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Pancoast Tumor

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101. Phase II Randomized Study on Locally Advanced NSCLC Escalated Dose on Individual Basis Treatment With Radiochemotherapy

ClinicalTrials.gov Identifier: Other Study ID Numbers: PLANET First Posted: August 14, 2012 Last Update Posted: December 9, 2014 Last Verified: December 2014 Keywords provided by Ass. Prof. Jan Nyman, Swedish Lung Cancer Study Group: Radiotherapy Dose escalation Normal tissue constraints Locally advanced disease Good performance status Additional relevant MeSH terms: Layout table for MeSH terms Lung Neoplasms Carcinoma, Non-Small-Cell Lung Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site (...) months (> 10%). Supraclavicular nodes. Apical tumors-pancoast. T4 tumors with separate manifestations in different lobes. Evidence of active serious infections. Inadequate liver function. Inadequate kidney function. Pregnancy. Breast feeding. Serious concomitant systemic disorder. Second primary malignancy the last 5 years. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using

2012 Clinical Trials

102. Robert R. Shaw, MD: Thoracic Surgical Hero, Afghanistan Medical Pioneer, Champion for the Patient, Never a Surgical Society President. (Abstract)

love for Texas, he ended up as a partner of Dr Shaw in Dallas. Together, they pursued the development of this very large surgical lung cancer center. Dr Shaw and his wife Ruth went to Afghanistan with Medico multiple times to teach men modern cardiac and thoracic surgery. They also served as consultants on Medico's Ship of Hope in Africa. Dr Shaw initiated multiple new operations including: 1) resection of Pancoast's cancer of the lung after preoperative irradiation; 2) upper lobe of the lung (...) getting credit for himself. From 1937 to 1970, Dr Shaw established one of the largest lung cancer surgical centers in the world in Dallas, Texas. It was larger than M.D. Anderson and Memorial Sloan-Kettering Hospitals put together regarding the surgical treatment of lung cancer patients. To accomplish this, he had the help of Dr Donald L. Paulson, who trained at the Mayo Clinic and served as Chief of Thoracic Surgery at Brook Army Hospital during the Second World War. Following the War, because of his

2012 Annals of Thoracic Surgery

103. THE SUPERIOR PULMONARY SULCUS “TUMOR OF PANCOAST” IN RELATION TO HARE'S SYNDROME Full Text available with Trip Pro

THE SUPERIOR PULMONARY SULCUS “TUMOR OF PANCOAST” IN RELATION TO HARE'S SYNDROME 17857611 2007 09 17 2008 11 20 0003-4932 112 1 1940 Jul Annals of surgery Ann. Surg. THE SUPERIOR PULMONARY SULCUS "TUMOR OF PANCOAST" IN RELATION TO HARE'S SYNDROME. 1-21 Morris J H JH Harken D E DE eng Journal Article United States Ann Surg 0372354 0003-4932 1940 7 1 0 0 1940 7 1 0 1 1940 7 1 0 0 ppublish 17857611 PMC1387913

1940 Annals of Surgery

104. Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events

Pleurectomy and Decortication Pneumonectomy Esophagogastrectomy Mediastinal Tumor Resection Pancoast Tumor Completion Pneumonectomy Lobectomy (post-induction chemotherapy; or severe COPD) Segmentectomy Colorectal/ GYN Colon Resection with possible Sacrectomy Pelvic Exenteration Advanced ovarian cancer resection with or without liver resection Urology Radical Cystectomy Open Radical Prostatectomy Nephrectomy with Vena Caval Resection Head & Neck Thyroid Resection with Mediastinal involvement Major head (...) : July 13, 2018 Sponsor: Memorial Sloan Kettering Cancer Center Information provided by (Responsible Party): Memorial Sloan Kettering Cancer Center Study Details Study Description Go to Brief Summary: The purpose of this study is to look at a new method for finding out if patients have a risk of heart complications from surgery. At the present, to find out if patients have a risk of heart complications from surgery, look at whether the patient has heart disease, diabetes, kidney problems, and stroke

2010 Clinical Trials

105. Treatment of Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

relevant MeSH terms: Layout table for MeSH terms Lung Neoplasms Carcinoma, Non-Small-Cell Lung Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms Lung Diseases Respiratory Tract Diseases Carcinoma, Bronchogenic Bronchial Neoplasms Vorinostat Antineoplastic Agents Histone Deacetylase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action (...) Network Information provided by (Responsible Party): Fox Chase Cancer Center Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the maximum tolerated dose of the combination of vorinostat, cisplatin, pemetrexed, and radiation therapy in patients with unresectable stage IIIA/IIIB non-small cell lung cancer. Condition or disease Intervention/treatment Phase Locally Advanced Non-small Cell Lung Cancer Drug: vorinostat Phase 1 Detailed Description: This phase I

2010 Clinical Trials

106. Enabling medication management through health information technology

developed for use in the ambulatory care setting (28 studies), focused on the adult population (36 studies), and provided CDSS with alerts or reminders to support chronic disease management (12 studies). Studies that involved laboratory-based medication monitoring were most likely (76 percent of the time) to be associated with a greater than 50 percent improvement in a process outcome(s) than sign- or symptom-based medication monitoring. The most successful types of studies focused on changing (...) prescriber behavior, improving response time to generated alerts, and improving the diagnosis and management of chronic diseases. ES-9 Reconciliation. Two systematic reviews and four studies provided evidence for improved reconciliation of medications with health IT. Reconciliation is the matching of medication lists over time, from different health care systems or from different prescribers. The evidence on reconciliation of medication lists is sparse, especially for systems that are fully integrated

2011 EvidenceUpdates

107. Versatility of a mini-trapdoor incision in upper mediastinal exposure. (Abstract)

Versatility of a mini-trapdoor incision in upper mediastinal exposure. Exposure of the upper mediastinum and thoracic outlet can pose major surgical challenges. We report our application of a previously described mini-trapdoor incision to a variety of surgical problems involving the upper mediastinum and thoracic outlet, including subclavian vein thrombosis, penetrating subclavian artery injury, debridement of subjacent chest wall infection, lymph node excision, and Pancoast tumor resection

2011 Annals of Thoracic Surgery

108. Phineas Gage Full Text available with Trip Pro

died. At autopsy, reaccumulated pus was found: had blocked the opening in the ." By keeping the exit wound open, and elevating Gage's head to encourage drainage from the cranium into the sinuses (through the hole made by the tamping iron), Harlow "had not repeated Professor Pancoast's mistake". ​​ :675 :58 No attempt will be made by me to cite analo­gous cases, as after ran­sack­ing the lit­er­a­ture of sur­gery in quest of such, I learn that all, or nearly all, soon came to a fatal result. (1868 (...) settled") complained that, "In investigating reports on diseases and injuries of the brain, I am constantly being amazed at the inexactitude and distortion to which they are subject by men who have some pet theory to support. The facts suffer so frightfully ..." ​​ :1,75,197-99,464-65 ​​ More recently, neurologist refers to the "interpretations and misinterpretations [of Gage] from 1848 to the present", and Jarrett discusses the use of Gage to promote "the myth, found in hundreds of psychology

2012 Wikipedia

109. Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors

: September 25, 2009 Last Update Posted: June 30, 2016 Last Verified: June 2016 Keywords provided by M.D. Anderson Cancer Center: Superior Sulcus Tumor Lung Cancer Non-Small Cell Multimodality Treatment Surgery Segmentectomy Lobectomy Cisplatin CDDP Etoposide VP-16 VePesid Radiation Therapy Radiotherapy Chest Irradiation Prophylactic Cranial Irradiation PCI Additional relevant MeSH terms: Layout table for MeSH terms Pancoast Syndrome Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms (...) provided by (Responsible Party): M.D. Anderson Cancer Center Study Details Study Description Go to Brief Summary: To determine the outcome of patients with potentially resectable superior sulcus tumors of non-small cell histology treated by surgery followed by accelerated radiation therapy and chemotherapy. To evaluate toxicity, the initial local-regional control rate, sites of and time to local and distant failures. Condition or disease Intervention/treatment Phase Lung Cancer Procedure: Surgery

2009 Clinical Trials

110. Neoadjuvant IRESSA As Single Agent PreopTherapy for NSCLC With Molecular Correlates

) Symptomatic tumors (T3, N0-1) involving the superior sulcus (i.e., Pancoast tumors) Measurable disease by contrast-enhanced CT scan No metastatic disease (except peribronchial or hilar lymph node involvement [N1]) by fludeoxyglucose F 18 PET scan No malignant pleural effusion by preoperative evaluation Pleural effusions visible only on CT scan that are not large enough for safe thoracentesis are allowed No exudative effusions (even if cytologically negative), as evidenced by any of the following: Ratio (...) contraception Willing to provide tumor biopsy pre- and post-gefitinib administration AND undergo PET scan No known severe hypersensitivity to study drug or any of its excipients No uncontrolled major seizure disorder No unstable or uncontrolled diabetes mellitus No serious infection requiring IV antibiotics No grade 3 neuropathy No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix No other unstable or serious medical

2005 Clinical Trials

111. Ulnar Nerve Disorders

mellitus, hypothyroidism and rheumatoid arthritis. X-rays: Neck X-rays if cervical disc disease is suspected and to rule out cervical ribs. X-rays of the chest if a Pancoast's tumour is suspected. X-rays of the elbow and wrist are essential to rule out possible associated bone or joint abnormalities, or alternative diagnoses. Ultrasound of the cubital tunnel. [ ] High-resolution ultrasonic assessment of the ulnar nerve for swelling and textural abnormalities can be a powerful diagnostic method. [ ] MRI (...) and the fourth and fifth fingers). Positive Phalen's test with paraesthesiae in the fourth and fifth fingers (the patient holds their wrist in maximum flexion for 30-60 seconds). Differential diagnosis Cervical disc disease. Brachial plexus abnormalities, , . Elbow abnormalities, . Neuropathy associated with, for example, , , and . . Ulnar artery aneurysms or thrombosis at the wrist. Investigations Blood tests may be appropriate to rule out various disorders causing neuropathy - eg, anaemia, diabetes

2008 Mentor

112. Thoracic Back Pain

for inflammatory, degenerative, metabolic, infective and neoplastic conditions [ ] . Thoracic back pain and dysfunction are associated with conditions such as primary and secondary osteoporosis (especially vertebral fractures and hyperkyphosis arising from vertebral bone loss), ankylosing spondylitis, osteoarthritis and Scheuermann's disease [ ] . Presentation The presentation of thoracic back pain will depend on the underlying cause. Red flags [ ] Thoracic back pain is more likely than neck or low back pain (...) affecting the lung (including a Pancoast tumour), oesophagus, stomach, liver, gallbladder and pancreas can all cause referred pain in the interscapular area. Interscapular pain may also be referred from disc prolapse or spinal dysfunction affecting the cervical or lumbar spine. Investigations As with the lumbar spine, degenerative signs identified in imaging of the thoracic spine are not necessarily associated with pain [ ] . Investigations are mainly used to explore underlying musculoskeletal or other

2008 Mentor

113. Cervical Ribs and Thoracic Outlet Syndrome

, oestrogen or thyroid deficiency, inflammatory disease including rheumatoid arthritis, fibromyalgia and disorders of posture such as kyphosis and scoliosis. It is necessary to exclude thrombosis, embolism and nerve entrapment in other places. This includes Pancoast's syndrome, where lung cancer infiltrates the brachial plexus. Paget-Schrötter syndrome is thrombosis of the subclavian vein following heavy exercise of the upper limb [ ] . Differential diagnosis [ ] Acromioclavicular joint injury. Brachial (...) in sportsmen, especially swimmers and throwers. The interval between trauma and symptoms may be hours to weeks. Examination [ ] A careful neurological and musculoskeletal examination is required. Neurological examination is discussed elsewhere - see separate article. Disease of the neck and arm must be excluded. Stress tests or provocative manoeuvres form the basis of examination. They have very low specificity, sensitivity and predictive value [ ] . The most common tests are Adson's manoeuvres. The head

2008 Mentor

114. Horner's Syndrome

sympathetic control and is usually complete by the age of 2 years. Examine for the presence of lymphadenopathy (see table, below). Other signs depend on underlying cause (see table, below). Aetiology [ ] Causes of Horner's syndrome [ ] Central (first-order) nerve lesions Preganglionic (second-order) nerve lesions Postganglionic (third-order) nerve lesions Cerebrovascular accidents. Apical lung tumours (eg, Pancoast's tumour). Cluster headaches or migraine. Multiple sclerosis. Lymphadenopathy (lymphoma (...) fistula. Syringomyelia. Neuroblastoma. Temporal arteritis [ ] Arnold-Chiari malformation. Mandibular dental abscess. Spinal cord tumours. Horner's syndrome associated with pain always needs investigation. If there is arm, shoulder or hand pain think of Pancoast's syndrome. If pain is in the face or neck, think of carotid dissection. Pain and transient visual loss may be due to carotid dissection. [ ] In children, unless there is a known aetiology such as birth trauma, acquired Horner's syndrome

2008 Mentor

115. Examination of the Spine

posture may be due to neck problems but also other causes - eg, weakness of the ocular muscles. Asymmetry (eg, of scapulae) or supraclavicular fossae (eg, Pancoast's syndrome due to a malignant tumour at the apex of the lung). Torticollis (the affected side and chin are often tilted to the opposite side) or sternomastoid 'tumour' in infants. Causes of acquired torticollis include upper respiratory tract infection, and vertebral malalignment or trauma. Arms and hands: for wasting, fasciculation, motor (...) limbs may be important with a patient presenting with leg symptoms, to evaluate peripheral vascular disease. Consider primary malignancy sites which may have metastasised to the spine, especially breast cancer, thyroid cancer, renal cancer, prostate cancer and lung cancer. Hip and sacroiliac joint examination Check the hip joints for range of movement and for pain or limitation. Hip problems may present with predominantly back and buttock pain as well as pain in the groin. A loss of range

2008 Mentor

116. Pancoast's syndrome

Pancoast's syndrome Pancoast's syndrome - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search Pancoast's syndrome Pancoast's syndrome is due to a tumour, usually squamous cell carcinoma, near the apex of the lung which results in an ipsilateral Horner's syndrome. Erosion of the ribs results in severe pain in the shoulder. Infiltration of the lower part of the brachial plexus (C8-T2) results in: pain down the inner surface

2010 GP Notebook

117. Carboplatin, Gemcitabine, and Thalidomide in Patients Undergoing Surgery for Stage II or III Non-Small Cell Lung Cancer

. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically or cytologically confirmed non-small cell lung cancer (NSCLC), including any of the following histologic subtypes: Squamous cell carcinoma Adenocarcinoma Large cell undifferentiated carcinoma Stage II or IIIA disease Measurable disease, defined as ≥ 1 unidimensionally (...) treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or other malignancy that is unlikely to affect survival for the next 3 years Less than 5 years since prior resection of lung disease Prior systemic chemotherapy or radiotherapy for non-small cell lung cancer (NSCLC) Other concurrent chemotherapy or radiotherapy Concurrent hormonal therapy or immunotherapy Other concurrent anticancer therapy Other concurrent investigational agents Concurrent participation in another

2006 Clinical Trials

118. Mediastinal Staging of Lung Cancer With EBUS-TBNA and EUS-B-FNA

Last Verified: June 2009 Keywords provided by National Cancer Center, Korea: staging Endobronchial ultrasound Endoscopic ultrasound Additional relevant MeSH terms: Layout table for MeSH terms Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms by Site Neoplasms Lung Diseases Respiratory Tract Diseases (...) of EUS-B-FNA as compared to EBUS-TBNA alone will be estimated. Condition or disease Intervention/treatment Phase Lung Cancer Procedure: EBUS-TBNA, EUS-B-FNA (EUS-FNA with bronchoscope) Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 150 participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Diagnostic Official Title: Minimally Invasive Mediastinal Staging of Potentially

2008 Clinical Trials

119. Study of Carboplatin/Gemcitabine Plus Bevacizumab in Advanced Lung Cancer

informed consent Exclusion Criteria: brain metastases squamous (epidermoid) histology hemoptysis central airway disease Pancoast tumors previous chemotherapy or biologic therapy for lung cancer prior malignancy within the previous 5 years except non-melanoma skin cancer or cervical CIS pregnant or nursing women Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact (...) and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Histologically or cytologically proven non-small cell lung cancer, newly diagnosed or recurrent after previous surgery and/or radiation therapy Stage IV disease or stage IIIB with a malignant pleural effusion measurable or evaluable disease Performance status 0 or 1 (ECOG) adequate renal, hepatic, and bone marrow function adequate recovery from previous surgery or radiotherapy

2005 Clinical Trials

120. Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage III Non-Small Cell Lung Cancer

eligible Mediastinal nodal disease by mediastinoscopy, thoracoscopy, Chamberlain procedure, or transbronchial needle aspirate Nodes found positive by mediastinoscopy are defined as N2 disease Primary tumor must be accessible for high-dose radiotherapy Measurable disease Potential candidate for surgery No small cell lung cancer No bronchoalveolar carcinoma with lobar or multilobar involvement No malignant pleural effusion No distant metastases PATIENT CHARACTERISTICS: Age 18 and over Performance status (...) may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria DISEASE CHARACTERISTICS: Histologically or cytologically confirmed non-small cell lung cancer Stage IIIA (T1-3, N2) or IIIB (N3) No clinical or radiographic evidence of supraclavicular lymph node involvement Pancoast tumors

2004 Clinical Trials

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