Infiltrates: Clinicopathological Correlation and Outcome of 35 Cases (PubMed)

(MF)/Sézary syndrome (SS), 4 cases of subcutaneous panniculitis-like T-cell lymphoma (SPTCL), 5 cases of primary cutaneous acral CD8+ lymphoma [formerly indolent CD8+ lymphoid proliferation (ILP)] and 1 case of aggressive epidermotropic primary cutaneous T-cell lymphoma (AECTCL). Moreover, nine cases were classified as primary cutaneous peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) and three cases as systemic PTCL-NOS. Multiple skin lesions, a high proliferative index

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2016 Oncology and therapy

190. Factors influencing sessions' and speakers' evaluation: an analysis of seven consecutive EADV congress editions. (PubMed)

encompassed dermoscopy, screening programs, melanocytic naevi, panniculitis, organ transplanted and immunosuppressed patients, neutrophilic diseases, dermatopathology and history of dermatology. Finally, short thematic presentations, free communications and guidelines session showed overall poor scores.Focused and specialized topics are more prone to capture attention of participants when compared to sessions of heterogeneous content. Quite surprisingly, a practice-oriented topics such as guidelines, did

2018 Journal of the European Academy of Dermatology and Venereology

191. Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus. (PubMed)

Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus. Cutaneous and systemic lupus erythematosus (SLE) commonly involves the hair and scalp. Alopecia can result from direct activity of disease on the scalp or from the state of physical stress in the form of telogen effluvium. Discoid lupus erythematosus and lupus panniculitis/profundus are known to cause scarring alopecia, while accumulation of recent studies has shown that non-scarring alopecia in SLE may have different

2018 American journal of clinical dermatology

192. A Sweet Diagnosis for a Non-Resolving Rash (PubMed)

A Sweet Diagnosis for a Non-Resolving Rash Subcutaneous Sweet's syndrome (SSS) is a rare variant of Sweet's syndrome (SS), clinically characterized by erythematous plaques or nodules with a histologic pattern demonstrating a neutrophilic panniculitis (NP). We report a case of a 74-year-old woman with myelodysplastic syndrome (MDS) who presented with persistent fever, malaise, and non-resolving generalized erythematous nodules and was found to have an MDS-related SSS. SSS should be entertained

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2018 Cureus

193. Alpha1 antitrypsin deficiency due to an homozygous PI* Null Q0Cairo mutation: Early onset of pulmonary manifestations and variability of clinical expression (PubMed)

, the index case presented with many episodes of pulmonary infections concomitant with severe neutropenia. The third member of the family presented with ankylosing spondyloarthritis and developed panniculitis later but had no respiratory symptoms. The presence of this alpha-1-antitrypsin Q0cairo homozygous mutation could explain the severity of clinical manifestations. Moreover, our observations highlight a great variability of clinical expression for the same mutation: early severe bronchiectasis (...) , panniculitis, rheumatologic manifestations. This study further underlines the importance of genotyping by whole SERPINA1 gene sequencing in addition to serum alpha-1 antitrypsin determination, to enable detection of alpha-1 antitrypsin deficiency due to rare genotypes.

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2018 Respiratory Medicine Case Reports

194. A 36-Year-Old Renal Transplant Recipient Female with Leg Ulcer: A Case Report and Brief Review (PubMed)

right leg and ankle. Incisional biopsy of the subcutaneous nodule over the leg showed panniculitis with small- to medium-sized vasculitis associated with round yeast forms, and culture of the fragments revealed C. neoformans var. grubii.This article also reviews in brief the treatment of this rare complication. Reviewing the literature showed that since the cryptococcal cutaneous lesions are often nonspecific, the clinical picture solely is not enough to construct a definite diagnosis and there must

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2018 Case reports in infectious diseases

195. Panniculitides in Rheumatoid Syndromes: The Role of Histopathology (PubMed)

Dermatopathology (Basel) 101651125 2296-3529 Histopathology Panniculitis Rheumatoid syndromes 2017 12 15 2017 12 15 2018 5 3 6 0 2018 5 3 6 0 2018 5 3 6 1 epublish 29719824 10.1159/000486366 dpa-0005-0010 PMC5920951 J Cutan Pathol. 2003 Jan;30(1):1-10 12534797 Semin Cutan Med Surg. 2007 Jun;26(2):66-70 17544956 G Ital Dermatol Venereol. 2013 Aug;148(4):335-49 23900157

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2018 Dermatopathology

196. Safety, tolerability, and efficacy evaluation of the SlimME device for circumference reduction (PubMed)

and high intensity regimens (4.4 ± 1.5 and 4.9 ± 1.4, respectively). Mean SAT temperatures did not exceed 48.4 ± 2.5°C and were effectively maintained throughout the maintenance phase of the treatment session. Low-energy fluence led to localized fat coagulative necrotic lesions, surrounded by subacute rim of inflammation, while high-energy fluence induced fat coagulative necrosis alongside granulomatous panniculitis, which resolved within 90 days.The tested uniform ultrasound regimens elicited SAT

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2018 Lasers in surgery and medicine

197. Large Multilocular Cystic Lesions in the Uterine Cervix: Differential Diagnosis and Significance (PubMed)

complex nabothian follicles. There was an associated large adnexal mass with ascites. The patient was treated with total hysterectomy and omentectomy after aspiration of the fluid from the cervical cysts for debulking and limiting complications. Pathology revealed granulosa cell ovarian tumor, omental panniculitis, and cervical nabothian follicles.Large nabothian cysts should be kept in mind for differential diagnosis of cervical tumors. Ultrasonography is of value for the diagnosis of giant nabothian

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2018 Journal of medical ultrasound

198. Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin (PubMed)

Neonatal subcutaneous fat necrosis with hypercalcemia treatment using calcitonin Subcutaneous fat necrosis of newborn is a form of noninfectious panniculitis. It is an uncommon condition and mostly occurs in full-term infants within first weeks of life that have had a significant condition such as hypoxic-ischemic encephalopathy at the time of birth. Subcutaneous fat necrosis of newborn is usually a self-limiting condition but may be associated with hypercalcemia, which may lead to life

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2018 Saudi medical journal

199. Cartilage and bone damage in rheumatoid arthritis (PubMed)

to articular cartilage and bone damage in RA, including erosion precursors such as synovitis and osteitis and panniculitis, as well as the role of imaging techniques employed to detect early cartilage damage and bone erosions.

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2018 Reumatologia

200. Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom (PubMed)

Anti-MDA5 Antibody-Positive Dermatomyositis Presenting with Cellulitis-Like Erythema on the Mandible as an Initial Symptom Panniculitis is an uncommon skin eruption observed in patients with dermatomyositis (DM)/clinically amyopathic dermatomyositis (CADM), especially in anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM. We present here a 51-year-old Japanese woman with an anti-MDA5 antibody-positive DM who initially had cellulitis-like erythema on her right mandible (...) . Histopathological findings showed a subcutaneous lobular infiltration of lymphocytes. The patient developed typical skin eruptions of DM/CADM, rapidly progressive interstitial lung disease, and severe muscle weakness 2 weeks after the first visit. After the diagnosis of anti-MDA5 antibody-positive DM, she was treated with intravenous steroid pulse therapy (methylprednisolone, 1,000 mg/day for 3 days), oral prednisolone at 1.0 mg/kg/day, and tacrolimus at 4.0 mg/day. The lesions of panniculitis associated

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2018 Case reports in dermatology

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