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Pain Sensation

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9601. Neurectomy to prevent persistent pain after inguinal herniorraphy: a prospective study using objective criteria to assess pain. (PubMed)

pain, we prospectively studied 100 male patients with bilateral inguinal hernia who underwent tension-free surgical repair, combined with iliohypogastric neurectomy on the right side alone. Pain was evaluated postoperatively on days 1 and 7 and at 1 and 2 years by means of a visual analog scale. Patients were given a questionnaire including coded terms for describing pain. These terms were designed to compare pain on the neurectomized and non-neurectomized sides and assess altered sensation (...) Neurectomy to prevent persistent pain after inguinal herniorraphy: a prospective study using objective criteria to assess pain. Although tension-free mesh repair has markedly improved the outcome of inguinal hernia surgery, it has only minimally reduced the incidence of persistent postoperative pain. The pathogenesis of this complication and treatment remain unclear.In order to objectively assess whether iliohypogastric neurectomy reduces the incidence and intensity of persistent postoperative

2007 World Journal of Surgery

9602. Different lipid profiles as constituencies of liquid formula diets do not influence pain perception and the efficacy of opioids in a human model of acute pain and hyperalgesia. (PubMed)

for 2 h. Ongoing pain ratings as well as extension of pinprick-hyperalgesia and allodynia were compared between both liquid formula diets. In a second series of experiments, alfentanil (4.1+/-0.5 mg) was administered for 90 min using target-controlled infusions and measurements were performed as stated above. Oral administration of LCT as well as MCT may lead to different CCK blood levels, but we found no evidence for CCK-induced effects on pain sensation, touch-evoked allodynia, secondary (...) Different lipid profiles as constituencies of liquid formula diets do not influence pain perception and the efficacy of opioids in a human model of acute pain and hyperalgesia. Nutritional support and pain control by medication are often used concomitantly, but interactions are hardly investigated. A randomised, double-blind, cross-over study in ten right-handed volunteers was performed evaluating the influence of cholecystokinin (CCK)-excretion on the perception of pain in a standardised model

2003 Pain Controlled trial quality: uncertain

9603. Pain coping strategies play a role in the persistence of pain in post-herpetic neuralgia. (PubMed)

weeks later. Higher levels of ignoring pain sensations at baseline were prospectively correlated with more depressive symptoms 8 weeks later. These findings support a role for the continued investigation of cognitive-behavioral factors affecting the adaptation of elderly individuals experiencing PHN. (...) Pain coping strategies play a role in the persistence of pain in post-herpetic neuralgia. Post-herpetic neuralgia (PHN) is a neuropathic pain state that is often difficult to treat. Although frequently discussed in the clinical literature, little is known about the impact of pain on daily function and the extent to which psychosocial factors, in particular pain coping strategies, influence adaptation to this chronic illness. In the context of a crossover pharmacological trial, 68 patients

2003 Pain Controlled trial quality: uncertain

9604. The validity of the neuropathic pain scale for assessing diabetic neuropathic pain in a clinical trial. (PubMed)

The validity of the neuropathic pain scale for assessing diabetic neuropathic pain in a clinical trial. In controlled trials of analgesics for the treatment of neuropathic pain, the primary outcome variable is most often a measure of global pain intensity. However, because neuropathic pain is associated with a variety of pain sensations, the effects of analgesic treatments on different sensations could go undetected if specific pain qualities are not assessed. This study sought to evaluate (...) decreases in global pain intensity, pain unpleasantness, and sharp, dull, and deep pain sensations. Responder analyses indicated a higher rate of responding to the opioid condition, relative to placebo, for intense, unpleasant, deep, and surface pain. The opioid analgesic did not significantly reduce hot, cold, itchy, or sensitive pain sensations compared with placebo in either analysis.These findings support the utility of the NPS for characterizing the multidimensional nature of the neuropathic pain

2006 Clinical Journal of Pain Controlled trial quality: uncertain

9605. The impact of threatening information about pain on coping and pain tolerance. (PubMed)

of cognitive coping strategies (reinterpreting pain sensations, ignoring pain, diverting attention away from pain to other experiences, and using coping self-statements) than other respondents. A path analysis indicated that the relation between threat and pain tolerance was fully mediated by catastrophizing and cognitive coping. Together, findings suggest that pain appraised as threatening contributes to a specific pattern of coping responses associated with a reduced capacity to bear pain. (...) The impact of threatening information about pain on coping and pain tolerance. This study examined the impact of threatening information on coping and pain tolerance in a healthy adult sample. Prior to engaging in a Cold Pressor Test (CPT), 121 college students were randomly assigned to one of three conditions: a threat condition in which they read an orienting passage warning them about symptoms and consequences of frostbite (pain as a signal for nociception), a reassurance condition in which

2005 British journal of health psychology Controlled trial quality: uncertain

9606. The role of threat-expectancy in acute pain: effects on attentional bias, coping strategy effectiveness and response to pain. (PubMed)

pressor task while engaging in the relevant coping strategy. There was a significant effect of threat on bias towards affective vs sensory pain words. Participants in the threat condition showed a stronger bias towards affective pain words. In contrast, the no-threat condition displayed a stronger bias towards sensory pain words. Significant interaction effects were observed between threat and coping strategy for threshold and tolerance. These results indicated that focusing on sensory pain sensations (...) The role of threat-expectancy in acute pain: effects on attentional bias, coping strategy effectiveness and response to pain. The aims of this study were threefold. Firstly, to investigate the effect of increasing threat-expectancy on attentional biases towards pain-related words. Secondly, to determine the interaction between threat-expectancy and the effectiveness of two coping strategies on pain threshold and tolerance. Thirdly, to investigate the relationship between fear of pain

2005 Pain Controlled trial quality: uncertain

9607. Perception of pain after resistance exercise. (PubMed)

in heart rate, systolic blood pressure, and body awareness after exercise.A single bout of resistance exercise is capable of modifying the sensation of experimentally induced pain. (...) Perception of pain after resistance exercise. The main objective was to assess the influence of resistance exercise on pain threshold and pain ratings. Secondary objectives included measuring state anxiety, body awareness, systolic blood pressure, diastolic blood pressure, and heart rate responses.Pressure (3 kg force) was applied to the middle digit of the left hand for two minutes using a Forgione-Barber pain stimulator before and after (five minute and 15 minutes) resistance exercise

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1998 British Journal of Sports Medicine Controlled trial quality: uncertain

9608. Can gingko biloba cause loss of sensation in the perineum in males leading to reduced awareness of urination and ejaculation, and if so, how?

Can gingko biloba cause loss of sensation in the perineum in males leading to reduced awareness of urination and ejaculation, and if so, how? Can gingko biloba cause loss of sensation in the perineum in males leading to reduced awareness of urination and ejaculation, and if so, how? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only (...) for every single search. As well as research evidence we also allow clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Can gingko biloba cause loss of sensation in the perineum in males leading to reduced awareness of urination

2007 TRIP Answers

9609. Positron Emission Tomography to Measure Pain and Pain Control

that do not normally cause pain Ischemic stimulation - inflation of a blood pressure cuff on the arm or leg for up to 30 minutes These stimuli will be applied both before and during positron emission tomography (PET) scanning. This test shows which parts of the brain are active and which are not and is important for studying how different parts of the brain work together to feel and react to specific sensations. For this procedure, the subject lies on a table in the PET scanner while a series of scans (...) device is placed on the gel. The device emits high-frequency sound waves to produce a picture of the speed of blood flow in the artery and the diameter of the vessel. Condition or disease Intervention/treatment Healthy Hyperalgesia Pain Peripheral Nervous System Disease Drug: Oxygen-15 Water Drug: Capsaicin Detailed Description: Regional cerebral blood flow (rCBF) will be measured while normal subjects, patients with post-operative pain, and patients with neuropathic abnormalities of pain sensation

1999 Clinical Trials

9610. Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain. (PubMed)

, relative to stimulation of the homologous normal territory. LEP attenuation concerned not only patients with decreased pain/heat sensation, but also those with allodynia or hyperalgesia to laser pulses. In contrast, LEPs were never attenuated in patients with non-organic forms of pain, in whom LEPs could even be enhanced to stimulation of the painful territory. Increased responses in non-organic pain were a reminder of the cognitive modulation observed in normal subjects who direct attention to a laser (...) recorded, LEPs essentially reflect the activity of a 'lateral' pain system subserved at the periphery by rapidly conducting A-delta fibres. They are useful to document the sensorial deficits (deafferentation) leading to neuropathic pain syndromes. Conversely, in the case of deafferentation, they fail to index adequately the affective aspects of pain sensation. On practical grounds, chronic pain coupled with reduced LEPs substantiates the diagnosis of neuropathic pain, whereas the finding of normal

2002 Brain

9611. The postoperative pain experience: a description based on the McGill Pain Questionnaire. (PubMed)

pain tended to reflect greater intensity. The overall experience was characterized by 16 descriptors, selected by more than 30% of the sample and reflecting sensory, affective, and evaluative dimensions of the pain experience. Comparison of the findings from this combined sample drawn from hospitals in the northeastern United States were remarkably similar to those reported by Taenzer in Canada. The descriptors selected support, extend, and validate the kind of "sensation information" needed (...) The postoperative pain experience: a description based on the McGill Pain Questionnaire. In surgical nursing practice, postoperative pain is of particular concern because of its documented effect on recovery and behaviors associated with recovery. Yet, little is known about the nature of this pain, other than its intensity. In this study, a description of the nature of the postoperative pain experience was generated from analysis of patient responses to the McGill Pain Questionnaire in four

1992 Clinical nursing research Controlled trial quality: uncertain

9612. Underpredicted pain disrupts more than correctly predicted pain, but does not hurt more. (PubMed)

were informed that they would receive some painful (correct prediction) or non-painful tingling (underprediction) stimuli during the discrimination task. Starting just before five of the following 20 discrimination trials, 2 s of painful electrical stimulation was given. Subjects rated sensations and painfulness of the electrical stimulation, subjective anxiety, and degree of distraction from the task, after each pain stimulus. Reaction times of the discrimination task and heart rate were measured (...) Underpredicted pain disrupts more than correctly predicted pain, but does not hurt more. One of the explanations for the negative effects of underpredicted aversive experiences is that they have more impact than correctly predicted aversive experiences. In a laboratory experiment 40 normal female subjects executed an auditory discrimination task. Subjects were randomly assigned to a correct information condition and an underprediction information condition. After ten trials (baseline) subjects

1998 Behaviour research and therapy Controlled trial quality: uncertain

9613. Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain. (PubMed)

of sensibility and quantitative sensory testing (QST), i.e., assessments of perception thresholds for touch, touch-evoked pain, cold, warmth, painful heat, and cold, were performed. In the neuropathic area, sensation magnitude was rated by a visual analog scale (100 mm VAS) using a pin and at perception threshold for touch-evoked pain using von Frey filaments. Adenosine infusion reduced spontaneous pain (P < 0.05), and caused an increase of the touch-evoked pain threshold from 10.8 +/- 5.3 to 22.2 +/- 6.9 g (...) Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain. In seven patients with peripheral neuropathic pain, the effect of systemic adenosine infusion on pain symptoms was evaluated in a double-blind, placebo controlled, cross-over study. The study infusions, adenosine (50 micrograms.kg-1.min-1) or placebo, were given intravenously (IV) during 45-60 min at two separate occasions. Before and during infusions, bedside examination

1995 Anesthesia and analgesia Controlled trial quality: uncertain

9614. Transcutaneous electrical nerve stimulation: nonparallel antinociceptive effects on chronic clinical pain and acute experimental pain. (PubMed)

stimulation to the lumbosacral region for 60 minutes. The flexion reflex was elicited by an electrical stimulation applied to the subject's right sole and recorded electromyographically from the biceps femoris and the tibialis anterior muscles.Subjective sensation of low back pain and the electrically induced pain were measured by two separate visual analog scales, termed VAS(LBP) and VAS(FR), respectively. Data obtained before, during, and 60 minutes after TENS and placebo stimulations were analyzed (...) Transcutaneous electrical nerve stimulation: nonparallel antinociceptive effects on chronic clinical pain and acute experimental pain. To investigate to what extent a single 60-minute session of transcutaneous electrical nerve stimulation (TENS) would modify chronic clinical pain, acute experimental pain, and the flexion reflex evoked in chronic low back pain patients.Thirty young subjects with chronic low back pain were randomly allocated to two groups, receiving either TENS or placebo

1999 Archives of physical medicine and rehabilitation Controlled trial quality: uncertain

9615. Changes of cutaneous sensory thresholds induced by non-painful transcutaneous electrical nerve stimulation in normal subjects and in subjects with chronic pain. (PubMed)

Changes of cutaneous sensory thresholds induced by non-painful transcutaneous electrical nerve stimulation in normal subjects and in subjects with chronic pain. Transcutaneous electrical nerve stimulation (TENS) of the nervi cutaneus surae medialis was applied to 59 healthy subjects and 30 patients suffering from chronic myofascial pain in one lower limb, with an intensity of current that induced a well tolerated tingling sensation. Each period of stimulation lasted 24 minutes. The thresholds (...) of the tactile, tingling and painful sensations were tested at fixed intervals before, during and after stimulation. Trains of constant current square waves in the distribution area of the stimulated nerve (local thresholds) and in other areas (general thresholds) were used. In all subjects repeated changes of the current were necessary in order to maintain constant tingling during the first period of TENS (changing phase); after that few if any changes of the current were necessary (steady phase

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1981 Journal of neurology, neurosurgery, and psychiatry

9616. C nociceptor activity in human nerve during painful and non painful skin stimulation. (PubMed)

Frey hairs, varied between 2.3 and 13.1 g. The receptive field was circular or elliptical; for 33 units the mean axes were 6 mm and 7 mm. Mechanically evoked C fibre discharge even up to more than 10 spikes/s was not necessarily accompanied by pain sensation. Nettle sting evoked an irregular C fibre discharge (maximum 10 spikes/s) accompanied by a pricking and burning sensation; the sensation of itch which was sometimes reported, was not correlated with the discharge frequency. C fibre activation (...) by a chemical irritant (paint remover) also evoked an irregular discharge (maximum 3 to 6 spikes/s), accompanied by pricking and burning pain sensation. The C threshold for radiant heat usually lay below the subject's pain threshold. Increasing skin temperature produced increasing neural firing rate. The mean spike frequency rarely exceeded two spikes/s even with stimuli evoking strong heat pain. The occurrence of subjective heat pain response could be as well predicted from th C fibre spike frequency

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1981 Journal of neurology, neurosurgery, and psychiatry

9617. Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. (PubMed)

Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. Ten healthy volunteers and 13 patients with oesophageal motility disorders whose primary presenting complaint was chest pain were studied by distending an intraoesophageal balloon in 1 ml steps to the point of a sensation of discomfort. The net balloon pressure (intra-balloon pressure when inflated within the oesophagus minus the pressure recorded (...) differences between patients and controls of distending volume at perception of discomfort. Edrophonium, however, resulted in a significant reduction in distension threshold for pain (p less than 0.03) in patients. A similar though non-significant trend was seen in controls. In both controls and patients, distension volume for pain production after atropine was significantly (p less than 0.01) higher than after edrophonium. From these results and other published data, we suggest that the pain receptor

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1992 Gut

9618. Do fetuses feel pain? "Fetal pain" is a misnomer. (PubMed)

19;314(7088):1201 9146416 Fetus physiology Gestational Age Humans Pain physiopathology Perception physiology Sensation physiology Stress, Psychological Uncertainty 52097 Genetics and Reproduction KIE BoB Subject Heading: fetuses Full author name: Derbyshire, Stuart WG Full author name: Furedi, Ann Full author name: Glover, Vivette Full author name: Fisk, Nicholas Full author name: Szawarski, Zbigniew Full author name: Lloyd-Thomas, Adrian R Full author name: Fitzgerald, Maria 1996 9 28 1996 9 28 0 1 (...) Do fetuses feel pain? "Fetal pain" is a misnomer. 8842074 1996 11 05 2018 11 13 0959-8138 313 7060 1996 Sep 28 BMJ (Clinical research ed.) BMJ Do fetuses feel pain? "Fetal pain" is a misnomer. 795 Derbyshire S W SW University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford. Furedi A A eng Journal Article England BMJ 8900488 0959-8138 AIM E IM BMJ. 1997 Jan 25;314(7076):302-3 9022510 BMJ. 1997 Jan 25;314(7076):303 9022511 BMJ. 1997 Apr 19;314(7088):1201 9146415 BMJ. 1997 Apr

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1996 BMJ : British Medical Journal

9619. Do fetuses feel pain? Reflex responses do not necessarily signify pain. (PubMed)

Perception physiology Reflex physiology Sensation physiology 21 1996 9 28 1996 9 28 0 1 1996 9 28 0 0 ppublish 8842077 PMC2352206 Early Hum Dev. 1985 Nov;12(2):173-82 3905349 Dev Med Child Neurol. 1988 Apr;30(2):208-14 3384200 J Comp Neurol. 1988 May 15;271(3):355-86 2454966 J Comp Neurol. 1991 Aug 15;310(3):285-99 1787174 Pain. 1993 Mar;52(3):287-99 8460047 Lancet. 1993 Aug 7;342(8867):319-20 8101580 Pain. 1994 Jan;56(1):95-101 8159446 Lancet. 1994 Jul 9;344(8915):77-81 7912391 Pain. 1994 Mar;56(3):353 (...) Do fetuses feel pain? Reflex responses do not necessarily signify pain. 8842077 1996 11 05 2018 11 13 0959-8138 313 7060 1996 Sep 28 BMJ (Clinical research ed.) BMJ Do fetuses feel pain? Reflex responses do not necessarily signify pain. 797-8 Lloyd-Thomas A R AR Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London. Fitzgerald M M eng Journal Article Review England BMJ 8900488 0959-8138 AIM IM Fetus physiology Gestational Age Humans Pain physiopathology

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1996 BMJ : British Medical Journal

9620. Eliciting information on differential sensation of heat in those with and without poststroke aphasia using a visual analogue scale. (PubMed)

Eliciting information on differential sensation of heat in those with and without poststroke aphasia using a visual analogue scale. Aphasia can result in an inability to communicate the presence, location, or intensity of pain. Although visual analogue scales (VASs) exist, it is unknown whether they are useful in assessing pain in individuals with aphasia. The objective was to determine whether those with poststroke aphasia could respond differentially to thermal stimuli of varying intensities

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2006 Stroke

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