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Pain Sensation

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141. Peripheral nerve-field stimulation for chronic low back pain (IPG451)

the skin. The aim is to mask the back pain by modulating the transmission of pain signals to the brain. The patient uses a remote control to deliver low voltage electrical stimulation to the subcutaneous tissue layers of the lower back. The stimulation causes a tingling sensation (paraesthesia) in the area of the body associated with the pain, easing the discomfort. Stage 1 A70.4 Insertion of neurostimulator electrodes into peripheral nerve Y70.5 Temporary operations Y70.3 First stage of staged (...) Peripheral nerve-field stimulation for chronic low back pain (IPG451) Overview | Peripheral nerve-field stimulation for chronic low back pain | Guidance | NICE Peripheral nerve-field stimulation for chronic low back pain Interventional procedures guidance [IPG451] Published date: March 2013 Share Save Guidance The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on Peripheral nerve-field stimulation

2013 National Institute for Health and Clinical Excellence - Interventional Procedures

142. Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip Full Text available with Trip Pro

. Overall incidence of AEs was similar across subgroups. AEs of abnormal peripheral sensation were more frequently reported in tanezumab-treated patients compared with placebo or active comparator. Patients receiving active comparator had a slightly higher incidence of AEs suggestive of postganglionic sympathetic dysfunction.Tanezumab consistently provided significant improvement of pain, physical function, and PGA in individuals with OA, including patients with diabetes, severe OA symptoms, or aged ≥65 (...) Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip A pooled analysis was conducted to evaluate tanezumab efficacy and safety in patients with osteoarthritis (OA), including subgroup analyses of at-risk patients with diabetes, severe OA symptoms, and those aged ≥65 years.Data from phase III placebo-controlled clinical trials of patients with moderate-to-severe OA of the knee or hip were

2019 EvidenceUpdates

143. Neuropathic Pain

pain. This should be confirmed by clinical examination or detailed imaging. Sensory descriptors associated with neuropathic pain include burning, tingling, pins and needles, shooting and numbness. They are not diagnostic however. Confirm altered sensation in the area of pain by comparing responses with the non-painful contralateral or adjacent area of the body: allodynia – painful response to light touch, eg stroking the skin with a finger or cotton wool hypoaesthesia – an area of reduced sensation (...) Neuropathic Pain Scottish Palliative Care Guidelines - Neuropathic Pain Scottish Palliative Care Guidelines search / / / Neuropathic Pain Neuropathic Pain Introduction Neuropathic pain is pain due to a lesion, disease or pathological change in the somatosensory (nervous) system. Chronic neuropathic pain is common and may be related to: the underlying disease for which patients are referred to palliative care (eg cancer or multiple sclerosis) treatment (eg post-operative neuropathic pain

2016 Scottish Palliative Care Guidelines

144. Pain Sensation

Pain Sensation Pain Sensation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pain Sensation Pain Sensation Aka: Pain Sensation (...) , Allodynia , Hyperpathia From Related Chapters II. Definitions Allodynia Nonpainful stimulus results in perception of pain Hyperpathia Pain out of proportion to pain stimulus Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Pain Sensation." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Hyperalgesia (C0020429) Definition (MSH) An increased sensation

2015 FP Notebook

145. Pain Assessment

and radiation; a body diagram can help character; a list of descriptive words may help intensity and severity; a rating scale can help timing and duration exacerbating factors relieving factors, including medication effect on function, sleep and mood response to previous medication and treatment. Use a structured pain assessment tool to record the patient’s pain. Examine the patient to try and determine the cause of pain eg tender hepatomegaly, abnormal sensation. Assess the impact of the pain (...) nerve pain: burning, shooting, tingling, jagging, altered sensation, dermatomal distribution. Consider . liver pain: hepatomegaly, right upper quadrant tenderness, referred pain shoulder tip raised intracranial pressure: headache, or both, often worse in the morning or with lying down colic: intermittent cramping pain. Consider , bladder spasm. Consider adjuvant therapies (see guideline). Treatment-related pain: chemotherapy neuropathy, due to opioids, radiation-induced mucositis. Debility: pressure

2015 Scottish Palliative Care Guidelines

146. Scrotal pain and swelling

be a dragging sensation in the scrotum. Pain is present in 20–27% of people with testicular cancer. Most common in men 20–40 years of age, but can occur in older men, when it is usually a lymphoma. Usually presents with testicular enlargement. On palpation, there is a solid, firm swelling involving all or part of testis. There may be associated back or flank pain, breathlessness, supraclavicular lymphadenopathy, abdominal mass (enlarged para-aortic lymph nodes), weight loss, gynaecomastia, epididymo (...) Scrotal pain and swelling Scrotal pain and swelling - NICE CKS Share Scrotal pain and swellings: Summary Common, or important causes of scrotal swelling include: Testicular cancer. Squamous cell carcinoma of the scrotum. Testicular torsion (torsion of spermatic cord). Torsion of a testicular or epididymal appendage. Epididymo-orchitis. Epididymal cyst, or spermatocele. Varicocele. Hydrocele. Haematocele. To identify the cause of scrotal swelling, the man or boy should be asked about: Presence

2019 NICE Clinical Knowledge Summaries

147. Neuropathic pain - drug treatment

Neuropathic pain - drug treatment Neuropathic pain - drug treatment - NICE CKS Share Neuropathic pain - drug treatment: Summary Neuropathic pain is a symptom that develops as a result of damage to, or dysfunction of, the nervous system. The pain may be constant or intermittent, and it is typically described as shooting, stabbing, burning, tingling, numb, prickling, or itching. The causes of neuropathic pain are complex and diverse and include diabetic neuropathy, trigeminal neuralgia, stroke (...) , spinal cord injury, and multiple sclerosis. In many cases, it is not possible to completely cure the underlying disease or lesion or to reverse the neurological changes. Consequently, neuropathic pain is usually persistent in these cases. The general principles for prescribing drug treatment for neuropathic pain include considering: Contraindications and potential adverse effects, especially for people with comorbid conditions. Interactions with other medications. Comorbid conditions that may benefit

2019 NICE Clinical Knowledge Summaries

148. Acute pain management: scientific evidence (3rd Edition)

and preventive analgesia 12 1.5 Adverse physiological and psychological effects of acute pain 15 1.5.1 Acute pain and the injury response 15 1.5.2 Adverse physiological effects 16 1.5.3 Pain and analgesia: effects on injury-induced organ dysfunction 19 1.5.4 Acute rehabilitation and ‘fast-track’ surgery 20 1.5.5 Adverse psychological effects 21 1.6 Pharmacogenomics and acute pain 21 1.6.1 Loss of pain sensation 22 1.6.2 Reduced sensitivity to pain 22 1.6.3 Drug metabolism 23 References 25 2. ASSESSMENT (...) Acute pain management: scientific evidence (3rd Edition) ? ? ? ? Acute Pain Management: Scientific Evidence Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine ? ? ? Endorsed by: Faculty?of?Pain?Medicine,?Royal?College?of? Anaesthetists,?United?Kingdom?? Royal?College?of?Anaesthetists,? United?Kingdom?? Australian?Pain?Society? Australasian?Faculty?of?Rehabilitation?Medicine? College?of?Anaesthesiologists,?? Academy?of?Medicine,?Malaysia? College

2015 National Health and Medical Research Council

149. Altered White Matter and Sensory Response to Bodily Sensation in Female-to-Male Transgender Individuals Full Text available with Trip Pro

Altered White Matter and Sensory Response to Bodily Sensation in Female-to-Male Transgender Individuals While most people take identification with their body for granted, conditions such as phantom limb pain, alien hand syndrome, and xenomelia suggest that the feeling of bodily congruence is constructed and susceptible to alteration. Individuals with xenomelia typically experience one of their limbs as over-present and aversive, leading to a desire to amputate the limb. Similarly, many (...) (FtM)-identified transgender individuals-and the hand, a body part that feels congruent. We measured the sensory evoked response in right hemisphere somatosensory and body-related brain areas and found significantly reduced activation in the supramarginal gyrus and secondary somatosensory cortex, but increased activation at the temporal pole for chest sensation in the FtM group (N = 8) relative to non-transgender females (N = 8). In addition, we found increased white matter coherence

2016 Archives of Sexual Behavior

150. The effect of age and body mass index on plantar cutaneous sensation in healthy women Full Text available with Trip Pro

to their ages and body mass index values. Foot pain was measured with a visual analogue scale and plantar cutaneous sensation using Semmes-Weinstein monofilaments. [Results] Fifty-six (27.5%) of the participants had normal weights, 67 (33%) were overweight, and 80 (39%) were obese. Statistical analysis revealed that as age and body mass index values increased, plantar sensitivity decreased and the frequency and severity of pain increased. [Conclusion] It is possible that healthy women may experience (...) The effect of age and body mass index on plantar cutaneous sensation in healthy women [Purpose] This study was conducted to examine the effects of age and body mass index on plantar cutaneous sensation in healthy women. [Subjects and Methods] Two hundred and three healthy female volunteers over the age of 20 were included in the study. The statistical analyses were performed by considering the age and body mass index values of the individuals. The individuals were divided according

2016 Journal of physical therapy science

151. Acetylated tubulin is essential for touch sensation in mice Full Text available with Trip Pro

Acetylated tubulin is essential for touch sensation in mice At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals. Our understanding of this process, especially how the cytoskeleton influences it, remains unknown. Here we demonstrate that mice lacking the α-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical (...) stimuli. We show that all cutaneous afferent subtypes, including nociceptors have strongly reduced mechanosensitivity upon Atat1 deletion, and that consequently, mice are largely insensitive to mechanical touch and pain. We establish that this broad loss of mechanosensitivity is dependent upon the acetyltransferase activity of Atat1, which when absent leads to a decrease in cellular elasticity. By mimicking α-tubulin acetylation genetically, we show both cellular rigidity and mechanosensitivity can

2016 eLife

152. Pulse width affects scalp sensation of transcranial magnetic stimulation Full Text available with Trip Pro

Pulse width affects scalp sensation of transcranial magnetic stimulation Scalp sensation and pain comprise the most common side effect of transcranial magnetic stimulation (TMS), which can reduce tolerability and complicate experimental blinding.We explored whether changing the width of single TMS pulses affects the quality and tolerability of the resultant somatic sensation.Using a controllable pulse parameter TMS device with a figure-8 coil, single monophasic magnetic pulses inducing electric (...) 0-to-10 visual analog scales for Discomfort, Sharpness, and Strength of the sensation.Briefer TMS pulses with amplitude normalized to the motor threshold were perceived as slightly more uncomfortable than longer pulses (with an average 0.89 point increase on the Discomfort scale for pulse width of 30 µs compared to 120 µs). The sensation of the briefer pulses was felt to be substantially sharper (2.95 points increase for 30 µs compared to 120 µs pulse width), but not stronger than longer pulses

2016 Brain stimulation

153. Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal) Full Text available with Trip Pro

with dystonia or chronic pain secondary to major nervous system injury. In patients with ET, most Vc neurons responded to one of the four stimuli, each of which optimally activates one mechanoreceptor type. Sensations evoked by microstimulation were similar to those evoked by the optimal stimulus only among rapidly adapting neurons. In patients with ET, Vc was highly segmented somatotopically, and vibration, movement, pressure, and sharp sensations were usually evoked by microstimulation at separate sites (...) Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal) The normal organization and plasticity of the cutaneous core of the thalamic principal somatosensory nucleus (ventral caudal, Vc) have been studied by single-neuron recordings and microstimulation in patients undergoing awake stereotactic operations for essential tremor (ET) without apparent somatic sensory abnormality and in patients

2016 Journal of neurophysiology

154. Prechemotherapy Touch-Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer Full Text available with Trip Pro

Prechemotherapy Touch-Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer We examined the emergence of chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting toxicity of oxaliplatin, over the course of oxaliplatin-based chemotherapy for colorectal cancer (CRC). Predicting which patients will likely develop CIPN is an ongoing clinical challenge.Oxaliplatin-naïve patients with CRC underwent quantitative sensory testing (QST) before beginning (...) oxaliplatin-based chemotherapy and then rated CIPN-related symptoms via the MD Anderson Symptom Inventory (MDASI) weekly for 26 weeks. Mixed modeling examined the value of QST for predicting higher CIPN (MDASI numbness/tingling) during treatment. Trajectory analysis identified a patient subgroup with consistently higher CIPN symptoms.Numbness/tingling was the most frequent, most severe symptom, with 51% of patients clustering into a high CIPN subgroup. Touch sensation deficits (Bumps Detection test

2016 Oncology

155. Comparison between Subjective Sensations during First and Second Phacoemulsification Eye Surgeries in Patients with Bilateral Cataract Full Text available with Trip Pro

, including anxiety, eye bulges, pain, and light sensitivity. Changes in painful sensations experienced by patients between the two surgeries were also recorded. Comparisons were also performed for each subjective sensation between different age groups (<50, 50-59, 60-69, 70-79, and >79 years). Results. A total of 127 patients were included in the final evaluation. Statistical comparison of the results showed that there were significant differences in perception of anxiety, eye bulges, and pain scores (...) Comparison between Subjective Sensations during First and Second Phacoemulsification Eye Surgeries in Patients with Bilateral Cataract Purpose. To evaluate and compare the subjective sensations reported by patients during first and second cataract extractions. Methods. Consecutive patients undergoing bilateral sequential cataract extraction using phacoemulsification were recruited. Following cataract surgery, patients completed questionnaires designed to evaluate subjective sensations

2016 Journal of ophthalmology

156. Sexual Sensation Seeking, Sexual Compulsivity, and Gender Identity and Its Relationship With Sexual Functioning in a Population Sample of Men and Women. Full Text available with Trip Pro

Sexual Sensation Seeking, Sexual Compulsivity, and Gender Identity and Its Relationship With Sexual Functioning in a Population Sample of Men and Women. Despite awareness of the importance of psycho-affective factors in the development of sexual problems, there is a lack of studies exploring the relation of sexual sensation seeking (SSS) and sexual compulsivity (SC) to sexual functioning. Because sex differences in SSS and SC have been reported, gender identity (GI; an individual's own (...) experience of his or her gender that is unrelated to the actual biological sex) might act as a moderator in this relation.To understand the role of SSS and SC for men and women's sexual functioning and to explore whether these potential associations are moderated by GI.A population-based cross-sectional online survey targeted 279 individuals (69.2% women, 30.8% men; mean age = 32 years). Validated questionnaires, including the Sexual Sensation Seeking Scale, the Sexual Compulsivity Scale, the Female

2016 Journal Of Sexual Medicine

157. Phenotyping IBS: Perceptions and Modulations of Visceral Sensations

Phenotyping IBS: Perceptions and Modulations of Visceral Sensations Phenotyping IBS: Perceptions and Modulations of Visceral Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Phenotyping IBS (...) : Perceptions and Modulations of Visceral Sensations (PMVS-P) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02693730 Recruitment Status : Recruiting First Posted : February 29, 2016 Last Update Posted : October 16, 2018 See

2016 Clinical Trials

158. Urethral Sensory Profile: a New Technique to Evaluate Urethral Sensation Prospective Evaluation in Patients With or Without Neurological Disorders

to represent urethral sensation, in a simple and non-invasive way. Condition or disease Intervention/treatment Urethral Cyst Other: record of urethral pain sensation during urodynamics study Detailed Description: All patients consulting for urodynamics were included. During the introduction of the urinary catheter for urodynamic evaluation, patients were asked to report pain and/or desire to void felt at every centimeter (cm)of insertion, on an analogic visual scale graded from 0 to 10. The USP was defined (...) 2015 Actual Study Completion Date : March 2015 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Intervention Details: Other: record of urethral pain sensation during urodynamics study Record of pain using a VAS scale during the first catheterizing of urodynamics study, at every centimeter Outcome Measures Go to Primary Outcome Measures : Urethral Sensitive profile [ Time Frame: mars 2015 ] record of urethral pain sensation during the first

2016 Clinical Trials

159. A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye

A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02951910 Recruitment Status : Completed First Posted : November 1, 2016 Last Update Posted : November 1, 2016 Sponsor

2016 Clinical Trials

160. Relationship Between Gait Variability and Sensation

preferred speed.Phantom sensation and phantom pain will be asked as existence or not. Sensorial loss will evaluate with Semmes Weinstein Monofilaments Condition or disease Intervention/treatment Amputation, Traumatic Other: No intervention Detailed Description: Twenty participants with lower limb loss who were referred to receive amputee rehabilitation at Hacettepe University, Faculty of Health Sciences, department of Physiotherapy and Rehabilitation, Prosthetics and Biomechanics unit (...) , they asked to walk at their self selected speed for 6 minutes. Data was recorded between the 2nd and 4th minutes at walk. Phantom sensation and phantom pain will be asked as existence or not. Sensorial loss will evaluate with Semmes Weinstein Monofilaments. Study Design Go to Layout table for study information Study Type : Observational [Patient Registry] Estimated Enrollment : 20 participants Time Perspective: Prospective Target Follow-Up Duration: 20 Days Official Title: Investigating the Relationship

2016 Clinical Trials

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