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Pain Sensation

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461. Pain after cancer: A new model for pain psychology?

, how we interpret painful sensations is an integral part of assigning meaning and making sense of those experiences. So if pain is about threat – if it’s about meaning – an ideal model to study pain would be one where there is little tissue damage but a high level of perceived danger. Scientists have played around with this idea in the lab for a few decades now (like and ). The trouble is; thanks to our cushty[1] modern ethics system, making lab participants feel like they are in extreme, life (...) something isn’t right”. But if pain science has taught us anything over the last decade, it’s that . Our body, indeed our brain, can play tricks on us depending on the information we receive from the external world, through those pesky emotion and memory systems, and through our interpretation of those body sensations. I’m going to preempt what you’re thinking now: of course, the most important thing is not to miss a cancer recurrence. We should never ignore pain for so long that we miss signs

2017 Body in Mind blog

462. Effectiveness of Spiritist "passe" (Spiritual healing) for anxiety levels, depression, pain, muscle tension, well-being, and physiological parameters in cardiovascular inpatients: A randomized controlled trial. Full Text available with Trip Pro

Effectiveness of Spiritist "passe" (Spiritual healing) for anxiety levels, depression, pain, muscle tension, well-being, and physiological parameters in cardiovascular inpatients: A randomized controlled trial. Biofield therapies, such as laying on of hands, are used in association with Conventional Medicine as Spiritist "passe", among others. The aim of this study was to evaluate anxiety, depression, pain, muscle tension and well-being, as well as physiological parameters in cardiovascular (...) inpatients submitted to the Spiritist "passe", sham, and no intervention.In the total, 41 cardiovascular inpatients submitted to the Spiritist "passe", sham, and no intervention during a 10-min period on 3 consecutive days. They were evaluated through anxiety and depression level, pain, the perceptions of muscle tension and well-being and physiological parameters, before and after interventions.A significant reduction (p=0.001) in anxiety scores and muscle tension (p=0.011), improvement of well-being (p

2017 Complementary Therapies In Medicine Controlled trial quality: uncertain

463. Effect of Topically-Applied Hyaluronic-Acid on Pain and Palatal Epithelial Wound Healing: An Examiner-Blind, Randomized, Controlled Clinical Trial. (Abstract)

trial. After harvesting palatal grafts, 0.2% and 0.8% hyaluronic-acid gels were used in the test-1 and -2 groups, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups whereas the wound was covered only with periodontal dressing in the control group. On days 3-7-14 and 21, pain and burning sensation were recorded by using visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3-7-14-21-42 (...) .Test groups experienced less pain than the control group on days 3 and 7 (P<0.001 and P<0.001, respectively). The mean VAS score for burning sensation was higher in the control group on day 3 compared to the test-1 and -2 groups (P=0.033 and P=0.020, respectively). CE in all patients was achieved on day 21 in both test groups while it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P<0.001 and P<0.001, respectively

2017 Journal of periodontology Controlled trial quality: uncertain

464. Effect of prophylactic administration of Novafen for periodontal surgery on postoperative pain relief. (Abstract)

Effect of prophylactic administration of Novafen for periodontal surgery on postoperative pain relief. Pain is a subjective feeling and one of the defense and alerting mechanisms of the body, which is distinguished from the body senses, including touch sensation and perception of heat, cold, pressure, etc. Pain, discomfort, and edema are very common after dental procedures, especially after periodontal surgeries, usually occurring during the first 24 hours after surgery; such pains (...) are classified as medium to severe pains. Generally, medications are used to manage patients' pain and discomfort. One of the most commonly used medications for pain control is Ibuprofen, which is one of the NSAIDs and is a simple derivative of phenylpropionic acid. There is evidence that caffeine alone or in association with Acetaminophen, Ibuprofen, or Aspirin can increase their analgesic effects. Novafen is a new drug which consists of Acetaminophens, Ibuprofen and caffeine and has been marketed in Iran

2017 Journal of medicine and life Controlled trial quality: uncertain

465. An Evaluation of an SCCD on the Symptomatology of Painful DPN

Measures Go to Primary Outcome Measures : Reduction in Subjective Pain [ Time Frame: 30 days ] Reduction in pain as measured using a pain descriptive Visual Analog Scale (VAS). The SCCD treatment will be considered effective if the subjects treated with the SCCD demonstrate, on average, a 30% greater reduction in pain on the VAS as compared to the control subjects. Secondary Outcome Measures : Quantitative Sensation [ Time Frame: 30 days ] 1) The ability of the subject to discriminate temperature (...) An Evaluation of an SCCD on the Symptomatology of Painful DPN An Evaluation of an SCCD on the Symptomatology of Painful DPN - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. An Evaluation of an SCCD

2017 Clinical Trials

466. Neuropathic Pain in Children: Multimodal Assessment and Diagnosis

in children. This will help paediatricians and other doctors to recognise neuropathic pain and start appropriate treatment or know when to refer children to a chronic pain clinic.The Investigators will also measure the effects of neuropathic pain on mood, sleep, and quality of life (using questionnaires); identify changes in the sensitivity of the skin to touch and other sensations (using specialised sensory tests); and determine the feasibility of brain imaging for assessing changes in the brain (using (...) Neuropathic Pain in Children: Multimodal Assessment and Diagnosis Neuropathic Pain in Children: Multimodal Assessment and Diagnosis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Neuropathic Pain

2017 Clinical Trials

467. Examining Racial and SocioEconomic Disparities (ERASED) in Chronic Low Back Pain Study

will increase at a rate of .5 degrees Celsius/second until the participant responds by pressing a button on a handheld device. For heat pain threshold, participants will be instructed to press the button when the sensation "first becomes painful" Pain tolerance [ Time Frame: Baseline ] Pain tolerance refers to the maximum amount of pain produced by a stimulus that a person is able/willing to tolerate. Heat stimuli will again be delivered using the computer-controlled thermal stimulation system. From (...) a baseline of 32 degrees Celsius, the probe temperature will increase at a rate of .5 degrees Celsius/second until the participant responds by pressing a button on a handheld device. For heat pain tolerance, participants will be instructed to press the button when they are "no longer willing to tolerate" the painful sensation. Temporal summation of pain [ Time Frame: Baseline ] Temporal summation of pain refers to a form of endogenous pain facilitation characterized by the perception of increased pain

2017 Clinical Trials

468. Feasibility Study of ExAblate Thalamotomy for Treatment of Chronic Trigeminal Neuropathic Pain

trials of at least 3 prescription medications commonly used for symptomatic relief of neuropathic pain with current adjunctive use of at least one medication. An adequate medication trial is defined as a therapeutic dose of each medication without sufficient effect. Pain is treatment-resistant to at least one interventional therapies including injections, procedures, neuromodulation, and surgery. Able to communicate sensations during the focused ultrasound treatment Stable prescribed doses of all (...) Feasibility Study of ExAblate Thalamotomy for Treatment of Chronic Trigeminal Neuropathic Pain Feasibility Study of ExAblate Thalamotomy for Treatment of Chronic Trigeminal Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

469. Meditation and Exercise to Treat Chronic Back Pain

caused by low back pain. The patient is asked to tick a statement when it applies to him that specific day, this makes it possible to follow changes in time. The end score is the sum of the ticked boxes. The score ranges from 0 (no disability) to 24 (max. disability). Secondary Outcome Measures : Change in Cutaneous Sensation [ Time Frame: baseline and 4 weeks ] Subjects will be examined using cutaneous sensory filaments on the forearm with data recorded in grams. Fear Avoidance Beliefs Questionnaire (...) inventory consisting of 40 self-report items pertaining to anxiety affect. It distinguishes between a person's state and trait anxiety levels. The A-Trait and A-State scales comprise 20 items each, scored on a 4-point Likert-type response scale. Higher STAI scores suggest higher levels of anxiety. Change in Pressure Sensation [ Time Frame: baseline and 4 weeks ] Subjects will be examined using a pressure algometer to determine a pressure pain threshold, measured in Newtons Change in Heat unpleasantness

2017 Clinical Trials

470. The Enso Study for Chronic Low Back Pain

that the active device delivers can be done in a way that causes no sensation, so subjects are not unmasked. Primary Purpose: Treatment Official Title: A Multicenter Randomized Controlled Clinical Trial Evaluating the Effectiveness of a Novel Form of Non-Invasive Neuromodulation for Treatment of Chronic Low Back Pain Actual Study Start Date : November 9, 2017 Estimated Primary Completion Date : December 30, 2018 Estimated Study Completion Date : January 30, 2021 Resource links provided by the National Library (...) The Enso Study for Chronic Low Back Pain The Enso Study for Chronic Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. The Enso Study for Chronic Low Back Pain (EPS) The safety and scientific

2017 Clinical Trials

471. Virtual Reality Treatment for Phantom Limb Pain

Research Institute Information provided by (Responsible Party): University of Pennsylvania Study Details Study Description Go to Brief Summary: Patients with limb amputations experience the sensation of the missing extremity, which is sometimes coupled with a persistent and debilitating pain in the missing limb, a condition known as phantom limb pain (PLP). This study will test the use of virtual reality (VR) training as a possible treatment of PLP. Condition or disease Intervention/treatment Phase (...) Lower Limb Amputation Above Knee (Injury) Lower Limb Amputation Below Knee (Injury) Phantom Limb Pain Device: Distractor and Lower limb VR Not Applicable Detailed Description: Approximately 90% of patients with limb amputations experience the persistent sensation of the missing extremity, a phenomenon known as phantom limb (PL). Most patients with PL also experience a persistent and debilitating pain in the missing limb, a condition known as phantom limb pain (PLP).PLP is often attributed

2017 Clinical Trials

472. TransGrade Multimodal Neuromodulation of the Dorsal Root Ganglion Ensemble for Refractory Neuropathic Pain

using the EQ-5D, their disability using the ODI, Neuropathic pain using DN4 , Mental health using SF-36 and sensation using paraesthesia Map. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 24 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: TransGrade Multimodal Neuromodulation of the Dorsal Root Ganglion Ensemble for Refractory (...) Oswestry Disability index [ Time Frame: 12 Months ] To assess changes in disability and health Patient Global Impression of Change [ Time Frame: 12 Months ] To assess patient satisfaction with therapy Paraesthesia Map [ Time Frame: 12 Months ] To assess changes in location of pain sensation and therapy coverage. Pain Map [ Time Frame: Baseline ] To assess location of pain 7 day pain diary [ Time Frame: 12 Months ] To assess eligibility and improvements in pain Patient Satisfaction questionnaire [ Time

2017 Clinical Trials

473. Achilles Pain Block

system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT). These findings will motivate the development of future clinical studies that incorporate knowledge about pain processing and movement strategies in patients with tendinopathy. Participants with achilles tendinopathy will receive an anesthetic injection to the achilles tendon in order to examine how reduced pain, detected by the peripheral nervous system, alters task performance (...) Achilles Pain Block Achilles Pain Block - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Achilles Pain Block (APB) The safety and scientific validity of this study is the responsibility of the study sponsor

2017 Clinical Trials

474. Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety Full Text available with Trip Pro

in the amygdala. These results indicate not only that there is a distinct signature for the encoding of a painful experience in humans, but also that this encoding process involves a strong affective component.SIGNIFICANCE STATEMENT To convert the sensation of pain into a briefly maintainable construct is essential to guide human behavior and avoid dangerous situations. Although this working memory encoding process is implicitly contained in the majority of studies, the underlying neural mechanisms remain (...) Determining the Neural Substrate for Encoding a Memory of Human Pain and the Influence of Anxiety To convert a painful stimulus into a briefly maintainable construct when the painful stimulus is no longer accessible is essential to guide human behavior and avoid dangerous situations. Because of the aversive nature of pain, this encoding process might be influenced by emotional aspects and could thus vary across individuals, but we have yet to understand both the basic underlying neural

2017 The Journal of Neuroscience

475. A Review of Neuropathic Pain: From Diagnostic Tests to Mechanisms Full Text available with Trip Pro

A Review of Neuropathic Pain: From Diagnostic Tests to Mechanisms Neuropathic pain develops when the somatosensory nervous system is affected by a lesion or disease. Diagnostic tests aimed at assessing somatosensory afferent pathway damage are therefore useful for diagnosing neuropathic pain. Neuropathic pain manifests with a range of different symptoms such as ongoing burning pain, squeezing or pressure pain, paroxysmal electric shock-like sensations, stabbing pain, or mechanical dynamic (...) allodynia. The various types of neuropathic pain are associated with different underlying nerve fiber abnormalities. This article summarizes the available methods of somatosensory afferent pathway assessment and discusses the potential pathophysiology underlying the most representative neuropathic pain types, i.e., ongoing burning pain, paroxysmal pain, and mechanical dynamic allodynia.Pfizer, Italy.

2017 Pain and therapy

476. PACAP/Receptor System in Urinary Bladder Dysfunction and Pelvic Pain Following Urinary Bladder Inflammation or Stress Full Text available with Trip Pro

PACAP/Receptor System in Urinary Bladder Dysfunction and Pelvic Pain Following Urinary Bladder Inflammation or Stress Complex organization of CNS and PNS pathways is necessary for the coordinated and reciprocal functions of the urinary bladder, urethra and urethral sphincters. Injury, inflammation, psychogenic stress or diseases that affect these nerve pathways and target organs can produce lower urinary tract (LUT) dysfunction. Numerous neuropeptide/receptor systems are expressed in the neural (...) pathways of the LUT and non-neural components of the LUT (e.g., urothelium) also express peptides. One such neuropeptide receptor system, pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its cognate receptor, PAC1 (Adcyap1r1), have tissue-specific distributions in the LUT. Mice with a genetic deletion of PACAP exhibit bladder dysfunction and altered somatic sensation. PACAP and associated receptors are expressed in the LUT and exhibit neuroplastic changes with neural injury

2017 Frontiers in systems neuroscience

477. Do Tonic Itch and Pain Stimuli Draw Attention towards Their Location? Full Text available with Trip Pro

. Notwithstanding, participants were slower during itch and pain than during control blocks.In contrast with our hypotheses, no indications were found for spatial attention allocation towards the somatosensory stimuli. This may relate to dynamic shifts in attention over the time course of the tonic sensations. Our secondary finding that itch and pain interfere with task performance is in-line with attention theories of bodily perception. (...) Do Tonic Itch and Pain Stimuli Draw Attention towards Their Location? Although itch and pain are distinct experiences, both are unpleasant, may demand attention, and interfere with daily activities. Research investigating the role of attention in tonic itch and pain stimuli, particularly whether attention is drawn to the stimulus location, is scarce.In the somatosensory attention task, fifty-three healthy participants were exposed to 35-second electrical itch or pain stimuli on either the left

2017 BioMed research international

478. Neural Mechanisms of Attentional Switching Between Pain and a Visual Illusion Task: A Laser Evoked Potential Study Full Text available with Trip Pro

of noxious laser-evoked potentials (LEPs) on a single-trial basis. A laser heat stimulus was applied to the dorsum of the left hand while subjects either viewed the Rubin vase-face illusion (RVI), or focused on their pain and associated somatosensory sensations occurring on their stimulated hand. Pain-related sensations occurring with every laser stimulus were evaluated using a set of visual analogue scales. Factor analysis was used to identify the principal dimensions of pain experience. LEPs were (...) Neural Mechanisms of Attentional Switching Between Pain and a Visual Illusion Task: A Laser Evoked Potential Study Previous studies demonstrated that pain induced by a noxious stimulus during a distraction task is affected by both stimulus-driven and goal-directed processes which interact and change over time. The purpose of this exploratory study was to analyse associations of aspects of subjective pain experience and engagement with the distracting task with attention-sensitive components

2017 Brain topography

479. Evaluation of pain relief sufficiency using the Cumulative Analgesic Consumption Score (CACS) and its modification (MACS) Full Text available with Trip Pro

in patients treated with PCA. In conclusion, PCA devices are appropriate instruments for postoperative pain relief in bariatric patients. CACS is a practical tool for postoperative pain measurement, describing individual pain sensation more objectively, although holding further potential in modification. (...) Evaluation of pain relief sufficiency using the Cumulative Analgesic Consumption Score (CACS) and its modification (MACS) Postoperative pain is one of the major complications in general and bariatric surgery, associated with ongoing problems such as ileus, pneumonia and prolonged mobilization. In this study, patients undergoing bariatric surgery were analyzed according to their postoperative pain relief regime. In one group patients were treated with a patient-controlled analgesia (PCA) device

2017 Videosurgery and other Miniinvasive Techniques

480. Characterization of a novel capsaicin/heat ongoing pain model. Full Text available with Trip Pro

Characterization of a novel capsaicin/heat ongoing pain model. Human experimental pain models provide an important translational link between pre-clinical models and clinical pain. Using topical capsaicin and continuous heat application, the novel capsaicin/heat ongoing pain (CHOP) model induces long-lasting experimental pain of which the perceived intensity can be individually adjusted.In the CHOP model, capsaicin or control cream is applied to a 10 × 10 cm skin area and a heating pad (...) is applied over the area after cream removal. Two experiments in healthy participants were performed for model characterization. In Experiment 1, a constant temperature was applied for 60 min; in Experiment 2, temperature was adjusted to maintain a constant perceived intensity for 60 min.Experiment 1: across participants, constant temperature induced initial habituation followed by an increase in sensation back to baseline. Cluster analysis revealed that half the participants sensitized to the constant

2017 European Journal of Pain

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