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Pain Sensation

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9521. Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain

to agree to take adequate birth control precautions with their partner for 60 days following experimental drug exposure. Have unbroken skin with good perfusion over the painful area(s). Have the ability to feel capsaicin-mediated sensations, as evidenced by ability to feel topically applied OTC capsaicin cream. Are on a stable and continuous medication regimen, with no change in dosage for 21 days prior to study start, and are willing to maintain concomitant medications at current doses throughout (...) Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2002 Clinical Trials

9522. Influence of Genetics in Pain Sensitivity

Hyperalgesia Oral Surgery Cold Pain Peripheral Nerve Allodynia Spinal Cord Personality Traits Pain Ratings Additional relevant MeSH terms: Layout table for MeSH terms Hyperalgesia Somatosensory Disorders Sensation Disorders Neurologic Manifestations Nervous System Diseases Signs and Symptoms (...) Influence of Genetics in Pain Sensitivity Influence of Genetics in Pain Sensitivity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Influence of Genetics in Pain Sensitivity The safety and scientific

2000 Clinical Trials

9523. Pain Measurement in Healthy Volunteers

to Brief Summary: This study will attempt to develop and validate improved subjective measures of pain sensation and use these measures to evaluate pain sensitivity in patients. Normal healthy volunteers and dental patients undergoing third molar extraction may be eligible for this study. Participants will undergo the following procedures: Volunteers: Volunteers will participate in two 90-minute sessions in which they will receive and rate four heat stimuli per minute applied to the skin for a maximum (...) molar extraction, and the second session will be immediately before the dental procedure. The heat stimulus procedure will be identical to that described above for normal healthy volunteers. Condition or disease Healthy Pain Detailed Description: Mismanaged pain is still a major medical problem. Many pain syndromes have no effective treatment, and many are managed poorly. Basic and applied research on pain treatment is hampered by the unobservable nature of pain sensation and the lack of validated

1999 Clinical Trials

9524. Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00004647 Recruitment Status : Completed First Posted : February 25, 2000 Last Update Posted

2000 Clinical Trials

9525. Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors

at least 20% in subjects 65 years and older. Numerous data suggest that hyperglycemia may be an independent risk factor for macrovascular complications. Diabetic painful neuropathy (DPN) affects 5-50% of patients with diabetes and is exacerbated by poor glycemic control. DPN is characterized by acute functional abnormalities in nerve fibers followed by chronic nerve fiber loss and blunted nerve fiber regeneration. Symptoms include tingling and burning sensations in the calves, ankles and feet (...) Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Reiki

2001 Clinical Trials

9526. Transcranial Magnetic Stimulation for the Treatment of Phantom Pain

Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: Phantom pain refers to the sensation of pain felt by patients who have had a limb amputated. The treatment of phantom pain is often disappointing and is unable to provide adequate relief to the patients. The area of the brain involved (posterior parietal cortex [PPC]) is found on the opposite side of the amputated limb. For example, if a patient has the right arm amputated, the left posterior parietal cortex (...) for phantom pain is often disappointing. In amputees, hyperexcitability of the posterior parietal cortex area (PPC) contralateral to the side of the amputation has been linked with the presence of phantom sensations. PPC is an area overactive in different forms of chronic pain too. It is therefore conceivable that downregulation of activity in PPC could improve phantom limb pain, a condition poorly responsive to available treatments. We have previously demonstrated that low frequency TMS (1 Hz) results

1999 Clinical Trials

9527. Central neural contribution to the perception of chest pain in cardiac syndrome X Full Text available with Trip Pro

of neuronal activity.During similar doses of dobutamine, syndrome X patients and controls showed comparable regional cerebral blood flow changes in the hypothalamus, thalami, right orbito-frontal cortex, and anterior temporal poles, associated with the sensation of a fast or powerful heart beat. In patients, but not controls, the stress also generated severe chest pain associated with increased activity in the right anterior insula/frontal operculum junction. There were ischaemia-like ECG changes (...) Central neural contribution to the perception of chest pain in cardiac syndrome X To investigate the central neural contribution to chest pain perception in cardiac syndrome X (angina-like pain, ECG changes during stress, angiographically normal coronary arteriogram).Eight syndrome X patients and eight healthy volunteers.Dobutamine stress using echocardiography to assess myocardial function, and positron emission tomography to measure changes in regional cerebral blood flow, as an index

2002 Heart

9528. Cerebral potentials evoked by oesophageal distension in patients with non-cardiac chest pain. Full Text available with Trip Pro

Cerebral potentials evoked by oesophageal distension in patients with non-cardiac chest pain. Cerebral evoked potential recording was used to study the oesophagus-brain axis in 10 controls and 10 patients with non-cardiac chest pain with a manometric diagnosis of either nutcracker oesophagus or diffuse spasm and a positive edrophonium test. A series of 50 inflations (10/minute; inflation rate of 170 ml/second) of an intraoesophageal balloon (5 cm proximal to the lower oesophageal sphincter (...) ) was performed in each subject. Three different inflation volumes were used and were individually determined to cause no sensation, slight sensation, and definite sensation, respectively (volume ranges: 2-8 ml, 5-18 ml, and 8-22 ml). All signals were coded and their quality was scored on a scale from 0 (no recognisable pattern) to 5 (well defined potential of good quality) by four 'blinded' observers. The evoked potential quality scores and amplitude of the major peaks increased significantly (p less than

1992 Gut

9529. A curious double reference of mild pain produced by scratching the skin: with a note on the gentle art of snoring. Full Text available with Trip Pro

A curious double reference of mild pain produced by scratching the skin: with a note on the gentle art of snoring. 552176 1980 12 18 2018 11 13 0065-7778 91 1980 Transactions of the American Clinical and Climatological Association Trans. Am. Clin. Climatol. Assoc. A curious double reference of mild pain produced by scratching the skin: with a note on the gentle art of snoring. 147-57 Bean W B WB eng Journal Article United States Trans Am Clin Climatol Assoc 7507559 0065-7778 IM Humans Pain (...) physiopathology Respiratory Sounds physiopathology Sensation physiology Snoring physiopathology 1979 1 1 1979 1 1 0 1 1979 1 1 0 0 ppublish 552176 PMC2279451 Brain. 1949 Sep;72(3):364-72 15401754 Proc Natl Acad Sci U S A. 1977 Oct;74(10):4702-5 270709 J Physiol. 1969 Feb;200(3):763-96 4974746

1980 Transactions Of The American Clinical And Climatological Association

9530. Do fetuses feel pain? We don't know; better to err on the safe side from mid-gestation. Full Text available with Trip Pro

Gestational Age Humans Pain physiopathology Pain Measurement Perception physiology Sensation physiology 1996 9 28 1996 9 28 0 1 1996 9 28 0 0 ppublish 8842075 PMC2352200 Proc Biol Sci. 1991 Apr 22;244(1309):39-44 1677194 N Engl J Med. 1992 Jan 2;326(1):55-6 1727065 Cell Mol Neurobiol. 1993 Aug;13(4):321-47 8252606 Lancet. 1994 Jul 9;344(8915):77-81 7912391 Lancet. 1994 Aug 27;344(8922):615 7914980 Lancet. 1994 Aug 27;344(8922):615 7914981 Lancet. 1995 Feb 4;345(8945):291-2 7837863 Lancet. 1996 Mar 2;347 (...) Do fetuses feel pain? We don't know; better to err on the safe side from mid-gestation. 8842075 1996 11 05 2018 11 13 0959-8138 313 7060 1996 Sep 28 BMJ (Clinical research ed.) BMJ Do fetuses feel pain? We don't know; better to err on the safe side from mid-gestation. 796 Glover V V Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte's and Chelsea Hospital, London. Fisk N N eng Journal Article England BMJ 8900488 0959-8138 AIM IM Fetus physiology

1996 BMJ : British Medical Journal

9531. General practitioners' management of acute back pain: a survey of reported practice compared with clinical guidelines. Full Text available with Trip Pro

General practitioners' management of acute back pain: a survey of reported practice compared with clinical guidelines. To compare general practitioners' reported management of acute back pain with 'evidence based' guidelines for its management.Confidential postal questionnaire.One health district in the South and West region.236 general practitioners; 166 (70%) responded.Examination routinely performed, 'danger' symptoms and signs warranting urgent referral, advice given, and satisfaction (...) with management.A minority of general practitioners do not examine reflexes routinely (27%, 95% confidence interval 20% to 34%), and a majority do not examine routinely for muscle weakness or sensation. Although most would refer patients with danger signs, some would not seek urgent advice for saddle anaesthesia (6%, 3% to 11%), extensor plantar response (45%, 37% to 53%), or neurological signs at multiple levels (15%, 10% to 21%). A minority do not give advice about back exercises (42%, 34% to 49%), fitness

1996 BMJ : British Medical Journal

9532. Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans Full Text available with Trip Pro

as they discriminated differences in the intensity of innocuous and noxious heat stimuli applied to the left forearm. Each subject was instructed in magnitude estimation based on a scale for which 0 indicated 'no heat sensation'; 7, 'just barely painful' and 10, 'just barely tolerable'. Thermal stimuli were 40 degrees C or 50 degrees C heat, applied with a thermode as repetitive 5-s contacts to the volar forearm. Both male and female subjects rated the 40 degrees C stimuli as warm but not painful and the 50 degrees (...) Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans The purpose of the present study was to determine whether gender differences exist in the forebrain cerebral activation patterns of the brain during pain perception. Accordingly, positron emission tomography (PET) with intravenous injection of H2(15)O was used to detect increases in regional cerebral blood flow (rCBF) in normal right-handed male and female subjects

1998 Pain

9533. Percutaneous cervical cordotomy for the control of pain in patients with pleural mesothelioma Full Text available with Trip Pro

Percutaneous cervical cordotomy for the control of pain in patients with pleural mesothelioma Severe chest pain is common in mesothelioma. Percutaneous cervical cordotomy, which interrupts the spinothalamic tract at the C1/C2 level causing contralateral loss of pain sensation, is particularly appropriate in mesothelioma as the tumour is unilateral and systemic analgesia may be ineffective and is limited by harmful side effects.A retrospective review was performed to determine the effectiveness (...) and complication rate of this procedure.Fifty two patients were using opioids prior to cordotomy. The median daily dose of morphine before and after cordotomy was 100 mg (range 0-1000 mg) and 20 mg (range 0-520 mg), respectively (p < 0.001). Forty three patients (83%) had a reduction in pain such that their dose of opioid could be at least halved. Twenty patients (38%) were able to stop completely. Recurrence of pain requiring an increase in opioid medication was recorded in 18 patients at a median time

1999 Thorax

9534. Functional imaging of brain responses to pain. A review and meta-analysis (2000). (Abstract)

) and probably also by temporal summation and attention to the stimulus. In a number of studies, the thalamic response was bilateral, probably reflecting generalised arousal in reaction to pain. ACC does not seem to be involved in coding stimulus intensity or location but appears to participate in both the affective and attentional concomitants of pain sensation, as well as in response selection. ACC subdivisions activated by painful stimuli partially overlap those activated in orienting and target detection (...) Functional imaging of brain responses to pain. A review and meta-analysis (2000). Brain responses to pain, assessed through positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) are reviewed. Functional activation of brain regions are thought to be reflected by increases in the regional cerebral blood flow (rCBF) in PET studies, and in the blood oxygen level dependent (BOLD) signal in fMRI. rCBF increases to noxious stimuli are almost constantly observed in second

2000 Neurophysiologie clinique = Clinical neurophysiology

9535. Painful paresthesiae are infrequent during brachial plexus localization using low-current peripheral nerve stimulation. (Abstract)

to identify the brachial plexus in 64 consecutive patients having shoulder or arm surgery with an interscalene block. During nerve localization and while maintaining a motor response (0.20 mA-0.40 mA), the patients were queried regarding any radiating sensation or pain (paresthesia) in the shoulder or extremity on the side of the blockade. Sensory distribution of the block, motor strength of the arm muscles, and adequacy of anesthesia were used to assess the extent of blockade.Ninety-five percent (...) Painful paresthesiae are infrequent during brachial plexus localization using low-current peripheral nerve stimulation. Considerable controversy exists over the relationship of paresthesia to nerve stimulation. The purpose of this study was to determine the frequency with which patients report paresthesia at the point that an acceptable motor response is obtained to low-intensity current electrical stimulation.Low-intensity current nerve stimulation (0.6 mA, 200 microseconds, 2 Hz) was used

2003 Regional Anesthesia and Pain Medicine

9536. Pain catastrophizing and symptom severity during upper respiratory tract illness. (Abstract)

of pain catastrophizing may not be restricted to pain-specific domains. The data also provide some support for the view that the excessive focus on bodily sensations may account for more severe symptoms. (...) Pain catastrophizing and symptom severity during upper respiratory tract illness. The present study examined the relation of pain catastrophizing to the severity of upper respiratory tract illness.Participants included 50 adults (35 female subjects, 15 male) who were self-diagnosed with upper respiratory tract illness and who agreed to complete a diary of symptoms for 7 days. Illness symptoms were grouped into three categories: pain-related, constitutional, and respiratory symptoms.Results

2003 Clinical Journal of Pain

9537. Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. Full Text available with Trip Pro

Capsaicin and menthol in the treatment of itch and pain: recently cloned receptors provide the key. Topical capsaicin is reported to be an effective treatment for idiopathic intractable pruritus ani. While both capsaicin and menthol application produce a transient perianal burning sensation, only capsaicin relieves itching. Classical observations on functional desensitisation of nociceptors by capsaicin may explain the beneficial effects but the recent discovery of a range of receptors which

2003 Gut

9538. Postoperative pain and side effects after uvulopalatopharyngoplasty, laser-assisted uvulopalatoplasty, and radiofrequency tissue volume reduction in primary snoring. (Abstract)

. Postoperative side effects (trouble with smell and taste, pharyngeal dryness, globus sensation, voice change, and pharyngonasal reflux) were more present in the UPPP and LAUP groups than in the RFTVR group. Surgeon's assessment for postoperative complications reported more wound infection, dehiscence, and posterior pillar narrowing in the UPPP and LAUP groups than in the RFTVR group.RFTVR is a safer and less painful procedure than UPPP and LAUP for the treatment of primary snoring. Postoperative discomfort (...) Postoperative pain and side effects after uvulopalatopharyngoplasty, laser-assisted uvulopalatoplasty, and radiofrequency tissue volume reduction in primary snoring. We compared, in a prospective study, the side effects and the postoperative complications of three procedures commonly used for the treatment of primary snoring.Forty-nine patients underwent velopharyngeal surgery for primary snoring (17 for uvulopalatopharyngoplasty [UPPP]; 15 for laser-assisted uvulopalatoplasty [LAUP], and 17

2003 Laryngoscope

9539. Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients? (Abstract)

bowel habit, and overall GI symptom severity. In addition, the subgroups reported similar degrees of psychological distress, impaired quality of life, and increased patterns of health care use.Subgroups of moderate to severe IBS patients do report their predominant GI symptoms in terms of pain or nonpainful discomfort, regardless of severity of their overall GI symptoms or psychological symptoms. These findings are most consistent with a cognitive labeling bias of visceral sensations as either pain (...) Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients? The aims of this study were to: 1) determine the relative prevalence of self-reported pain-predominant and discomfort-predominant symptom patterns in irritable bowel syndrome (IBS) patients; and 2) test the hypotheses that pain-predominant patients report higher GI symptom severity, show higher psychological symptom severity, show worse quality of life, and demonstrate higher health care use.A total

2002 American Journal of Gastroenterology

9540. Description of stable pain in rheumatoid arthritis: a 6 year study. (Abstract)

significant difference in any measure over the 3 assessments. RA pain intensity was moderate. The MPQ showed that sensory components of the pain were described in terms of pressure and constriction. Pain related affect was described with adjectives suggesting positive psychological adaptation to pain.The results indicate a general profile of no change in pain sensation, affect, and emotional quality in clinic monitored patients with ongoing RA and ongoing, moderate levels of disease activity and function (...) Description of stable pain in rheumatoid arthritis: a 6 year study. To study pain quality and variability in patients with rheumatoid arthritis (RA).Pain, disease activity, and functional status were assessed 3 times over 6 years in an initial cohort of 120 clinic patients with chronic pain from RA. A pain visual analog scale and the McGill Pain Questionnaire (MPQ) were used to record pain intensity and quality. RA disease activity and function were measured.There was no statistically

2003 Journal of Rheumatology

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