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Pain Sensation

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481. Estradiol Sensitizes the Transient Receptor Potential Vanilloid 1 Receptor in Pain Responses. Full Text available with Trip Pro

Estradiol Sensitizes the Transient Receptor Potential Vanilloid 1 Receptor in Pain Responses. Sex differences exist in chronic pain pathologies, and gonadal estradiol (E2) alters the pain sensation. The nocisensor transient receptor potential vanilloid 1 (TRPV1) receptor plays a critical role in triggering pain. Here we examined the impact of E2 on the function of TRPV1 receptor in mice sensory neurons in vitro and in vivo. Both mechano- and thermonociceptive thresholds of the plantar surface (...) and upregulation of TRPV1 receptor by E2 in sensory neurons may explain the greater pain sensitivity in female mice.Copyright © 2017 Endocrine Society.

2017 Endocrinology

482. Brain processing of the temporal dimension of acute pain in short-term memory. (Abstract)

Brain processing of the temporal dimension of acute pain in short-term memory. The dynamics of noxious sensation shapes pain perception, yet the memory of the temporal dimension of pain remains almost completely unexplored. Here, brain activity during the memory of pain duration was contrasted with that associated with the memory of pain intensity using functional magnetic resonance imaging and a delayed reproduction task. Participants encoded, maintained during a short delay, and reproduced (1 (...) in the supramarginal gyrus extending to the parietal operculum (possibly SII) and primary somatosensory cortex (SI). In contrast, the memory delay of the dynamic task involved the bilateral supplementary motor area and the frontoparietal attentional network. Although SI, SII, and insula may contribute to the memory trace of pain sensation, other areas less commonly reported in pain studies are associated with time processing and may therefore contribute to the processing of temporal aspects of pain. Results

2017 Pain

483. Chronic pain in Pachyonychia Congenita: evidence for neuropathic origin. Full Text available with Trip Pro

to investigate the pathophysiology of PC.Patients (n = 62) and controls (n = 45) completed the McGill and Douleur Neuropathique-4 (DN4) questionnaires. Sensory testing included detection and pain thresholds, pathological sensations, conditioned pain modulation (CPM) and temporal summation of pain.A moderate-to-severe chronic pain in the feet, throbbing and stabbing in quality, was highly prevalent among patients with PC (86%) and was especially debilitating during weight bearing. In addition, the majority (...) Chronic pain in Pachyonychia Congenita: evidence for neuropathic origin. Pachyonychia congenita (PC) is a rare autosomal dominant skin disease, with chronic pain being the most prominent complaint. Histological studies showing alterations in sensory innervation, along with reports on alterations in mechanical sensitivity, suggest that PC may be a form of neuropathy.Here, for the first time, we aim to evaluate systematically the sensory function of patients with PC vs. controls, in order

2017 British Journal of Dermatology

484. Is burning mouth syndrome a neuropathic pain condition? (Abstract)

Is burning mouth syndrome a neuropathic pain condition? Primary burning mouth syndrome (BMS) is defined as an "intraoral burning or dysaesthetic sensation, recurring daily… more than 3 months, without clinically evident causative lesions" (IHS 2013). In addition to pain, taste alterations are frequent (dysgeusia, xerostomia). Although lacking clinical signs of neuropathy, more accurate diagnostic methods have shown neuropathic involvement at various levels of the neuraxis in BMS: peripheral (...) function). Abnormalities in electrogustatometry indicate the involvement of the small Aδ taste afferents, in addition to somatosensory small fibers. According to these findings, the clinical entity of BMS can be divided into 2 main subtypes compatible with either peripheral or central neuropathic pain, which may overlap in individual patients. The central type does not respond to local treatments and associates often with psychiatric comorbidity (depression or anxiety), whereas the peripheral type

2017 Pain

485. Chronic Pain and Neuropathy Following Adjuvant Chemotherapy. (Abstract)

Chronic Pain and Neuropathy Following Adjuvant Chemotherapy. To determine symptoms and characteristics of chronic sensory neuropathy in patients treated with oxaliplatin and docetaxel, including patterns of somatosensory abnormalities, pain descriptors, and psychological functioning.A retrospective cross-sectional study.A chronic pain research center.Thirty-eight patients with chronic peripheral pain and/or dysesthesia following chemotherapy.Sensory profiles, psychological functioning (...) in thermal sensory limen and the presence of paradoxical heat sensation seem to be sensitive markers of small fiber loss. Both groups had mainly sensory, axonal large fiber or mixed fiber polyneuropathy, which tended to be most severe in the oxaliplatin group.Both oxaliplatin-induced and docetaxel-induced polyneuropathies represent a significant problem that affects the daily life of the patients. Our results, defining the somatosensory phenotype, can improve the understanding of the pathophysiological

2017 Pain Medicine

486. Limb Laterality Recognition Score: A Reliable Clinical Measure Related to Phantom Limb Pain. Full Text available with Trip Pro

(N = 1).Subjects self-reported amputated limb pain using the sensation subsection of the Prosthetic Evaluation Questionnaire and back and sound limb pain. Using numbered iPads that corresponded to the self-reports, subjects played the Recognise Foot game to assess limb laterality recognition ability. Subjects identified the laterality of 20 foot images, within two seconds each. The software collected accuracy and speed scores in basic, vanilla, and context conditions for two rounds in random (...) Limb Laterality Recognition Score: A Reliable Clinical Measure Related to Phantom Limb Pain. To explore the usefulness of the limb laterality recognition score as a clinical measure of phantom limb pain, regarding test-retest reliability and association of limb laterality recognition scores with phantom limb pain measures.Retrospective cohort.Community support group.Eleven adults who averaged 4.8 years since lower limb amputation due to vascular pathologies (N = 9), trauma (N = 1), and cancer

2017 Pain Medicine

487. Investigation of the Efficacy and Safety of Topical Vibration Anesthesia to Reduce Pain From Cosmetic Botulinum Toxin A Injections in Chinese Patients: A Multicenter, Randomized, Self-Controlled Study. (Abstract)

of pain sensation was statistically analyzed.The patients experienced both clinically and statistically significant pain reduction when a vibration was coadministered with injections. Patients reported less pain on the treated side compared with the control side. Overall, 75% of patients preferred to receive vibration with their next treatment. No adverse events were reported.Vibration is an effective and safe way to reduce pain during cosmetic BTX-A injections and may have applications in other (...) Investigation of the Efficacy and Safety of Topical Vibration Anesthesia to Reduce Pain From Cosmetic Botulinum Toxin A Injections in Chinese Patients: A Multicenter, Randomized, Self-Controlled Study. Vibration has been proved to be effective to reduce pain during facial cosmetic injections, but it has not been studied in Chinese patients.To investigate the efficacy and safety of vibration for pain reduction associated with cosmetic botulinum toxin A (BTX-A) injections in Chinese patients.In

2017 Dermatologic Surgery Controlled trial quality: uncertain

488. Efficacy of Motor Control and Diathermy Treatment in Acute Low Back Pain

diathermy without therapeutic effects Device: microwave diathermy Application of microwave diathermy with Monopolar CapacitiveResistive Radiofrequency Therapy (INDIBA) Outcome Measures Go to Primary Outcome Measures : Pain [ Time Frame: 4 weeks ] An unpleasant sensation induced by noxious stimuli which are detected by nerve endings of nociceptive neurons. The measurement tool that will be used is Visual Analog Scale. This scale is a unidimensional measure of pain intensity. It has a continuous scale (...) Efficacy of Motor Control and Diathermy Treatment in Acute Low Back Pain Efficacy of Motor Control and Diathermy Treatment in Acute Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy

2017 Clinical Trials

489. Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management

is voluntary breathing controlled electrical stimulation. tDCS is transcranial direct current stimulation. Device: BreEStim BreEStim will applied for 10 to 20 minutes. Device: tDCS tDCS will be applied for 20 minutes. Device: tDCS sham Outcome Measures Go to Primary Outcome Measures : Change in electrical sensation threshold [ Time Frame: baseline and 10 minutes after treatment ] Secondary Outcome Measures : Change in electrical pain threshold [ Time Frame: baseline and 10 minutes after treatment (...) Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Healthy Subjects - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2017 Clinical Trials

490. Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management

stimulation was started from the sensation threshold level (determined in outcome measure 3) and increased in steps of 1 mA; and subjects were instructed to close their eyes and to say ''yes'' when they first felt electrical stimulation painful. The electrical pain threshold is the mA level at which a participant first felt electrical stimulation painful. To improve consistency among subjects, they were advised that the pain threshold level was equivalent to 1 on the 0-10 VAS scale. Three repetitions were (...) made and the average was used as the electrical pain threshold. Electrical Sensation Threshold [ Time Frame: baseline, 10 minutes after tDCS, 10 minutes after BreEstim ] Trimmed surface electrodes (1 inch by 1 inch) were used to examine electrical sensation threshold upon application of electrical stimulation (electrical stimulator 7SA, Digitimer). To measure electrical sensation threshold, a pair of electrodes was placed next to each other centered on the thenar eminence (which is a group

2017 Clinical Trials

491. Behavioral Interventions for Chronic Pain and Opioid-Related Problems

Behavioral Interventions for Chronic Pain and Opioid-Related Problems Behavioral Interventions for Chronic Pain and Opioid-Related Problems - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Behavioral (...) Interventions for Chronic Pain and Opioid-Related Problems The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03298269 Recruitment Status : Active, not recruiting First Posted : October 2, 2017 Last Update Posted : February 26, 2019 Sponsor: University of Utah Information provided by (Responsible Party): Eric

2017 Clinical Trials

492. Dry Needling and Low-level Laser Therapy to Treat Myofascial Pain

: This measured will be obtained before the intervention (baseline) ] Measured through Pressure Algometry. The force measured in kilograms per square centimeter (kg / cm²) will correspond to the quantity of pressure needed so the subject report change in pressure pain sensation. Pain Pressure Threshold [ Time Frame: This measured will be obtained soon after the intervention (T1) ] Measured through Pressure Algometry. The force measured in kilograms per square centimeter (kg / cm²) will correspond (...) to the quantity of pressure needed so the subject report change in pressure pain sensation. Pain Pressure Threshold [ Time Frame: This measured will be obtained 30 minutes after the intervention (T2) ] Measured through Pressure Algometry. The force measured in kilograms per square centimeter (kg / cm²) will correspond to the quantity of pressure needed so the subject report change in pressure pain sensation. Muscle activity [ Time Frame: Electromyographic data will be collected before the intervention and 5

2017 Clinical Trials

493. Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering

Status : Recruiting First Posted : December 15, 2017 Last Update Posted : March 25, 2019 See Sponsor: The University of Texas Medical Branch, Galveston Information provided by (Responsible Party): The University of Texas Medical Branch, Galveston Study Details Study Description Go to Brief Summary: Few studies have used quantitative sensory tests to study the effect of chronic opioid treatment on sensation. The investigators will test chronic pain patients who are on different MEDDs, normal (...) Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2017 Clinical Trials

494. Exploring the Role of the GABAergic Modulation in Pain Transmission in Human

is moved along the 8 radial lines defined by the center (erythema) and the corners of a regular octagon. Testing starts outside the hyperalgesic area and the probe is moved towards the center in steps of 5 mm. The position is marked where the pin-prick sensation changes to become painful. Once complete boundaries had been defined, the areas are transcribed onto clear film and weighed. The surface area will then be calculated based on a standard measure of the weight of an area of 100cm2. Secondary (...) Outcome Measures : Change in static mechanical pain threshold (SMPT) from baseline [ Time Frame: Hour 1, Hour 2, Hour 3, Hour 4, Hour 5, Hour 6, Hour 7, Hour 8, Hour 9, Hour 10 following drug administration ] Increasing pressure will be manually delivered at a constant rate of 10 g / sec with a von Frey electronic device (Bioseb, Id-Tech Bioseb, Chaville, France). SMPT is defined as the lowest pressure that produces a sensation of pain. This threshold will be determined at DAY1 before UVB exposition

2017 Clinical Trials

495. Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children

Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Effect of the DentalVibe Injection System on Pain During Local Anesthesia Injections in Children The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03374982 Recruitment Status : Recruiting

2017 Clinical Trials

496. Lidocaine for Pain After Urodynamic Testing

periurethral or vaginal abrasions, ulcerations, or lacerations Neurologic disease affecting urethral sensation Chronic pelvic pain Contraindication or allergy to topical anesthetic Pregnancy Syncopal episode during preparation for or execution of uroflowometry Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study (...) Lidocaine for Pain After Urodynamic Testing Lidocaine for Pain After Urodynamic Testing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Lidocaine for Pain After Urodynamic Testing The safety and scientific

2017 Clinical Trials

497. Comparison of rTMS and H Coil in Neuropathic Pain

Comparison of rTMS and H Coil in Neuropathic Pain Comparison of rTMS and H Coil in Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Comparison of rTMS and H Coil in Neuropathic Pain (HNEP (...) by (Responsible Party): Nadine ATTAL, Hospital Ambroise Paré Paris Study Details Study Description Go to Brief Summary: rTMS of the motor cortex is an increasingly established analgesic technique for the treatment of neuropathic pain. However its efficacy is generally modest. One reason may be the that conventional rTMS targets only superficial and small cortical regions of the human brain. A newer cooled coil, the Hesed (H) coils, now allows deep and larger surface of stimulation and has been suggested

2017 Clinical Trials

498. The Effect of Light Therapy on Chronic Pain

, disability status, type of work, whether a previous pain physician has evaluated or provided treatment in the past, if there is any ongoing litigation, a detailed description of the pain (burning, electrical, shooting…etc.) and its location. If the participants are being seen in the clinic for their normal care a detailed physical examination assessing the motor strength of the upper extremities, sensation to light touch and reflexes that is part of the standard of care will be provided (...) the one the participants were assigned. For the follow up clinic visit or phone call (Week 10), data similar to the information gathered at the initial visit will be collected. The description of the pain (burning, electrical, shooting…etc.) and its location will be reviewed. A physical examination assessing for pain and sensation to light touch that is part of the standard of care will be provided for the participants. At the end of the study, the participants will be asked to return the LED strip

2017 Clinical Trials

499. Effect of Hypnosis Combined to Transcranial Direct Stimulation in Pain

, in which a thermode delivers a heat stimulus of increasing magnitude. Heat thermal threshold (HTT) is the averaged temperature for 3 stimuli where participant indicates the first heat sensation. Change in Heat pain threshold [ Time Frame: 60 minutes ] The measure will be assessed by Quantitative Sensorial Test - QST, in which a thermode delivers a heat stimulus of increasing magnitude. Heat pain threshold (HPT) is the averaged temperature for 3 stimuli where participant indicates the first heat pain (...) sensation. Change in Heat pain tolerance [ Time Frame: 60 minutes ] The measure will be assessed by Quantitative Sensorial Test - QST, in which a thermode delivers a heat stimulus of increasing magnitude. Heat pain tolerance (HPTo) is the temperature for the stimulus where participant indicates the maximum pain tolerance. Change in Numeric pain scale during CPM task [ Time Frame: 60 minutes ] The measure will be assessed by the conditioned pain modulation (CPM) task in which an ice cold water (0 a 1

2017 Clinical Trials

500. Incidence of carnitine deficiency in patients with cancer pain: A pilot study Full Text available with Trip Pro

Incidence of carnitine deficiency in patients with cancer pain: A pilot study Carnitine deficiency is reportedly associated with increased pain sensation in diabetes mellitus and fibromyalgia, but the association between serum carnitine concentration and cancer pain has not been fully elucidated. We investigated the incidence of carnitine deficiency in patients with cancer pain, and examined the effect of the patients' demographic and clinical characteristics on pain intensity and carnitine (...) deficiency. The serum carnitine concentration was measured in 50 patients with cancer pain receiving non-steroidal anti-inflammatory drugs, but not opioids. Multivariate regression analysis was used to determine the association of carnitine concentration, pain intensity, age and gender with hemoglobin and C-reactive protein (CRP) concentrations. Carnitine deficiency was detected in 9 of the patients (18.0%) and found to be significantly correlated with an elevated CRP concentration (P=0.039

2017 Molecular and clinical oncology

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