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Pain Sensation

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9561. Segmental noxious versus innocuous electrical stimulation for chronic pain relief and the effect of fading sensation during treatment. (Abstract)

Segmental noxious versus innocuous electrical stimulation for chronic pain relief and the effect of fading sensation during treatment. It is not clear whether segmental innocuous stimulation has a stronger analgesic effect than segmental noxious stimulation for chronic pain and whether the fading of current sensation during treatment interferes with the analgesic effect, as suggested by the gate control theory. Electrical stimulation (by way of Interferential Current) applied at the pain area (...) (segmental) was administered to 4 groups of patients with osteoarthritis (OA) knee pain. Two groups were administered with noxious stimulation (30% above pain threshold) and two with innocuous stimulation (30% below pain threshold). In each group half of the patients received a fixed current intensity while the other half raised the intensity continuously during treatment whenever fading of sensation was perceived. Group 5 and 6 received sham stimulation and no treatment, respectively. The outcome

2005 Pain Controlled trial quality: uncertain

9562. Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis. (Abstract)

Menstrual cycle affects bladder pain sensation in subjects with interstitial cystitis. Using psychophysical methods we compared the effect of the menstrual cycle on bladder sensation in subjects with the diagnosis of interstitial cystitis (IC) and in controls.Female participants with normal menstrual cycles, including 7 with IC and 8 healthy controls, were recruited into this study. They completed daily diaries related to bladder pain and other body pain, and tracked daily micturition frequency (...) . In a subset formal psychophysical testing of thermal and ischemic pain was performed at 2 times of the menstrual cycle, corresponding to the luteal and follicular phases. Cystometrograms were performed at the same time.Subjects with IC had higher pain scores and frequency than controls throughout the entire menstrual cycle. Pain scores were highest in the perimenstrual period in subjects with IC and controls. Micturition frequency was highest in the perimenstrual period in subjects with IC. Cystometric

2005 Journal of Urology

9563. Quantitative measurement of pain sensation in patients with Parkinson disease. (Abstract)

Quantitative measurement of pain sensation in patients with Parkinson disease. Pain is common in patients with Parkinson disease (PD) and can precede the diagnosis of the disease. Experimental studies and clinical evidence indicate involvement of basal ganglia and dopaminergic pathways in central pain processing.To quantitatively assess and compare pain perception in patients with unilateral PD with and without pain and in patients with response fluctuations.Thirty-six patients with PD (mean (...) age, 61.8 +/- 11.2 years) with predominantly unilateral disease, 15 patients with response fluctuations (mean age, 65.3 +/- 10.4 years), and 28 age-matched healthy control subjects participated in the study. Subjective pain was assessed using the visual analog scale with von Frey filaments for tactile thresholds and contact thermode for warm sensation (WS) and heat pain thresholds (HPTs).Tactile and WS thresholds did not differ between patients in both patient groups and control subjects nor

2004 Neurology

9564. The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation. (Abstract)

The role of heterosynaptic facilitation in long-term potentiation (LTP) of human pain sensation. Long-term potentiation (LTP) of nociceptive synaptic transmission induced by high-frequency electrical stimulation (HFS) predominantly modulates natural somatosensory perceptions mediated by Adelta- and Abeta-fibers in humans at the site of conditioning stimulation. The relative contribution of homo- and heterosynaptic mechanisms underlying those perceptual changes remained unclear. We therefore (...) : a significant decrease of pain threshold and an increase of pain sensation to suprathreshold pinprick stimuli (punctate mechanical hyperalgesia; p<0.001) as well as pain to light tactile stimuli (dynamic mechanical allodynia; p<0.01). Changes at the heterotopic zone were about 30% less than at the homotopic conditioned zone, but they were highly correlated between both zones for suprathreshold painful stimuli (r=0.85-0.90) and for pain thresholds (r=0.51-0.66). Moreover, a small decrease of thresholds

2008 Pain

9565. Spatial summation and spatial discrimination of pain sensation. (Abstract)

Spatial summation and spatial discrimination of pain sensation. The aims of this study were to explore: (a) the interrelation between spatial summation (SS) and spatial discrimination (SD) of pain, (b) whether the two phenomena are subserved by different sensory channels. SS and SD of pain were measured with contact heat stimuli delivered at slow (0.50 degrees C/s) and fast (40 degrees C/s) rise times. Pressure nerve block of the radial nerve was employed to assess whether differential (...) activation of C and A delta fibers is obtained by these different rates of rise. Two discrete stimuli (each 3x3 cm) were applied to the forearm with separation distances between them varying from 0 to 30 cm. A single stimulus or two applied simultaneously were employed. For each distance heat-pain threshold (HPT) and suprathreshold pain ratings were obtained and subjects were asked to report the number of pain spots perceived (SD). SS of HPT occurred at separations smaller than 10 cm whereas significant

2006 Pain

9566. Persistent pain and uncomfortable sensations in persons with multiple sclerosis. (Abstract)

Persistent pain and uncomfortable sensations in persons with multiple sclerosis. The experience of pain has been documented in small studies of individuals with multiple sclerosis (MS). The present study examines the prevalence of persistent pain and uncomfortable sensations among participants in the large North American Research Committee on MS (NARCOMS) Patient Registry. Registrants (10,176) responded to a questionnaire on pain and 7579 reported experiencing some level of pain during (...) satisfaction with management of intense pain, and the perceived interference with quality of life indicators necessitate greater attention by healthcare providers to the management of pain and uncomfortable sensations in the MS population.

2007 Pain

9567. An unusual case of painful phantom-limb sensations during regional anesthesia. (Abstract)

An unusual case of painful phantom-limb sensations during regional anesthesia. The objective of this article is to describe a late-onset phantom-limb pain during a continuous analgesic popliteal nerve block after foot surgery and its alleviation and recurrence when stopping and resuming the local anesthetic infusion.A 29-year-old woman undergoing a left hallux valgus repair received a continuous popliteal sciatic nerve block for postoperative analgesia. Postoperatively, 6 hours after (...) the commencement of a ropivacaine 0.2% infusion, she reported feelings of tingling, clenching pain, and missing-limb sensation below the ankle. The surgical site remained painless. Sensation elicited by touch and propioception were normally perceived. Only sensations for pinprick and heat were impaired. The ropivacaine infusion was stopped, followed 2.5 hours later by the complete regression of any abnormal sensation. Meanwhile, pain at the surgical site was scored at 50 mm on a 100-mm visual analogic scale

2004 Regional Anesthesia and Pain Medicine

9568. Phantom breast sensations and phantom breast pain: a 2-year prospective study and a methodological analysis of literature. (Abstract)

Phantom breast sensations and phantom breast pain: a 2-year prospective study and a methodological analysis of literature. The first aim of this study was to assess prospectively the incidence of phantom breast sensations (PB sensations) and phantom breast pain (PB pain) in a sample of patients treated for breast cancer (n=204) by means of a modified radical mastectomy (n=82). Patients were assessed 6 weeks, 6, 12 and 24 months after mastectomy, by means of a questionnaire. After 24 months (...) , assessments of 74 (90%) patients were available. Two years after mastectomy, PB sensations were present in 19% (n=14) of the patients and PB pain was present in 1% (n=1) of the patients. Over time the percentage of patients with PB sensations remained relatively stable (around 20%) but for PB pain the percentage reduced from 7% to 1%. The amount of suffering as a result of PB sensations or PB pain was very limited. PB sensations and PB pain are of little clinical relevance in the 24 months following

2007 European Journal of Pain

9569. Prospective diary study of nonpainful and painful phantom sensations in a preselected sample of child and adolescent amputees reporting phantom limbs. (Abstract)

Prospective diary study of nonpainful and painful phantom sensations in a preselected sample of child and adolescent amputees reporting phantom limbs. To prospectively study factors associated with the occurrence of phantom sensations and pains in a pre-selected sample of child and adolescent amputees reporting phantom limbs.Prospective diary study over 1 month.Fourteen child and adolescent amputees from 10-18 years of age who were missing a limb due to trauma (n = 12) or congenital limb (...) deficiency (n = 2), and who had previously reported having phantom sensations and pain.Diary used to assess the occurrence of non-painful and painful phantom sensations. Items included age, sex, location and cause of amputation, past experience with stump pain and pre-amputation pain, and intensity, quality, duration, and triggers of the sensations and pains.Thirteen amputees reported having 104 incidents of non-painful phantom sensations with an average intensity of 4.17 (SD = 2.14) on a 0-10 rating

2004 Clinical Journal of Pain

9570. Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. (Abstract)

Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. To our knowledge there are no studies evaluating the prevalence and characteristics of itch, pain, and burning sensation among patients with mild to moderate chronic venous insufficiency or assessing the impact of these symptoms on quality of life. In this report 100 patients met the inclusion criteria. Patients who suffered from itch were also assessed (...) with the use of a validated questionnaire and a modified Skindex-16 questionnaire. We found that the prevalence of itch was 66%. Concomitant itch and burning sensation as well as itch and pain were noted in 47% and 44% of the patients, respectively. No correlation was noted between the severity of these symptoms and the degree of venous insufficiency. Itch had a negative impact on quality of life. A limitation of this study is that the participants, who were primarily hospital employees, are more likely

2005 Journal of American Academy of Dermatology

9571. Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. (Abstract)

Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. To test the hypothesis that abdominal pain related to functional gastrointestinal disorders is associated with visceral hypersensitivity and abnormal perception of visceral sensations.We examined 35 children (10-17.6 years old) fulfilling the Rome II criteria with irritable bowel syndrome (IBS; n = 21), functional abdominal pain (FAP; n = 8) or functional (...) dyspepsia (FD; n = 6) compared with 10 control subjects (10.2-16.1 years). All underwent a rectal barostat examination. Painful sensations were reported on a human body diagram. The projections of sensations induced by rectal distension, the rectal sensory threshold for pain (RSTP) and the diagnostic value of RSTP measurements were measured.Rectal distension induced sensations that projected to the S3 dermatome in the control subjects and FD and to aberrant sites in children with IBS and FAP. The RSTP

2007 Journal of Pediatrics

9572. Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. Full Text available with Trip Pro

Pain drawing scoring is not improved by inclusion of patient-reported pain sensation. This is a retrospective study of 250 patients who describe low back pain with pain drawings. A computer application using artificial neural networks was designed to analyze pain drawings and evaluate the contribution of pain sensation to drawing classification.The primary goal of this study was to assess the contribution of patient recorded pain sensation marks in classifying pain drawings into one of five (...) broadly defined categories. The hypothesis was that including pain sensation would improve classification.With no perfect diagnostic test for patients with low back pain, many approaches have been proposed and are used. One common diagnostic tool is the pain drawing. Several quantitative methods have been proposed to score the drawings. Some methods use pain sensation in the scoring; however, the contribution of pain sensation has not been defined.A custom computer application classified the pain

2006 Spine

9573. Investigation of the paradoxical painful sensation ('illusion of pain') produced by a thermal grill. (Abstract)

Investigation of the paradoxical painful sensation ('illusion of pain') produced by a thermal grill. A paradoxical painful sensation can be elicited by the simultaneous application of innocuous warm and cold stimuli to the skin. In the present study, we analyzed the conditions of production of this unique experimental illusion of pain in 52 healthy volunteers (27 men, 25 women). The stimuli were produced by a thermode composed of six bars whose temperature was controlled by Peltier elements (...) . The temperature of alternate (even- and odd-numbered) bars could be controlled independently to produce various patterns of the 'thermal grill'. After measuring the cold and heat pain thresholds, a series of combinations of warm and cold stimuli, whose distance to the thermal pain threshold was at least 4 degrees C, were applied on the palmar surface of the right hand during 30s. After each stimulus, the subjects had to describe and rate their sensations on visual analog scales. Paradoxical painful sensations

2005 Pain

9574. Cortical representation of first and second pain sensation in humans Full Text available with Trip Pro

Cortical representation of first and second pain sensation in humans Single painful stimuli evoke two successive and qualitatively distinct sensations referred to as first and second pain sensation. Peripherally, the neural basis of this phenomenon is a dual pathway for pain with Adelta and C fibers mediating first and second pain, respectively. Yet, the differential cortical correlates of both sensations are largely unknown. We therefore used magnetoencephalography to record and directly (...) of S1 whereas second pain was closely related to anterior cingulate cortex activation. Both sensations were associated with S2 activation. These results correspond to the different perceptual characteristics of both sensations and probably reflect different biological functions of first and second pain. First pain signals threat and provides precise sensory information for an immediate withdrawal, whereas second pain attracts longer-lasting attention and motivates behavioral responses to limit

2002 Proceedings of the National Academy of Sciences of the United States of America

9575. Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients. Full Text available with Trip Pro

Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients. Small and large fibre function was studied in 40 non-ketotic, newly diagnosed Type 1 diabetic patients and 48 age-matched controls, using 12 quantitative tests for assessment of cutaneous sensation. Patients were aged 10-39 years and had been treated with insulin for 4-31 days. Thermal discrimination (foot), warm and cold thermal perception (thenar eminence and foot), and heat and cold (...) pain perception thresholds (thenar eminence) were significantly elevated in the patients as compared with the controls (p less than 0.05 to p less than 0.001). No significant differences in thermal discrimination (thenar), heat and cold pain perception (foot), and metacarpal as well as malleolar vibration perception thresholds were noted between the groups. The rates of abnormalities among the individual tests ranged from 0% to 27.5%, being lowest for vibration perception and highest for thermal

1988 Journal of neurology, neurosurgery, and psychiatry

9576. Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs. (Abstract)

Fentanyl reduces the intensity of painful tooth pulp sensations: controlling for detection of active drugs. This study assessed whether experimentally determined narcotic analgesia in human subjects represents a pharmacologic effect or a psychological effect of detecting the administration of an active medication. Forty dental patients used a verbal descriptor procedure to assess both the intensity and unpleasantness of sensations produced by electrical stimulation of intact teeth. Stimuli were (...) that the reduction in pain intensity following fentanyl administration represents an analgesic effect and not an artifact of detecting the administration of an active medication. They also suggest that diazepam at this dose does not alter pain sensations produced by electrical tooth pulp stimulation.

1982 Anesthesia and analgesia

9577. Comparison of pain and heat sensation of contrast media in aortofemoral angiography: meglumine-amidotrizoate (Angiografin) mixed with lidocaine versus sodium-meglumine-ioxaglate (Hexabrix). (Abstract)

Comparison of pain and heat sensation of contrast media in aortofemoral angiography: meglumine-amidotrizoate (Angiografin) mixed with lidocaine versus sodium-meglumine-ioxaglate (Hexabrix). A total of 116 translumbar aortofemoral angiograms were performed in 92 patients. At random, 58 contrast injections were done with Hexabrix and 58 with Angiografin mixed with lidocaine. Pain and heat sensation was evaluated by a verbal rating system. Most patients in both groups had no or mild pain sensation (...) . There was, however, a slight but statistically significant difference (p less than 0.05) in favor of Hexabrix. No difference was found in heat sensation in either of the groups.

1983 Diagnostic imaging Controlled trial quality: uncertain

9578. Biofeedback of somatosensory event-related potentials: can individual pain sensations be modified by biofeedback-induced self-control of event-related potentials? (Abstract)

Biofeedback of somatosensory event-related potentials: can individual pain sensations be modified by biofeedback-induced self-control of event-related potentials? This study investigates the effects of biofeedback based upon event-related brain potentials evoked by nociceptive electrical stimuli. In a visual and monetary feedback paradigm, 10 subjects received positive feedback within one training session when systematically showing two different behavior patterns: one pattern correlated (...) with a decrease (down-training) and one with an increase (up-training) of the peak-to-peak size of the N150-P260 complex, respectively. Training conditions were changed randomly from trial to trial over 300 trials. All subjects achieved control on both behavior patterns resulting in a simultaneous modification of the size of this complex according to the training conditions. Furthermore, the individual pain report measured with a visual analogue scale was altered in accordance with the biofeedback-induced

1988 Pain Controlled trial quality: uncertain

9579. Pain sensation in transurethral microwave thermotherapy for benign prostatic hyperplasia: the rationale for prophylactic sedation. (Abstract)

Pain sensation in transurethral microwave thermotherapy for benign prostatic hyperplasia: the rationale for prophylactic sedation. Transurethral microwave thermotherapy (TUMT) can be painful. Pain sensation limits treatment tolerance and consequently also treatment efficacy. Of our population of patients treated with TUMT, 22% (63/288) needed intravenous analgesia and, nevertheless, 6% (17/288) needed definitive treatment interruption. The aim of this study was to identify the mechanism of pain (...) tolerance in group B in comparison with group A was found. Pain sensation during TUMT seemed to be mostly due to anxiety. It is concluded that the prophylactic use of a sedative drug is advisable in patients undergoing TUMT in order to improve treatment tolerance.

1994 European urology Controlled trial quality: uncertain

9580. [Semiquantitative detection of pain and heat sensations in evaluation of contrast media in pelvic/leg angiography. Intraindividual double-blind study with iomeprol 350 and iopentol 350]. (Abstract)

[Semiquantitative detection of pain and heat sensations in evaluation of contrast media in pelvic/leg angiography. Intraindividual double-blind study with iomeprol 350 and iopentol 350]. The effect on pain and heat sensation of monomere non-ionic contrast media with different osmolality was assessed in a randomized double-blind study. Peripheral angiography was performed in 29 patients who suffered from chronic occlusive vessel disease. The two non-ionic contrast media iomeprol and iopentol (...) ). The median after the first injection was calculated as 40 for iomeprol and 70 for iopentol. The comparison of heat and pain sensations after the second injection showed a less distinct difference with a scale rating of 60 for iomeprol and of 65 for iopentol. The statistical variance was highly significant (p < 0.01) in favor of iomeprol.

1996 Der Radiologe Controlled trial quality: uncertain

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