How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

9,678 results for

Pain Sensation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

9501. Managing pain during mediastinal chest tube removal. (Abstract)

Managing pain during mediastinal chest tube removal. To compare four analgesic regimens used in preparing patients for chest tube removal.Prospective, randomized, controlled multiple-group comparison.Mid-atlantic university affiliated tertiary medical center.80 adult patients who underwent heart surgery and who had two mediastinal chest tubes.Subject's pain intensity rating on a 0 to 100 mm visual analog scale and subject's description of sensations blindly rated by six nurses.Before chest tube (...) removal, subjects were medicated with either: (1) intravenous morphine sulfate (morphine), (2) intravenous morphine and subfascial angiocatheter lidocaine hydrochloride (lidocaine), (3) intravenous morphine and subfascial angiocatheter normal saline solution, or (4) subfascial angiocatheter lidocaine.Mean pain rating scores for groups 1, 2, 3, and 4 were 43.7 40.9, 36.4, and 38.1, respectively. Analysis of variance showed no significant difference between scores (p = 0.8948). The percentage

1995 Heart & Lung Controlled trial quality: uncertain

9502. Dose-related effects of ibuprofen on pain-related potentials. Full Text available with Trip Pro

concentrations applied to the right nostril. The left nostril was stimulated with a constant stream of dry air which produced a tonic painful sensation described as dull and burning. Subjects rated the intensity of the painful stimuli by means of visual analogue scales. In addition, chemo-somatosensory event-related potentials (CSSERP) were also recorded in response to phasic painful CO2 stimuli. 3. While mean intensity estimates of both tonic and phasic painful stimuli showed a non-significant dose-related (...) Dose-related effects of ibuprofen on pain-related potentials. 1. The aim of this study was to investigate the dose-related effects of ibuprofen (placebo, 400 and 800 mg rac-ibuprofen [Aktren], administered orally) on experimentally-induced tonic and phasic pain. 2. Eighteen volunteers participated in this randomized, double-blind, three-fold cross-over study. Measurements were obtained before and 90 min after administration of the drugs. Phasic pain was produced by CO2 pulses of two

1994 British journal of clinical pharmacology Controlled trial quality: uncertain

9503. Preventive pain management in the postoperative hand surgery patient. (Abstract)

Preventive pain management in the postoperative hand surgery patient. The purpose of this quasi-experimental clinical study was to investigate differences in postoperative pain management within the hand surgical population. The research question proposed: Is there a difference in the pain experience between postoperative patients who receive an analgesic upon onset of sensation and those who receive an analgesic upon onset of pain? The effectiveness of pain management was compared for two (...) groups of randomly assigned, adult, orthopaedic patients who had undergone elective hand surgery using axillary block anesthesia. The results of this study concluded that more effective pain control was achieved when patients were medicated upon onset of sensation versus onset of pain.

1994 Orthopaedic nursing / National Association of Orthopaedic Nurses Controlled trial quality: uncertain

9504. [Mexiletine in treatment of painful diabetic neuropathy]. (Abstract)

) of the McGill scale just failed the level of significance. More specific exploratory evaluation of subclasses of the McGill scale, representing different qualities of pain, gave remarkable differences between mexiletine and placebo. According to types of complaints an evaluation showed substantial advantages of the mexiletine treatment with both the VAS and the McGill scale. There is strong evidence that particularly patients with stabbing or burning pain, heat sensations or formication will benefit most (...) [Mexiletine in treatment of painful diabetic neuropathy]. The objective of this double-blind placebo controlled multicenter study was to prove the efficacy of mexiletine in painful diabetic neuropathy. Treatment was provided for in three dosages. For pain measurements a visual analogue scale (VAS) and McGill's verbal rating scale were chosen. 95 patients were included. A global assessment of the VAS showed no differences in treatment. The total evaluation (PRIT = Pain Rating Index Total

1994 Medizinische Klinik (Munich, Germany : 1983) Controlled trial quality: uncertain

9505. Alcohol neurolysis for persistent pain caused by superior cluneal nerves injury after iliac crest bone graft harvesting in orthopedic surgery: report of four cases and review of the literature. (Abstract)

Alcohol neurolysis for persistent pain caused by superior cluneal nerves injury after iliac crest bone graft harvesting in orthopedic surgery: report of four cases and review of the literature. Harvesting of autologous bone graft from the posterior iliac crest for lumbar spinal fusions is a frequently performed procedure in orthopedic surgery. The most common complication associated with this procedure is an alteration in sensation over the donor site manifested as chronic pain, hyperesthesia (...) , dysesthesia, or diminished sensitivity resulting from superior cluneal nerve (SCN) injury.To predict the effectiveness of alcohol neurolysis in the treatment of persistent pain caused by the entrapment of superior cluneal nerves.The subjects of this study were patients with intractable pain in donor area after conventional treatments using a transverse incision, which is parallel to posterior iliac crest. The study group was composed of four patients who underwent surgery in a 1-year period

2002 Spine

9506. [Treatment of upper-abdominal pain in chronic gastritis. Results of therapy with the motility regulating drug Bromopride]. (Abstract)

[Treatment of upper-abdominal pain in chronic gastritis. Results of therapy with the motility regulating drug Bromopride]. After discussing the aetiological role of the reflux from the duodenum in causing and maintenance of chronic gastritis, the author studied the effect of bromopride, a drug regulating gastrointestinal motility, on the subjective complaints of individuals suffering from the disease. In a randomized double-blind trial, 31 subjects with upper abdominal complaints (...) , histologically established antrum gastritis and endoscopic signs for disorders of pyloric function were treated with one capsule three times daily of bromopride or a placebo, over a period of three weeks. The positive therapeutic results in 12 of 13 patients on bromopride provide support for the clinical use of a drug regulating gastrointestinal motility in the treatment of duodeno-gastric reflux causing the discomfort of individuals with chronic gastritis. Subjects exhibiting a sensation of fullness

1980 Fortschritte der Medizin Controlled trial quality: uncertain

9507. [Contrast media and pain in peripheral arteriography. Randomized, intra-individual double-blind trial: ioglicinate, ioglicinate-lidocaine, ioxaglate]. (Abstract)

[Contrast media and pain in peripheral arteriography. Randomized, intra-individual double-blind trial: ioglicinate, ioglicinate-lidocaine, ioxaglate]. The intravasal application of contrast media (CM) can induce pain and heat. We assessed these local side effects by an intraindividual comparison in 60 patients with occlusive arterial disease. A dolorimeter and calorimeter (graduated scales) were employed to register and differentiate the subjective sensations experienced by the patient, while (...) objective reactions (peripheral motoric reactions, circulatory parameters) were recorded by the trial list at the same time. Ioxaglate, an ionic dimer, was distinctly superior to Ioglicinate, an ionic CM. However, the differences were less marked in the comparison with a Ioglicinate-Lidocaine-mixture. Emphasis is given to the fact osmolality is the most important parameter in the generation of pain. Potential points at which the intraarterially administered local anaesthetic could attack are discussed

1982 Der Radiologe Controlled trial quality: uncertain

9508. Naloxone fails to reverse hypnotic alleviation of chronic pain. (Abstract)

Naloxone fails to reverse hypnotic alleviation of chronic pain. The hypothesis that the alleviation of chronic pain with hypnosis is mediated by endorphins was tested. Six patients with chronic pain secondary to peripheral nerve irritation were taught to control the pain utilizing self-hypnosis. Each subject was tested at 5-min intervals during four 1-h sessions for the amount of reduction of pain sensation and suffering associated with hypnosis while being given, in a random double-blind (...) crossover fashion, an IV injection of either 10 mg naloxone or a saline placebo through an indwelling catheter. The patients demonstrated significant alleviation of the pain with hypnosis, but this effect was not significantly diminished in the naloxone condition. These findings contradict the hypothesis that endorphins are involved in hypnotic analgesia.

1983 Psychopharmacology Controlled trial quality: uncertain

9509. Most patients with active symptomatic duodenal ulcers fail to develop ulcer-type pain in response to gastroduodenal acidification. (Abstract)

to have pain with the pH 1 citric acid, while one developed pain. Five of the eight patients tested with 0.15 mM hydrochloric acid had no pain. Of the three who developed pain with hydrochloric acid, two had endoscopic evidence of esophagitis (one developed retrosternal pain and one both retrosternal and epigastric pain), and one had the sensation of epigastric "fullness" with both the pH 0.85 and pH 7 solutions. There were no significant differences (p greater than 0.1) between the responses (...) Most patients with active symptomatic duodenal ulcers fail to develop ulcer-type pain in response to gastroduodenal acidification. The most frequent symptom of duodenal ulcer is epigastric pain. However, the pathogenesis of duodenal ulcer pain is not established, although it is often attributed to duodenal acidification. The purpose of this study was to determine whether or not gastroduodenal acidification with either 400 ml of pH 1 citric acid or pH 0.85 hydrochloric acid resulted in ulcer

1982 Journal of clinical gastroenterology Controlled trial quality: uncertain

9510. Effects of preoperative teaching on postoperative pain: a replication and expansion. (Abstract)

Effects of preoperative teaching on postoperative pain: a replication and expansion. This study was designed to test the effectiveness of brief relaxation training on postoperative pain, replicating and extending a study of Flaherty and Fitzpatrick (1978). A two-group pre- and post-test experimental design was used to determine if vital signs, analgesic consumption, anxiety, self-reported incisional pain sensation and distress differ in postsurgical patients who have or have not received (...) relaxation training. Seventy-two adult, elective abdominal surgery patients were randomly assigned to treatment groups. Subjects in both groups were visited on the eve of surgery. Experimental subjects were taught a relaxation technique. Equal time was spent with control subjects. Following surgery all subjects were observed during ambulation. Vital signs were measured pre- and postoperatively, as were self-report of pain sensation and distress. Results showed that distress caused by painful sensations

1985 International journal of nursing studies Controlled trial quality: uncertain

9511. Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings. (Abstract)

Injection pain of rocuronium and vecuronium is evoked by direct activation of nociceptive nerve endings. Rocuronium and, to a lesser extent, vecuronium can induce burning sensations associated with withdrawal reactions during administration. Dermal microdialysis in human and electrophysiological recordings of nociceptors in mouse skin were used to elucidate the underlying mechanisms of pain induction.Microdialysis catheters were inserted intradermally into the forearm of 10 volunteers and were (...) with rocuronium or vecuronium solutions (10 mg mL(-1)) at physiological pH.In accordance with clinical observations, microdialysis of rocuronium (10 mg mL(-1)) induced sharp burning pain (NRS 4.1 +/- 1.8), whereas vecuronium given in the usual clinical concentration (1 mg mL(-1)) induced only minor pain sensations (NRS 0.6 +/- 1.3). At equimolar concentrations, pain sensation and concomitant mediator release evoked by both drugs were similar. No correlations were found between pain rating and mediator release

2003 European Journal of Anaesthesiology

9512. Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy

exposure, with primary symptoms of pain, burning or dysesthetic discomfort in both feet for at least 2 months prior to Screening Visit, and absent or diminished ankle reflexes, and at least one of the following: distal diminution of vibration sensation or pain or temperature sensation in the legs Either no neurotoxic antiretroviral (didanosine, zalcitabine or stavudine) exposure for at least 8 weeks prior to Screening Visit, or currently on stable dose(s) of any neurotoxic antiretroviral(s (...) Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study of NGX

2003 Clinical Trials

9513. Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy

reflexes, AND/OR Distal diminution of either vibration sensation or pain or temperature sensation in the legs. Either no neurotoxic antiretroviral (i.e., didanosine [ddI], zalcitabine [ddC], or stavudine [d4T]) exposure for at least 8 weeks prior to Screening Visit, OR Currently on stable dose(s) of any of the neurotoxic antiretrovirals listed above for at least 8 weeks prior to Screening Visit, without a foreseeable need to change doses or medications for duration of study. Screening Pain Sum Score (...) Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy Pilot Study of High-Concentration Capsaicin Patches in the Treatment of Painful HIV-Associated Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2003 Clinical Trials

9514. Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain

to agree to take adequate birth control precautions with their partner for 60 days following experimental drug exposure. Have unbroken skin with good perfusion over the painful area(s). Have the ability to feel capsaicin-mediated sensations, as evidenced by ability to feel topically applied OTC capsaicin cream. Are on a stable and continuous medication regimen, with no change in dosage for 21 days prior to study start, and are willing to maintain concomitant medications at current doses throughout (...) Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2002 Clinical Trials

9515. Influence of Genetics in Pain Sensitivity

Hyperalgesia Oral Surgery Cold Pain Peripheral Nerve Allodynia Spinal Cord Personality Traits Pain Ratings Additional relevant MeSH terms: Layout table for MeSH terms Hyperalgesia Somatosensory Disorders Sensation Disorders Neurologic Manifestations Nervous System Diseases Signs and Symptoms (...) Influence of Genetics in Pain Sensitivity Influence of Genetics in Pain Sensitivity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Influence of Genetics in Pain Sensitivity The safety and scientific

2000 Clinical Trials

9516. Pain Measurement in Healthy Volunteers

to Brief Summary: This study will attempt to develop and validate improved subjective measures of pain sensation and use these measures to evaluate pain sensitivity in patients. Normal healthy volunteers and dental patients undergoing third molar extraction may be eligible for this study. Participants will undergo the following procedures: Volunteers: Volunteers will participate in two 90-minute sessions in which they will receive and rate four heat stimuli per minute applied to the skin for a maximum (...) molar extraction, and the second session will be immediately before the dental procedure. The heat stimulus procedure will be identical to that described above for normal healthy volunteers. Condition or disease Healthy Pain Detailed Description: Mismanaged pain is still a major medical problem. Many pain syndromes have no effective treatment, and many are managed poorly. Basic and applied research on pain treatment is hampered by the unobservable nature of pain sensation and the lack of validated

1999 Clinical Trials

9517. Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy

Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Phase III Randomized, Double-Blind, Placebo-Controlled Study of Mexiletine for Painful Diabetic Neuropathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00004647 Recruitment Status : Completed First Posted : February 25, 2000 Last Update Posted

2000 Clinical Trials

9518. Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors

at least 20% in subjects 65 years and older. Numerous data suggest that hyperglycemia may be an independent risk factor for macrovascular complications. Diabetic painful neuropathy (DPN) affects 5-50% of patients with diabetes and is exacerbated by poor glycemic control. DPN is characterized by acute functional abnormalities in nerve fibers followed by chronic nerve fiber loss and blunted nerve fiber regeneration. Symptoms include tingling and burning sensations in the calves, ankles and feet (...) Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors Effects of Reiki on Painful Neuropathy and Cardiovascular Risk Factors - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Reiki

2001 Clinical Trials

9519. Transcranial Magnetic Stimulation for the Treatment of Phantom Pain

Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: Phantom pain refers to the sensation of pain felt by patients who have had a limb amputated. The treatment of phantom pain is often disappointing and is unable to provide adequate relief to the patients. The area of the brain involved (posterior parietal cortex [PPC]) is found on the opposite side of the amputated limb. For example, if a patient has the right arm amputated, the left posterior parietal cortex (...) for phantom pain is often disappointing. In amputees, hyperexcitability of the posterior parietal cortex area (PPC) contralateral to the side of the amputation has been linked with the presence of phantom sensations. PPC is an area overactive in different forms of chronic pain too. It is therefore conceivable that downregulation of activity in PPC could improve phantom limb pain, a condition poorly responsive to available treatments. We have previously demonstrated that low frequency TMS (1 Hz) results

1999 Clinical Trials

9520. Central neural contribution to the perception of chest pain in cardiac syndrome X Full Text available with Trip Pro

of neuronal activity.During similar doses of dobutamine, syndrome X patients and controls showed comparable regional cerebral blood flow changes in the hypothalamus, thalami, right orbito-frontal cortex, and anterior temporal poles, associated with the sensation of a fast or powerful heart beat. In patients, but not controls, the stress also generated severe chest pain associated with increased activity in the right anterior insula/frontal operculum junction. There were ischaemia-like ECG changes (...) Central neural contribution to the perception of chest pain in cardiac syndrome X To investigate the central neural contribution to chest pain perception in cardiac syndrome X (angina-like pain, ECG changes during stress, angiographically normal coronary arteriogram).Eight syndrome X patients and eight healthy volunteers.Dobutamine stress using echocardiography to assess myocardial function, and positron emission tomography to measure changes in regional cerebral blood flow, as an index

2002 Heart

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>