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Pain Sensation

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41. Low back pain and radicular pain: evaluation and management

back pain »), Maurits Van Tulder (multiple scientific studies in the field of low back pain, financed by ZonMW ; principal investigator of studies about radiofrequency denervation for facet join pain and sacro-iliacale joints, endoscopic transforaminal discectomy and epidural injections McKenzieplus ; investigator at NHMRC in Australia), Johan Vlaeyen (Methusalem programme « From acute aversive sensations to chronic bodily symptons » (FNO)). A grant, fees or funds for a member of staff or another (...) Low back pain and radicular pain: evaluation and management 2017 www.kce.fgov.be KCE REPORT 287 LOW BACK PAIN AND RADICULAR PAIN: ASSESSMENT AND MANAGEMENT BVOT 2017 www.kce.fgov.be KCE REPORT 287 GOOD CLINICAL PRACTICE LOW BACK PAIN AND RADICULAR PAIN: ASSESSMENT AND MANAGEMENT PETER VAN WAMBEKE, ANJA DESOMER, LUC AILLIET, ANNE BERQUIN, CHRISTOPHE DEMOULIN, BART DEPREITERE, JOHAN DEWACHTER, MIEKE DOLPHENS, PATRICE FORGET, VIRGINIE FRASELLE, GUY HANS, DAVY HOSTE, GENEVIÈVE MAHIEU, JEF

2017 Belgian Health Care Knowledge Centre

42. Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic pain

nerves and pathways in the nervous system. It can occur in a heterogeneous group of disorders, including painful diabetic neuropathy, post-herpetic neuralgia and trigeminal neuralgia. People with neuropathic pain may have altered pain sensation, areas of numbness or burning, and continuous or intermittent evoked or spontaneous pain. Neuropathic pain is an unpleasant sensory and emotional experience that can have a significant effect on a person's quality of life. Current treatments 2.2 A range (...) Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic pain T T r ranscr anscranial MRI-guided focused ultr anial MRI-guided focused ultrasound asound thalamotom thalamotomy for neuropathic pain y for neuropathic pain Interventional procedures guidance Published: 28 November 2018 nice.org.uk/guidance/ipg632 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

43. Pulsatile Mass Sensation with Intense Abdominal Pain; Atypical Presentation of the Nutcracker Syndrome Full Text available with Trip Pro

Pulsatile Mass Sensation with Intense Abdominal Pain; Atypical Presentation of the Nutcracker Syndrome Patients with Nutcracker syndrome generally present with nonspecific abdominal pain, with the left renal vein (LRV) lodged between the aorta and the superior mesenteric artery. In rare cases this can result in atypical gastrointestinal symptoms, making the diagnosis of Nutcracker syndrome challenging.A 28-year-old female patient presented with complaints of severe abdominal pain and palpable

2016 Polish Journal of Radiology

44. Dorsal root ganglion neurons and tyrosine hydroxylase – An intriguing association with implications for sensation and pain Full Text available with Trip Pro

Dorsal root ganglion neurons and tyrosine hydroxylase – An intriguing association with implications for sensation and pain 26447702 2016 10 13 2018 11 13 1872-6623 157 2 2016 Feb Pain Pain Dorsal root ganglion neurons and tyrosine hydroxylase--an intriguing association with implications for sensation and pain. 314-20 10.1097/j.pain.0000000000000381 Brumovsky Pablo R PR aInstitute of Research on Translational Medicine, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET (...) ) - Austral University, Pilar, Buenos Aires, ArgentinabDepartment of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA. eng R01 DK093525 DK NIDDK NIH HHS United States R01 NS035790 NS NINDS NIH HHS United States DK093525 DK NIDDK NIH HHS United States NS035790 NS NINDS NIH HHS United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review United States Pain 7508686 0304-3959 EC 1.14.16.2 Tyrosine 3-Monooxygenase

2016 Pain

45. Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data Full Text available with Trip Pro

Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data Every individual varies in character and so do their sensory functions and perceptions. The molecular mechanism and the molecular candidates involved in these processes are assumed to be similar if not same. So far several molecular factors have been identified which are fairly conserved across the phylogenetic tree and are involved in these complex sensory functions (...) . Among all, members belonging to Transient Receptor Potential (TRP) channels have been widely characterized for their involvement in thermo-sensation. These include TRPV1 to TRPV4 channels which reveal complex thermo-gating behavior in response to changes in temperature. The molecular evolution of these channels is highly correlative with the thermal response of different species. However, recent 2504 human genome data suggest that these thermo-sensitive TRPV channels are highly variable and carry

2016 Channels

46. Cognitive Coping Style and the Effectiveness of Distraction or Sensation-Focused Instructions in Chronic Pain Patients Full Text available with Trip Pro

Cognitive Coping Style and the Effectiveness of Distraction or Sensation-Focused Instructions in Chronic Pain Patients This study set out to investigate whether cognitive coping strategies that match participants' preferred coping style effectively reduce pain intensity and situational anxiety in a population of people with chronic pain.Chronic pain patients (N = 43) completed questionnaires on coping style, pain intensity, self-efficacy, and situational/trait anxiety. Participants were (...) classified as Monitors (n = 16) or Blunters (n = 19) based on their Miller Behavioural Style Scale score. Participants were then provided with an audiotaped intervention in which they were instructed to focus on pain sensations or to engage in a distraction task and then to rate the pain intensity and their anxiety during and after the attentional focus and distraction conditions. The two interventions were each completed by all participants, having been presented in counterbalanced order.Findings

2016 PloS one

47. Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates Full Text available with Trip Pro

Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates Approximately 20% of the adult population suffer from chronic pain that is not adequately treated by current therapies, highlighting a great need for improved treatment options. To develop effective analgesics, experimental human and animal models of pain are critical. Topically/intra-dermally applied capsaicin induces hyperalgesia and allodynia to thermal and tactile (...) stimuli that mimics chronic pain and is a useful translation from preclinical research to clinical investigation. Many behavioral and self-report studies of pain have exploited the use of the capsaicin pain model, but objective biomarker correlates of the capsaicin augmented nociceptive response in nonhuman primates remains to be explored.Here we establish an aversive capsaicin-induced fMRI model using non-noxious heat stimuli in Cynomolgus monkeys (n = 8). BOLD fMRI data were collected during thermal

2016 PloS one

48. Thermal temporal summation and decay of after-sensations in temporomandibular myofascial pain patients with and without comorbid fibromyalgia Full Text available with Trip Pro

Thermal temporal summation and decay of after-sensations in temporomandibular myofascial pain patients with and without comorbid fibromyalgia Chronic myofascial temporomandibular disorders (TMD) may have multiple etiological and maintenance factors. One potential factor, central pain sensitization, was quantified here as the response to the temporal summation (TS) paradigm, and that response was compared between case and control groups.As previous research has shown that fibromyalgia (FM (...) ) is diagnosed iñ20% of TMD patients, Aim 1 determined whether central sensitization is found preferentially in myofascial TMD cases that have orofacial pain as a regional manifestation of FM. Aim 2 determined if the report of after-sensations (AS) following TS varied depending on whether repeated stimuli were rated as increasingly painful.One hundred sixty-eight women, 43 controls, 100 myofascial TMD-only cases, and 25 myofascial TMD + FM cases, were compared on thermal warmth and pain thresholds, thermal

2016 Journal of pain research

49. Comparison of two different doses of lidocaine on the pain sensation during transrectal ultrasound-guided prostate biopsy Full Text available with Trip Pro

Comparison of two different doses of lidocaine on the pain sensation during transrectal ultrasound-guided prostate biopsy To compare two different doses of lidocaine used for periprostatic nerve block on pain perception during transrectal ultrasound (TRUS) guided prostate biopsy.A total of 288 patients with elevated prostate specific antigen (PSA) levels and/or abnormal digital rectal examination who underwent TRUS-guided prostate biopsy were included in the study. The patients were divided (...) into 3 groups: Group 1 (n=103) prostate biopsy were performed after administering perianal intrarectal application of 10 mL 2% lidocaine gel, Group 2 (n=98) 2 mL of 2% lidocaine injection on each side following rectal installation of lidocaine gel and Group 3 (n=87) 4 mL of 2% lidocaine injection on each side after rectal instillation of lidocaine gel. Patients' pain scores during biopsy procedure were reported using visual analogue score (VAS). Independent sample t test, ANOVA test and Tukey test

2016 Turkish journal of urology Controlled trial quality: uncertain

50. 10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain

10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain Published March 2020 Volume 20, Number 6 ONTARIO HEALTH TECHNOLOGY ASSESSMENT SERIES 10-kHz High-Frequency Spinal Cord Stimulation for Adults With Chronic Noncancer Pain: A Health Technology Assessment KEY MESSAGES What Is This Health Technology Assessment About? Chronic pain is pain that lasts for a long time, usually more than 3 months. People may develop chronic pain because of an injury, an infection (...) , a disease, or a surgery—or there may be no obvious reason for the pain. Chronic pain has a negative effect on people’s physical, emotional, social, and mental health. People may try a range of treatment options to manage their chronic pain, including physiotherapy, mindfulness practices, and medications. Spinal cord stimulation is typically recommended if these options do not work to relieve a person's pain. It delivers low-voltage electricity to the nerves in the spine to suppress pain signals

2020 Health Quality Ontario

52. Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations

Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations (AMUPS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02429960 Recruitment Status : Completed First Posted : April 29, 2015 Last Update Posted : December 3, 2015 Sponsor: Universitätsklinikum Hamburg-Eppendorf

2015 Clinical Trials

53. Modulation of non-painful phantom sensation in subjects with spinal cord injury by means of rTMS. (Abstract)

Modulation of non-painful phantom sensation in subjects with spinal cord injury by means of rTMS. We aimed in this study to investigate whether repetitive transcranial magnetic stimulation (rTMS), given as theta burst stimulation (TBS), can interfere with non-painful phantom sensations in subjects with spinal cord injury (SCI). In double-blind, sham-controlled experiments in five subjects with cervical or thoracic traumatic SCI, we evaluated the effects of a single session of inhibitory (...) (continuous) TBS, excitatory (intermittent) TBS, or placebo TBS, on simplex and complex non-painful phantom sensations. The interventions targeted the contralateral primary motor cortex (M1), the primary sensory cortex (S1) and the posterior parietal cortex (PPC). Measurements were carried out at baseline (T0), 5 min (T1) and 30 min later (T2) after the intervention. Descriptive evaluation of results shows that non-painful phantom sensations were not affected by rTMS applied over M1. Continuous

2015 Brain Research Bulletin Controlled trial quality: uncertain

54. Clinical study of pain sensation during phacoemulsification with and without cryoanalgesia. (Abstract)

Clinical study of pain sensation during phacoemulsification with and without cryoanalgesia. To compare the analgesic efficacy of 2 types of anesthetic techniques-topical and topical associated with cryoanalgesia-during cataract surgery.Department of Ophthalmology, University of São Paulo, Ribeirão Preto, Brazil.Prospective randomized study.Patients with symmetrical bilateral cataract had phacoemulsification with the use of an intraocular irrigation solution at room temperature in 1 eye (...) and a cold (4°C) solution in the contralateral eye (Group 2). The pain related to the procedure was assessed using a visual analog scale ranging from 0 to 100, with 0 representing no pain and 100 the worst pain. In addition, endothelial cell loss, the change in corneal thickness, and visual acuity were evaluated 30 days ± 2 (SD) after each surgery. The surgery duration, total irrigation volume, phacoemulsification time, and ultrasound power used were analyzed.The study enrolled 25 patients (50 eyes

2015 Journal of cataract and refractive surgery Controlled trial quality: uncertain

55. Central mechanisms of airway sensation and cough hypersensitivity. Full Text available with Trip Pro

Central mechanisms of airway sensation and cough hypersensitivity. The airway sensory nervous system is composed of two anatomically distinct processing pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory behaviours in response to sensing an airway irritation. Disordered sensory processing is a hallmark feature of many pulmonary disorders and results in the development of cough hypersensitivity syndrome, characterised by chronic cough and a persistent (...) urge-to-cough in affected individuals. However, the mechanism underpinning how the airway sensory circuits become disordered, especially at the level of the central nervous system, is not well understood. In this mini-review we present well-defined mechanisms that lead to the development of chronic pain as a framework to explore the evidence that cough disorders may manifest due to neuroplasticity and sensitisation of important components of the airway sensory circuitry in the brain. We highlight

2017 Pulmonary Pharmacology & Therapeutics

56. Investigation of the Phenomenon of Propagated Sensation along the Channels in the Upper Limb Following Administration of Acupuncture and Mock Laser. Full Text available with Trip Pro

Investigation of the Phenomenon of Propagated Sensation along the Channels in the Upper Limb Following Administration of Acupuncture and Mock Laser. Similar to De Qi psychophysical responses, propagated sensation along the channels (PSC) is considered an important phenomenon in traditional Chinese acupuncture. In acupuncture clinical trials, different acupuncture manipulation techniques are used to enhance the propagation of sensation along the channels to facilitate an optimum therapeutic (...) result.To examine and compare the PSC reported by participants in a clinical trial following the administration of acupuncture and inactive mock laser.The study was embedded in a two-arm parallel design multicenter, randomized clinical trial, the Tennis Elbow Acupuncture-International Study-China, Hong Kong, Australia, Italy (TEA IS CHAI). Needle sensations were measured using a validated instrument, the Massachusetts General Hospital Acupuncture Sensation Spreading Scale. Ninety-six participants

2017 Journal of acupuncture and meridian studies Controlled trial quality: uncertain

57. Prosthesis With Sensations

of Sensations From the Lost Limb to Amputees for Fall Avoidance, Regular Walking, Phantom Limb Pain Diminishment and Embodiment of Prosthesis Actual Study Start Date : November 12, 2017 Actual Primary Completion Date : August 1, 2018 Estimated Study Completion Date : August 1, 2020 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: SENSY benefit Sensory feedback elicited by intraneural stimulation will be provided (...) Prosthesis With Sensations Prosthesis With Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prosthesis With Sensations The safety and scientific validity of this study is the responsibility

2017 Clinical Trials

58. Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation. (Abstract)

Mas-Related G Protein-Coupled Receptors and the Biology of Itch Sensation. Chronic, persistent itch is a devastating symptom that causes much suffering. In recent years, there has been great progress made in understanding the molecules, cells, and circuits underlying itch sensation. Once thought to be carried by pain-sensing neurons, itch is now believed to be capable of being transmitted by dedicated sensory labeled lines. Members of the Mas-related G protein-coupled receptor (Mrgpr) family (...) on the role of Mrgprs in mediating itch sensation.

2017 Annual Review of Genetics

59. Acute corneal epithelial debridement unmasks the corneal stromal nerve responses to ocular stimulation in rats: implications for abnormal sensations of the eye Full Text available with Trip Pro

Acute corneal epithelial debridement unmasks the corneal stromal nerve responses to ocular stimulation in rats: implications for abnormal sensations of the eye It is widely accepted that the mechanisms for transducing sensory information reside in the nerve terminals. Occasionally, however, studies have appeared demonstrating that similar mechanisms may exist in the axon to which these terminals are connected. We examined this issue in the cornea, where nerve terminals in the epithelial cell (...) layers are easily accessible for debridement, leaving the underlying stromal (axonal) nerves undisturbed. In isoflurane-anesthetized rats, we recorded extracellularly from single trigeminal ganglion neurons innervating the cornea that are excited by ocular dryness and cooling: low-threshold (<2°C cooling) and high-threshold (>2°C) cold-sensitive plus dry-sensitive neurons playing possible roles in tearing and ocular pain. We found that the responses in both types of neurons to dryness, wetness

2017 Journal of neurophysiology

60. Relationships between catastrophic thought, bodily sensations and physical symptoms Full Text available with Trip Pro

Relationships between catastrophic thought, bodily sensations and physical symptoms Researchers have recently begun to seek cognitive explanations for physical symptoms with no obvious biological cause. Concepts such as somatization, somatosensory amplification, and somatosensory catastrophizing have been invoked to explain these phenomena. Somatosensory amplification occurs when these bodily sensations become stronger and more painful. Somatosensory catastrophizing is the tendency to attribute (...) these bodily sensations to unbearable functional modulation or as signs of serious illness. This causes the sufferer to pay excessive attention to these physical sensations. However, there is no scale for evaluating somatosensory catastrophizing, and there are no standard diagnostic criteria. There were two objectives for this study: to develop a scale for evaluating somatosensory catastrophizing and to investigate relationships between somatosensory amplification, somatosensory catastrophizing

2017 BioPsychoSocial medicine

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