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Pancuronium

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1. Pancuronium

Pancuronium Pancuronium Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pancuronium Pancuronium Aka: Pancuronium , Pavulon II (...) Nitrogen at position 2 is only difference Significantly different effects than Primarily renal excretion (up to 70%) due to vagolytic and Significantly longer duration of action VI. Dose Initial Dose Pancuronium alone: 0.06 to 0.1 mg/kg IV Pancuronium after : 0.05 mg/kg IV Maintenance dosing (if needed) Starts 25-60 minutes after initial dose Please see other references for maintenance dosing Renal Cut dose by 50% if 10-50 ml/min Do not use Pancuronium if <10 ml/min Do not use by intramuscular dosing

2018 FP Notebook

2. The effect of defasciculating doses of pancuronium and atracurium on succinylcholine neuromuscular blockade. (PubMed)

The effect of defasciculating doses of pancuronium and atracurium on succinylcholine neuromuscular blockade. A defasciculating dose of non-depolarizing muscle relaxant administered prior succinylcholine decrease its side effects including fasciculations and postoperative myalgias; however it is believed that the dosage of succinylcholine should be increased when such a pre-treatment is used.We hypothesized that a defasciculating dose of pancuronium as a pre-treatment could prolong its duration (...) of effect.Forty patients scheduled for elective orthopaedic surgery were consecutively assigned into 5 groups, a first group without pre-treatment (succinylcholine 1 mg/kg) and 4 subsequent groups of pretreatment with atracurium 0.05 mg/kg + succinylcholine 1 or 1.5 mg/kg and pancuronium 7.5 µg /kg + succinylcholine 1 and 1.5 mg/kg. The muscle relaxant effect of succinylcholine was assessed with a force transducer using train of four stimulations every 12 seconds. Kruskall Wallis Anova test was used

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2014 Anesthesiology and pain medicine

3. [Effect of atracurium on pancuronium-induced neuromuscular block recovery.]. (PubMed)

[Effect of atracurium on pancuronium-induced neuromuscular block recovery.]. Additional neuromuscular blocker doses are in general needed during wall closing after abdominal surgeries. This study aimed at determining during partial pancuronium-induced neuromuscular block recovery, the effect of additional atracurium dose on spontaneous neuromuscular block recovery.Participated in this study 30 patients divided in two groups: pancuronium group (n = 14) and atracurium group (n = 16 (...) ). Neuromuscular function was continuously monitored by accelerometry of abductor pollicis muscle using TOF to supramaximally stimulate ulnar nerve. Anesthesia was induced with propofol, fentanyl and 0.08 mg.kg-1 pancuronium, and was maintained with 60% N2O in oxygen and 0.5% isoflurane expired concentration. When T1 returned to 25% of control, 0.025 mg.kg-1 pancuronium or 0.20 mg.kg-1 atracurium were administered to pancuronium or atracurium group, respectively. Time for spontaneous T1 recovery = 10%, 25%, 75

2012 Revista brasileira de anestesiologia

4. Pancuronium

Pancuronium Pancuronium Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pancuronium Pancuronium Aka: Pancuronium , Pavulon II (...) Nitrogen at position 2 is only difference Significantly different effects than Primarily renal excretion (up to 70%) due to vagolytic and Significantly longer duration of action VI. Dose Initial Dose Pancuronium alone: 0.06 to 0.1 mg/kg IV Pancuronium after : 0.05 mg/kg IV Maintenance dosing (if needed) Starts 25-60 minutes after initial dose Please see other references for maintenance dosing Renal Cut dose by 50% if 10-50 ml/min Do not use Pancuronium if <10 ml/min Do not use by intramuscular dosing

2015 FP Notebook

5. A clinical comparison between tubocurarine and pancuronium in children. (PubMed)

A clinical comparison between tubocurarine and pancuronium in children. 4121281 1973 06 07 2018 01 26 0007-0912 45 1 1973 Jan British journal of anaesthesia Br J Anaesth A clinical comparison between tubocurarine and pancuronium in children. 63-70 Nightingale D A DA Bush G H GH eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Anaesth 0372541 0007-0912 0 Androstanes 0 Neuromuscular Nondepolarizing Agents J76UF062FS Pancuronium W9YXS298BM Tubocurarine (...) IM Adolescent Age Factors Androstanes pharmacology Blood Pressure drug effects Child Child, Preschool Clinical Trials as Topic Histamine Release drug effects Humans Infant Intubation, Intratracheal Motor Activity drug effects Neuromuscular Nondepolarizing Agents pharmacology Pancuronium administration & dosage pharmacology Preanesthetic Medication Time Factors Tubocurarine administration & dosage pharmacology 1973 1 1 1973 1 1 0 1 1973 1 1 0 0 ppublish 4121281 S0007-0912(17)48922-7

1973 British Journal of Anaesthesia

6. The reversal of non-depolarising relaxants. A comparison of tubocurarine, gallamine and pancuronium. (PubMed)

The reversal of non-depolarising relaxants. A comparison of tubocurarine, gallamine and pancuronium. 4261166 1972 09 11 2013 11 21 0003-2409 27 3 1972 Jul Anaesthesia Anaesthesia The reversal of non-depolarising relaxants. A comparison of tubocurarine, gallamine and pancuronium. 313-8 Monks P S PS eng Clinical Trial Journal Article Randomized Controlled Trial England Anaesthesia 0370524 0003-2409 0 Androstanes 0 Neuromuscular Nondepolarizing Agents 3982TWQ96G Neostigmine 7C0697DR9I Atropine (...) J76UF062FS Pancuronium Q3254X40X2 Gallamine Triethiodide W9YXS298BM Tubocurarine AIM IM Androstanes antagonists & inhibitors Anesthesia Atropine pharmacology Electric Stimulation Gallamine Triethiodide antagonists & inhibitors Humans Neostigmine pharmacology Neuromuscular Nondepolarizing Agents antagonists & inhibitors Pancuronium antagonists & inhibitors Tubocurarine antagonists & inhibitors 1972 7 1 1972 7 1 0 1 1972 7 1 0 0 ppublish 4261166

1972 Anaesthesia

7. The cardiovascular effects of pancuronium bromide. (PubMed)

The cardiovascular effects of pancuronium bromide. 4246973 1970 09 09 2018 11 30 0003-2409 25 3 1970 Jul Anaesthesia Anaesthesia The cardiovascular effects of pancuronium bromide. 356-63 Loh L L eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Anaesthesia 0370524 0003-2409 0 Analgesics 0 Androstanes 0 Bis-Trimethylammonium Compounds 0 Bromides 0 Isonipecotic Acids 0 Neuromuscular Nondepolarizing Agents 0 Piperidines 98PI200987 Lidocaine DAA13NKG2Q

1970 Anaesthesia

8. [A double-blind comparison of pancuronium bromide and d-tubo-curarine]. (PubMed)

[A double-blind comparison of pancuronium bromide and d-tubo-curarine]. 4263087 1972 11 29 2013 11 21 0023-7205 69 39 1972 Sep 20 Lakartidningen Lakartidningen [A double-blind comparison of pancuronium bromide and d-tubo-curarine]. 4322-4 Lee P P Tydén H H swe Clinical Trial Comparative Study Controlled Clinical Trial Journal Article Randomized Controlled Trial En jämförelse mellan pancuroniumbromid och d-tubokurarin med dubbel-blind-teknik. Sweden Lakartidningen 0027707 0023-7205 0 Androstanes (...) 0 Neuromuscular Nondepolarizing Agents J76UF062FS Pancuronium W9YXS298BM Tubocurarine IM Adult Androstanes Blood Pressure drug effects Depression, Chemical Dose-Response Relationship, Drug Female Humans Injections, Intravenous Intubation, Intratracheal Male Neuromuscular Nondepolarizing Agents Pancuronium administration & dosage Stimulation, Chemical Time Factors Tubocurarine administration & dosage 1972 9 20 1972 9 20 0 1 1972 9 20 0 0 ppublish 4263087

1972 Lakartidningen

9. The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man. (PubMed)

The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man. 4264060 1973 01 30 2013 11 21 0003-2409 27 4 1972 Oct Anaesthesia Anaesthesia The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man. 415-22 Coleman A J AJ Downing J W JW Leary W P WP Moyes D G DG Styles M M eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Anaesthesia 0370524 0003-2409 0 Allyl Compounds 0 Androstanes 0 Neuromuscular (...) Nondepolarizing Agents 7C0697DR9I Atropine 9M7D9K3OJI Toxiferine J76UF062FS Pancuronium W9YXS298BM Tubocurarine AIM IM Adult Allyl Compounds pharmacology Androstanes pharmacology Anesthesia, General Atropine pharmacology Blood Pressure drug effects Cardiac Output drug effects Cardiac Volume drug effects Cardiovascular System drug effects Central Venous Pressure drug effects Heart Rate drug effects Humans Male Neuromuscular Nondepolarizing Agents pharmacology Pancuronium antagonists & inhibitors pharmacology

1973 Anaesthesia

10. Kinetic analysis of pancuronium interaction with sodium channels in squid axon membranes (PubMed)

Kinetic analysis of pancuronium interaction with sodium channels in squid axon membranes The interaction of pancuronium with sodium channels was investigated in squid axons. Sodium current turns on normally but turns off more quickly than the control with pancuronium 0.1-1mM present internally; The sodium tail current associated with repolarization exhibits an initial hook and then decays more slowly than the control. Pancuronium induces inactivation after the sodium inactivation has been (...) removed by internal perfusion of pronase. Such pancuronium-induced sodium inactivation follows a single exponential time course, suggesting first order kinetics which represents the interaction of the pancuronium molecule with the open sodium channel. The rate constant of association k with the binding site is independent of the membrane potential ranging from 0 to 80 mV, but increases with increasing internal concentration of pancuronium. However, the rate constant of dissociation l is independent

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1977 The Journal of general physiology

11. Potentiation of cardiac sympathetic nerve responses in vivo by pancuronium bromide [proceedings] (PubMed)

Potentiation of cardiac sympathetic nerve responses in vivo by pancuronium bromide [proceedings] 588823 1978 02 18 2018 11 13 0007-1188 61 3 1977 Nov British journal of pharmacology Br. J. Pharmacol. Potentiation of cardiac sympathetic nerve responses in vivo by pancuronium bromide [proceedings]. 472P-473P Docherty J R JR McGrath J C JC eng Journal Article England Br J Pharmacol 7502536 0007-1188 J76UF062FS Pancuronium IM Animals Heart innervation In Vitro Techniques Pancuronium pharmacology

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1977 British journal of pharmacology

12. Sympathomimetic effects of pancuronium bromide on the cardiovascular system of the pithed rat: a comparison with the effects of drugs blocking the neuronal uptake of noradrenaline. (PubMed)

Sympathomimetic effects of pancuronium bromide on the cardiovascular system of the pithed rat: a comparison with the effects of drugs blocking the neuronal uptake of noradrenaline. 1. The effects of pancuronium bromide on the cardiovascular system of the pithed rat were examined. Pancuronium had two effects, a short-lasting cardiovascular stimulation following injection and a longer-lasting potentiation of responses to sympathetic nerve stimulation. 2 The initial effect of pancuronium (...) was compared with that of tyramine. The cardioaccelerator but not the pressor responses to both pancuronium and tyramine were significantly reduced following sympathectomy with 6-hydroxydopamine (6-OHDA). 3 The action of pancuronium in potentiating sympathetic nerve responses was compared with that of known blockers of the neuronal uptake of noradrenaline (NA). Pancuronium (1 mg/kg) and cocaine (0.5 mg/kg) potentiated cardioaccelerator and pressor responses to sympathetic stimulation. These effects

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1978 British journal of pharmacology

13. Pancuronium inactivates alamethicin-induced conductance in artificial membranes. (PubMed)

Pancuronium inactivates alamethicin-induced conductance in artificial membranes. The effect of pancuronium on alamethicin-induced currents was studied in negatively charged lipid bilayer membranes. Pancuronium induces inactivation of the alamethicin-induced current. Inactivation is only observed if this compound is added to the compartment containing alamethicin. Moreover, the process of inactivation is reduced or abolished if pancuronium is added to the alamethicin-free side of the membrane (...) . The time needed to recover from inactivation is greatly reduced if the aqueous solution in the alamethicin-free compartment is stirred. These data suggest that pancuronium permeates through the membrane when the alamethicin-induced conductance is "turned on," binds to the other membrane surface, and changes the surface potential.

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1979 Biophysical journal

14. On the mechanism of pancuronium-induced supersensitivity to noradrenaline in rat smooth muscle. (PubMed)

On the mechanism of pancuronium-induced supersensitivity to noradrenaline in rat smooth muscle. 1. Pancuronium bromide (5 x 10(-5) M) caused supersensitivity to noradrenaline in the rat isolated vas deferens and hepatic portal vein. This supersensitivity was manifest as a parallel leftward shift of the dose-response curve for noradrenaline with no alteration of the maximum response to the agonist. 2. Pancuronium did not potentiate the response of the vas and portal vein to St 91, an alpha (...) -adrenoceptor agonist which is not a substrate for Uptake1. 3. Pancuronium did not potentiate the response of the vas to CaCl2. 4. In vasa deferentia made supersensitive to noradrenaline by treatment with cocaine (1 x 10(-5) M) pancuronium induced no further potentiation of the response to noradrenaline. However, the supersensitivity to noradrenaline induced by pancuronium alone was augmented by the addition of cocaine. 5. Histofluorescence studies showed that pancuronium inhibited neuronal uptake of alpha

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1979 British journal of pharmacology

15. Cardiovascular effects of pancuronium in anaesthetized man. (PubMed)

Cardiovascular effects of pancuronium in anaesthetized man. 5497826 1971 03 23 2018 11 13 0007-1188 40 3 1970 Nov British journal of pharmacology Br. J. Pharmacol. Cardiovascular effects of pancuronium in anaesthetized man. 567P-568P Kelman G R GR Kennedy B R BR eng Journal Article England Br J Pharmacol 7502536 0007-1188 0 Androstanes 0 Bromides IM Androstanes pharmacology Anesthesia, General Bromides pharmacology 1970 11 1 1970 11 1 0 1 1970 11 1 0 0 ppublish 5497826 PMC1703116 Eur J

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1970 British journal of pharmacology

16. Clinical experience with pancuronium. (PubMed)

Clinical experience with pancuronium. 4247246 1970 09 22 2018 11 13 0035-9157 63 7 1970 Jul Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Clinical experience with pancuronium. 697-700 Baird W L WL eng Comparative Study Journal Article England Proc R Soc Med 7505890 0035-9157 0 Androstanes 0 Neuromuscular Nondepolarizing Agents 0 Piperidines W9YXS298BM Tubocurarine IM Aged Androstanes administration & dosage adverse effects Anesthesia, General Blood Pressure drug effects Humans

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1970 Proceedings of the Royal Society of Medicine

17. The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent. (PubMed)

The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent. 4171017 1968 05 09 2018 11 13 0366-0826 32 3 1968 Mar British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The pharmacology of pancuronium bromide (Org.NA97), a new potent steroidal neuromuscular blocking agent. 671-82 Buckett W R WR Marjoribanks C E CE Marwick F A FA Morton M B MB eng Comparative Study Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0

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1968 British journal of pharmacology and chemotherapy

18. Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen. (PubMed)

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen. 4433494 1975 03 17 2018 11 13 0007-1161 58 9 1974 Sep The British journal of ophthalmology Br J Ophthalmol Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen. 806-10 Al-Abrak M H MH Samuel J R JR eng Journal Article England Br J Ophthalmol 0421041 0007-1161 142M471B3J (...) Carbon Dioxide J76UF062FS Pancuronium K50XQU1029 Nitrous Oxide S88TT14065 Oxygen W9YXS298BM Tubocurarine IM Adult Aged Anesthesia, General Blood Pressure drug effects Carbon Dioxide analysis Central Venous Pressure drug effects Heart Rate drug effects Humans Intraocular Pressure drug effects Male Middle Aged Nitrous Oxide pharmacology Oxygen pharmacology Pancuronium pharmacology Respiration, Artificial Tonometry, Ocular Tubocurarine pharmacology 1974 9 1 1974 9 1 0 1 1974 9 1 0 0 ppublish 4433494

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1974 The British journal of ophthalmology

19. Conditions for tracheal intubation following fazadinium and pancuronium. (PubMed)

Conditions for tracheal intubation following fazadinium and pancuronium. Intubating conditions were studied in two groups of patients who received either fazadinium 1 mg/kg or pancuronium 0.1 mg/kg (group 1), or either fazadinium 0.5 mg/kg or pancuronium 0.08 mg/kg (group 2). In group 1 intubating conditions were studied at 30, 45, 60 and 75 s after injection of the relaxant drug, and in group 2 at 60 s after injection. Fazadinium provided better intubating conditions than pancuronium during

1977 British Journal of Anaesthesia

20. Intraocular pressures after suxamethonium and endotracheal intubation in patients pretreated with pancuronium. (PubMed)

Intraocular pressures after suxamethonium and endotracheal intubation in patients pretreated with pancuronium. Intraocular pressures were recorded after the administration of suxamethonium and endotracheal intubation in a series of 20 patients who had not received pancuronium 1 mg 4 min before the suxamethonium. The pressures were compared with those in a control group of 20 patients who had not received pancuronium. The increase in intraocular pressure which followed the suxamethonium

1976 British Journal of Anaesthesia

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