How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

9,679 results for

Pain Sensation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

9581. Pain coping strategies play a role in the persistence of pain in post-herpetic neuralgia. (Abstract)

weeks later. Higher levels of ignoring pain sensations at baseline were prospectively correlated with more depressive symptoms 8 weeks later. These findings support a role for the continued investigation of cognitive-behavioral factors affecting the adaptation of elderly individuals experiencing PHN. (...) Pain coping strategies play a role in the persistence of pain in post-herpetic neuralgia. Post-herpetic neuralgia (PHN) is a neuropathic pain state that is often difficult to treat. Although frequently discussed in the clinical literature, little is known about the impact of pain on daily function and the extent to which psychosocial factors, in particular pain coping strategies, influence adaptation to this chronic illness. In the context of a crossover pharmacological trial, 68 patients

2003 Pain Controlled trial quality: uncertain

9582. The postoperative pain experience: a description based on the McGill Pain Questionnaire. (Abstract)

pain tended to reflect greater intensity. The overall experience was characterized by 16 descriptors, selected by more than 30% of the sample and reflecting sensory, affective, and evaluative dimensions of the pain experience. Comparison of the findings from this combined sample drawn from hospitals in the northeastern United States were remarkably similar to those reported by Taenzer in Canada. The descriptors selected support, extend, and validate the kind of "sensation information" needed (...) The postoperative pain experience: a description based on the McGill Pain Questionnaire. In surgical nursing practice, postoperative pain is of particular concern because of its documented effect on recovery and behaviors associated with recovery. Yet, little is known about the nature of this pain, other than its intensity. In this study, a description of the nature of the postoperative pain experience was generated from analysis of patient responses to the McGill Pain Questionnaire in four

1992 Clinical nursing research Controlled trial quality: uncertain

9583. Transcutaneous electrical nerve stimulation: nonparallel antinociceptive effects on chronic clinical pain and acute experimental pain. (Abstract)

stimulation to the lumbosacral region for 60 minutes. The flexion reflex was elicited by an electrical stimulation applied to the subject's right sole and recorded electromyographically from the biceps femoris and the tibialis anterior muscles.Subjective sensation of low back pain and the electrically induced pain were measured by two separate visual analog scales, termed VAS(LBP) and VAS(FR), respectively. Data obtained before, during, and 60 minutes after TENS and placebo stimulations were analyzed (...) Transcutaneous electrical nerve stimulation: nonparallel antinociceptive effects on chronic clinical pain and acute experimental pain. To investigate to what extent a single 60-minute session of transcutaneous electrical nerve stimulation (TENS) would modify chronic clinical pain, acute experimental pain, and the flexion reflex evoked in chronic low back pain patients.Thirty young subjects with chronic low back pain were randomly allocated to two groups, receiving either TENS or placebo

1999 Archives of physical medicine and rehabilitation Controlled trial quality: uncertain

9584. Underpredicted pain disrupts more than correctly predicted pain, but does not hurt more. (Abstract)

were informed that they would receive some painful (correct prediction) or non-painful tingling (underprediction) stimuli during the discrimination task. Starting just before five of the following 20 discrimination trials, 2 s of painful electrical stimulation was given. Subjects rated sensations and painfulness of the electrical stimulation, subjective anxiety, and degree of distraction from the task, after each pain stimulus. Reaction times of the discrimination task and heart rate were measured (...) Underpredicted pain disrupts more than correctly predicted pain, but does not hurt more. One of the explanations for the negative effects of underpredicted aversive experiences is that they have more impact than correctly predicted aversive experiences. In a laboratory experiment 40 normal female subjects executed an auditory discrimination task. Subjects were randomly assigned to a correct information condition and an underprediction information condition. After ten trials (baseline) subjects

1998 Behaviour research and therapy Controlled trial quality: uncertain

9585. Pain sensitization in male chronic pelvic pain syndrome: why are symptoms so difficult to treat? (Abstract)

thermode programmed to deliver 2 series of 4 rapid bursts of noxious heat stimuli to the perineum and the anterior thigh. The subjects reported sensation on a computerized visual analog scale (COVAS) with a manual sliding lever. The average peak COVAS values and time to peak values from thigh and perineum of each series of thermal bursts were compared between CPPS and controls.The mean pain score on questionnaires was 9.7 (4 or greater indicating significant pain), mean urinary score was 4.7 (range 0 (...) to 10) and mean quality of life impact score was 7.3 (range 3 to 13). Compared to controls men with CPPS reported higher mean peak COVAS values in the perineum. There was no difference between groups in the peak COVAS value on the thigh.Men with CPPS have altered heat sensation/pain sensitization in the perineum compared to controls. This finding is another that supports the resemblance of CPPS to other chronic pain syndromes and may help explain why CPPS is often refractory to treatment. Further

2003 Journal of Urology

9586. Positron Emission Tomography to Measure Pain and Pain Control

that do not normally cause pain Ischemic stimulation - inflation of a blood pressure cuff on the arm or leg for up to 30 minutes These stimuli will be applied both before and during positron emission tomography (PET) scanning. This test shows which parts of the brain are active and which are not and is important for studying how different parts of the brain work together to feel and react to specific sensations. For this procedure, the subject lies on a table in the PET scanner while a series of scans (...) device is placed on the gel. The device emits high-frequency sound waves to produce a picture of the speed of blood flow in the artery and the diameter of the vessel. Condition or disease Intervention/treatment Healthy Hyperalgesia Pain Peripheral Nervous System Disease Drug: Oxygen-15 Water Drug: Capsaicin Detailed Description: Regional cerebral blood flow (rCBF) will be measured while normal subjects, patients with post-operative pain, and patients with neuropathic abnormalities of pain sensation

1999 Clinical Trials

9587. Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. Full Text available with Trip Pro

Site and mechanism of pain perception with oesophageal balloon distension and intravenous edrophonium in patients with oesophageal chest pain. Ten healthy volunteers and 13 patients with oesophageal motility disorders whose primary presenting complaint was chest pain were studied by distending an intraoesophageal balloon in 1 ml steps to the point of a sensation of discomfort. The net balloon pressure (intra-balloon pressure when inflated within the oesophagus minus the pressure recorded (...) differences between patients and controls of distending volume at perception of discomfort. Edrophonium, however, resulted in a significant reduction in distension threshold for pain (p less than 0.03) in patients. A similar though non-significant trend was seen in controls. In both controls and patients, distension volume for pain production after atropine was significantly (p less than 0.01) higher than after edrophonium. From these results and other published data, we suggest that the pain receptor

1992 Gut

9588. Do fetuses feel pain? "Fetal pain" is a misnomer. Full Text available with Trip Pro

19;314(7088):1201 9146416 Fetus physiology Gestational Age Humans Pain physiopathology Perception physiology Sensation physiology Stress, Psychological Uncertainty 52097 Genetics and Reproduction KIE BoB Subject Heading: fetuses Full author name: Derbyshire, Stuart WG Full author name: Furedi, Ann Full author name: Glover, Vivette Full author name: Fisk, Nicholas Full author name: Szawarski, Zbigniew Full author name: Lloyd-Thomas, Adrian R Full author name: Fitzgerald, Maria 1996 9 28 1996 9 28 0 1 (...) Do fetuses feel pain? "Fetal pain" is a misnomer. 8842074 1996 11 05 2018 11 13 0959-8138 313 7060 1996 Sep 28 BMJ (Clinical research ed.) BMJ Do fetuses feel pain? "Fetal pain" is a misnomer. 795 Derbyshire S W SW University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford. Furedi A A eng Journal Article England BMJ 8900488 0959-8138 AIM E IM BMJ. 1997 Jan 25;314(7076):302-3 9022510 BMJ. 1997 Jan 25;314(7076):303 9022511 BMJ. 1997 Apr 19;314(7088):1201 9146415 BMJ. 1997 Apr

1996 BMJ : British Medical Journal

9589. Do fetuses feel pain? Reflex responses do not necessarily signify pain. Full Text available with Trip Pro

Perception physiology Reflex physiology Sensation physiology 21 1996 9 28 1996 9 28 0 1 1996 9 28 0 0 ppublish 8842077 PMC2352206 Early Hum Dev. 1985 Nov;12(2):173-82 3905349 Dev Med Child Neurol. 1988 Apr;30(2):208-14 3384200 J Comp Neurol. 1988 May 15;271(3):355-86 2454966 J Comp Neurol. 1991 Aug 15;310(3):285-99 1787174 Pain. 1993 Mar;52(3):287-99 8460047 Lancet. 1993 Aug 7;342(8867):319-20 8101580 Pain. 1994 Jan;56(1):95-101 8159446 Lancet. 1994 Jul 9;344(8915):77-81 7912391 Pain. 1994 Mar;56(3):353 (...) Do fetuses feel pain? Reflex responses do not necessarily signify pain. 8842077 1996 11 05 2018 11 13 0959-8138 313 7060 1996 Sep 28 BMJ (Clinical research ed.) BMJ Do fetuses feel pain? Reflex responses do not necessarily signify pain. 797-8 Lloyd-Thomas A R AR Department of Anaesthesia, Great Ormond Street Hospital for Children NHS Trust, London. Fitzgerald M M eng Journal Article Review England BMJ 8900488 0959-8138 AIM IM Fetus physiology Gestational Age Humans Pain physiopathology

1996 BMJ : British Medical Journal

9590. The effects of A-fiber pressure block on perception and neurophysiological correlates of brief non-painful and painful CO2 laser stimuli in humans. (Abstract)

of pain reports from 39% to 10%. The quality of sensations became mainly 'light touch' and the 'pricking' sensation almost vanished. The stimulus-VAS curve shifted to the right and the slope was reduced. Signal Detection Theory analysis revealed that discrimination performance (P(A)) was significantly depressed and that response bias (B) evolved from a neutral towards a stoical attitude. Median RT increased from 492 to 1355ms. The late LEPs, attributed to the activation of Adelta-fibers, disappeared (...) The effects of A-fiber pressure block on perception and neurophysiological correlates of brief non-painful and painful CO2 laser stimuli in humans. This study examined the relative capacity of Adelta- and C-fibers to encode non-painful and painful brief CO(2) laser stimuli by comparing the effects of Adelta/C-fiber activation versus C-fiber activation alone. In nine normal subjects, brief CO(2) laser pulses of four different intensities (range 5.8-10.6mJ/mm(2)) were delivered at random

2003 European Journal of Pain

9591. Laser-evoked potential abnormalities in central pain patients: the influence of spontaneous and provoked pain. (Abstract)

, relative to stimulation of the homologous normal territory. LEP attenuation concerned not only patients with decreased pain/heat sensation, but also those with allodynia or hyperalgesia to laser pulses. In contrast, LEPs were never attenuated in patients with non-organic forms of pain, in whom LEPs could even be enhanced to stimulation of the painful territory. Increased responses in non-organic pain were a reminder of the cognitive modulation observed in normal subjects who direct attention to a laser (...) recorded, LEPs essentially reflect the activity of a 'lateral' pain system subserved at the periphery by rapidly conducting A-delta fibres. They are useful to document the sensorial deficits (deafferentation) leading to neuropathic pain syndromes. Conversely, in the case of deafferentation, they fail to index adequately the affective aspects of pain sensation. On practical grounds, chronic pain coupled with reduced LEPs substantiates the diagnosis of neuropathic pain, whereas the finding of normal

2002 Brain

9592. Comparison of the pain suppressive effects of clinical and experimental painful conditioning stimuli. (Abstract)

patients presenting with a traumatic peripheral nerve injury associated with dynamic mechano-allodynia (i.e. pain triggered by brushing) or static mechano-allodynia (i.e. pain triggered by light pressure stimuli) were included in this study. To investigate counterirritation mechanisms in these patients, we analysed the RIII nociceptive flexion reflex and concomitant painful sensation elicited by electrical stimulation of the sural nerve. We compared the effects of heterotopic 'clinical' conditioning (...) stimuli (i.e. pain evoked by brushing or pressure within the allodynic area located in the upper limb or chest) to those of experimental heterotopic noxious stimuli (HNCS) consisting of a cold pressor test or tourniquet test applied to the normal upper limb. Static mechano-allodynia induced inhibitions of both the RIII reflex and the concomitant painful sensation. These effects were similar to those induced by HNCS and were probably due to an increased activation of DNIC. In contrast, in patients

2003 Brain

9593. Selective attention to pain-related information in chronic musculoskeletal pain patients. (Abstract)

Selective attention to pain-related information in chronic musculoskeletal pain patients. Cognitive-behavioural models of chronic pain contend that appraisals of harm affect the individual's response to pain. It has been suggested that fear of pain and/or anxiety sensitivity predispose individuals to chronicity. According to this view, pain is maintained through hypervigilance towards painful sensations and subsequent avoidance. The present study investigates the nature of cognitive biases (...) in chronic pain patients. A sample of 169 consecutive patients referred to a specialist pain management centre participated in the study. Questionnaires measuring different aspects of pain and a computerised version of the Dot-Probe Task were administered. Four types of words related to different dimensions of pain and matched, neutral words were used as stimuli. Reaction times in response to the stimuli were recorded. A factorial design 3 x 4 x 2 x 2 and ANOVAs were employed to analyse the data. Chronic

2003 Pain

9594. How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation Full Text available with Trip Pro

How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation Recognition of temperature is a critical element of sensory perception and allows us to evaluate both our external and internal environments. In vertebrates, the somatosensory system can discriminate discrete changes in ambient temperature, which activate nerve endings of primary afferent fibers. These thermosensitive nerves can be further segregated into those that detect either innocuous or noxious (painful) temperatures (...) ; the latter neurons being nociceptors. We now know that thermosensitive afferents express ion channels of the transient receptor potential (TRP) family that respond at distinct temperature thresholds, thus establishing the molecular basis for thermosensation. Much is known of those channels mediating the perception of noxious heat; however, those proposed to be involved in cool to noxious cold sensation, TRPM8 and TRPA1, have only recently been described. The former channel is a receptor for menthol

2005 Molecular pain

9595. Inside information – The unique features of visceral sensation Full Text available with Trip Pro

Inside information – The unique features of visceral sensation Most of what is written and believed about pain and nociceptors originates from studies of the "somatic" (non-visceral) sensory system. As a result, the unique features of visceral pain are often overlooked. In the clinic, the management of visceral pain is typically poor, and drugs that are used with some efficacy to treat somatic pain often present unwanted effects on the viscera. For these reasons, a better understanding

2008 Molecular interventions

9596. Effect of intravesical Resiniferatoxin (RTX) on lower urinary tract symptoms, urodynamic parameters, and quality of life of patients with urodynamic increased bladder sensation. (Abstract)

Effect of intravesical Resiniferatoxin (RTX) on lower urinary tract symptoms, urodynamic parameters, and quality of life of patients with urodynamic increased bladder sensation. Intravesical resiniferatoxin (RTX) has been used with variable efficacy in the treatment of detrusor overactivity (DO). Patients with interstitial cystitis (IC) failed to benefit from this treatment, but a single placebo-controlled study in patients with non-IC painful bladders showed that RTX was effective in the short (...) -term. We investigated the efficacy of intravesical RTX in patients with urgency and frequency due to increased bladder sensation.Patients with intractable urgency and frequency, with or without urgency incontinence or bladder pain/discomfort, and with no urodynamic evidence of DO were recruited. After a single intravesical instillation of 100ml 50 nM RTX solution, patients were followed at 1, 3, and 6 mo for changes in urodynamics, bladder diary, the King's Health Questionnaire (KHQ), and degree

2006 European Urology

9597. Salvage of sensation in a hallux-to-thumb transfer by nerve tube reconstruction. (Abstract)

Salvage of sensation in a hallux-to-thumb transfer by nerve tube reconstruction. We report a patient in whom, at 3 years after successful reconstruction of a right avulsed thumb with a microvascular hallux transfer, the insensate transfer had sensibility restored. The radial sensory and both volar digital nerves of the thumb were reconstructed using 2.3-mm-diameter bioabsorbable neural conduits. At 30 months after reconstruction, static 2-point discrimination of the hallux was 4 mm at 14.7 g/mm (...) (2) in this now 42-year-old right-handed man. The cutaneous pressure threshold for 1-point static touch was 0.7 g/mm(2). There were no painful neuromas at the nerve reconstruction sites.

2006 Journal of Hand Surgery - American

9598. Dyspnea as a noxious sensation: inspiratory threshold loading may trigger diffuse noxious inhibitory controls in humans. Full Text available with Trip Pro

Dyspnea as a noxious sensation: inspiratory threshold loading may trigger diffuse noxious inhibitory controls in humans. Dyspnea, a leading respiratory symptom, shares many clinical, physiological, and psychological features with pain. Both activate similar brain areas. The neural mechanisms of dyspnea are less well described than those of pain. The present research tested the hypothesis of common pathways between the two sensations. Six healthy men (age 30-40 yr) were studied. The spinal (...) . The myotatic H-reflex was not inhibited by inspiratory loading, arguing against postsynaptic alpha motoneuron inhibition. Dyspnea, like pain, thus induced counterirritation, possibly indicating a C-fiber stimulation and activation of diffuse noxious inhibitory descending controls known to project onto spinal dorsal horn wide dynamic range neurons. This confirms the noxious nature of certain types of breathlessness, thus opening new physiological and perhaps therapeutic perspectives.

2007 Journal of neurophysiology Controlled trial quality: uncertain

9599. Qualitative descriptors used by patients following orthognathic surgery to portray altered sensation. Full Text available with Trip Pro

and inflammation ("swollen," "tender," and "burning") than patients without genioplasty; however, this difference decreased with time after surgery.The current findings indicate that patients' selection of words differentiates individuals who experienced only a simple loss in sensation (ie, present negative symptoms), those who experienced active sensations that are not normally present (ie, present positive symptoms), and those whose active sensations are additionally uncomfortable or painful. It is possible (...) Qualitative descriptors used by patients following orthognathic surgery to portray altered sensation. Following orthognathic surgery, patients use qualitatively different words to describe the altered sensation on their face that results from tissue inflammation and nerve injury. These words indicate normal, hypoesthetic, paresthetic, and dysesthetic sensations, and reflect the intrusiveness of the alteration. Our intent was to study the words chosen by patients from a standardized list

2006 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Controlled trial quality: uncertain

9600. Sensory retraining after orthognathic surgery: effect on patients' perception of altered sensation. Full Text available with Trip Pro

alone.A total of 186 subjects were enrolled in a multicenter, double-blind, 2 parallel group-stratified block randomized clinical trial. Oral and facial pain, unusual sensations, numbness, and loss of sensitivity were scored from "no problem" to "serious problem" before surgery and 1 month, 3 months, and 6 months after surgery. A proportional odds model for the ordered multinomial response was used to compare the responses of the 2 exercise groups.The 2 exercise groups did not differ significantly (...) at any postsurgical time in terms of perceived problem level from intraoral of facial pain. The difference between the 2 groups at each visit was not statistically significant for unusual sensations, although the trend was for the sensory retraining group to have a higher likelihood of reporting fewer problems. By 6 months, the likelihood of a subject reporting lower problem or interference level related to numbness or decreased lip sensitivity was significantly higher in the sensory-retraining group

2007 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>