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Pain Sensation

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381. Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls

system is examined using pressure algometry and cuff algometry. A pressure algometer is a pistol shaped device that elicits pressure through a rod and a cuff algometer is akin to a blood pressure cuff. Different thresholds will be measured, such as when the sensation of pressure becomes painful and when the painful pressure becomes unbearable. Participants will also get hand strength tested, have their joints examined and answer questionnaires regarding daily function and quality of life. Furthermore (...) Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

382. Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy

for eligibility information Ages Eligible for Study: 18 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Probability Sample Study Population Meet the diagnosis of diabetic peripheral neuropathy (at the same time meets the following three items, of which painful neuropathy patients have pain symptom): (1) neuropathy occurs not earlier than the diagnosis of diabetes; (2) having clinical manifestations of pain, numbness, and abnormal sensation; (3) any (...) abnormality in the following 5 examinations: ankle reflex, vibratory sensation, pressure sensation, temperature sensation, and acupuncture pain. Criteria Inclusion Criteria: Voluntary participation and signing informed consent 18 to 60 years old with junior high school education or above meeting the 1999 WHO type 2 diabetes diagnostic criteria: having symptoms of diabetes (polydipsia, polyphagia, polyuria and unexplained weight loss) plus one of the following 3 items: (1) random blood glucose more than

2018 Clinical Trials

383. Perfusion index as a reliable parameter of vasomotor disturbance in complex regional pain syndrome. Full Text available with Trip Pro

Perfusion index as a reliable parameter of vasomotor disturbance in complex regional pain syndrome. Discrepancy between a patient's subjective thermal symptoms and objective measured temperature value is common in complex regional pain syndrome (CRPS) in clinical settings. For that reason, the diagnostic validity of a single temperature measurement method has been criticised. Several studies showed that the perfusion index (PI), which is derived from pulse oximetry, is a more sensitive (...) and earlier indicator of sympathetic blockade than temperature measurement.Forty-six participants (CRPS group, n=23; healthy control group, n=23) were enrolled. CRPS patients with subjective sensation of coldness on the affected side were chosen for this study. Temperature and PI were measured at the affected and contralateral hands in the CRPS group, and right and left hands in the healthy control group. To evaluate each method's efficacy for detecting thermal symptoms, differences in the parameters

2018 British Journal of Anaesthesia

384. Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. (Abstract)

and repeated up to 10 h postdose.Paracetamol did not show a significant reduction in pain sensation or subjective cognitive functioning compared to placebo. Promethazine induced a statistically significant reduction in PTT for cold pressor and pressure stimulation. Furthermore, reduced subjective alertness was observed. Δ9-THC showed a statistically significant decrease in PTT for electrical and pressure stimulation. Δ9-THC also demonstrated subjective effects, including changes in alertness and calmness (...) Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating

2018 European Journal of Pain Controlled trial quality: uncertain

385. Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain. Full Text available with Trip Pro

evaluations, patients were selected asking if they had ever experienced neural pain. Data analyses of their pain characteristics, clinical examination results, and both the Douleur Neuropathique 4 Questionnaire and Hamilton Depression Scale scores were used to classify these patients. The most common word they used to describe the sensation of pain for 25 (60%) of these patients was "burning." In the early stages of the disease and before leprosy diagnosis, 19 (45%) had already complained about NP (...) Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain. Neural pain is a frequent symptom in leprosy disease. There is a paucity of data regarding neural pain diagnostics resulting in common prescriptive errors when neuritis is confused with neuropathic or mixed nociceptive-neuropathic pain. The present study identified important demographic, clinical, and neurophysiological features of 42 leprosy neuropathy patients presenting neuropathic pain (NP). During routine

2018 American Journal of Tropical Medicine & Hygiene

386. Lumbar Sympathetic Plexus Block as a Treatment for Postamputation Pain: Methodology for a Randomized Controlled Trial. Full Text available with Trip Pro

was also performed, which included vibration sensation testing, pinprick sensation testing, brush sensation testing, Von Frey repeated weighted pinprick sensation, and thermal quantitative sensory testing.In the four described cases, treatment of PAP with a single lumbar sympathetic block but not sham intervention resulted in reduction of both residual limb pain and phantom limb pain as well as perceived disability on the PDI at three-month follow-up.An appropriately powered randomized controlled study (...) Lumbar Sympathetic Plexus Block as a Treatment for Postamputation Pain: Methodology for a Randomized Controlled Trial. We present a technical protocol for rigorous assessment of patient-reported outcomes and psychophysical testing relevant to lumbar sympathetic blocks for the treatment of postamputation pain (PAP). This description is intended to inform future prospective investigation.Series of four participants from a blinded randomized sham-controlled trial.Tertiary, urban, academic pain

2018 Pain Medicine Controlled trial quality: uncertain

387. Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity Full Text available with Trip Pro

(DRGs) and spinal cord nor the function determination by NECAB2 has been defined. A combination of histochemical analyses and single-cell RNA-sequencing showed NECAB2 in small- and medium-sized C- and Aδ D-hair low-threshold mechanoreceptors in DRGs, as well as in protein kinase C γ excitatory spinal interneurons. NECAB2 was downregulated by peripheral nerve injury, leading to the hypothesis that NECAB2 loss of function could limit pain sensation. Indeed, Necab2-/- mice reached a pain-free state (...) Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity Pain signals are transmitted by multisynaptic glutamatergic pathways. Their first synapse between primary nociceptors and excitatory spinal interneurons gates the sensory load. In this pathway, glutamate release is orchestrated by Ca2+-sensor proteins, with N-terminal EF-hand Ca2+-binding protein 2 (NECAB2) being particular abundant. However, neither the importance of NECAB2+ neuronal contingents in dorsal root ganglia

2018 The Journal of clinical investigation

388. Quantitative SSEP and EEG as Objective Pain Biomarker

of a person's electrical brain activity do reflect pain sensation. Condition or disease Intervention/treatment Phase Pain Other: Standard EEG or SSEP Not Applicable Detailed Description: Over the past few years, significant advances have begun to be made in the development of particular measures as valid biomarkers or surrogate markers for the presence of acute and/or chronic pain. Many of these advances have been made because of the development of new and improved technologies, for example in the fields (...) Quantitative SSEP and EEG as Objective Pain Biomarker Quantitative SSEP and EEG as Objective Pain Biomarker - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Quantitative SSEP and EEG as Objective Pain

2018 Clinical Trials

389. Perceptual Distortions in Acute Neck Pain

), a real needle will be shown to the participants to imitate and produce the anticipation of a pain experience. A pinprick sensation will be produced by a weighted stimulus applied perpendicularly to the skin without piercing the skin. A stimulus of 512 millinewtons (mN) will be used to produce a pinprick sensation and activation of cutaneous nociceptors. Adhesive tapes covering stimulation points will also be provided. The stimuli will be applied in exactly the same spot as the real injection (...) in previous experimental condition. Other Name: Pain induced by sham injection No Intervention: Control Participants in the control condition will not receive any kind of pain or pinprick sensation. Outcome Measures Go to Primary Outcome Measures : Tactile acuity measured by two-point discrimination test (TPD). [ Time Frame: TPD change from baseline at 30 seconds post-manipulation period (e.g. saline injection). ] Mechanical callipers will be delicately applied to the spot just below the location where

2018 Clinical Trials

390. Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

pain. Opioid consumption [ Time Frame: Baseline, postoperative days 1, 2 and 8; Months 1, 3, 6, 9, and 12 ] All opioids consumed (reported as oral morphine equivalents) Non-painful phantom limb sensations frequency [ Time Frame: Baseline, postoperative days 1, 2 and 8; Months 1, 3, 6, 9, and 12 ] non-painful sensations referred to the lost body part (frequency) Non-painful phantom limb sensations duration [ Time Frame: Baseline, postoperative days 1, 2 and 8; Months 1, 3, 6, 9, and 12 ] non-painful (...) sensations referred to the lost body part (duration) Phantom limb pain frequency [ Time Frame: Baseline, postoperative days 1, 2 and 8; Months 1, 3, 6, 9, and 12 ] painful sensations referred to the lost body part (frequency) Phantom limb pain average duration [ Time Frame: Baseline, postoperative days 1, 2 and 8; Months 1, 3, 6, 9, and 12 ] painful sensations referred to the lost body part (average duration) Residual limb pain frequency [ Time Frame: Baseline, postoperative days 1, 2 and 8; Months 1, 3

2018 Clinical Trials

391. Incidence of Postoperative Pain After Glide Path Preparation Using Three Different Instruments

University Information provided by (Responsible Party): Cangül Keskin, Ondokuz Mayıs University Study Details Study Description Go to Brief Summary: Endodontic postoperative pain is described as a sensation of discomfort following the completion of root canal treatment and is experienced by the 25-40% of the patients regardless of pulp and periradicular diseases (1, 2). Prevalence of pain has been reported to decrease from 40% in the first 48 hours to 11% after 7 days (2). Mechanisms of endodontic (...) Incidence of Postoperative Pain After Glide Path Preparation Using Three Different Instruments Incidence of Postoperative Pain After Glide Path Preparation Using Three Different Instruments - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

392. Effectiveness of Physical Therapy Interventions for Low Back Pain Targeting the Low Back Only or Low Back Plus Hips

Effectiveness of Physical Therapy Interventions for Low Back Pain Targeting the Low Back Only or Low Back Plus Hips Effectiveness of Physical Therapy Interventions for Low Back Pain Targeting the Low Back Only or Low Back Plus Hips - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Effectiveness of Physical Therapy Interventions for Low Back Pain Targeting the Low Back Only or Low Back Plus Hips The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

393. Postoperative Pain and Discomfort After Orbital Decompression

represents the worst discomfort; this scale has been confirmed to be sensitive and reliable. Discomfort was defined as "sensation other than pain" and included nausea, vomiting, headache, and dizziness. Clinically significant postoperative discomfort was considered serious discomfort (NRS score ≥5) any time postoperatively. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family (...) Postoperative Pain and Discomfort After Orbital Decompression Postoperative Pain and Discomfort After Orbital Decompression - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Postoperative Pain and Discomfort

2018 Clinical Trials

394. Effects of Hipopressive Exercises in Nonspecific Low Back Pain

Effects of Hipopressive Exercises in Nonspecific Low Back Pain Effects of Hipopressive Exercises in Nonspecific Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effects of Hipopressive (...) Exercises in Nonspecific Low Back Pain (HPvsMT-LBP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03565926 Recruitment Status : Completed First Posted : June 21, 2018 Last Update Posted : August 20, 2018 Sponsor: University of Valencia Information provided by (Responsible Party): GEMMA V ESPÍ LÓPEZ

2018 Clinical Trials

395. Cryoanalgesia to Prevent Acute and Chronic Pain Following Mastectomy and Limb Amputation: A Randomized, Double-Masked, Sham-Controlled Study

months 1, 3, 6, and 12 ] How many times in the previous 3 days subject experienced phantom pain (the number of times experienced--not based on a scale or instrument) Phantom sensation incidence [ Time Frame: Postoperative months 1, 3, 6, and 12 ] How many times in the previous 3 days subject experienced phantom sensations (the number of times experienced--not based on a scale or instrument) Residual limb or wound pain incidence [ Time Frame: Postoperative months 1, 3, 6, and 12 ] How many times (...) in the previous 3 days subject experienced residual limb or wound pain (the number of times experienced--not based on a scale or instrument) Phantom pain duration [ Time Frame: Postoperative months 1, 3, 6, and 12 ] The average duration of phantom pain occurrences in the previous 3 days Phantom sensation incidence [ Time Frame: Postoperative months 1, 3, 6, and 12 ] The average duration of phantom sensation occurrences in the previous 3 days Residual limb or wound pain duration [ Time Frame: Postoperative

2018 Clinical Trials

396. Paracetamol and Neuropathic Pain

Paracetamol and Neuropathic Pain Paracetamol and Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Paracetamol and Neuropathic Pain (PAeoNy) The safety and scientific validity of this study (...) -Ferrand Study Details Study Description Go to Brief Summary: The aim of this study is to evaluate the analgesic effect of paracetamol in patients suffering from pain with a peripheral neuropathic component in the presence of their usual treatment. Condition or disease Intervention/treatment Phase Neuropathic Pain Drug: paracetamol Other: Placebo comparator Phase 2 Detailed Description: This is an interventional, randomized, placebo-controlled, double-blind, crossover study about the use of paracetamol

2018 Clinical Trials

397. Floating for Chronic Pain

Floating for Chronic Pain Floating for Chronic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Floating for Chronic Pain (Float4Pain) The safety and scientific validity of this study (...) Study Details Study Description Go to Brief Summary: In recent years there has been a novel approach for the treatment of chronic pain: Floatation REST (restricted environmental stimulation therapy). Floating is a therapeutic approach, in which patients float in a specialized pool or tank on water that contains high concentrations of Epsom salt (Magnesium sulfate). Water is kept at skin temperature (35-36°C) and the pool or tank is shielded to provide almost complete darkness and silence

2018 Clinical Trials

398. Botulinum Toxin Injections for Oral Neuropathic Pain

to the conclusions of the European task force committee for intraoral quantitative sensory testing (QST), the QST is defined by : Brush-induced allodynia will be evaluated stroking the skin with a standardized brush and will be considered as present if evoking a clear sensation of pain. The intensity of allodynia will be recorded on a 100 mm visual analog scale. Area of Brush-induced allodynia will be traced on a transparent plastic foil, and then digitized for measurement on Image J software. Mechanical (...) sensations (detection thresholds to non-painful stimuli) and pain thresholds will be measured with calibrated von Frey hairs (0.06-300gm) (Bioseb, France) (or electronic von Frey, Bioseb France). Thermal sensations and pain thresholds (in °C) will be assessed with a thermoalgometer (TSA II; Medoc, Israel) with an intraoral thermode by the method of limits, with baseline temperatures adjusted to the patient's skin temperature . Emotional state with Hospital Anxiety and Depression Scale (HADS) [ Time Frame

2018 Clinical Trials

399. Spinal Cord Burst Stimulation for Chronic Radicular Pain Following Lumbar Spine Surgery

has been to replace the pain sensation with paresthesia. The anticipation is that the electrical current alters pain processing by masking the sensation of pain with a comfortable tingling or paresthesia. Although patients mostly cope with paresthesia, a significant proportion reports that the sensation is unpleasant. 'Burst' SCS utilizes complex programming to deliver high-frequency stimuli. This SCS technique seems to provide paresthesia-free stimulation, resulting in better pain relief of low (...) back and leg pain then traditional tonic stimulation. The widespread use of SCS has not been backed by solid evidence. The absence of placebo-controlled trials has long been an important point of criticism, but due to the nature of the intervention with sensation of paresthesia, studies with placebo control have so far not been considered possible. When 'burst' SCS is used the stimulation is often unnoticed by the patient, allowing comparison with placebo stimulation. The aim of this randomized

2018 Clinical Trials

400. Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS)

to 10). "0" in this case means "no pain". Each "pricking", "stinging" or "burning" sensation is defined as a painful sensation, which should always be evaluated by giving a value greater than "0". "10" corresponds to the individual maximum pain imaginable. Change from baseline to Week 12 in the pressure pain threshold (PPT) ratio for the thenar muscle/abductor hallucis muscle. [ Time Frame: Change from baseline (Visit 2 [Day 1]) to Visit 8 (Week 12) ] Pressure pain threshold: using a pressure (...) Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2018 Clinical Trials

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