How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

9,679 results for

Pain Sensation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

9621. Effects of gender and age on esophageal biomechanical properties and sensation. (Abstract)

Effects of gender and age on esophageal biomechanical properties and sensation. The effects of gender and age on human esophageal function is poorly defined. Our aim was to investigate the sensory perception and the biomechanical properties of the esophagus both at the smooth muscle and the striated muscle segments in age- and gender-matched healthy subjects. Eleven older individuals (five men and six women, aged 55-82 yr) and 11 younger healthy individuals (five male and six female, aged 22-45 (...) and women. In contrast, at both of these segments, the cross-sectional area was larger (p < 0.05), the circumferential wall tension-strain association had shifted significantly (p < 0.05) to the left (i.e., the wall was stiffer), and the median thresholds for discomfort and pain were higher (p < 0.05) in older subjects. The biomechanical properties and thresholds for sensory perception also varied between the two esophageal segments.Aging was associated with a larger lumen and a stiffer but less

2003 The American journal of gastroenterology

9622. Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation. (Abstract)

Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation. Our aim was to investigate the effect of motilin on postprandial proximal gastric motor and sensory function in healthy volunteers. Ten fasted, healthy volunteers were infused intravenously with synthetic motilin or placebo over 90 min. A liquid meal (200 ml) was ingested within 2 min at the start of the infusion. Proximal gastric volume was measured with a barostat device. Abdominal symptoms were (...) scored by visual analog scales. Plasma motilin concentrations were measured using RIA. Endogenous motilin levels were not affected by meal ingestion. After meal intake, gastric relaxation was similar for motilin and placebo. After postprandial relaxation, motilin resulted in a faster return of gastric volume to baseline (P = 0.007). Motilin significantly increased postprandial feelings of nausea (P = 0.03) and tended to increase abdominal pain and abdominal tension. In conclusion, after normal

2002 Digestive diseases and sciences Controlled trial quality: uncertain

9623. Antipruritic and thermal sensation effects of hydrocortisone creams in human skin. (Abstract)

, random, comparative, controlled, single-dose and single-center study. Itch was experimentally induced in both forearms by intracutaneous injection of histamine in 18 subjects. Hydrocortisone 1%, 2.5% and placebo were applied to test sites on both forearms. The thermal threshold for warmth sensation, cold sensation, cold and heat pain was measured with the TSA. Itch magnitude was measured each minute after histamine injection for 10 min with a visual analogue scale (VAS). Itch duration was also (...) recorded. In comparison to placebo, 2.5% hydrocortisone significantly (p = 0.03) reduced itch duration from 12.6 +/- 11.0 min (mean +/- SD) to 8.6 +/- 8.2 min (the reducing rate was 32%) as well as itch magnitude (at minutes 3, 6, 7 and overall). Placebo, 1% and 2.5% hydrocortisone significantly altered (p <0.05) the cold sensation threshold. No treatment altered cold or heat pain thresholds. These data suggest that topical application of 2.5% hydrocortisone may be significantly beneficial

2001 Skin pharmacology and applied skin physiology Controlled trial quality: uncertain

9624. Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. (Abstract)

Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. Alosetron, a 5-HT3-receptor antagonist, relieves abdominal pain and improves bowel function in non-constipated, female patients with irritable bowel syndrome. 5-HT3 antagonists delay colonic transit, increase colonic compliance, and increase small intestinal water absorption.To evaluate the effects of alosetron on gastrointestinal and colonic transit, rectal compliance (...) and rectal sensation in irritable bowel syndrome.A double-blind, placebo-controlled, two-dose study of alosetron was performed in 25 non-constipated irritable bowel syndrome patients, with paired studies before and after 4 weeks of treatment with placebo (n=5), 1 mg alosetron (n=10) or 4 mg (n=10) alosetron b.d. Gastrointestinal and colonic transit were measured by scintigraphy. Rectal compliance and sensation were assessed by rectal balloon distention with a barostat.There was a trend (P=0.06) for 1 mg

2000 Alimentary pharmacology & therapeutics Controlled trial quality: uncertain

9625. Effect of pulse repetition rate on the perception of thermal sensation with pulsed shortwave diathermy. (Abstract)

Effect of pulse repetition rate on the perception of thermal sensation with pulsed shortwave diathermy. Pulsed shortwave diathermy (PSWD) is a form of therapy commonly used to enhance tissue repair and reduce pain. It is normally considered to be an athermal form of treatment; however, there is some evidence to suggest that thermal effects can arise with adequate dosage. The purpose of this study was to determine the pulse repetition rate (PRR) required to generate a 'possible' and 'definite (...) ' thermal sensation when PSWD was applied to the thigh.Thirty healthy subjects were randomly assigned to placebo or treatment groups. The treatment group was exposed to PSWD at a constant setting of pulse duration (400 microseconds) and pulse power (190 W) while the PRR was increased from 26 Hz to 400 Hz in 10 increments. Each dose was applied for a period of two minutes. At the end of each application, subjects were asked if they felt a (1) 'possible' or (2) 'definite' thermal sensation. Skin

2000 Physiotherapy research international : the journal for researchers and clinicians in physical therapy Controlled trial quality: uncertain

9626. Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. (Abstract)

Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. To compare the effect of topical 0.5% ketorolac tromethamine and 0.1% diclofenac sodium on human corneal sensitivity and to assess the intensity of burning sensation at specific intervals after drop instillation.Double-masked parallel clinical study.Eleven women and 4 men (8 white, 4 Hispanic, 3 Asian), 22 to 60 years of age (mean [ +/- SD], 34 +/- 10 years).Repeated instillation of either ketorolac (...) and placebo or diclofenac and placebo at 5-minute intervals.Assessment of corneal sensitivity before instillation, immediately after instillation, and after termination of drop application; and subjective evaluation of burning sensation by asking participants to rate burning on a scale ranging from 0 (none) to 3 (severe) after each drop application.Both diclofenac (P < .01) and ketorolac (P < .01) decreased corneal sensitivity significantly, while the placebo had no measurable effect. After administration

1996 Archives of ophthalmology Controlled trial quality: uncertain

9627. Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls. (Abstract)

and ACh had no additional effect on the magnitude of the sensation. In AE patients, the intensity was similar to that experienced by the control subjects, but the quality of sensation was different: ACh induced pain in the control subjects, pruritus in AE patients, and a mixture of pain and itching in AE patients showing no symptoms. Our results suggest that VIP- and ACh-induced skin reactions and the quality of the sensations depend on the activity of the atopic eczema. Confirming our former studies (...) Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls. We analysed vasoreactions and sensations of atopic eczema (AE) patients and healthy controls after intracutaneous (i.c.) injection of vasoactive intestinal polypeptide (VIP) and acetylcholine (ACh). Blood flow was measured by laser Doppler flowmetry (LDF). Plasma extravasation and flare size were evaluated planimetrically

1998 Archives of dermatological research Controlled trial quality: uncertain

9628. Effect of preoperative extradural bupivacaine and morphine on stump sensation in lower limb amputees. (Abstract)

Effect of preoperative extradural bupivacaine and morphine on stump sensation in lower limb amputees. We have examined the effect of preoperative extradural bupivacaine and morphine on postoperative stump sensation in 31 patients undergoing amputation of the lower limb in a prospective, randomized, double-blind study. Patients were allocated randomly to one of two groups: group 1 received extradural 0.25% bupivacaine 4-7 ml h-1 and morphine 0.16-0.28 ml h-1 before and during operation; group 2 (...) received extradural saline before and during amputation and conventional analgesics for pain treatment. All patients received general anaesthesia for the amputation and extradural bupivacaine and morphine after operation. Sensory examination of the limb/stump was carried out before amputation, and after 1 week and 6 months. The following were measured: pressure pain thresholds (pressure algometry), touch and pain detection thresholds (von Frey hairs), thermal sensibility (thermal rolls), and allodynia

1998 British Journal of Anaesthesia Controlled trial quality: uncertain

9629. Sensational developments in the irritable bowel. Full Text available with Trip Pro

Sensational developments in the irritable bowel. 9014782 1997 02 19 2018 11 13 0017-5749 39 5 1996 Nov Gut Gut Sensational developments in the irritable bowel. 770-1 Naliboff B B CURE Digestive Diseases Research Center/Neuroenteric Biology Group UCLA 90073, USA. Mayer E A EA eng Comment Journal Article England Gut 2985108R 0017-5749 50-56-6 Oxytocin AIM IM Gut. 1996 Nov;39(5):741-7 9014776 Afferent Pathways Colonic Diseases, Functional drug therapy psychology Humans Intestines innervation (...) Oxytocin therapeutic use Pain Threshold drug effects Perception drug effects 1996 11 1 1996 11 1 0 1 1996 11 1 0 0 ppublish 9014782 PMC1383408 Neurogastroenterol Motil. 1996 Mar;8(1):9-18 8697187 Gastroenterology. 1995 Dec;109(6):1742-9 7498637 Pain. 1977 Jun;3(3):187-211 327401 Pain. 1977 Aug;3(4):295-305 909711 Gastroenterology. 1995 Jul;109(1):40-52 7797041 Gastroenterology. 1994 Dec;107(6):1686-96 7958680 Pain. 1983 Nov;17(3):257-66 6657286 Gastroenterology. 1990 Oct;99(4):1008-15 2394323 Am J

1996 Gut

9630. Oesophageal sensation assessed by electrical stimuli and brain evoked potentials--a new model for visceral nociception. Full Text available with Trip Pro

-specific ('electrical') sensations were provoked at 28 cm (10 of 12). Thresholds of sensation and of pain were lower at the initial than the second determination, but did not differ with respect to stimulation site. The pain summation threshold to repeated stimuli (2 Hz, 5 stimuli) was determined for the first time in a viscus. This threshold was lower than the pain threshold to single stimuli at 38 cm (p < 0.02). Evoked potential latencies did not change significantly over a six month period while (...) Oesophageal sensation assessed by electrical stimuli and brain evoked potentials--a new model for visceral nociception. Sensory thresholds and brain evoked potentials were determined in 12 healthy volunteers using electrical stimulation of the oesophagus 28 and 38 cm from the nares. The peaks of the evoked potentials were designated N for negative deflections and P for positive. Continuous electrical stimulation (40 Hz) at the 38 cm position resembled heartburn (five of 12 subjects) while non

1995 Gut

9631. Relation between rectal sensation and anal function in normal subjects and patients with faecal incontinence. Full Text available with Trip Pro

seconds. Internal sphincter relaxation occurred before the sensation was perceived in three of 27 normal subjects and 11 of 16 patients (p less than 0.001), and could be associated with anal leakage, which stopped as soon as sensation was perceived. The lowest rectal volumes required to induce anal relaxation, to cause sustained relaxation, or to elicit sensations of a desire to defecate or pain were similar in patients and normal subjects. In conclusion, these results show the close association (...) Relation between rectal sensation and anal function in normal subjects and patients with faecal incontinence. The relation between sensory perception of rapid balloon distension of the rectum and the motor responses of the rectum and external and internal anal sphincters in 27 normal subjects and 16 patients with faecal incontinence who had impaired rectal sensation but normal sphincter pressures was studied. In both patients and normal subjects, the onset and duration of rectal sensation

1990 Gut

9632. Cognitive modulation of the cerebral processing of human oesophageal sensation using functional magnetic resonance imaging. Full Text available with Trip Pro

Cognitive modulation of the cerebral processing of human oesophageal sensation using functional magnetic resonance imaging. While cortical processing of visceral sensation has been described, the role that cognitive factors play in modulating this processing remains unclear.To investigate how selective and divided attention modulate the cerebral processing of oesophageal sensation.In seven healthy volunteers (six males, mean age 33 years; ranging from 24 to 41 years old) from the general (...) community, phasic visual and oesophageal (non-painful balloon distension) stimuli were presented simultaneously. During the selective attention task, subjects were instructed to press a button either to a change in frequency of oesophageal or visual stimuli. During a divided attention task, subjects received simultaneous visual and oesophageal stimuli and were instructed to press a button in response to a change in frequency of both stimuli.Selectively focussing attention on oesophageal stimuli

2003 Gut

9633. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. (Abstract)

Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation.In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were (...) measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model.Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic

1996 Gastroenterology Controlled trial quality: uncertain

9634. Southampton needle sensation questionnaire: development and validation of a measure to gauge acupuncture needle sensation. (Abstract)

Southampton needle sensation questionnaire: development and validation of a measure to gauge acupuncture needle sensation. The specific sensations (deqi) generated during acupuncture are thought to be important for a positive clinical outcome, particularly when treating pain. It is important to be able to measure these sensations and discriminate between deqi and pain. A greater understanding of this will greatly aid researchers who wish to conduct mechanistic studies of acupuncture. Previous (...) questionnaire designs failed to consider patient experience and, hence, may have been flawed. The aim of this study was to generate and validate a new sensation questionnaire, that was able to discriminate between pain and deqi, taking into account patient experience and expert opinions.The questionnaire was designed following qualitative interviews with patients, literature review, and consultation with experts. The questionnaire was piloted and then validated. It was successfully completed by 227 patients

2008 Journal of Alternative and Complementary Medicine

9635. Modification of neuropathic pain sensation through microglial ATP receptors Full Text available with Trip Pro

Modification of neuropathic pain sensation through microglial ATP receptors Neuropathic pain that typically develops when peripheral nerves are damaged through surgery, bone compression in cancer, diabetes, or infection is a major factor causing impaired quality of life in millions of people worldwide. Recently, there has been a rapidly growing body of evidence indicating that spinal glia play a critical role in the pathogenesis of neuropathic pain. Accumulating findings also indicate (...) that nucleotides play an important role in neuron-glia communication through P2 purinoceptors. Damaged neurons release or leak nucleotides including ATP and UTP to stimulate microglia through P2 purinoceptors expressing on microglia. It was shown in an animal model of neuropathic pain that microglial P2X(4) and P2X(7) receptors are crucial in pain signaling after peripheral nerve lesion. In this review, we describe the modification of neuropathic pain sensation through microglial P2X(4) and P2X(7

2007 Purinergic signalling

9636. Impaired pain sensation in mice lacking prokineticin 2 Full Text available with Trip Pro

Impaired pain sensation in mice lacking prokineticin 2 Prokineticins (PKs), consisting of PK1 and PK2, are a pair of newly identified regulatory peptides. Two closely related G-protein coupled receptors, PKR1 and PKR2, mediate the signaling of PKs. PKs/PKRs participate in the regulation of diverse biological processes, ranging from development to adult physiology. A number of studies have indicated the involvement of PKs/PKRs in nociception. Here we show that PK2 is a sensitizer for nociception

2006 Molecular pain

9637. Intracellular alkalization causes pain sensation through activation of TRPA1 in mice Full Text available with Trip Pro

Intracellular alkalization causes pain sensation through activation of TRPA1 in mice Vertebrate cells require a very narrow pH range for survival. Cells accordingly possess sensory and defense mechanisms for situations where the pH deviates from the viable range. Although the monitoring of acidic pH by sensory neurons has been attributed to several ion channels, including transient receptor potential vanilloid 1 channel (TRPV1) and acid-sensing ion channels (ASICs), the mechanisms by which (...) . Analyses of mutants suggested that the two N-terminal cysteine residues in TRPA1 were involved in activation by intracellular alkalization. Furthermore, intraplantar injection of ammonium chloride into the mouse hind paw caused pain-related behaviors that were not observed in TRPA1-deficient mice. These results suggest that alkaline pH causes pain sensation through activation of TRPA1 and may provide a molecular explanation for some of the human alkaline pH-related sensory disorders whose mechanisms

2008 The Journal of clinical investigation

9638. Heat/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome? (Abstract)

Heat/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome? To investigate the feasibility, safety, and efficacy of perineal cutaneous application of capsaicin as a test for the diagnosis, as well as a potential therapeutic tool, in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).We recruited 22 patients (mean age 34.5 years, range 19 to 56 (...) Symptom Index score decreased from 27 to 16 (P <0.01).We found a statistically significant difference in the pain visual analogue scale and interval between topical application and the onset of the heat/burning sensation between patients with CP/CPPS and healthy controls. The small sample size strongly suggests the need for additional larger and more controlled studies.

2006 Urology

9639. Painful and nonpainful phantom and stump sensations in acute traumatic amputees. (Abstract)

Painful and nonpainful phantom and stump sensations in acute traumatic amputees. The formation, prevalence, intensity, course, and predisposing factors of phantom limb pain were investigated to determine possible mechanisms of the origin of phantom limb pain in traumatic upper limb amputees.Ninety-six upper limb amputees participated in the study. A questionnaire assessed the following question: side, date, extension, and cause of amputation; preamputation pain; and presence or absence (...) of phantom pain, phantom and stump sensations or stump pain or both.The response rate was 84%. Sixty-five (81%) participants returned the questionnaire. In 64 (98.5%) participants a traumatic injury led to amputation; the amputation was necessary because of infection in one patient (1.5%). The median follow-up time (from amputation to evaluation) was 3.2 years (range, 0.9-3.8 years) The prevalence of phantom pain was 44.6%, phantom sensation 53.8%, stump pain 61.5%, and stump sensation 78.5%. After its

2008 Journal of Trauma

9640. Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. (Abstract)

Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: a double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. Diabetic peripheral neuropathy (DPN) has been thought to be progressive and irreversible. Recently, symptomatic reversal of DPN was reported after treatments with a near-infrared medical device, the Anodyne Therapy System (ATS). However, the study was not controlled nor was the investigator (...) blinded. We initiated this study to determine whether treatments with the ATS would decrease pain and/or improve sensation diminished due to DPN under a sham-controlled, double-blind protocol.Tests involved the use of the 5.07 and 6.65 Semmes Weinstein monofilament (SWM) and a modified Michigan Neuropathy Screening Instrument (MNSI). Twenty-seven patients, nine of whom were insensitive to the 6.65 SWM and 18 who were sensitive to this filament but insensitive to the 5.07 SWM, were studied. Each lower

2004 Diabetes Care Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>