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Pain Sensation

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81. Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation. (PubMed)

Congenital insensitivity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation. Congenital insensitivity to pain with anhidrosis is a rare autosomal recessive hereditary disorder that is characterized by having both sensory neuropathy and anhidrosis. A 6-year-old Japanese boy presented with recurrent fever, lack of sweating, occult bone fractures and impaired pain sensation without mental retardation. Genetic analyses revealed compound (...) sensation after histamine and a burning sensation after topical capsaicin application. Consistent with these findings, PGP9.5+ nerve fibre innervation of the papillary dermis was observed, although the fibres were completely absent around the eccrine glands. These findings suggest that there was a partial preservation of the nerve endings that express the H(1) receptor and/or TRPV1 in the upper dermis, even though there were mutations of the NTRK1 gene in this case.© 2011 The Authors. BJD © 2011

2011 British Journal of Dermatology

82. Mindfulness and CBT for chronic low back pain

(body scan, yoga, and meditation – attention to thoughts emotions, and sensations in the present moment without trying to change them, sitting meditation with awareness of breathing, and walking meditation). CBT The CBT intervention included techniques most commonly applied and studied for chronic LBP. The program included: psychoeducation about chronic pain, the relationships between thoughts and emotional and physical reactions, sleep hygiene, relapse prevention, and maintenance of gains (...) Mindfulness and CBT for chronic low back pain RACGP - Mindfulness and CBT for chronic low back pain Search Become a student member today for free and be part of the RACGP community A career in general practice Starting the GP journey Enrolments for the 2019.1 OSCE FRACGP exams closing 29 March 2019 Fellowship FRACGP exams Research Practice Experience Program is a self-directed education program designed to support non vocationally registered doctors on their pathway to RACGP Fellowship

2017 Handbook of Non-Drug interventions (HANDI)

83. Tramadol for neuropathic pain in adults. (PubMed)

Tramadol for neuropathic pain in adults. This review is an update of a review of tramadol for neuropathic pain, published in 2006; updating was to bring the review in line with current standards. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Peripheral neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity (...) to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the peripheral nervous system.To assess the analgesic efficacy of tramadol compared with placebo or other active interventions for chronic neuropathic pain in adults, and the adverse events associated with its use in clinical trials.We searched CENTRAL, MEDLINE, and Embase for randomised controlled trials from inception to January 2017. We also searched the reference lists of retrieved studies and reviews, and online

2017 Cochrane

84. Morphine for chronic neuropathic pain in adults. (PubMed)

Morphine for chronic neuropathic pain in adults. Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the nervous system. Opioid drugs, including morphine, are commonly used (...) to treat neuropathic pain. Most reviews have examined all opioids together. This review sought evidence specifically for morphine; other opioids are considered in separate reviews.To assess the analgesic efficacy and adverse events of morphine for chronic neuropathic pain in adults.We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, and Embase for randomised controlled trials from inception to February 2017. We also searched the reference lists of retrieved studies

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2017 Cochrane

85. Altered White Matter and Sensory Response to Bodily Sensation in Female-to-Male Transgender Individuals (PubMed)

Altered White Matter and Sensory Response to Bodily Sensation in Female-to-Male Transgender Individuals While most people take identification with their body for granted, conditions such as phantom limb pain, alien hand syndrome, and xenomelia suggest that the feeling of bodily congruence is constructed and susceptible to alteration. Individuals with xenomelia typically experience one of their limbs as over-present and aversive, leading to a desire to amputate the limb. Similarly, many (...) (FtM)-identified transgender individuals-and the hand, a body part that feels congruent. We measured the sensory evoked response in right hemisphere somatosensory and body-related brain areas and found significantly reduced activation in the supramarginal gyrus and secondary somatosensory cortex, but increased activation at the temporal pole for chest sensation in the FtM group (N = 8) relative to non-transgender females (N = 8). In addition, we found increased white matter coherence

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2016 Archives of Sexual Behavior

86. Comparison between Subjective Sensations during First and Second Phacoemulsification Eye Surgeries in Patients with Bilateral Cataract (PubMed)

, including anxiety, eye bulges, pain, and light sensitivity. Changes in painful sensations experienced by patients between the two surgeries were also recorded. Comparisons were also performed for each subjective sensation between different age groups (<50, 50-59, 60-69, 70-79, and >79 years). Results. A total of 127 patients were included in the final evaluation. Statistical comparison of the results showed that there were significant differences in perception of anxiety, eye bulges, and pain scores (...) Comparison between Subjective Sensations during First and Second Phacoemulsification Eye Surgeries in Patients with Bilateral Cataract Purpose. To evaluate and compare the subjective sensations reported by patients during first and second cataract extractions. Methods. Consecutive patients undergoing bilateral sequential cataract extraction using phacoemulsification were recruited. Following cataract surgery, patients completed questionnaires designed to evaluate subjective sensations

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2016 Journal of ophthalmology

87. The effect of age and body mass index on plantar cutaneous sensation in healthy women (PubMed)

to their ages and body mass index values. Foot pain was measured with a visual analogue scale and plantar cutaneous sensation using Semmes-Weinstein monofilaments. [Results] Fifty-six (27.5%) of the participants had normal weights, 67 (33%) were overweight, and 80 (39%) were obese. Statistical analysis revealed that as age and body mass index values increased, plantar sensitivity decreased and the frequency and severity of pain increased. [Conclusion] It is possible that healthy women may experience (...) The effect of age and body mass index on plantar cutaneous sensation in healthy women [Purpose] This study was conducted to examine the effects of age and body mass index on plantar cutaneous sensation in healthy women. [Subjects and Methods] Two hundred and three healthy female volunteers over the age of 20 were included in the study. The statistical analyses were performed by considering the age and body mass index values of the individuals. The individuals were divided according

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2016 Journal of physical therapy science

88. Pulse width affects scalp sensation of transcranial magnetic stimulation (PubMed)

Pulse width affects scalp sensation of transcranial magnetic stimulation Scalp sensation and pain comprise the most common side effect of transcranial magnetic stimulation (TMS), which can reduce tolerability and complicate experimental blinding.We explored whether changing the width of single TMS pulses affects the quality and tolerability of the resultant somatic sensation.Using a controllable pulse parameter TMS device with a figure-8 coil, single monophasic magnetic pulses inducing electric (...) 0-to-10 visual analog scales for Discomfort, Sharpness, and Strength of the sensation.Briefer TMS pulses with amplitude normalized to the motor threshold were perceived as slightly more uncomfortable than longer pulses (with an average 0.89 point increase on the Discomfort scale for pulse width of 30 µs compared to 120 µs). The sensation of the briefer pulses was felt to be substantially sharper (2.95 points increase for 30 µs compared to 120 µs pulse width), but not stronger than longer pulses

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2016 Brain stimulation

89. Urethral Sensory Profile: a New Technique to Evaluate Urethral Sensation Prospective Evaluation in Patients With or Without Neurological Disorders

to represent urethral sensation, in a simple and non-invasive way. Condition or disease Intervention/treatment Urethral Cyst Other: record of urethral pain sensation during urodynamics study Detailed Description: All patients consulting for urodynamics were included. During the introduction of the urinary catheter for urodynamic evaluation, patients were asked to report pain and/or desire to void felt at every centimeter (cm)of insertion, on an analogic visual scale graded from 0 to 10. The USP was defined (...) 2015 Actual Study Completion Date : March 2015 Resource links provided by the National Library of Medicine related topics: Groups and Cohorts Go to Intervention Details: Other: record of urethral pain sensation during urodynamics study Record of pain using a VAS scale during the first catheterizing of urodynamics study, at every centimeter Outcome Measures Go to Primary Outcome Measures : Urethral Sensitive profile [ Time Frame: mars 2015 ] record of urethral pain sensation during the first

2016 Clinical Trials

90. Phenotyping IBS: Perceptions and Modulations of Visceral Sensations

Phenotyping IBS: Perceptions and Modulations of Visceral Sensations Phenotyping IBS: Perceptions and Modulations of Visceral Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Phenotyping IBS (...) : Perceptions and Modulations of Visceral Sensations (PMVS-P) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT02693730 Recruitment Status : Recruiting First Posted : February 29, 2016 Last Update Posted : October 16, 2018 See

2016 Clinical Trials

91. Relationship Between Gait Variability and Sensation

preferred speed.Phantom sensation and phantom pain will be asked as existence or not. Sensorial loss will evaluate with Semmes Weinstein Monofilaments Condition or disease Intervention/treatment Amputation, Traumatic Other: No intervention Detailed Description: Twenty participants with lower limb loss who were referred to receive amputee rehabilitation at Hacettepe University, Faculty of Health Sciences, department of Physiotherapy and Rehabilitation, Prosthetics and Biomechanics unit (...) , they asked to walk at their self selected speed for 6 minutes. Data was recorded between the 2nd and 4th minutes at walk. Phantom sensation and phantom pain will be asked as existence or not. Sensorial loss will evaluate with Semmes Weinstein Monofilaments. Study Design Go to Layout table for study information Study Type : Observational [Patient Registry] Estimated Enrollment : 20 participants Time Perspective: Prospective Target Follow-Up Duration: 20 Days Official Title: Investigating the Relationship

2016 Clinical Trials

92. A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye

A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. A Study of the Effect of Zinc-Hyaluronate on Ocular Surface Sensations in Patients With Dry Eye The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02951910 Recruitment Status : Completed First Posted : November 1, 2016 Last Update Posted : November 1, 2016 Sponsor

2016 Clinical Trials

93. Sexual Sensation Seeking, Sexual Compulsivity, and Gender Identity and Its Relationship With Sexual Functioning in a Population Sample of Men and Women. (PubMed)

Sexual Sensation Seeking, Sexual Compulsivity, and Gender Identity and Its Relationship With Sexual Functioning in a Population Sample of Men and Women. Despite awareness of the importance of psycho-affective factors in the development of sexual problems, there is a lack of studies exploring the relation of sexual sensation seeking (SSS) and sexual compulsivity (SC) to sexual functioning. Because sex differences in SSS and SC have been reported, gender identity (GI; an individual's own (...) experience of his or her gender that is unrelated to the actual biological sex) might act as a moderator in this relation.To understand the role of SSS and SC for men and women's sexual functioning and to explore whether these potential associations are moderated by GI.A population-based cross-sectional online survey targeted 279 individuals (69.2% women, 30.8% men; mean age = 32 years). Validated questionnaires, including the Sexual Sensation Seeking Scale, the Sexual Compulsivity Scale, the Female

2016 Journal Of Sexual Medicine

94. [Different Warm Sensations May Induce Different Therapeutic Effects in Primary Dysmenorrhea Patients Undergoing Moxibustion Treatment Based on Propensity Score: A Prospective Cohort Study]. (PubMed)

beginning 5 days before dysmenorrheal attack, once daily for (7 ± 2) days in one menstrual cycle, and for 3 menstrual cycles for heat-sensitive group, wheras routine moxibustion for conventional warm sensation group. The McGill Pain Questionnaire (MPQ) composed of pain rating index (PRI), visual analogue scale (VAS) and present pain intensity (PPI) and COX Menstrual Symptom Scale (CMSS) containing 18 items (0 - 4 grades/item) were used to evaluate the therapeutic effect of moxibustion treatment. Follow (...) [Different Warm Sensations May Induce Different Therapeutic Effects in Primary Dysmenorrhea Patients Undergoing Moxibustion Treatment Based on Propensity Score: A Prospective Cohort Study]. To compare the effectiveness difference between the "heat-sensitive" sensation and conventional warm sensation of moxibustion stimulation of Guanyuan (GV 4) in primary dysmenorrhea (PD) patients.Cohort study design was used in the present study. A total of 189 PD patients were divided into heat-sensitive

2016 Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji]

95. The immediate effects of lidocaine iontophoresis using interferential current on pressure sense threshold and tactile sensation. (PubMed)

The immediate effects of lidocaine iontophoresis using interferential current on pressure sense threshold and tactile sensation. Iontophoresis is the noninvasive delivery of ions using direct current. The direct current has some disadvantages such as skin burning. Interferential current is a kind of alternating current without limitations of direct current; so the purpose of this study is to investigate and compare the effects of lidocaine, interferential current and lidocaine iontophoresis (...) using interferential current. 30 healthy women aged 20-24 years participated in this randomized clinical trial study. Pressure, tactile and pain thresholds were evaluated before and after the application of treatment methods. Pressure, tactile and pain sensitivity increased significantly after the application of lidocaine alone (p < 0.005) and lidocaine iontophoresis using interferential current (p < 0.0001). Lidocaine iontophoresis using interferential current can increase perception threshold

2016 Therapeutic delivery

96. Prechemotherapy Touch-Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer (PubMed)

Prechemotherapy Touch-Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer We examined the emergence of chemotherapy-induced peripheral neuropathy (CIPN), a dose-limiting toxicity of oxaliplatin, over the course of oxaliplatin-based chemotherapy for colorectal cancer (CRC). Predicting which patients will likely develop CIPN is an ongoing clinical challenge.Oxaliplatin-naïve patients with CRC underwent quantitative sensory testing (QST) before beginning (...) oxaliplatin-based chemotherapy and then rated CIPN-related symptoms via the MD Anderson Symptom Inventory (MDASI) weekly for 26 weeks. Mixed modeling examined the value of QST for predicting higher CIPN (MDASI numbness/tingling) during treatment. Trajectory analysis identified a patient subgroup with consistently higher CIPN symptoms.Numbness/tingling was the most frequent, most severe symptom, with 51% of patients clustering into a high CIPN subgroup. Touch sensation deficits (Bumps Detection test

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2016 Oncology

97. Acetylated tubulin is essential for touch sensation in mice (PubMed)

Acetylated tubulin is essential for touch sensation in mice At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals. Our understanding of this process, especially how the cytoskeleton influences it, remains unknown. Here we demonstrate that mice lacking the α-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical (...) stimuli. We show that all cutaneous afferent subtypes, including nociceptors have strongly reduced mechanosensitivity upon Atat1 deletion, and that consequently, mice are largely insensitive to mechanical touch and pain. We establish that this broad loss of mechanosensitivity is dependent upon the acetyltransferase activity of Atat1, which when absent leads to a decrease in cellular elasticity. By mimicking α-tubulin acetylation genetically, we show both cellular rigidity and mechanosensitivity can

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2016 eLife

98. Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal) (PubMed)

with dystonia or chronic pain secondary to major nervous system injury. In patients with ET, most Vc neurons responded to one of the four stimuli, each of which optimally activates one mechanoreceptor type. Sensations evoked by microstimulation were similar to those evoked by the optimal stimulus only among rapidly adapting neurons. In patients with ET, Vc was highly segmented somatotopically, and vibration, movement, pressure, and sharp sensations were usually evoked by microstimulation at separate sites (...) Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal) The normal organization and plasticity of the cutaneous core of the thalamic principal somatosensory nucleus (ventral caudal, Vc) have been studied by single-neuron recordings and microstimulation in patients undergoing awake stereotactic operations for essential tremor (ET) without apparent somatic sensory abnormality and in patients

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2016 Journal of neurophysiology

99. Ketamine Analgesia for Acute Pain in the Emergency Department

Ketamine Analgesia for Acute Pain in the Emergency Department Emergency Medicine > Journal Club > Archive > April 2016 Toggle navigation April 2016 Ketamine Analgesia for Acute Pain in the Emergency Department Vignette It's two o'clock in the afternoon during a typical weekend TCC shift, when you get a page that a triage patient is coming to room 4. You look at the chart and see that it's a 45-year-old man who was riding his horse and got bucked off, landing on his left arm in an awkward (...) position. The triage nurse has noted a deformity to the upper arm with intact pulses and sensation distally. You notice that the triage doctor has ordered IV lidocaine for the man, which you find most confusing. Your evaluation of the patient confirms much of the triage note. He has swelling and bruising to the left upper arm, concerning for a mid-shaft humerus fracture. He is neurovascularly intact and has stable vital signs. He denies any past medical history and has no allergies. You decide to ask

2017 Washington University Emergency Medicine Journal Club

100. The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01950078 Recruitment Status : Completed First

2013 Clinical Trials

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