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Pain Sensation

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161. The immediate effects of lidocaine iontophoresis using interferential current on pressure sense threshold and tactile sensation. (PubMed)

The immediate effects of lidocaine iontophoresis using interferential current on pressure sense threshold and tactile sensation. Iontophoresis is the noninvasive delivery of ions using direct current. The direct current has some disadvantages such as skin burning. Interferential current is a kind of alternating current without limitations of direct current; so the purpose of this study is to investigate and compare the effects of lidocaine, interferential current and lidocaine iontophoresis (...) using interferential current. 30 healthy women aged 20-24 years participated in this randomized clinical trial study. Pressure, tactile and pain thresholds were evaluated before and after the application of treatment methods. Pressure, tactile and pain sensitivity increased significantly after the application of lidocaine alone (p < 0.005) and lidocaine iontophoresis using interferential current (p < 0.0001). Lidocaine iontophoresis using interferential current can increase perception threshold

2016 Therapeutic delivery

162. [Different Warm Sensations May Induce Different Therapeutic Effects in Primary Dysmenorrhea Patients Undergoing Moxibustion Treatment Based on Propensity Score: A Prospective Cohort Study]. (PubMed)

beginning 5 days before dysmenorrheal attack, once daily for (7 ± 2) days in one menstrual cycle, and for 3 menstrual cycles for heat-sensitive group, wheras routine moxibustion for conventional warm sensation group. The McGill Pain Questionnaire (MPQ) composed of pain rating index (PRI), visual analogue scale (VAS) and present pain intensity (PPI) and COX Menstrual Symptom Scale (CMSS) containing 18 items (0 - 4 grades/item) were used to evaluate the therapeutic effect of moxibustion treatment. Follow (...) [Different Warm Sensations May Induce Different Therapeutic Effects in Primary Dysmenorrhea Patients Undergoing Moxibustion Treatment Based on Propensity Score: A Prospective Cohort Study]. To compare the effectiveness difference between the "heat-sensitive" sensation and conventional warm sensation of moxibustion stimulation of Guanyuan (GV 4) in primary dysmenorrhea (PD) patients.Cohort study design was used in the present study. A total of 189 PD patients were divided into heat-sensitive

2016 Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] Controlled trial quality: uncertain

163. A decision aid for women having their first baby and considering their choices for labour pain relief

decisions. 54 7 Sue’s story I’d planned to let my labour take its natural course for as long as I could without drugs, but was willing to accept them if I felt overwhelmed. After reading the “Pain relief for labour” book, I remembered my experience with gas for a dental procedure and was adamant that I wouldn’t use it. I didn’t like the sensation, and if I needed something, I planned to use pethidine rather than gas or an epidural, but still wanted to avoid drugs if possible. At 39 weeks very early (...) Most effective pain relief Chance of caesarean section More likely to have an instrumental birth Satisfaction with pain relief Chance of nausea/vomiting May still require further pain relief for actual birth Long term back pain May lengthen labour More likely to need artificial oxytocin More likely to have a fever Increased risk of hypotension May experience an itching sensation May experience severe headache Some rare side effects Now go to your notes page and place a mark in the box to show how

2015 SickKids Supportive Care Guidelines

164. Scrotal pain and swelling

be a dragging sensation in the scrotum. Pain is present in 20–27% of people with testicular cancer. Most common in men 20–40 years of age, but can occur in older men, when it is usually a lymphoma. Usually presents with testicular enlargement. On palpation, there is a solid, firm swelling involving all or part of testis. There may be associated back or flank pain, breathlessness, supraclavicular lymphadenopathy, abdominal mass (enlarged para-aortic lymph nodes), weight loss, gynaecomastia, epididymo (...) Scrotal pain and swelling Scrotal pain and swelling - NICE CKS Share Scrotal pain and swellings: Summary Common, or important causes of scrotal swelling include: Testicular cancer. Squamous cell carcinoma of the scrotum. Testicular torsion (torsion of spermatic cord). Torsion of a testicular or epididymal appendage. Epididymo-orchitis. Epididymal cyst, or spermatocele. Varicocele. Hydrocele. Haematocele. To identify the cause of scrotal swelling, the man or boy should be asked about: Presence

2019 NICE Clinical Knowledge Summaries

165. Neuropathic pain - drug treatment

Neuropathic pain - drug treatment Neuropathic pain - drug treatment - NICE CKS Share Neuropathic pain - drug treatment: Summary Neuropathic pain is a symptom that develops as a result of damage to, or dysfunction of, the nervous system. The pain may be constant or intermittent, and it is typically described as shooting, stabbing, burning, tingling, numb, prickling, or itching. The causes of neuropathic pain are complex and diverse and include diabetic neuropathy, trigeminal neuralgia, stroke (...) , spinal cord injury, and multiple sclerosis. In many cases, it is not possible to completely cure the underlying disease or lesion or to reverse the neurological changes. Consequently, neuropathic pain is usually persistent in these cases. The general principles for prescribing drug treatment for neuropathic pain include considering: Contraindications and potential adverse effects, especially for people with comorbid conditions. Interactions with other medications. Comorbid conditions that may benefit

2019 NICE Clinical Knowledge Summaries

166. Pain Assessment

and radiation; a body diagram can help character; a list of descriptive words may help intensity and severity; a rating scale can help timing and duration exacerbating factors relieving factors, including medication effect on function, sleep and mood response to previous medication and treatment. Use a structured pain assessment tool to record the patient’s pain. Examine the patient to try and determine the cause of pain eg tender hepatomegaly, abnormal sensation. Assess the impact of the pain (...) nerve pain: burning, shooting, tingling, jagging, altered sensation, dermatomal distribution. Consider . liver pain: hepatomegaly, right upper quadrant tenderness, referred pain shoulder tip raised intracranial pressure: headache, or both, often worse in the morning or with lying down colic: intermittent cramping pain. Consider , bladder spasm. Consider adjuvant therapies (see guideline). Treatment-related pain: chemotherapy neuropathy, due to opioids, radiation-induced mucositis. Debility: pressure

2015 Scottish Palliative Care Guidelines

167. Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome. (PubMed)

Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome. Stress-induced visceral hypersensitivity may play an important role in the pathogenesis of irritable bowel syndrome (IBS) but not in functional abdominal pain syndrome (FAPS). We examined rectal sensation in those patients.Experiment 1: Rectal thresholds of pain (PT) and maximum tolerance were assessed by barostat with ramp distention before and after repetitive rectal (...) painful distention (RRD). Experiment 2, PT was measured in basal state and after intravenous CRF (100 µg) or vehicle, together with or without RRD. Experiment 3: Three phasic distentions at physiological range were randomly loaded. The subjects were asked to mark the visual analogue scale (VAS) in reference to subjective intensity of sensation.Experiment 1: Majority of IBS patients showed rectal hypersensitivity before RRD in contrast to FAPS. All IBS patients developed hypersensitivity after RRD

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2011 Journal of gastroenterology and hepatology Controlled trial quality: uncertain

168. Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid

Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01449487 Recruitment Status : Completed First Posted : October 10, 2011

2011 Clinical Trials

169. Therapeutic mechanisms of a mindfulness-based treatment for IBS: Effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations (PubMed)

Therapeutic mechanisms of a mindfulness-based treatment for IBS: Effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations Irritable bowel syndrome (IBS) is a prevalent functional disorder characterized by abdominal pain and hypervigilance to gastrointestinal sensations. We hypothesized that mindfulness training (MT), which promotes nonreactive awareness of emotional and sensory experience, may target underlying mechanisms of IBS including affective pain (...) processing and catastrophic appraisals of gastrointestinal sensations. Seventy five female IBS patients were randomly assigned to participate in either 8 weeks of MT or a social support group. A theoretically grounded, multivariate path model tested therapeutic mediators of the effect of MT on IBS severity and quality of life. Results suggest that MT exerts significant therapeutic effects on IBS symptoms by promoting nonreactivity to gut-focused anxiety and catastrophic appraisals of the significance

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2011 Journal of behavioral medicine Controlled trial quality: uncertain

170. CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch (PubMed)

CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what stimuli these neurons detect in vitro or in vivo. To facilitate functional studies of these neurons, we genetically targeted an axonal tracer (farnesylated enhanced green fluorescent protein; GFP) and a LoxP-stopped cell ablation (...) study provides direct evidence that CGRPα(+) DRG neurons respond to agonists that evoke pain and itch and constitute a sensory circuit that is largely distinct from nonpeptidergic circuits and TRPM8(+)/cool temperature circuits. In future studies, it should be possible to conditionally ablate CGRPα-expressing neurons to evaluate sensory and non-sensory functions for these neurons.

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2012 PloS one

171. Pulsed radiofrequency ablation for residual and phantom limb pain: a case series. (PubMed)

neuropathic pain because of the inhibition of evoked synaptic activity. We present 4 amputees who were treated with PRFA after failing conservative management for their RLP and PLP. All 4 patients underwent PRFA and demonstrated at least 80% relief of RLP for over 6 months. One patient reported a complete resolution of phantom sensation while another patient had significantly decreased frequency of spontaneous PLP and resolution of evoked PLP. In addition, all patients reported improved overall function (...) Pulsed radiofrequency ablation for residual and phantom limb pain: a case series. Residual limb pain (RLP) and phantom limb pain (PLP) can be debilitating and can prevent functional gains following amputation. High correlations have been reported between RLP and the stump neuromas following amputation. Many treatment methods including physical therapy, medications, and interventions, have been used with limited success. Pulsed radiofrequency ablation (PRFA) has shown promise in treating

2020 Pain Practice

172. Comparison of Two Lidocaine Administration Techniques on Perceived Pain From Bedside Procedures: A Randomized Clinical Trial

Comparison of Two Lidocaine Administration Techniques on Perceived Pain From Bedside Procedures: A Randomized Clinical Trial Lidocaine is used to alleviate procedural pain but paradoxically increases pain during injection. Pain perception can be modulated by non-noxious stimuli such as temperature or touch according to the gate control theory of pain. We postulated that lidocaine dripped onto the skin prior to injection would cool or add the sensation of touch at the skin surface to reduce pain (...) (severity of pain from the procedure) using a visual analog scale.A total of 481 patients provided consent and were randomized to treatment. There was a significant improvement in the primary outcome of procedural pain (control, 16.6 ± 24.8 mm vs 12.2 ± 19.4 mm; P = .03) with the intervention group as assessed by using the visual analog scale score. Pain scores were primarily improved for peripherally inserted central catheters (control, 18.8 ± 25.6 mm vs 12.2 ± 18.2 mm; P = .02) upon subgroup

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2018 EvidenceUpdates

173. PK2/PKR1 Signaling Regulates Bladder Function and Sensation in Rats with Cyclophosphamide-Induced Cystitis (PubMed)

time points (4 h, 48 h, and 8 d) after CYP treatment. Combining a nonselective antagonist of prokineticin receptors (PKRA), we further evaluated the regulatory role of PK2 in modulating bladder function and visceral pain sensation via conscious cystometry and pain behavioral scoring. PK2 and prokineticin receptor 1 (PKR1), but not prokineticin receptor 2, were detected in normal and upregulated in CYP-treated rat bladders at several levels. Immunohistochemistry staining localized PKR1 primarily (...) in the urothelium. Blocking PKRs with PKRA showed no effect on micturition reflex activity and bladder sensation in control rats while it increased the voiding volume, prolonged voiding interval, and ameliorated visceral hyperalgesia in rats suffering from CYP-induced cystitis. In conclusion, PK2/PKR1 signaling pathway contributes to the modulation of inflammation-mediated voiding dysfunction and spontaneous visceral pain. Local blockade of PKRs may represent a novel and promising therapeutic strategy

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2015 Mediators of inflammation

174. Comparing Ways to Freeze the Nerve That Provides Thigh Sensation

Information provided by (Responsible Party): Gaurav Gupta, Canadian Forces Health Services Centre Ottawa Study Details Study Description Go to Brief Summary: Background The sensation on the outside of portion of our thighs is provided by a nerve called the lateral femoral cutaneous nerve (LFCN). The investigators can inject freezing around the nerve to reduce the feeling around the thigh (i.e. anesthesia). Anesthesia, or freezing, of the lateral femoral cutaneous nerve can reduce pain for patients having (...) Comparing Ways to Freeze the Nerve That Provides Thigh Sensation Comparing Ways to Freeze the Nerve That Provides Thigh Sensation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparing Ways to Freeze

2015 Clinical Trials

175. Surface electrical stimulation to evoke referred sensation. (PubMed)

Surface electrical stimulation to evoke referred sensation. Surface electrical stimulation (SES) is being investigated as a noninvasive method to evoke natural sensations distal to electrode location. This may improve treatment for phantom limb pain as well as provide an alternative method to deliver sensory feedback. The median and/or ulnar nerves of 35 subjects were stimulated at the elbow using surface electrodes. Strength-duration curves of hand sensation were found for each subject. All (...) subjects experienced sensation in their hand, which was mostly described as a paresthesia-like sensation. The rheobase and chronaxie values were found to be lower for the median nerve than the ulnar nerve, with no significant difference between sexes. Repeated sessions with the same subject resulted in sufficient variability to suggest that recalculating the strength-duration curve for each electrode placement is necessary. Most of the recruitment curves in this study were generated with 28 to 36 data

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2015 Journal of rehabilitation research and development Controlled trial quality: uncertain

176. Evaluation of Pressure Sense Threshold and Tactile Sensation After Lidocaine Iontophoresis Using Interferential Current

in mm. Pain and tactile thresholds were investigated using an electrical stimulator.The intensity was gradually increased to the extent that the participant reported a tingling sensation. The displayed intensity was considered as the tactile sense threshold. Then, the intensity was increased to the extent to be intolerable for the participant and this intensity was considered as the maximum pain threshold. The thresholds were recorded in milliampere. Lidocaine iontophoresis using interferential (...) Evaluation of Pressure Sense Threshold and Tactile Sensation After Lidocaine Iontophoresis Using Interferential Current Evaluation of Pressure Sense Threshold and Tactile Sensation After Lidocaine Iontophoresis Using Interferential Current - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum

2015 Clinical Trials

177. Pulsed application of focused ultrasound to the LI4 elicits deqi sensations: Pilot study. (PubMed)

and sham acupuncture. We also measured the presence of sharp pain, unpleasantness, and anxiety level during each condition.The FUS acupuncture given at 3 W/cm(2) elicited deqi sensation ratings similar to those acquired during the needle-based acupuncture condition across the subjects, with significantly reduced levels of non-deqi related sensations, such as sharp pain, anxiety and unpleasantness. The lower acoustic intensity also generated deqi sensations, but at a lesser degree than the ones acquired (...) Pulsed application of focused ultrasound to the LI4 elicits deqi sensations: Pilot study. Focused ultrasound (FUS) techniques enable the delivery of acoustic pressure waves to a localized, specific region of anatomy, and mechanically stimulate the sonicated region when given in a train of pulses. The present pilot study examines if the pulsed application of acoustic waves focused to an acupuncture point (LI4, Hegu), i.e. FUS acupuncture, can elicit deqi sensations.The FUS was generated

2014 Complementary Therapies In Medicine

178. Preservation of greater auricular nerve during parotidectomy: sensation, quality of life, and morbidity issues. A systematic review. (PubMed)

sensation, pain, thermal sensitivity, and quality of life.Although quality of life does not seem to be adversely affected when the greater auricular nerve is sacrificed, preservation of the posterior branch was recommended in 8 studies. When preserving the nerve, the incremental operative time increase is no more than 10 to 5 minutes after a rapid learning curve.There is level Ib evidence that preservation of the greater auricular nerve minimizes the postoperative sensory disturbance and should (...) Preservation of greater auricular nerve during parotidectomy: sensation, quality of life, and morbidity issues. A systematic review. Our objectives were to assess the evidence of preservation of the greater auricular nerve in parotidectomy with regard to morbidity and quality of life.This was a systematic review. Inclusion criteria were: English literature, prospective and retrospective studies. Exclusion criteria were: single case reports, "teaching" reviews. Outcome measures were: tactile

2014 Head & neck

179. Corneal Sensation and Dry Eye Symptoms after Conventional versus Inverted Side-Cut Femtosecond LASIK: A Prospective Randomized Study. (PubMed)

, linear-scaled Quality of Vision questionnaire.Objective corneal sensation and self-reported light sensitivity, dryness, foreign body sensation, and pain/discomfort.Preoperative corneal sensation as measured by mean Cochet-Bonnet aethesiometry was equal between the inverted and conventional side cut groups but was better in eyes with an inverted side cut compared with a conventional side cut at all postoperative months (inverted vs. conventional: 1 month, 14.5 vs. 13.2 mm; 3 months, 24.9 vs. 18.4 mm (...) Corneal Sensation and Dry Eye Symptoms after Conventional versus Inverted Side-Cut Femtosecond LASIK: A Prospective Randomized Study. To compare corneal sensation and self-reported dry eye symptoms after femtosecond-assisted LASIK with conventional versus inverted side cuts.Prospective, randomized, eye-to-eye study.A total of 120 eyes in 60 participants with myopia.Fellow eyes were randomized to receive femtosecond-assisted LASIK with a conventional 70-degree side cut made with the 60 kHz

2014 Ophthalmology Controlled trial quality: uncertain

180. A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome. (PubMed)

and postprandial), bowel pattern, abdominal pain (average and worst severity) and bloating scores, IBS quality of life and safety profile.Rectal sensation ratings post-treatment were significantly associated with baseline (pre-treatment) ratings and with level of anxiety or stress recorded at the time of the sensation testing. There were no effects of TU-100 treatment on rectal sensation ratings, sensation thresholds, rectal fasting or postprandial tone, rectal compliance, bowel function, abdominal pain (...) A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome. Daikenchuto (TU 100), a botanical agent that modulates gastrointestinal nerves, is used in the treatment of motility and functional disorders. Our aim was to study the effects of TU-100 on rectal compliance and sensation in patients with irritable bowel syndrome (IBS).In 20 patients per treatment arm, we conducted a single-center, randomized, parallel-group, double-blind, placebo-controlled

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2015 Journal of neurogastroenterology and motility Controlled trial quality: uncertain

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