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Pain Sensation

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9521. Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia. (Abstract)

experiences frightening.Visual sensations are experienced by approximately 90% of the patients despite full pain control, and surgeons should warn patients of these possibilities because they can be frightening. This should minimize patients' anxiety and stress during the surgery. (...) Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia. To investigate the visual sensations experienced by patients during vitrectomy under retrobulbar anesthesia.Cross-sectional study.Fifty-six men and 45 women with a mean age of 62.2 +/- 11.9 years (range, 30 to 89 years) were studied. Twenty-two eyes had an idiopathic epiretinal membrane, 10 had an idiopathic macular hole, 29 had macular edema (16 resulting from diabetic retinopathy and 13

2007 American Journal of Ophthalmology

9522. Acupuncture needle sensations associated with De Qi: a classification based on experts' ratings. (Abstract)

in de qi.An established scale in the literature provides a list of 25 sensations associated with acupuncture needling that patients might experience. An international group of acupuncture experts rated these 25 sensations in two categories: those predominantly associated with de qi and those with acute pain at the site of needling. For each category, sensations were classified into hierarchic clusters, one for de qi and one for acute pain, and the results were presented in dendrograms.Twenty-nine (...) international experts were invited to participate; 22 (76%) responded and 20 completed the questionnaire. On average, they had 21 years' experience in acupuncture practice (range 10-30 years). Seven sensations were found to be in the cluster associated with de qi: aching, dull, heavy, numb, radiating, spreading, and tingling. Nine sensations were found to be in a cluster associated with acute pain at the site of needling: burning, hot, hurting, pinching, pricking, sharp, shocking, stinging, and tender

2006 Journal of Alternative and Complementary Medicine

9523. Gut sensations in diabetic autonomic neuropathy. (Abstract)

Gut sensations in diabetic autonomic neuropathy. The pathogenesis of gastrointestinal symptoms in diabetes mellitus is complex and multi-factorial. Diabetes induced peripheral and central changes in the neuronal pain matrix may be of importance and were explored using a new multi-modal and multi-segmental sensory testing approach. The sensitivity to mechanical, thermal and electrical stimulations in the oesophagus and duodenum was assessed in 12 type-1 diabetic patients with proven autonomic (...) neuropathy and severe gastrointestinal symptoms using a comprehensive stimulation device aiming to activate different gut nerves and pain mechanisms. Twelve healthy subjects served as controls. The sensory response and the somatic referred pain areas were recorded. In the diabetic patients an overall hyposensitivity to the combination of all stimulations was found in the oesophagus and duodenum (P=0.02). Post hoc analysis revealed hyposensitivity to mechanical stimulations in the oesophagus (P=0.006

2007 Pain

9524. I have a patient who had a traumatic amputation of most of her hand in a road traffic accident a few months ago. She is getting phantom limb sensations and shooting pains where her index finger was. I

I have a patient who had a traumatic amputation of most of her hand in a road traffic accident a few months ago. She is getting phantom limb sensations and shooting pains where her index finger was. I I have a patient who had a traumatic amputation of most of her hand in a road traffic accident a few months ago. She is getting phantom limb sensations and shooting pains where her index finger was. Is there anything other than amytriptiline to offer for this? - Trip Database or use your Google (...) questions please contact us via jon.brassey@tripdatabase.com I have a patient who had a traumatic amputation of most of her hand in a road traffic accident a few months ago. She is getting phantom limb sensations and shooting pains where her index finger was. Is there anything other than amytriptiline to offer for this? A NHS Centre for Review and Dissemination systematic review (1) determines the optimal management of phantom limb pain (PLP) in the pre- and post-operative phases of amputation

2004 TRIP Answers

9525. Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. (Abstract)

Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon. Psychosensory stimulation increases the perception of stimuli in different regions of the human colon. The aim of this study was to determine the perception of pain and gas during distention of two colonic regions in healthy volunteers during stress and relaxation.In 22 healthy subjects, phasic distentions of transverse and sigmoid colon were performed using infinitely compliant balloons, and symptoms were (...) measured before and during one of three randomized treatments: sham or active relaxation or mental stress. Anxiety ratings and somatic cold-pain sensitivity were included in a multivariate regression model.Mental stress increased levels of anxiety (P < 0.05) and the sensation of gas (P < 0.01), but not pain (P = NS), during transverse colon distentions and the sensations of gas and pain during sigmoid distentions (P < 0.05). Active relaxation reduced only sensation of gas in the sigmoid colon. Somatic

1996 Gastroenterology Controlled trial quality: uncertain

9526. Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. (Abstract)

Corneal sensitivity and burning sensation. Comparing topical ketorolac and diclofenac. To compare the effect of topical 0.5% ketorolac tromethamine and 0.1% diclofenac sodium on human corneal sensitivity and to assess the intensity of burning sensation at specific intervals after drop instillation.Double-masked parallel clinical study.Eleven women and 4 men (8 white, 4 Hispanic, 3 Asian), 22 to 60 years of age (mean [ +/- SD], 34 +/- 10 years).Repeated instillation of either ketorolac (...) and placebo or diclofenac and placebo at 5-minute intervals.Assessment of corneal sensitivity before instillation, immediately after instillation, and after termination of drop application; and subjective evaluation of burning sensation by asking participants to rate burning on a scale ranging from 0 (none) to 3 (severe) after each drop application.Both diclofenac (P < .01) and ketorolac (P < .01) decreased corneal sensitivity significantly, while the placebo had no measurable effect. After administration

1996 Archives of ophthalmology Controlled trial quality: uncertain

9527. Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls. (Abstract)

and ACh had no additional effect on the magnitude of the sensation. In AE patients, the intensity was similar to that experienced by the control subjects, but the quality of sensation was different: ACh induced pain in the control subjects, pruritus in AE patients, and a mixture of pain and itching in AE patients showing no symptoms. Our results suggest that VIP- and ACh-induced skin reactions and the quality of the sensations depend on the activity of the atopic eczema. Confirming our former studies (...) Cutaneous reactions and sensations after intracutaneous injection of vasoactive intestinal polypeptide and acetylcholine in atopic eczema patients and healthy controls. We analysed vasoreactions and sensations of atopic eczema (AE) patients and healthy controls after intracutaneous (i.c.) injection of vasoactive intestinal polypeptide (VIP) and acetylcholine (ACh). Blood flow was measured by laser Doppler flowmetry (LDF). Plasma extravasation and flare size were evaluated planimetrically

1998 Archives of dermatological research Controlled trial quality: uncertain

9528. Relation between rectal sensation and anal function in normal subjects and patients with faecal incontinence. Full Text available with Trip Pro

seconds. Internal sphincter relaxation occurred before the sensation was perceived in three of 27 normal subjects and 11 of 16 patients (p less than 0.001), and could be associated with anal leakage, which stopped as soon as sensation was perceived. The lowest rectal volumes required to induce anal relaxation, to cause sustained relaxation, or to elicit sensations of a desire to defecate or pain were similar in patients and normal subjects. In conclusion, these results show the close association (...) Relation between rectal sensation and anal function in normal subjects and patients with faecal incontinence. The relation between sensory perception of rapid balloon distension of the rectum and the motor responses of the rectum and external and internal anal sphincters in 27 normal subjects and 16 patients with faecal incontinence who had impaired rectal sensation but normal sphincter pressures was studied. In both patients and normal subjects, the onset and duration of rectal sensation

1990 Gut

9529. Oesophageal sensation assessed by electrical stimuli and brain evoked potentials--a new model for visceral nociception. Full Text available with Trip Pro

-specific ('electrical') sensations were provoked at 28 cm (10 of 12). Thresholds of sensation and of pain were lower at the initial than the second determination, but did not differ with respect to stimulation site. The pain summation threshold to repeated stimuli (2 Hz, 5 stimuli) was determined for the first time in a viscus. This threshold was lower than the pain threshold to single stimuli at 38 cm (p < 0.02). Evoked potential latencies did not change significantly over a six month period while (...) Oesophageal sensation assessed by electrical stimuli and brain evoked potentials--a new model for visceral nociception. Sensory thresholds and brain evoked potentials were determined in 12 healthy volunteers using electrical stimulation of the oesophagus 28 and 38 cm from the nares. The peaks of the evoked potentials were designated N for negative deflections and P for positive. Continuous electrical stimulation (40 Hz) at the 38 cm position resembled heartburn (five of 12 subjects) while non

1995 Gut

9530. Sensational developments in the irritable bowel. Full Text available with Trip Pro

Sensational developments in the irritable bowel. 9014782 1997 02 19 2018 11 13 0017-5749 39 5 1996 Nov Gut Gut Sensational developments in the irritable bowel. 770-1 Naliboff B B CURE Digestive Diseases Research Center/Neuroenteric Biology Group UCLA 90073, USA. Mayer E A EA eng Comment Journal Article England Gut 2985108R 0017-5749 50-56-6 Oxytocin AIM IM Gut. 1996 Nov;39(5):741-7 9014776 Afferent Pathways Colonic Diseases, Functional drug therapy psychology Humans Intestines innervation (...) Oxytocin therapeutic use Pain Threshold drug effects Perception drug effects 1996 11 1 1996 11 1 0 1 1996 11 1 0 0 ppublish 9014782 PMC1383408 Neurogastroenterol Motil. 1996 Mar;8(1):9-18 8697187 Gastroenterology. 1995 Dec;109(6):1742-9 7498637 Pain. 1977 Jun;3(3):187-211 327401 Pain. 1977 Aug;3(4):295-305 909711 Gastroenterology. 1995 Jul;109(1):40-52 7797041 Gastroenterology. 1994 Dec;107(6):1686-96 7958680 Pain. 1983 Nov;17(3):257-66 6657286 Gastroenterology. 1990 Oct;99(4):1008-15 2394323 Am J

1996 Gut

9531. Spinal and supraspinal modulation of visceral sensation Full Text available with Trip Pro

psychology Fear Humans Pain physiopathology Perception physiology Sensation Disorders complications Stress, Psychological complications Viscera physiology 47 2000 11 15 11 0 2001 2 28 10 1 2000 11 15 11 0 ppublish 11076922 PMC1766817 Proc Annu Meet Am Psychopathol Assoc. 1965;53:62-82 5897310 Neurosci Biobehav Rev. 1999 May;23(5):743-60 10392663 Gastroenterology. 1986 Oct;91(4):845-52 3743962 Gastroenterology. 1987 Oct;93(4):727-33 3623019 Gastroenterology. 1988 Sep;95(3):709-14 3396818 Gastroenterology (...) Spinal and supraspinal modulation of visceral sensation 11076922 2001 01 04 2018 11 13 0017-5749 47 Suppl 4 2000 Dec Gut Gut Spinal and supraspinal modulation of visceral sensation. iv69-72; discussion iv76 Mayer E A EA Department of Medicine and Physiology, UCLA School of Medicine, WLA VAMC/CURE building 115, Room 223, 11301 Wilshire Blvd, Los Angeles, California 90073, USA. emayer@pop.ben2.ucla.edu eng Journal Article Review England Gut 2985108R 0017-5749 AIM IM Colonic Diseases, Functional

2000 Gut

9532. Effects of gender and age on esophageal biomechanical properties and sensation. (Abstract)

Effects of gender and age on esophageal biomechanical properties and sensation. The effects of gender and age on human esophageal function is poorly defined. Our aim was to investigate the sensory perception and the biomechanical properties of the esophagus both at the smooth muscle and the striated muscle segments in age- and gender-matched healthy subjects. Eleven older individuals (five men and six women, aged 55-82 yr) and 11 younger healthy individuals (five male and six female, aged 22-45 (...) and women. In contrast, at both of these segments, the cross-sectional area was larger (p < 0.05), the circumferential wall tension-strain association had shifted significantly (p < 0.05) to the left (i.e., the wall was stiffer), and the median thresholds for discomfort and pain were higher (p < 0.05) in older subjects. The biomechanical properties and thresholds for sensory perception also varied between the two esophageal segments.Aging was associated with a larger lumen and a stiffer but less

2003 The American journal of gastroenterology

9533. Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation. (Abstract)

Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation. Our aim was to investigate the effect of motilin on postprandial proximal gastric motor and sensory function in healthy volunteers. Ten fasted, healthy volunteers were infused intravenously with synthetic motilin or placebo over 90 min. A liquid meal (200 ml) was ingested within 2 min at the start of the infusion. Proximal gastric volume was measured with a barostat device. Abdominal symptoms were (...) scored by visual analog scales. Plasma motilin concentrations were measured using RIA. Endogenous motilin levels were not affected by meal ingestion. After meal intake, gastric relaxation was similar for motilin and placebo. After postprandial relaxation, motilin resulted in a faster return of gastric volume to baseline (P = 0.007). Motilin significantly increased postprandial feelings of nausea (P = 0.03) and tended to increase abdominal pain and abdominal tension. In conclusion, after normal

2002 Digestive diseases and sciences Controlled trial quality: uncertain

9534. Antipruritic and thermal sensation effects of hydrocortisone creams in human skin. (Abstract)

, random, comparative, controlled, single-dose and single-center study. Itch was experimentally induced in both forearms by intracutaneous injection of histamine in 18 subjects. Hydrocortisone 1%, 2.5% and placebo were applied to test sites on both forearms. The thermal threshold for warmth sensation, cold sensation, cold and heat pain was measured with the TSA. Itch magnitude was measured each minute after histamine injection for 10 min with a visual analogue scale (VAS). Itch duration was also (...) recorded. In comparison to placebo, 2.5% hydrocortisone significantly (p = 0.03) reduced itch duration from 12.6 +/- 11.0 min (mean +/- SD) to 8.6 +/- 8.2 min (the reducing rate was 32%) as well as itch magnitude (at minutes 3, 6, 7 and overall). Placebo, 1% and 2.5% hydrocortisone significantly altered (p <0.05) the cold sensation threshold. No treatment altered cold or heat pain thresholds. These data suggest that topical application of 2.5% hydrocortisone may be significantly beneficial

2001 Skin pharmacology and applied skin physiology Controlled trial quality: uncertain

9535. Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. (Abstract)

Effects of alosetron on gastrointestinal transit time and rectal sensation in patients with irritable bowel syndrome. Alosetron, a 5-HT3-receptor antagonist, relieves abdominal pain and improves bowel function in non-constipated, female patients with irritable bowel syndrome. 5-HT3 antagonists delay colonic transit, increase colonic compliance, and increase small intestinal water absorption.To evaluate the effects of alosetron on gastrointestinal and colonic transit, rectal compliance (...) and rectal sensation in irritable bowel syndrome.A double-blind, placebo-controlled, two-dose study of alosetron was performed in 25 non-constipated irritable bowel syndrome patients, with paired studies before and after 4 weeks of treatment with placebo (n=5), 1 mg alosetron (n=10) or 4 mg (n=10) alosetron b.d. Gastrointestinal and colonic transit were measured by scintigraphy. Rectal compliance and sensation were assessed by rectal balloon distention with a barostat.There was a trend (P=0.06) for 1 mg

2000 Alimentary pharmacology & therapeutics Controlled trial quality: uncertain

9536. Effect of pulse repetition rate on the perception of thermal sensation with pulsed shortwave diathermy. (Abstract)

Effect of pulse repetition rate on the perception of thermal sensation with pulsed shortwave diathermy. Pulsed shortwave diathermy (PSWD) is a form of therapy commonly used to enhance tissue repair and reduce pain. It is normally considered to be an athermal form of treatment; however, there is some evidence to suggest that thermal effects can arise with adequate dosage. The purpose of this study was to determine the pulse repetition rate (PRR) required to generate a 'possible' and 'definite (...) ' thermal sensation when PSWD was applied to the thigh.Thirty healthy subjects were randomly assigned to placebo or treatment groups. The treatment group was exposed to PSWD at a constant setting of pulse duration (400 microseconds) and pulse power (190 W) while the PRR was increased from 26 Hz to 400 Hz in 10 increments. Each dose was applied for a period of two minutes. At the end of each application, subjects were asked if they felt a (1) 'possible' or (2) 'definite' thermal sensation. Skin

2000 Physiotherapy research international : the journal for researchers and clinicians in physical therapy Controlled trial quality: uncertain

9537. Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans. Full Text available with Trip Pro

Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans. To characterize alpha(2)-adrenergic control of motor and sensory functions of gastrointestinal tract and colon, we studied dose-related effects of clonidine (placebo or up to 0.3 mg po) by random assignment in 55 healthy humans. Gastrointestinal transit was measured in all subjects; in 35, we assessed colonic compliance, tone, and sensations of gas and pain during phasic distensions (...) . Clonidine did not significantly alter gastrointestinal or colonic transit, but it increased colonic compliance and reduced fasting tone without altering colonic response to a meal. Clonidine significantly reduced aggregate sensation to distensions overall and had significant linear dose-related sensory effects at 8- and 24-mmHg distensions. Effect on pain (including dose-response relationship) was due to 0.3-mg dose for distensions at 24 mmHg. We confirmed that clonidine relaxes fasting colonic tone

2001 American journal of physiology. Gastrointestinal and liver physiology Controlled trial quality: uncertain

9538. Impact of osmolality on burning sensations during and immediately after intramuscular injection of 0.5 ml of vaccine suspensions in healthy adults. (Abstract)

-inactivated Poliomyelitis-Haemophilus influenzae type b paediatric vaccine (DtacP-IPV-Hib, PENTAVAC). The results did not show any dose-effect relationship between burning or pain sensations and the different osmolalities tested. Although mild and not clinically relevant, these sensations seemed to occur more frequently following injection of an isotonic saline solution (P<0.05). Thus, the osmolality of vaccine like suspensions does not appear to be a potential cause of local pain or burning sensation (...) Impact of osmolality on burning sensations during and immediately after intramuscular injection of 0.5 ml of vaccine suspensions in healthy adults. A randomised placebo controlled double-blind cross-over trial was performed on twenty healthy adults to assess the effect of osmolality (300,600,850 and 1100 mOsm) on local tolerance of an intramuscular injection (0.5 ml) of five suspensions containing the same components as the excipients of a combined Diphtheria-Tetanus-acellular Pertussis

2001 Vaccine Controlled trial quality: uncertain

9539. Effect of preoperative extradural bupivacaine and morphine on stump sensation in lower limb amputees. (Abstract)

Effect of preoperative extradural bupivacaine and morphine on stump sensation in lower limb amputees. We have examined the effect of preoperative extradural bupivacaine and morphine on postoperative stump sensation in 31 patients undergoing amputation of the lower limb in a prospective, randomized, double-blind study. Patients were allocated randomly to one of two groups: group 1 received extradural 0.25% bupivacaine 4-7 ml h-1 and morphine 0.16-0.28 ml h-1 before and during operation; group 2 (...) received extradural saline before and during amputation and conventional analgesics for pain treatment. All patients received general anaesthesia for the amputation and extradural bupivacaine and morphine after operation. Sensory examination of the limb/stump was carried out before amputation, and after 1 week and 6 months. The following were measured: pressure pain thresholds (pressure algometry), touch and pain detection thresholds (von Frey hairs), thermal sensibility (thermal rolls), and allodynia

1998 British Journal of Anaesthesia Controlled trial quality: uncertain

9540. Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans. Full Text available with Trip Pro

Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans. The cholinesterase inhibitor neostigmine indirectly stimulates muscarinic M(1)/M(2)/M(3) receptors, thereby reducing colonic distension in acute colonic pseudo-obstruction. We investigated the dose-response profile for the colonic sensorimotor effects of neostigmine and bethanechol, a direct muscarinic M(2)/M(3) agonist in humans. A barostat-manometric assembly recorded phasic pressures, tone (...) , and pressure-volume relationships (compliance) in the descending colon and rectum of 30 healthy subjects who received intravenous neostigmine (0.25, 0.75, or 1.5 mg; n = 15) or subcutaneous bethanechol (2.5, 5, or 10 mg; n = 15). Sensation to luminal distension was also assessed. Thereafter, the effects of neostigmine and bethanechol on colonic transit (geometric center) were compared with those of saline by scintigraphy in 21 subjects. Both drugs increased colonic phasic pressure activity, reduced rectal

2001 American journal of physiology. Gastrointestinal and liver physiology Controlled trial quality: uncertain

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