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Pain Sensation

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121. An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks

An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x (...) × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Evaluation of a Customized Insole to Provide Relief From Heel Pain Due to Plantar Fasciitis or General Heel Pain When Used in Footwear Over a Period of Four Weeks The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated

2018 Clinical Trials

122. Changes of Pain and Functional Parameters in Back Pain Patients Over Time

Date : December 2020 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Outcome Measures Go to Primary Outcome Measures : Changes from baseline pain sensation at 1, 2, 3, 4, 5 and 9 months [ Time Frame: 6 measurement time points through study completion, an average of 9 months ] Changes of pain, sensory malfunction and numbness assessed by pain drawings and the visual analog scale. The visual analog scale ranges from 0 to 10 points, where 0 (...) indicates no pain, no numbness or no impairment of sensation and 10 stands for the highest pain value, total numbness or unsustainable paresthesia. Secondary Outcome Measures : Changes from baseline neurological status at 1, 2, 3, 4, 5 and 9 months [ Time Frame: 6 measurement time points through study completion, an average of 9 months ] The neurological status will be assessed by the straight leg raise test. The hydrogoniometer serves as assessment tool and measures the range of motion in degrees

2018 Clinical Trials

123. The added value of bedside examination and screening QST to improve neuropathic pain identification in patients with chronic pain Full Text available with Trip Pro

, von Frey hair], and vibration). The NASQ paradigm (pressure algometry, electrical pain thresholds, and conditioned pain modulation) was assessed in 58 patients to generate new insights.BSE revealed a low association of differences between patients with either absent or present NePC: heat, cold, and pricking sensations with a von Frey hair were statistically significantly less common in patients with present NePC. NASQ did not reveal any differences between patients with and without (...) The added value of bedside examination and screening QST to improve neuropathic pain identification in patients with chronic pain The assessment of a neuropathic pain component (NePC) to establish the neurological criteria required to comply with the clinical description is based on history taking, clinical examination, and quantitative sensory testing (QST) and includes bedside examination (BSE). The objective of this study was to assess the potential association between the clinically

2018 Journal of pain research

124. Pain quality descriptors and sex-related differences in patients with shoulder pain Full Text available with Trip Pro

sensations (eg, sore, pulled, torsion, and taut) were relatively more predominant than superficial pain sensations (eg, pricking and lacerating). In terms of sex-related differences, female patients used more pain quality descriptors than the male patients (5.5 vs 3.7, P<0.001). The frequency of paroxysmal, dullness, and constriction-related pain quality descriptors, such as "shooting", "faint", "clicking", and "squeezing", were higher in females than in males (all P<0.05).The results provide commonly (...) Pain quality descriptors and sex-related differences in patients with shoulder pain Pain quality assessment is applicable to pain evaluation and treatment. However, shoulder pain quality descriptors mostly remain unknown. Furthermore, sex-related differences considerably affect clinical pain experience. The aim of this study was to investigate pain quality descriptors and to compare sex-related differences in using pain descriptors among patients with shoulder pain.A sample of 120 patients (41

2018 Journal of pain research

125. First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain Full Text available with Trip Pro

events were generally mild to moderate in severity and no patients discontinued as a result of adverse events. Adverse events of abnormal peripheral sensation were more common with higher doses of tanezumab (≥100 μg/kg) than with placebo. These were generally mild to moderate in severity. Tanezumab provided up to 12 weeks of effective analgesia for OA knee pain, with statistically significant improvements at doses ≥100 μg/kg (P < 0.05). By contrast, no trend for analgesic activity was found when (...) First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology.Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerability, and analgesic efficacy of single doses of tanezumab, a humanized anti-nerve growth factor monoclonal antibody, in chronic

2018 Pain Reports Controlled trial quality: uncertain

126. Influence of transient spatial attention on the P3 component and perception of painful and non-painful electric stimuli in crossed and uncrossed hands positions. Full Text available with Trip Pro

Influence of transient spatial attention on the P3 component and perception of painful and non-painful electric stimuli in crossed and uncrossed hands positions. Recent reports show that focusing attention on the location where pain is expected can enhance its perception. Moreover, crossing the hands over the body's midline is known to impair the ability to localise stimuli and decrease tactile and pain sensations in healthy participants. The present study investigated the role of transient (...) spatial attention on the perception of painful and non-painful electrical stimuli in conditions in which a match or a mismatch was induced between skin-based and external frames of reference (uncrossed and crossed hands positions, respectively). We measured the subjective experience (Numerical Rating Scale scores) and the electrophysiological response elicited by brief electric stimuli by analysing the P3 component of Event-Related Potentials (ERPs). Twenty-two participants underwent eight painful

2017 PLoS ONE

127. Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care.

Rating Scale (NRS) with the endpoints no pain" (0) and "excruciating pain" (10) Secondary Outcome Measures : 5 minute walk test (5MWT) [ Time Frame: Change from Baseline 5MWT after treatment and at 4 weeks ] Subjects need to walk as far as possible in 5 minutes Pressure Pain Threshold (PPT) [ Time Frame: Change from Baseline Pressure Pain Threshold after treatment and at 4 weeks ] This measures deep tissue hyperalgesia, defined as the point at witch the pressure sensation turned into pain. Temporal (...) Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care. Pain Relief in Patients With Chronic Low Back Pain Using HeatTens vs. Standard Care. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

128. Pain Sensory Profile Changes Following Treatment of Chronic Low Back Pain

tolerable (pain tolerance threshold, PTT) are measured with a computer controlled pressure cuff. The cuff is placed on the lower leg and is gradually inflated (1kPa/sec). The first onset of pain (VAS 1, measured on an electronic VAS scale: 0=no pain, 10=worst pain imaginable) is indicated when the sensation of pressure around the leg changes to pain. The pressure continues to rise until the PTT is reached. PTT is defined as the point where the subject cannot endure more increase in pressure. Sensitivity (...) Pain Sensory Profile Changes Following Treatment of Chronic Low Back Pain Pain Sensory Profile Changes Following Treatment of Chronic Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain

2018 Clinical Trials

129. Experimental pain tolerance is decreased and independent of clinical pain intensity in patients with endometriosis. Full Text available with Trip Pro

Experimental pain tolerance is decreased and independent of clinical pain intensity in patients with endometriosis. To investigate alterations in tactile, pain thresholds and pain tolerance thresholds in patients with endometriosis using a multimodality approach.Cross-sectional study.Multidisciplinary referral center.Women with proven endometriosis (N = 35) and healthy controls (N = 38).Pain processing was tested using quantitative sensory testing (QST) to investigate sensation, pain, and pain (...) tolerance thresholds for thermal, electrical, and pressure stimuli.Differences in QST measures in patients with endometriosis and in healthy controls on the endometriosis site and control sites, and the association between QST outcomes and patient characteristics.We observed a significantly decreased pain tolerance in patients with endometriosis, independent of clinical pain intensity or revised American Society for Reproductive Medicine stage, compared with healthy controls.Increasing knowledge

2018 Fertility and Sterility

130. The influence of pain-related expectations on intensity perception of non-painful somatosensory stimuli. (Abstract)

The influence of pain-related expectations on intensity perception of non-painful somatosensory stimuli. The extent to which pain-related expectations, known to affect pain perception, also affect perception of nonpainful sensations remains unclear, as well as the potential role of unpredictability in this context.In a proprioceptive fear conditioning paradigm, various arm extension movements were associated with predictable and unpredictable electrocutaneous pain or its absence. During (...) a subsequent test phase, nonpainful electrocutaneous stimuli with a high or low intensity were presented during movement execution. We used hierarchical drift diffusion modeling to examine the influence of expecting pain on the perceptual decision-making process underlying intensity perception of nonpainful sensations. In the first experiment (n = 36), the pain stimulus was never presented during the test phase after conditioning. In the second experiment (n = 39), partial reinforcement was adopted

2018 Psychosomatic Medicine

131. Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. (Abstract)

characterized by pronounced thermal and mechanical sensory loss, but also mild pinprick hyperalgesia and paradoxical heat sensations. Primary hyperalgesia was characterized by pronounced gain for heat, pressure and pinprick pain, and mild thermal sensory loss. Secondary hyperalgesia was characterized by pronounced pinprick hyperalgesia and mild thermal sensory loss. Topical lidocaine plus topical capsaicin induced a combined phenotype of NB plus PH. Topical menthol was the only model with significant cold (...) Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain to underlying mechanisms, we used a published sorting algorithm to estimate the prevalence of denervation, peripheral and central sensitization in 657 healthy subjects undergoing experimental models of nerve block (NB) (compression block

2018 Pain

132. Brief Mindfulness and Nutrition-Based Interventions for Opioid-Treated Chronic Pain: Strategies to Ease Pain

on a BMBI which demonstrated analgesic effects in a previous study. Relative to full-length interventions, we will employ a brief intervention; the 20-minute BMBI session will include education on the foundational concepts of mindfulness and its relevance to chronic pain (5 minutes) and a guided mindfulness practice involving focused attention on the breath and monitoring of thoughts, feelings, and body sensations (15 minutes). BMBI participants will be encouraged to practice the taught mindfulness (...) Brief Mindfulness and Nutrition-Based Interventions for Opioid-Treated Chronic Pain: Strategies to Ease Pain Brief Mindfulness and Nutrition-Based Interventions for Opioid-Treated Chronic Pain: Strategies to Ease Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies

2018 Clinical Trials

133. Pain Modulatory Profiles in Massage for Individuals With Neck Pain

pain symptom intensity rated as 4/10 or higher during the last 24 hours neck pain for greater than or equal to 3 months Exclusion Criteria: non-English speaking systemic medical conditions known to affect sensation (e.g. diabetes, hypertension) history of neck surgery or fracture within the past 6 months current history of chronic pain condition other than neck pain diagnosis of cervical radiculopathy or cervical myelopathy history of whiplash; g) currently using blood thinning medication any blood (...) Pain Modulatory Profiles in Massage for Individuals With Neck Pain Pain Modulatory Profiles in Massage for Individuals With Neck Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain Modulatory Profiles

2018 Clinical Trials

134. STUDIES ON PAIN: QUANTITATIVE MEASUREMENTS OF TWO PAIN SENSATIONS OF THE SKIN, WITH REFERENCE TO THE NATURE OF THE “HYPERALGESIA OF PERIPHERAL NEURITIS” Full Text available with Trip Pro

STUDIES ON PAIN: QUANTITATIVE MEASUREMENTS OF TWO PAIN SENSATIONS OF THE SKIN, WITH REFERENCE TO THE NATURE OF THE “HYPERALGESIA OF PERIPHERAL NEURITIS” 16695239 2006 05 31 2018 11 13 0021-9738 24 4 1945 Jul The Journal of clinical investigation J. Clin. Invest. STUDIES ON PAIN: QUANTITATIVE MEASUREMENTS OF TWO PAIN SENSATIONS OF THE SKIN, WITH REFERENCE TO THE NATURE OF THE "HYPERALGESIA OF PERIPHERAL NEURITIS". 503-12 Bigelow N N New York Hospital, New York City. Harrison I I Goodell H H

1945 Journal of Clinical Investigation

135. The amygdala between sensation and affect: a role in pain Full Text available with Trip Pro

The amygdala between sensation and affect: a role in pain The amygdala is a structure of the temporal lobe thought to be involved in assigning emotional significance to environmental information and triggering adapted physiological, behavioral and affective responses. A large body of literature in animals and human implicates the amygdala in fear. Pain having a strong affective and emotional dimension, the amygdala, especially its central nucleus (CeA), has also emerged in the last twenty years (...) as key element of the pain matrix. The CeA receives multiple nociceptive information from the brainstem, as well as highly processed polymodal information from the thalamus and the cerebral cortex. It also possesses the connections that allow influencing most of the descending pain control systems as well as higher centers involved in emotional, affective and cognitive functions. Preclinical studies indicate that the integration of nociceptive inputs in the CeA only marginally contributes to sensory

2013 Journal of Molecular Psychiatry

136. The Origin of Phantom Limb Sensation and Phantom Limb Pain in Amputees

The Origin of Phantom Limb Sensation and Phantom Limb Pain in Amputees The Origin of Phantom Limb Sensation and Phantom Limb Pain in Amputees - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Origin (...) of Phantom Limb Sensation and Phantom Limb Pain in Amputees The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01936558 Recruitment Status : Unknown Verified January 2014 by National Taiwan University Hospital. Recruitment status was: Recruiting First Posted : September 6, 2013 Last Update Posted : January

2013 Clinical Trials

137. Motor and parietal cortex stimulation for phantom limb pain and sensations. (Abstract)

Motor and parietal cortex stimulation for phantom limb pain and sensations. Limb amputation may lead to chronic painful sensations referred to the absent limb, ie phantom limb pain (PLP), which is likely subtended by maladaptive plasticity. The present study investigated whether transcranial direct current stimulation (tDCS), a noninvasive technique of brain stimulation that can modulate neuroplasticity, can reduce PLP. In 2 double-blind, sham-controlled experiments in subjects with unilateral (...) lower or upper limb amputation, we measured the effects of a single session of tDCS (2 mA, 15 min) of the primary motor cortex (M1) and of the posterior parietal cortex (PPC) on PLP, stump pain, nonpainful phantom limb sensations and telescoping. Anodal tDCS of M1 induced a selective short-lasting decrease of PLP, whereas cathodal tDCS of PPC induced a selective short-lasting decrease of nonpainful phantom sensations; stump pain and telescoping were not affected by parietal or by motor tDCS

2013 Pain

138. The Use of a CoolSense Device to Lower Pain Sensation During Finger Pricking While Measuring Blood Glucose in Diabetes Patients-A Randomized Placebo. (Abstract)

The Use of a CoolSense Device to Lower Pain Sensation During Finger Pricking While Measuring Blood Glucose in Diabetes Patients-A Randomized Placebo. Patients with type 1 diabetes and a significant portion of patients with type 2 diabetes must use subcutaneous insulin injections, in order to maintain normoglycemia and to prevent immediate and long-term complications. For these patients, testing blood glucose levels more frequently is necessary to safely achieve glycated hemoglobin targets (...) . In the current study, the effects of a CoolSense™ device (CoolSense Medical Ltd., Tel Aviv, Israel) were examined in relieving pain caused by needle-pricking for glucose measurements in adult patients with diabetes.One hundred seventy-seven patients assessed the severity of pain they experienced during needle-pricking. The patients were randomly divided into an experimental group or a control group that used either a cooled CoolSense instrument or a non-cooled device, respectively. Participants were asked

2013 Diabetes technology & therapeutics Controlled trial quality: uncertain

139. Investigating the effects of three needling parameters (manipulation, retention time, and insertion site) on needling sensation and pain profiles: a study of eight deep needling interventions. Full Text available with Trip Pro

Investigating the effects of three needling parameters (manipulation, retention time, and insertion site) on needling sensation and pain profiles: a study of eight deep needling interventions. Introduction. In traditional Chinese acupuncture, needle sensation (deqi) is purported to contribute to a therapeutic outcome. While researchers have attempted to define deqi qualitatively, few have examined the effects of needling parameters on its intensity. Methods. 24 healthy subjects completed eight (...) interventions scheduled at least one week apart, which involved manual acupuncture to LI4 or a designated nonacupoint (NAP) on the hand, with real or simulated manipulation each three minutes and needle retentions of one or 21 minutes. Intensities of needling sensation and pain were reported every three minutes and sensation qualities were reported post-intervention. Results. Immediately after needle insertion, similar levels of mean needle sensation and of pain were reported independent of intervention

2013 Evidence-based Complementary and Alternative Medicine (eCAM)

140. Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip Full Text available with Trip Pro

. Overall incidence of AEs was similar across subgroups. AEs of abnormal peripheral sensation were more frequently reported in tanezumab-treated patients compared with placebo or active comparator. Patients receiving active comparator had a slightly higher incidence of AEs suggestive of postganglionic sympathetic dysfunction.Tanezumab consistently provided significant improvement of pain, physical function, and PGA in individuals with OA, including patients with diabetes, severe OA symptoms, or aged ≥65 (...) Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip A pooled analysis was conducted to evaluate tanezumab efficacy and safety in patients with osteoarthritis (OA), including subgroup analyses of at-risk patients with diabetes, severe OA symptoms, and those aged ≥65 years.Data from phase III placebo-controlled clinical trials of patients with moderate-to-severe OA of the knee or hip were

2019 EvidenceUpdates

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