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Pancoast Tumor

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81. Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors

: September 25, 2009 Last Update Posted: June 30, 2016 Last Verified: June 2016 Keywords provided by M.D. Anderson Cancer Center: Superior Sulcus Tumor Lung Cancer Non-Small Cell Multimodality Treatment Surgery Segmentectomy Lobectomy Cisplatin CDDP Etoposide VP-16 VePesid Radiation Therapy Radiotherapy Chest Irradiation Prophylactic Cranial Irradiation PCI Additional relevant MeSH terms: Layout table for MeSH terms Pancoast Syndrome Lung Neoplasms Respiratory Tract Neoplasms Thoracic Neoplasms Neoplasms (...) Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2009 Clinical Trials

82. Special Treatment Issues in Non-small Cell Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (PubMed)

Special Treatment Issues in Non-small Cell Lung Cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. This guideline updates the second edition and addresses patients with particular forms of non-small cell lung cancer that require special considerations, including Pancoast tumors, T4 N0,1 M0 tumors, additional nodules in the same lobe (T3), ipsilateral different lobe (T4) or contralateral lung (M1a (...) possible, we also reference other consensus opinion statements. Recommendations were developed by the writing committee, graded by a standardized method, and reviewed by all members of the Lung Cancer Guidelines panel prior to approval by the Thoracic Oncology NetWork, Guidelines Oversight Committee, and the Board of Regents of the American College of Chest Physicians.In patients with a Pancoast tumor, a multimodality approach appears to be optimal, involving chemoradiotherapy and surgical resection

2013 Chest

83. Survival After Extended Resection for Mediastinal Advanced Lung Cancer: Lessons Learned on 167 Consecutive Cases. (PubMed)

patients (25%) were considered unresectable (explorative thoracotomy [ET]), and 125 (75%) underwent ER. The types of ER were superior vena cava in 43 patients (34.4%), carina in 33 (26.4%), combined with superior vena cava in 18 (14.4%), with the left atrium in 35 (28%), and with the aorta in 14 (11.2%). We excluded Pancoast tumors and vertebral resections. The minimum follow-up was 6 months. Kaplan-Meier method and log-rank test were used for statistical analysis of survival.There were 136 men (81.4

2013 Annals of Thoracic Surgery

84. Effects of Inspiratory Muscle Training After Lung Cancer Surgery, a Randomized Controlled Trial

other cancer sites without activity within none year, other tumor types requiring resection of lung tissue; Furthermore, for RCT, one of the following: Age ≥ 70 years or FEV1 ≤ 70% predicted or DLCO ≤ 70% predicted or scheduled pneumonectomy) Exclusion Criteria: physical or mental deficits that adversely influence physical performance; can neither speak nor read Danish; previous ipsilateral lung resection; tumor activity in other sites or organs; pancoast tumor Contacts and Locations Go (...) this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Age >18 years; scheduled for thoracic surgery on the suspicion/confirmed lung tumor via open thoracotomy or Visual Assisted Thoracotomy(includes primary lung cancer, metastases from

2013 Clinical Trials

85. Phase II Randomized Study on Locally Advanced NSCLC Escalated Dose on Individual Basis Treatment With Radiochemotherapy

months (> 10%). Supraclavicular nodes. Apical tumors-pancoast. T4 tumors with separate manifestations in different lobes. Evidence of active serious infections. Inadequate liver function. Inadequate kidney function. Pregnancy. Breast feeding. Serious concomitant systemic disorder. Second primary malignancy the last 5 years. Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using

2012 Clinical Trials

86. Shoulder Pain

Shoulder Pain Cardiac (e.g. , ) Left arm, or Neck, lower jaw, and interscapular Pulmonary (Carcinoma, , or abscess) Pancoast (Apical Tumor of superior sulcus lung) Other mediastinal, aorta, esophageal causes VII. Causes: Malignant Sources of Referred Shoulder Pain Bone Metastases ( most common) metastases (less common) Ribs, spine, and (more common) XRay and bone scans have high Periosteal bone formation Results in cranial or spinal impingement Usually minimal or no symptoms Increased pain Think tous

2015 FP Notebook

87. Lung Cancer

spread (40% at diagnosis) Nerve injury Recurrent laryngeal nerve paralysis Weak cough Phrenic nerve lesion Left diaphragm elevated lesion Presents as Horner Syndrome ( , myosis, facial anhidrosis) Associated with Pancoast's tumor ( and muscle wasting C8-T3) wall invasion Malignant Decreased breath sounds Malignant Decreased heart sounds Cardiomegaly on Esophageal invasion or obstruction Facial swelling Upper extremity edema Plethora VIII. Presentations: Extrathoracic spread (33% at diagnosis) Long (...) , Bronchogenic Carcinoma From Related Chapters II. Epidemiology Lung Cancer is the top U.S. cause of cancer death Lung Cancer accounts for 27% of all U.S. cancer deaths Lung Cancer accounts for 33% of overall mortality in heavy smokers Exceeds deaths from combination of 3 cancers : 200,000 in U.S. (2010) Mortality: 160,000 in U.S. (2010) Age at diagnosis: 68 to 70 years old on average III. Pathophysiology Hematogenous seeding occurs at 1-2 mm Earliest detection of Tumor by CT : 2 mm Tumor 1 cm size shed 3

2015 FP Notebook

88. Versatility of a mini-trapdoor incision in upper mediastinal exposure. (PubMed)

Versatility of a mini-trapdoor incision in upper mediastinal exposure. Exposure of the upper mediastinum and thoracic outlet can pose major surgical challenges. We report our application of a previously described mini-trapdoor incision to a variety of surgical problems involving the upper mediastinum and thoracic outlet, including subclavian vein thrombosis, penetrating subclavian artery injury, debridement of subjacent chest wall infection, lymph node excision, and Pancoast tumor resection

2011 Annals of Thoracic Surgery

89. Combined Application of EBUS and EUS in Lung Cancer

CT. Confirmed supraclavicular lymph node metastasis Pancoast tumors Medically inoperable patients Contraindications for bronchoscopy and esophageal endoscopy Drug reaction to lidocaine, midazolam,fentanyl Pregnancy Ground glass-dominant nodule ( < 3cm) Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study

2011 Clinical Trials

90. Consolidation Chemotherapy/Concurrent Chemo-radiotherapy for Inoperable Stage III Non-small Cell Lung Cancer (NSCLC)

requiring medication, psychiatric illness that would impair patients ability to comply with study requirements. Pregnant or lactating women (any women becoming pregnant during the study will be withdrawn from the study) Patient with documented or symptoms of peripheral neuropathy. History of allergic reaction to compounds similar to the ones used in this study. Malignant effusions (pleural or pericardial) Superior sulcus (Pancoast) tumors. Any condition that would hamper ability to give informed consent (...) biopsy, fluorodeoxyglucose positron emission tomography (PET), and or CT scan if nodes are more than 2 cm. Stage IIIB patients must have N3 or T4 status. N3 status must be documented by presence of contralateral (to the primary tumor) mediastinal lymph node or supraclavicular or scalene lymph node proven by either biopsy, fluorodeoxyglucose PET, or more than 2 cm on CT scan. No prior treatment for lung cancer ECOG Performance status of 0-1. Initiation of consolidation chemotherapy within 4-8 weeks

2011 Clinical Trials

91. THE SUPERIOR PULMONARY SULCUS “TUMOR OF PANCOAST” IN RELATION TO HARE'S SYNDROME (PubMed)

THE SUPERIOR PULMONARY SULCUS “TUMOR OF PANCOAST” IN RELATION TO HARE'S SYNDROME 17857611 2007 09 17 2008 11 20 0003-4932 112 1 1940 Jul Annals of surgery Ann. Surg. THE SUPERIOR PULMONARY SULCUS "TUMOR OF PANCOAST" IN RELATION TO HARE'S SYNDROME. 1-21 Morris J H JH Harken D E DE eng Journal Article United States Ann Surg 0372354 0003-4932 1940 7 1 0 0 1940 7 1 0 1 1940 7 1 0 0 ppublish 17857611 PMC1387913

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1940 Annals of Surgery

92. Lung Carcinoma

and/or chemotherapy; immunotherapy may be added Stage IV: Systemic targeted therapy, chemotherapy, or immunotherapy —each with or without palliative radiation therapy Complications SVC syndrome Paraneoplastic syndromes Hemoptysis, airway obstruction, pneumonia, pleuritic involvement with pain, pleural effusion, SVC syndrome, Pancoast tumor (causing shoulder or arm pain), hoarseness due to laryngeal nerve involvement, neurologic symptoms due to brain metastasis, pathologic fractures due to bone metastasis (...) and can cause headache or a sensation of head fullness, facial or upper-extremity swelling, breathlessness when supine, dilated veins in the neck, face, and upper trunk, and facial and truncal flushing (plethora). Pancoast syndrome occurs when apical tumors, usually NSCLC (Pancoast tumor), invade the brachial plexus, pleura, or ribs, causing shoulder and upper-extremity pain and weakness or atrophy of the ipsilateral hand. Pancoast syndrome can also include Horner syndrome . Horner syndrome (ptosis

2013 Merck Manual (19th Edition)

93. Phineas Gage

died. At autopsy, reaccumulated pus was found: had blocked the opening in the ." By keeping the exit wound open, and elevating Gage's head to encourage drainage from the cranium into the sinuses (through the hole made by the tamping iron), Harlow "had not repeated Professor Pancoast's mistake". ​​ :675 :58 No attempt will be made by me to cite analo­gous cases, as after ran­sack­ing the lit­er­a­ture of sur­gery in quest of such, I learn that all, or nearly all, soon came to a fatal result. (1868 (...) (if hyperbolically) attributed to Gage would inspire surgical imitation, there is no such link, according to Macmillan: There is simply no evidence that any of these operations were deliberately designed to produce the kinds of changes in Gage that were caused by his accident, nor that knowledge of Gage's fate formed part of the rationale for them :F ‍... [W]hat his case did show came solely from his surviving his accident: major operations [such as for tumors] could be performed on the brain without the outcome

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2012 Wikipedia

94. Treatment of Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

with current radiation field. More than 10% weight loss in 6 months. Pancoast tumors, supraclavicular or contralateral hilar lymph node involvement Known HIV positive Prior treatment with an HDAC inhibitor Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number (...) /PET scans will be done after 12 weeks of therapy and at 12 week intervals until documented progression ] To evaluate response rates with this combination [ Time Frame: CT/PET will be done following 12 weeks of therapy. ] To assess if pre-treatment tumor expression of TS, ERCC1 and HDAC1, 2, 3 are associated with response rate. [ Time Frame: Archival tissue will be tested and correlated to response rates. ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing

2010 Clinical Trials

95. Patients Undergoing Major Cancer Surgery: Incidence and Predictive Value for Postoperative Cardiac Events

Pleurectomy and Decortication Pneumonectomy Esophagogastrectomy Mediastinal Tumor Resection Pancoast Tumor Completion Pneumonectomy Lobectomy (post-induction chemotherapy; or severe COPD) Segmentectomy Colorectal/ GYN Colon Resection with possible Sacrectomy Pelvic Exenteration Advanced ovarian cancer resection with or without liver resection Urology Radical Cystectomy Open Radical Prostatectomy Nephrectomy with Vena Caval Resection Head & Neck Thyroid Resection with Mediastinal involvement Major head

2010 Clinical Trials

96. Chemotherapy and Radiation in Treating Patients With Stage 3 Non-Small Cell Lung Cancer

as part of their care plan, such as Pancoast or superior sulcus tumors Participants who had prior thoracic radiation. However, other prior radiotherapy is allowed. Participants must have recovered from the toxic effects of the treatment prior to study enrollment. Participants may not have received whole pelvis radiation or radiation to more than 25% of their bone marrow. Prior radiotherapy must have been completed at least 30 days prior to study treatment. Participants who have a radiation treatment (...) Evaluation Criteria in Solid Tumors (RECIST, v1.1) guidelines. CR is defined as the disappearance of all target and non-target lesions, normalization of tumor marker level of non-target lesions, and any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 millimeter (mm). PR is an at least 30% decrease in the sum of the diameters of target lesions (taking as reference the baseline sum diameter) without progression of non-target lesions or appearance of new

2008 Clinical Trials

97. Mediastinal Staging of Lung Cancer With EBUS-TBNA and EUS-B-FNA

invasion of the mediastinal lymph node visible on chest CT. Confirmed supraclavicular lymph node metastasis Pancoast tumors Medically inoperable patients Contraindications for bronchoscopy Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00741247

2008 Clinical Trials

98. CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Lung Cancer

radiation therapy in the same field as the planned treatment area in the past. The patient has completed chemotherapy within less than 30 days of treatment. T2: Tumor size > 5 cm, T3 tumors (except T3 by virtue of chest wall invasion and ≤ 5 cm), T4 tumors. Presence of N1, N2 or N3 disease per previously described criteria would be excluded. Pancoast tumors would be excluded. Current distant metastatic disease (M1) (preferably biopsy proven). The patient is a female with child-bearing potential who (...) Completion Date : February 2020 Estimated Study Completion Date : February 2020 Resource links provided by the National Library of Medicine related topics: related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: CyberKnife Stereotactic Radiosurgery Radiation: CyberKnife Stereotactic Radiosurgery Central tumors defined as < 2 cm from carina and < 2 cm from right and left mainstem bronchus and/or < 2 cms from the right and left upper lobe bronchus, bronchus intermedius, middle

2008 Clinical Trials

99. Inoperable Pancoast tumors treated with hyperthermia-inclusive multimodality therapies. (PubMed)

Inoperable Pancoast tumors treated with hyperthermia-inclusive multimodality therapies. This study aimed to assess the feasibility, efficacy and complication of hyperthermia-inclusive multimodality therapies for patient with inoperable Pancoast tumor.Five patients with inoperable Pancoast tumor were treated with hyperthermia-inclusive multimodality therapies. They received thermoradiotherapy with/without chemotherapy. Radiation therapy was delivered using 10 MV X-rays with total dose of 68-70 (...) at 66.9 and 78.5 months after treatment. The other 2 patients are disease-free survivor for 4 and 5 years after treatment. No severe non-hematological toxicity was observed in each patient.These data suggested that hyperthermia-inclusive multimodality therapies might be a promising approach for inoperable Pancoast tumor.

2008 Lung Cancer

100. Pancoast's Syndrome

(April 2011) ; Pancoast tumors: characteristics and preoperative assessment. J Thorac Dis. 2014 Mar6 Suppl 1:S108-15. doi: 10.3978/j.issn.2072-1439.2013.12.29. ; Superior sulcus (Pancoast) tumors: current evidence on diagnosis and radical treatment. J Thorac Dis. 2013 Sep5(Suppl 4):S342-S358. ; Case report of Pancoast tumour mimicking temporal arteritis BMJ Case Reports 2012 ; Pancoast syndrome: A rare presentation of non-Hodgkin's lymphoma. Lung India. 2013 Jul30(3):209-11. doi: 10.4103/0970 (...) -2113.116266. ; Metastatic colon cancer presenting as Pancoast's disease. Am J Surg. 2009 May197(5):e51-2. Epub 2009 Feb 13. ; Unusually located intrathoracic extrapulmonary mediastinal hydatid cyst manifesting as Pancoast syndrome. J Thorac Cardiovasc Surg. 2005 Mar129(3):688-9. ; Pancaost syndrome related to hydatid cyst. Pan Afr Med J. 2013 Mar 2714:118. doi: 10.11604/pamj.2013.14.118.1754. Print 2013. ; Superior pulmonary sulcus tumors and Pancoast's syndrome. N Engl J Med. 1997 Nov 6337(19):1370-6

2008 Mentor

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