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Pain Sensation

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9641. The effect of real and sham acupuncture on thermal sensation and thermal pain thresholds. Full Text available with Trip Pro

The effect of real and sham acupuncture on thermal sensation and thermal pain thresholds. To compare the effect of real and sham acupuncture and a control intervention on thermal sensation and thermal pain thresholds.Single-blind, randomized controlled, repeated-measures trial.Laboratory.Eighteen acupuncture-naive, healthy subjects with no history of upper-limb pathology or acupuncture contraindications.Subjects were randomly assigned (blind card allocation) to 1 of 6 possible orders (...) of application of the interventions, which consisted of 25 minutes each of control, real, and sham acupuncture.Thermal sensation and thermal pain thresholds measured with a thermal sensory analyzer before and after each intervention.There were increases in cold and hot pain and cold sensation thresholds with real acupuncture. The level of increase did not differ significantly from the changes that occurred with sham acupuncture and control interventions.Although we observed a trend toward a decreased

2005 Archives of physical medicine and rehabilitation Controlled trial quality: uncertain

9642. Segmental noxious versus innocuous electrical stimulation for chronic pain relief and the effect of fading sensation during treatment. (Abstract)

Segmental noxious versus innocuous electrical stimulation for chronic pain relief and the effect of fading sensation during treatment. It is not clear whether segmental innocuous stimulation has a stronger analgesic effect than segmental noxious stimulation for chronic pain and whether the fading of current sensation during treatment interferes with the analgesic effect, as suggested by the gate control theory. Electrical stimulation (by way of Interferential Current) applied at the pain area (...) (segmental) was administered to 4 groups of patients with osteoarthritis (OA) knee pain. Two groups were administered with noxious stimulation (30% above pain threshold) and two with innocuous stimulation (30% below pain threshold). In each group half of the patients received a fixed current intensity while the other half raised the intensity continuously during treatment whenever fading of sensation was perceived. Group 5 and 6 received sham stimulation and no treatment, respectively. The outcome

2005 Pain Controlled trial quality: uncertain

9643. Analgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a 'virtual' limb upon phantom limb pain, sensation and movement. (Abstract)

Analgesia through the looking-glass? A randomized controlled trial investigating the effect of viewing a 'virtual' limb upon phantom limb pain, sensation and movement. The extent to which viewing a 'virtual' limb, the mirror image of an intact limb, modifies the experience of a phantom limb, was investigated in 80 lower limb amputees before, during and after repeated attempts to simultaneously move both intact and phantom legs. Subjects were randomly assigned to one of two conditions, a control (...) condition in which they only viewed the movements of their intact limb and a mirror condition in which they additionally viewed the movements of a 'virtual' limb. Although the mirror condition elicited a significantly greater number of phantom limb movements than the control condition, it did not attenuate phantom limb pain and sensations any more than the control condition. The potential of a 'virtual' limb as a treatment for phantom limb pain was discussed in terms of its ability to halt

2007 European Journal of Pain Controlled trial quality: uncertain

9644. Pain sensation during intradermal injections of three different botulinum toxin preparations in different doses and dilutions. (Abstract)

Pain sensation during intradermal injections of three different botulinum toxin preparations in different doses and dilutions. Pain sensation associated with injections of botulinum neurotoxin (BoNT) is commonly reported. To date differences in pain sensation between the commercially available products containing BoNT have not been quantified.The pain sensations during injection of Dysport, Botox, Neurobloc, and pure saline (control) were compared. In addition, the nociceptive effect (...) of different volumes used for the dilution of the same BoNT dose was investigated.In a prospective, double-blind, controlled trial, 10 healthy subjects were injected intradermally with Dysport (12 U), Botox (3 and 4 U), Neurobloc (150 and 300 U) reconstituted in 0.9% saline, and pure saline. Pain sensation was quantified during injections.Neurobloc injections caused significantly more injection pain than Botox, Dysport, and saline. No significant differences between Dysport, Botox, and saline were found

2006 Dermatologic Surgery Controlled trial quality: uncertain

9645. The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation. (Abstract)

The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation. Long-term potentiation (LTP) of nociceptive synaptic transmission induced by high-frequency electrical stimulation (HFS) predominantly modulates natural somatosensory perceptions mediated by Adelta- and Abeta-fibers in humans at the site of conditioning stimulation. The relative contribution of homo- and heterosynaptic mechanisms underlying those perceptual changes remained unclear. We therefore (...) : a significant decrease of pain threshold and an increase of pain sensation to suprathreshold pinprick stimuli (punctate mechanical hyperalgesia; p<0.001) as well as pain to light tactile stimuli (dynamic mechanical allodynia; p<0.01). Changes at the heterotopic zone were about 30% less than at the homotopic conditioned zone, but they were highly correlated between both zones for suprathreshold painful stimuli (r=0.85-0.90) and for pain thresholds (r=0.51-0.66). Moreover, a small decrease of thresholds

2008 Pain

9646. Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis. (Abstract)

Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis. Using psychophysical methods we compared the effect of the menstrual cycle on bladder sensation in subjects with the diagnosis of interstitial cystitis (IC) and in controls.Female participants with normal menstrual cycles, including 7 with IC and 8 healthy controls, were recruited into this study. They completed daily diaries related to bladder pain and other body pain, and tracked daily micturition frequency (...) . In a subset formal psychophysical testing of thermal and ischemic pain was performed at 2 times of the menstrual cycle, corresponding to the luteal and follicular phases. Cystometrograms were performed at the same time.Subjects with IC had higher pain scores and frequency than controls throughout the entire menstrual cycle. Pain scores were highest in the perimenstrual period in subjects with IC and controls. Micturition frequency was highest in the perimenstrual period in subjects with IC. Cystometric

2005 Journal of Urology

9647. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain Full Text available with Trip Pro

Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is expressed on sensory nerves to cause neurogenic inflammation. Transient receptor potential A1 (TRPA1) is an excitatory ion channel on primary sensory nerves of pain pathway. Here, we show that a functional interaction of PAR2 and TRPA1 in dorsal root ganglion (DRG) neurons could contribute to the sensation of inflammatory pain (...) . Thus, the increased TRPA1 sensitivity may have been due to activation of PLC, which releases the inhibition of TRPA1 from plasma membrane PIP(2). These results identify for the first time to our knowledge a sensitization mechanism of TRPA1 and a novel mechanism through which trypsin or tryptase released in response to tissue inflammation might trigger the sensation of pain by TRPA1 activation.

2007 Journal of Clinical Investigation

9648. The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers

The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. The Effect of Intravenous Lidocaine on Normal Sensation and Pain in Healthy Volunteers The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00657358 Recruitment Status : Completed First Posted : April 14, 2008 Results First Posted : January 13, 2014 Last Update Posted : May 17, 2017

2008 Clinical Trials

9649. The Emerging Role of TRP Channels in Mechanisms of Temperature and Pain Sensation Full Text available with Trip Pro

The Emerging Role of TRP Channels in Mechanisms of Temperature and Pain Sensation Pain is universal and vital to survival. It is an essential component of our sense of touch; together, touch and pain have evolved to enable our awareness of the intricacies of our environment and to warn us of danger and possible injury. There is a clear link between temperature sensation and pain-painful temperature sensations occur acutely and are a hallmark of inflammatory and chronic pain disorders (...) -derived small molecules and endogenous inflammatory mediators. All thermoTRPs are expressed in tissues essential to cutaneous thermal and pain sensation. This review examines the contribution of thermoTRP channels to our understanding of temperature and pain transduction at the molecular level.

2006 Current neuropharmacology

9650. An unusual case of painful phantom-limb sensations during regional anesthesia. (Abstract)

An unusual case of painful phantom-limb sensations during regional anesthesia. The objective of this article is to describe a late-onset phantom-limb pain during a continuous analgesic popliteal nerve block after foot surgery and its alleviation and recurrence when stopping and resuming the local anesthetic infusion.A 29-year-old woman undergoing a left hallux valgus repair received a continuous popliteal sciatic nerve block for postoperative analgesia. Postoperatively, 6 hours after (...) the commencement of a ropivacaine 0.2% infusion, she reported feelings of tingling, clenching pain, and missing-limb sensation below the ankle. The surgical site remained painless. Sensation elicited by touch and propioception were normally perceived. Only sensations for pinprick and heat were impaired. The ropivacaine infusion was stopped, followed 2.5 hours later by the complete regression of any abnormal sensation. Meanwhile, pain at the surgical site was scored at 50 mm on a 100-mm visual analogic scale

2004 Regional Anesthesia and Pain Medicine

9651. Prospective diary study of nonpainful and painful phantom sensations in a preselected sample of child and adolescent amputees reporting phantom limbs. (Abstract)

Prospective diary study of nonpainful and painful phantom sensations in a preselected sample of child and adolescent amputees reporting phantom limbs. To prospectively study factors associated with the occurrence of phantom sensations and pains in a pre-selected sample of child and adolescent amputees reporting phantom limbs.Prospective diary study over 1 month.Fourteen child and adolescent amputees from 10-18 years of age who were missing a limb due to trauma (n = 12) or congenital limb (...) deficiency (n = 2), and who had previously reported having phantom sensations and pain.Diary used to assess the occurrence of non-painful and painful phantom sensations. Items included age, sex, location and cause of amputation, past experience with stump pain and pre-amputation pain, and intensity, quality, duration, and triggers of the sensations and pains.Thirteen amputees reported having 104 incidents of non-painful phantom sensations with an average intensity of 4.17 (SD = 2.14) on a 0-10 rating

2004 Clinical Journal of Pain

9652. Diabetic neuropathy: review of a surgical approach to restore sensation, relieve pain, and prevent ulceration and amputation. (Abstract)

Diabetic neuropathy: review of a surgical approach to restore sensation, relieve pain, and prevent ulceration and amputation. Diabetic neuropathy occurs in a stocking and glove distribution consistent with a systemic metabolic disease. Historically, this concept led to the conclusion that the only role for surgery in a patient with diabetic neuropathy is for treatment of wounds, amputation, or reconstruction of a Charcot foot. This article reviews the basic scientific and clinical research (...) that support the concepts that metabolic neuropathy renders the peripheral nerve susceptible to compression in patients with diabetes and that decompression of lower extremity peripheral nerves in these patients can relieve pain, restore sensation, and prevent ulceration and amputation.

2004 Foot & Ankle International

9653. Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. (Abstract)

Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. To test the hypothesis that abdominal pain related to functional gastrointestinal disorders is associated with visceral hypersensitivity and abnormal perception of visceral sensations.We examined 35 children (10-17.6 years old) fulfilling the Rome II criteria with irritable bowel syndrome (IBS; n = 21), functional abdominal pain (FAP; n = 8) or functional (...) dyspepsia (FD; n = 6) compared with 10 control subjects (10.2-16.1 years). All underwent a rectal barostat examination. Painful sensations were reported on a human body diagram. The projections of sensations induced by rectal distension, the rectal sensory threshold for pain (RSTP) and the diagnostic value of RSTP measurements were measured.Rectal distension induced sensations that projected to the S3 dermatome in the control subjects and FD and to aberrant sites in children with IBS and FAP. The RSTP

2007 Journal of Pediatrics

9654. Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. (Abstract)

Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. To our knowledge there are no studies evaluating the prevalence and characteristics of itch, pain, and burning sensation among patients with mild to moderate chronic venous insufficiency or assessing the impact of these symptoms on quality of life. In this report 100 patients met the inclusion criteria. Patients who suffered from itch were also assessed (...) with the use of a validated questionnaire and a modified Skindex-16 questionnaire. We found that the prevalence of itch was 66%. Concomitant itch and burning sensation as well as itch and pain were noted in 47% and 44% of the patients, respectively. No correlation was noted between the severity of these symptoms and the degree of venous insufficiency. Itch had a negative impact on quality of life. A limitation of this study is that the participants, who were primarily hospital employees, are more likely

2005 Journal of American Academy of Dermatology

9655. Quantitative measurement of pain sensation in patients with Parkinson disease. (Abstract)

Quantitative measurement of pain sensation in patients with Parkinson disease. Pain is common in patients with Parkinson disease (PD) and can precede the diagnosis of the disease. Experimental studies and clinical evidence indicate involvement of basal ganglia and dopaminergic pathways in central pain processing.To quantitatively assess and compare pain perception in patients with unilateral PD with and without pain and in patients with response fluctuations.Thirty-six patients with PD (mean (...) age, 61.8 +/- 11.2 years) with predominantly unilateral disease, 15 patients with response fluctuations (mean age, 65.3 +/- 10.4 years), and 28 age-matched healthy control subjects participated in the study. Subjective pain was assessed using the visual analog scale with von Frey filaments for tactile thresholds and contact thermode for warm sensation (WS) and heat pain thresholds (HPTs).Tactile and WS thresholds did not differ between patients in both patient groups and control subjects nor

2004 Neurology

9656. Spatial summation and spatial discrimination of pain sensation. (Abstract)

Spatial summation and spatial discrimination of pain sensation. The aims of this study were to explore: (a) the interrelation between spatial summation (SS) and spatial discrimination (SD) of pain, (b) whether the two phenomena are subserved by different sensory channels. SS and SD of pain were measured with contact heat stimuli delivered at slow (0.50 degrees C/s) and fast (40 degrees C/s) rise times. Pressure nerve block of the radial nerve was employed to assess whether differential (...) activation of C and A delta fibers is obtained by these different rates of rise. Two discrete stimuli (each 3x3 cm) were applied to the forearm with separation distances between them varying from 0 to 30 cm. A single stimulus or two applied simultaneously were employed. For each distance heat-pain threshold (HPT) and suprathreshold pain ratings were obtained and subjects were asked to report the number of pain spots perceived (SD). SS of HPT occurred at separations smaller than 10 cm whereas significant

2006 Pain

9657. Persistent pain and uncomfortable sensations in persons with multiple sclerosis. (Abstract)

Persistent pain and uncomfortable sensations in persons with multiple sclerosis. The experience of pain has been documented in small studies of individuals with multiple sclerosis (MS). The present study examines the prevalence of persistent pain and uncomfortable sensations among participants in the large North American Research Committee on MS (NARCOMS) Patient Registry. Registrants (10,176) responded to a questionnaire on pain and 7579 reported experiencing some level of pain during (...) satisfaction with management of intense pain, and the perceived interference with quality of life indicators necessitate greater attention by healthcare providers to the management of pain and uncomfortable sensations in the MS population.

2007 Pain

9658. Phantom breast sensations and phantom breast pain: a 2-year prospective study and a methodological analysis of literature. (Abstract)

Phantom breast sensations and phantom breast pain: a 2-year prospective study and a methodological analysis of literature. The first aim of this study was to assess prospectively the incidence of phantom breast sensations (PB sensations) and phantom breast pain (PB pain) in a sample of patients treated for breast cancer (n=204) by means of a modified radical mastectomy (n=82). Patients were assessed 6 weeks, 6, 12 and 24 months after mastectomy, by means of a questionnaire. After 24 months (...) , assessments of 74 (90%) patients were available. Two years after mastectomy, PB sensations were present in 19% (n=14) of the patients and PB pain was present in 1% (n=1) of the patients. Over time the percentage of patients with PB sensations remained relatively stable (around 20%) but for PB pain the percentage reduced from 7% to 1%. The amount of suffering as a result of PB sensations or PB pain was very limited. PB sensations and PB pain are of little clinical relevance in the 24 months following

2007 European Journal of Pain

9659. Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. Full Text available with Trip Pro

Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. This is a retrospective study of 250 patients who describe low back pain with pain drawings. A computer application using artificial neural networks was designed to analyze pain drawings and evaluate the contribution of pain sensation to drawing classification.The primary goal of this study was to assess the contribution of patient recorded pain sensation marks in classifying pain drawings into one of five (...) broadly defined categories. The hypothesis was that including pain sensation would improve classification.With no perfect diagnostic test for patients with low back pain, many approaches have been proposed and are used. One common diagnostic tool is the pain drawing. Several quantitative methods have been proposed to score the drawings. Some methods use pain sensation in the scoring; however, the contribution of pain sensation has not been defined.A custom computer application classified the pain

2006 Spine

9660. Investigation of the paradoxical painful sensation ('illusion of pain') produced by a thermal grill. (Abstract)

Investigation of the paradoxical painful sensation ('illusion of pain') produced by a thermal grill. A paradoxical painful sensation can be elicited by the simultaneous application of innocuous warm and cold stimuli to the skin. In the present study, we analyzed the conditions of production of this unique experimental illusion of pain in 52 healthy volunteers (27 men, 25 women). The stimuli were produced by a thermode composed of six bars whose temperature was controlled by Peltier elements (...) . The temperature of alternate (even- and odd-numbered) bars could be controlled independently to produce various patterns of the 'thermal grill'. After measuring the cold and heat pain thresholds, a series of combinations of warm and cold stimuli, whose distance to the thermal pain threshold was at least 4 degrees C, were applied on the palmar surface of the right hand during 30s. After each stimulus, the subjects had to describe and rate their sensations on visual analog scales. Paradoxical painful sensations

2005 Pain

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