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Pain Sensation

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41. A Double-Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles. Full Text available with Trip Pro

in the Massachusetts General Hospital Acupuncture Sensation Scale (MASS), "heaviness" was the strongest and most frequently reported sensation with the 10 mm needles, but not with the 5 mm needles. There were no significant differences in number of sensations elicited, MASS index, range of spreading, and intensity of needle pain for 5 mm penetration versus 1 mm skin press and 10 mm penetration versus 2 mm skin press. The MASS index with 2 mm skin-touch needles was significantly larger than that with 1 mm skin (...) A Double-Blind Study on Acupuncture Sensations with Japanese Style of Acupuncture: Comparison between Penetrating and Placebo Needles. To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch placebo needles were randomly administered at various insertion depths (5 and 10 mm for the penetrating needles and 1 and 2 mm for the placebo needles) at LI4 to 50 healthy subjects. Among the 12 acupuncture sensations

2018 Evidence-based Complementary and Alternative Medicine (eCAM) Controlled trial quality: uncertain

42. Nipple-Areola Complex Sensation after Nipple-sparing Mastectomy Full Text available with Trip Pro

operation. In the first 6 months, 11 patients (44%) showed partial sensation recovery, and 3 more patients had partial recovery after 1-year follow-up. Only 1 patient (2%) had complete sensation recovery in all area of the NAC. In late evaluation group, 7 out of 10 patients had partial recovery. Most pain sensation remained in the lower aspect of the areola away from surgical incision.NSM is technically feasible in selected patients with low rates of NAC removal. Some patients can preserve the NAC (...) Nipple-Areola Complex Sensation after Nipple-sparing Mastectomy Nipple-sparing mastectomy (NSM) has been proven to be oncologically safe for treating breast cancer. This procedure had been developed to optimize the esthetic outcome and reduce feeling mutilation after mastectomy. Risks of necrotic complications and diminishing nipple-areola complex (NAC) sensation are common complications affecting the patient's satisfaction after the surgery. The evaluation of NAC sensation should be also

2018 Plastic and Reconstructive Surgery Global Open

43. Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic pain

nerves and pathways in the nervous system. It can occur in a heterogeneous group of disorders, including painful diabetic neuropathy, post-herpetic neuralgia and trigeminal neuralgia. People with neuropathic pain may have altered pain sensation, areas of numbness or burning, and continuous or intermittent evoked or spontaneous pain. Neuropathic pain is an unpleasant sensory and emotional experience that can have a significant effect on a person's quality of life. Current treatments 2.2 A range (...) Transcranial MRI-guided focused ultrasound thalamotomy for neuropathic pain T T r ranscr anscranial MRI-guided focused ultr anial MRI-guided focused ultrasound asound thalamotom thalamotomy for neuropathic pain y for neuropathic pain Interventional procedures guidance Published: 28 November 2018 nice.org.uk/guidance/ipg632 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising

2018 National Institute for Health and Clinical Excellence - Interventional Procedures

44. Comparison of two different doses of lidocaine on the pain sensation during transrectal ultrasound-guided prostate biopsy Full Text available with Trip Pro

Comparison of two different doses of lidocaine on the pain sensation during transrectal ultrasound-guided prostate biopsy To compare two different doses of lidocaine used for periprostatic nerve block on pain perception during transrectal ultrasound (TRUS) guided prostate biopsy.A total of 288 patients with elevated prostate specific antigen (PSA) levels and/or abnormal digital rectal examination who underwent TRUS-guided prostate biopsy were included in the study. The patients were divided (...) into 3 groups: Group 1 (n=103) prostate biopsy were performed after administering perianal intrarectal application of 10 mL 2% lidocaine gel, Group 2 (n=98) 2 mL of 2% lidocaine injection on each side following rectal installation of lidocaine gel and Group 3 (n=87) 4 mL of 2% lidocaine injection on each side after rectal instillation of lidocaine gel. Patients' pain scores during biopsy procedure were reported using visual analogue score (VAS). Independent sample t test, ANOVA test and Tukey test

2016 Turkish journal of urology Controlled trial quality: uncertain

45. Thermal temporal summation and decay of after-sensations in temporomandibular myofascial pain patients with and without comorbid fibromyalgia Full Text available with Trip Pro

Thermal temporal summation and decay of after-sensations in temporomandibular myofascial pain patients with and without comorbid fibromyalgia Chronic myofascial temporomandibular disorders (TMD) may have multiple etiological and maintenance factors. One potential factor, central pain sensitization, was quantified here as the response to the temporal summation (TS) paradigm, and that response was compared between case and control groups.As previous research has shown that fibromyalgia (FM (...) ) is diagnosed iñ20% of TMD patients, Aim 1 determined whether central sensitization is found preferentially in myofascial TMD cases that have orofacial pain as a regional manifestation of FM. Aim 2 determined if the report of after-sensations (AS) following TS varied depending on whether repeated stimuli were rated as increasingly painful.One hundred sixty-eight women, 43 controls, 100 myofascial TMD-only cases, and 25 myofascial TMD + FM cases, were compared on thermal warmth and pain thresholds, thermal

2016 Journal of pain research

46. Pulsatile Mass Sensation with Intense Abdominal Pain; Atypical Presentation of the Nutcracker Syndrome Full Text available with Trip Pro

Pulsatile Mass Sensation with Intense Abdominal Pain; Atypical Presentation of the Nutcracker Syndrome Patients with Nutcracker syndrome generally present with nonspecific abdominal pain, with the left renal vein (LRV) lodged between the aorta and the superior mesenteric artery. In rare cases this can result in atypical gastrointestinal symptoms, making the diagnosis of Nutcracker syndrome challenging.A 28-year-old female patient presented with complaints of severe abdominal pain and palpable

2016 Polish Journal of Radiology

47. Dorsal root ganglion neurons and tyrosine hydroxylase – An intriguing association with implications for sensation and pain Full Text available with Trip Pro

Dorsal root ganglion neurons and tyrosine hydroxylase – An intriguing association with implications for sensation and pain 26447702 2016 10 13 2018 11 13 1872-6623 157 2 2016 Feb Pain Pain Dorsal root ganglion neurons and tyrosine hydroxylase--an intriguing association with implications for sensation and pain. 314-20 10.1097/j.pain.0000000000000381 Brumovsky Pablo R PR aInstitute of Research on Translational Medicine, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET (...) ) - Austral University, Pilar, Buenos Aires, ArgentinabDepartment of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA. eng R01 DK093525 DK NIDDK NIH HHS United States R01 NS035790 NS NINDS NIH HHS United States DK093525 DK NIDDK NIH HHS United States NS035790 NS NINDS NIH HHS United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review United States Pain 7508686 0304-3959 EC 1.14.16.2 Tyrosine 3-Monooxygenase

2016 Pain

48. Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data Full Text available with Trip Pro

Why individual thermo sensation and pain perception varies? Clue of disruptive mutations in TRPVs from 2504 human genome data Every individual varies in character and so do their sensory functions and perceptions. The molecular mechanism and the molecular candidates involved in these processes are assumed to be similar if not same. So far several molecular factors have been identified which are fairly conserved across the phylogenetic tree and are involved in these complex sensory functions (...) . Among all, members belonging to Transient Receptor Potential (TRP) channels have been widely characterized for their involvement in thermo-sensation. These include TRPV1 to TRPV4 channels which reveal complex thermo-gating behavior in response to changes in temperature. The molecular evolution of these channels is highly correlative with the thermal response of different species. However, recent 2504 human genome data suggest that these thermo-sensitive TRPV channels are highly variable and carry

2016 Channels

49. Cognitive Coping Style and the Effectiveness of Distraction or Sensation-Focused Instructions in Chronic Pain Patients Full Text available with Trip Pro

Cognitive Coping Style and the Effectiveness of Distraction or Sensation-Focused Instructions in Chronic Pain Patients This study set out to investigate whether cognitive coping strategies that match participants' preferred coping style effectively reduce pain intensity and situational anxiety in a population of people with chronic pain.Chronic pain patients (N = 43) completed questionnaires on coping style, pain intensity, self-efficacy, and situational/trait anxiety. Participants were (...) classified as Monitors (n = 16) or Blunters (n = 19) based on their Miller Behavioural Style Scale score. Participants were then provided with an audiotaped intervention in which they were instructed to focus on pain sensations or to engage in a distraction task and then to rate the pain intensity and their anxiety during and after the attentional focus and distraction conditions. The two interventions were each completed by all participants, having been presented in counterbalanced order.Findings

2016 PloS one

50. Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates Full Text available with Trip Pro

Distinct BOLD fMRI Responses of Capsaicin-Induced Thermal Sensation Reveal Pain-Related Brain Activation in Nonhuman Primates Approximately 20% of the adult population suffer from chronic pain that is not adequately treated by current therapies, highlighting a great need for improved treatment options. To develop effective analgesics, experimental human and animal models of pain are critical. Topically/intra-dermally applied capsaicin induces hyperalgesia and allodynia to thermal and tactile (...) stimuli that mimics chronic pain and is a useful translation from preclinical research to clinical investigation. Many behavioral and self-report studies of pain have exploited the use of the capsaicin pain model, but objective biomarker correlates of the capsaicin augmented nociceptive response in nonhuman primates remains to be explored.Here we establish an aversive capsaicin-induced fMRI model using non-noxious heat stimuli in Cynomolgus monkeys (n = 8). BOLD fMRI data were collected during thermal

2016 PloS one

51. Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations

Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Comparison of Different Analgesia-Monitors in Tracing Unconscious Pain Sensations (AMUPS) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02429960 Recruitment Status : Completed First Posted : April 29, 2015 Last Update Posted : December 3, 2015 Sponsor: Universitätsklinikum Hamburg-Eppendorf

2015 Clinical Trials

52. Clinical study of pain sensation during phacoemulsification with and without cryoanalgesia. (Abstract)

Clinical study of pain sensation during phacoemulsification with and without cryoanalgesia. To compare the analgesic efficacy of 2 types of anesthetic techniques-topical and topical associated with cryoanalgesia-during cataract surgery.Department of Ophthalmology, University of São Paulo, Ribeirão Preto, Brazil.Prospective randomized study.Patients with symmetrical bilateral cataract had phacoemulsification with the use of an intraocular irrigation solution at room temperature in 1 eye (...) and a cold (4°C) solution in the contralateral eye (Group 2). The pain related to the procedure was assessed using a visual analog scale ranging from 0 to 100, with 0 representing no pain and 100 the worst pain. In addition, endothelial cell loss, the change in corneal thickness, and visual acuity were evaluated 30 days ± 2 (SD) after each surgery. The surgery duration, total irrigation volume, phacoemulsification time, and ultrasound power used were analyzed.The study enrolled 25 patients (50 eyes

2015 Journal of cataract and refractive surgery Controlled trial quality: uncertain

53. Modulation of non-painful phantom sensation in subjects with spinal cord injury by means of rTMS. (Abstract)

Modulation of non-painful phantom sensation in subjects with spinal cord injury by means of rTMS. We aimed in this study to investigate whether repetitive transcranial magnetic stimulation (rTMS), given as theta burst stimulation (TBS), can interfere with non-painful phantom sensations in subjects with spinal cord injury (SCI). In double-blind, sham-controlled experiments in five subjects with cervical or thoracic traumatic SCI, we evaluated the effects of a single session of inhibitory (...) (continuous) TBS, excitatory (intermittent) TBS, or placebo TBS, on simplex and complex non-painful phantom sensations. The interventions targeted the contralateral primary motor cortex (M1), the primary sensory cortex (S1) and the posterior parietal cortex (PPC). Measurements were carried out at baseline (T0), 5 min (T1) and 30 min later (T2) after the intervention. Descriptive evaluation of results shows that non-painful phantom sensations were not affected by rTMS applied over M1. Continuous

2015 Brain Research Bulletin Controlled trial quality: uncertain

55. Overview of musculoskeletal pain

=bestpractice.com Most commonly results from motor vehicle accidents, gunshot or stab wounds, contact sports, or workplace accidents during heavy physical labour. The effects of the injury include paralysis, loss of sensation, and pain. The specific clinical presentation will depend on the nerve roots involved and the degree of injury to each root. A bursa is a sac containing a small amount of synovial fluid that lies between a tendon and either skin or bone to act as a friction buffer. In bursitis (...) Overview of musculoskeletal pain Overview of musculoskeletal pain - Summary of relevant conditions | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Overview of musculoskeletal pain Last reviewed: February 2019 Last updated: July 2018 Introduction Musculoskeletal pain is very common, may be acute or chronic, and is a major cause of morbidity and occupational sickness absence. Studies have found a prevalence of chronic musculoskeletal pain

2018 BMJ Best Practice

56. Aptiva for painful diabetic neuropathy

of each treatment session, the electrical dose is set by the clinician, based on the sensation felt by the patient: the electrical stimulation should be felt but should not be painful. The duration of a treatment session is 35 minutes with a treatment cycle comprising 10 daily sessions. The company's suggested treatment frequency is 3 cycles per year, depending on the response to treatment. The device was formerly known as PhysioFlog ETS 501. Innovations Aptiva is designed to provide a non-drug (...) in the change in nerve conductance velocity (NCV) between groups. Night-time and daytime pain was significantly reduced in the intervention group up to 37 weeks after initial treatment. T otal follow-up was 51 weeks. The difference in pain between groups was not significant 3 months after the last treatment. There was no significant difference in the change in tactile sensation between groups. There was a significant increase in cold sensation threshold in the intervention group compared with the placebo

2017 National Institute for Health and Clinical Excellence - Advice

57. Electrical Stimulation for Improving Postoperative Breast Sensation

, a common complaint is the lack of sensation to the skin and nipple of the reconstructed breast due to injury and stretch of the sensory nerves. Numbness of the breast, nipple, and areola is an unnatural feeling for the patient, as well as a potential risk for injury or burns as the woman is unable to feel pain. Our laboratory has previously shown that electrical stimulation (ES) is an effective way of improving nerve regeneration after injury to the nerves of the upper and lower extremities. Proven (...) similarly is improved with immediate postoperative ES for one hour. Methods: Thirty patients that will be undergoing bilateral prophylactic skin-sparing mastectomy with immediate implant-based breast reconstruction will be identified from the practice of two plastic surgeons. Preoperatively, women will be undergo sensory testing to the 4 quadrants of both breasts and the nipples, including testing for tactile sensation, cool detection, 2-point discrimination, heat-pain detection threshold, and sharp

2017 Clinical Trials

58. Palatability and Postprandial Sensations

in fullness sensation measured after the test meal [ Time Frame: 1 day ] Change in average fullness measured by 10 score scales at the end of the test meal Change in abdominal discomfort/pain sensation measured after the test meal [ Time Frame: 1 day ] Change in average abdominal discomfort/pain measured by 10 score scales at the end of the test meal Change in mood measured after the test meal [ Time Frame: 1 day ] Change in average mood measured by 10 score scales at the end of the test meal. Eligibility (...) Palatability and Postprandial Sensations Palatability and Postprandial Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Palatability and Postprandial Sensations The safety and scientific validity

2017 Clinical Trials

59. Genetic Variants and Chemotherapy-induced Abnormal Thermal Sensation

. Patients with colorectal cancer Diagnostic Test: Genetic variants of TRPV1, TRPM2, TRPA1 and ORAI Genetic variants of TRPV1, TRPM2, TRPA1 and ORAI1 will be analyzed. Quantitative Sensory Test, QST, will be used to determined if there is abnormal thermal sensation. Outcome Measures Go to Primary Outcome Measures : The change of thermal pain threshold [ Time Frame: before chemotherapy & 3, 6, and 9 months after chemotherapy ] The threshold of detecting heat-induced pain Eligibility Criteria Go (...) Genetic Variants and Chemotherapy-induced Abnormal Thermal Sensation Genetic Variants and Chemotherapy-induced Abnormal Thermal Sensation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Genetic Variants

2017 Clinical Trials

60. Prosthesis With Sensations

of Sensations From the Lost Limb to Amputees for Fall Avoidance, Regular Walking, Phantom Limb Pain Diminishment and Embodiment of Prosthesis Actual Study Start Date : November 12, 2017 Actual Primary Completion Date : August 1, 2018 Estimated Study Completion Date : August 1, 2020 Resource links provided by the National Library of Medicine related topics: Arms and Interventions Go to Arm Intervention/treatment Experimental: SENSY benefit Sensory feedback elicited by intraneural stimulation will be provided (...) Prosthesis With Sensations Prosthesis With Sensations - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prosthesis With Sensations The safety and scientific validity of this study is the responsibility

2017 Clinical Trials

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