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Pain Sensation

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21. Impact of Injection Speed, Volume, and Site on Pain Sensation Full Text available with Trip Pro

Impact of Injection Speed, Volume, and Site on Pain Sensation Painful subcutaneous insulin injections may decrease treatment compliance. Improving injection comfort therefore represents a particular area of technological research in which steady progress has been made since the introduction of the insulin pen in 1985. Injection pain can be influenced by many variables, but relatively little is known about their impact. This study investigated the impact of injection volume (range 0-2250 µL (...) ), speed (range 0-800 µL/sec), and site (abdomen vs thigh) on pain sensation.In random order, patients (n = 80) with type 1 or type 2 diabetes received 24 saline injections subcutaneously through a 27G ultra-thin-wall needle. Injections were performed in the abdomen (n = 19) and thigh (n = 5) with predefined speed-volume combinations. For each injected speed-volume combination, patients scored their pain sensation on a 100 mm visual analog scale (VAS).The mean pain scores for speed-volume combinations

2017 Journal of diabetes science and technology Controlled trial quality: uncertain

22. Peripheral and orofacial pain sensation is unaffected by the loss of p39 Full Text available with Trip Pro

Peripheral and orofacial pain sensation is unaffected by the loss of p39 Cdk5 is a key neuronal kinase necessary for proper brain development, which has recently been implicated in modulating nociception. Conditional deletion of Cdk5 in pain-sensing neurons attenuates pain responses to heat in both the periphery and orofacial regions. Cdk5 activity is regulated by binding to the activators p35 and p39, both of which possess a cyclin box. Our previous examination of the nociceptive role (...) effects that result from the deletion of p35. Our data demonstrate different and nonoverlapping roles of Cdk5 activators in the regulation of orofacial as well as peripheral nociception with a crucial role for Cdk5/p35 in pain signaling.

2017 Molecular pain

23. Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe Full Text available with Trip Pro

Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain, hyperalgesia, and other disabling symptoms. Although the brain response to experimental pain in FM patients has been the object of intense investigation, the biological underpinnings of painful after-sensations (PAS), and their relation to negative affect have received little (...) . These results suggest that the MTL plays a role in PAS in FM patients.PAS are more common and severe in FM, and are associated with clinical pain and catastrophizing. PAS severity is also associated with less MTL deactivation, suggesting that the MTL, a core node of the default mode network, may be important in the prolongation of pain sensation in FM.Copyright © 2017 American Pain Society. Published by Elsevier Inc. All rights reserved.

2017 The journal of pain : official journal of the American Pain Society

24. Aqua Cycling Does Not Affect Recovery of Performance, Damage Markers, and Sensation of Pain. (Abstract)

Aqua Cycling Does Not Affect Recovery of Performance, Damage Markers, and Sensation of Pain. Wahl, P, Sanno, M, Ellenberg, K, Frick, H, Böhm, E, Haiduck, B, Goldmann, J-P, Achtzehn, S, Brüggemann, G-P, Mester, J, and Bloch, W. Aqua cycling does not affect recovery of performance, damage markers, and sensation of pain. J Strength Cond Res 31(1): 162-170, 2017-To examine the effects of aqua cycling (AC) vs. passive recovery (P) on performance, markers of muscle damage, delayed onset of muscle

2017 Journal of Strength And Conditioning Research Controlled trial quality: uncertain

25. Pain Sensation During Colposcopy and Cervical Biopsy, With or Without Local Anesthesia: A Randomized Trial. (Abstract)

Pain Sensation During Colposcopy and Cervical Biopsy, With or Without Local Anesthesia: A Randomized Trial. The aim of the study was to determine whether an injection of a local anesthetic is more painful than a cervical punch biopsy without local anesthesia.The study was a randomized controlled trial, conducted at the Helsinki University Central Hospital. It consisted of 204 women referred for colposcopic assessments. Half of them were randomized to receive local anesthesia before (...) their cervical punch biopsies. After the injection of the local anesthetic, the cervical punch biopsy, and the endocervical curettage, the women scored their actual pain using a 10-cm visual analog scale (VAS).To measure the difference in VAS scores between two groups, a linear regression model was used. Binomial regression model was applied for comparing the probability of experiencing unbearable pain between the groups. Applying modeling approach allowed also for proper adjustment for other potential risk

2017 Journal of lower genital tract disease Controlled trial quality: uncertain

26. Pain sensation in human osteoarthritic knee joints is strongly enhanced by diabetes mellitus. (Abstract)

Pain sensation in human osteoarthritic knee joints is strongly enhanced by diabetes mellitus. The major burden of knee joint osteoarthritis (OA) is pain. Since in elder patients diabetes mellitus is an important comorbidity of OA, we explored whether the presence of diabetes mellitus has a significant influence on pain intensity at the end stage of knee OA, and we aimed to identify factors possibly related to changes of pain intensity in diabetic patients. In 23 diabetic and 47 nondiabetic (...) patients with OA undergoing total knee arthroplasty, we assessed the pain intensity before the operation using the "Knee Injury and Osteoarthritis Outcome Score". Furthermore, synovial tissue, synovial fluid (SF), cartilage, and blood were obtained. We determined the synovitis score, the concentrations of prostaglandin E2 and interleukin-6 (IL-6) in the SF and serum, and of C-reactive protein and HbA1c and other metabolic parameters in the serum. We performed multivariate regression analyses to study

2017 Pain

27. γ-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects. Full Text available with Trip Pro

γ-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects. In burning mouth patients, analgesia after oral administration of clonazepam may result from modulation of peripheral γ-aminobutyric acid (GABA) receptors.The effect of oral administration of test solutions (water, 0.5 mol/L or 0.05 mol/L GABA, 1% lidocaine) was investigated for the amelioration of pain and sensitivity induced (...) by application of capsaicin (1%, 2 min) to the tongue of thirty healthy male and female subjects in this four-session, randomized, placebo-controlled, double-blinded, cross-over study. Intra-oral quantitative sensory testing was used to assess cold (CDT), warm (WDT) and mechanical (MDT) detection thresholds as well as mechanical (MPT) and heat (HPT) pain thresholds. Capsaicin-induced pain intensity was continuously rated on a 0-10 electronic visual analogue scale (VAS). The area under the VAS curve (VASAUC

2017 European Journal of Pain Controlled trial quality: uncertain

28. Pain Sensation

Pain Sensation Pain Sensation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pain Sensation Pain Sensation Aka: Pain Sensation (...) , Allodynia , Hyperpathia From Related Chapters II. Definitions Allodynia Nonpainful stimulus results in perception of pain Hyperpathia Pain out of proportion to pain stimulus Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Pain Sensation." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Hyperalgesia (C0020429) Definition (MSH) An increased sensation

2018 FP Notebook

29. Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation. Full Text available with Trip Pro

Deletion of Gpr55 Results in Subtle Effects on Energy Metabolism, Motor Activity and Thermal Pain Sensation. The G-protein coupled receptor 55 (GPR55) is activated by cannabinoids and non-cannabinoid molecules and has been speculated to play a modulatory role in a large variety of physiological and pathological processes, including in metabolically perturbed states. We therefore generated male mice deficient in the gene coding for the cannabinoid/lysophosphatidylinositol (LPI) receptor Gpr55

2016 PLoS ONE

30. Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats Full Text available with Trip Pro

Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats Although previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inhibition) and affective (avoidance motivation) components contributes (...) to the divergent effects of depression on them. Depressive-like behavior was produced in male Wistar rats by unpredictable chronic mild stress (UCMS). Tone-laser conditioning and formalin-induced conditioned place avoidance (F-CPA) were used to explore avoidance motivation in evoked and spontaneous pain, respectively. Behavioral pharmacology experiments were conducted to examine descending inhibition of both evoked (thermal stimulation) and spontaneous pain behavior (formalin pain). The results revealed

2016 Frontiers in behavioral neuroscience

31. Why Harmless Sensations Might Hurt in Individuals with Chronic Pain: About Heightened Prediction and Perception of Pain in the Mind Full Text available with Trip Pro

Why Harmless Sensations Might Hurt in Individuals with Chronic Pain: About Heightened Prediction and Perception of Pain in the Mind In individuals with chronic pain harmless bodily sensations can elicit anticipatory fear of pain resulting in maladaptive responses such as taking pain medication. Here, we aim to broaden the perspective taking into account recent evidence that suggests that interoceptive perception is largely a construction of beliefs, which are based on past experience (...) and that are kept in check by the actual state of the body. Taking a Bayesian perspective, we propose that individuals with chronic pain display a heightened prediction of pain [prior probability p(pain)], which results in heightened pain perception [posterior probability p(pain|sensation)] due to an assumed link between pain and a harmless bodily sensation [p(sensation|pain)]. This pain perception emerges because their mind infers pain as the most likely cause for the sensation. When confronted with a mismatch

2016 Frontiers in psychology

32. Viewing the body modulates both pain sensations and pain responses Full Text available with Trip Pro

Viewing the body modulates both pain sensations and pain responses Viewing the body can influence pain perception, even when vision is non-informative about the noxious stimulus. Prior studies used either continuous pain rating scales or pain detection thresholds, which cannot distinguish whether viewing the body changes the discriminability of noxious heat intensities or merely shifts reported pain levels. In Experiment 1, participants discriminated two intensities of heat-pain stimulation (...) were presented in separate blocks of trials. Viewing the hand shifted perceived pain levels irrespective of actual stimulus intensity, biasing responses toward 'high pain' judgments. In Experiment 3, participants saw the noxious stimulus as it approached and touched their hand or the object. Seeing the pain-inducing event counteracted the reduction in discriminability found when viewing the hand alone. These findings show that viewing the body can affect both perceptual processing of pain

2016 Experimental Brain Research

33. Arthropathy-related pain in a patient with congenital impairment of pain sensation due to hereditary sensory and autonomic neuropathy type II with a rare mutation in the WNK1/HSN2 gene: a case report. Full Text available with Trip Pro

Arthropathy-related pain in a patient with congenital impairment of pain sensation due to hereditary sensory and autonomic neuropathy type II with a rare mutation in the WNK1/HSN2 gene: a case report. Hereditary sensory and autonomic neuropathy (HSAN) type II with WNK1/HSN2 gene mutation is a rare disease characterized by early-onset demyelination sensory loss and skin ulceration. To the best of our knowledge, no cases of an autonomic disorder have been reported clearly in a patient with WNK (...) /HSN2 gene mutation and only one case of a Japanese patient with the WNK/HSN2 gene mutation of HSAN type II was previously reported.Here we describe a 54-year-old woman who had an early childhood onset of insensitivity to pain; superficial, vibration, and proprioception sensation disturbances; and several symptoms of autonomic failure (e.g., orthostatic hypotension, fluctuation in body temperature, and lack of urge to defecate). Genetic analyses revealed compound homozygous mutations in the WNK1

2016 BMC Neurology

34. Making sense of bodily sensations: Do shared cancer narratives influence symptom appraisal? Full Text available with Trip Pro

Making sense of bodily sensations: Do shared cancer narratives influence symptom appraisal? Though new or altered bodily sensations are a common occurrence they rarely transition to biomedically defined symptoms. When they do, sensations are subject to an appraisal process that can culminate in help-seeking. The transition has particular relevance for cancer diagnoses. Studies of 'symptom appraisal' in cancer patients typically conclude that failure to regard sensations as serious or 'symptom (...) -monitoring strategies and severe or painful changes prompted help-seeking. Far from misattributing symptoms, responses to bodily changes were sensible and measured; responses are particularly apt in relation to current policy rhetoric, which urges measured use of services. Our findings have resonance across healthcare settings as patients are required to negotiate a narrow and challenging space when making decisions to seek help. There is a pressing need for a more realistic approach to symptom appraisal

2019 Social Science & Medicine

35. Influence of the Intensity, Components, and Spreading of the Deqi Sensation on the Analgesic Effect of SP6 Needling in Primary Dysmenorrhea Patients: A Secondary Analysis of a Randomised Controlled Trial. Full Text available with Trip Pro

needle removal were evaluated by the Visual Analogue Scale for pain. The deqi sensation was evaluated by the Acupuncture Deqi Clinical Assessment Scale. Patients who experienced a genuine deqi sensation (n=39) were selected for further analysis. Compared with patients in the non-deqi group who experienced deqi (n=25), patients who self-reported deqi in the deqi group (n=14) felt a stronger deqi sensation, experienced soreness and fullness more frequently, felt a greater intensity of soreness (...) , fullness, electric sensation, spreading, and radiating, and experienced larger spreading distances. In those who experienced the deqi sensation in the deqi group, the intensity of the sensation, as well as their degree of soreness and fullness, was negatively correlated with pain reduction. In patients who experienced the deqi sensation in the non-deqi group, deqi intensity was positively correlated with pain reduction, while soreness was negatively correlated with pain reduction. The distance

2019 Evidence-based Complementary and Alternative Medicine (eCAM) Controlled trial quality: uncertain

36. Low back pain and radicular pain: development of a clinical pathway

of a clinical pathway KCE Report 295 • Can be associated with neurological symptoms and signs (numbness and/or tingling, following a dermatome pattern, reflex disturbances or motor weakness in an associated myotome), although this is not always the case. In spite of neurological symptoms and signs, pain is usually the predominant complaint. • In some cases, the radicular pain can present a neuropathic component (sensation of continuous burning, unchanged by movement and can be accompanied by strange (...) sensations like tingling or allodynia i.e. a sensation of pain triggered by a normally painless stimulus). In this case, the management becomes very difficult (e.g. decompression surgery is rarely effective). Radiculopathy and radicular syndrome are included in this report under the generic term "radicular pain". It has indeed decided that considering them as separate entities might be confusing because there is no consensus on their definition and clinical manifestations. Acute pain is usually defined

2017 Belgian Health Care Knowledge Centre

37. Low back pain and radicular pain: evaluation and management

back pain »), Maurits Van Tulder (multiple scientific studies in the field of low back pain, financed by ZonMW ; principal investigator of studies about radiofrequency denervation for facet join pain and sacro-iliacale joints, endoscopic transforaminal discectomy and epidural injections McKenzieplus ; investigator at NHMRC in Australia), Johan Vlaeyen (Methusalem programme « From acute aversive sensations to chronic bodily symptons » (FNO)). A grant, fees or funds for a member of staff or another (...) Low back pain and radicular pain: evaluation and management 2017 www.kce.fgov.be KCE REPORT 287 LOW BACK PAIN AND RADICULAR PAIN: ASSESSMENT AND MANAGEMENT BVOT 2017 www.kce.fgov.be KCE REPORT 287 GOOD CLINICAL PRACTICE LOW BACK PAIN AND RADICULAR PAIN: ASSESSMENT AND MANAGEMENT PETER VAN WAMBEKE, ANJA DESOMER, LUC AILLIET, ANNE BERQUIN, CHRISTOPHE DEMOULIN, BART DEPREITERE, JOHAN DEWACHTER, MIEKE DOLPHENS, PATRICE FORGET, VIRGINIE FRASELLE, GUY HANS, DAVY HOSTE, GENEVIÈVE MAHIEU, JEF

2017 Belgian Health Care Knowledge Centre

38. Identifying criteria for diagnosis of post-traumatic pain and altered sensation of the maxillary and mandibular branches of the trigeminal nerve: a systematic review

Identifying criteria for diagnosis of post-traumatic pain and altered sensation of the maxillary and mandibular branches of the trigeminal nerve: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email salutation (e.g

2015 PROSPERO

39. Comparison of masseter muscle referred sensations following mechanical and glutamate stimulation: a randomized, double-blind, controlled, crossover study. (Abstract)

Comparison of masseter muscle referred sensations following mechanical and glutamate stimulation: a randomized, double-blind, controlled, crossover study. Referred sensations (RS) are commonly found in various musculoskeletal pain conditions. Experimental studies have shown that RS can be elicited through glutamate injection and mechanical stimulation. Despite this, differences and similarities between these modalities in RS outcomes remain unclear. The aim of this study was to assess (...) differences between mechanical-induced and glutamate injection-induced RS in the trigeminal region. The present randomized, double-blind, controlled, cross-over study recruited 60 healthy participants who were assessed in 2 different sessions. In both sessions, pressure was applied to the masseter muscle with 4 different forces (0.5, 1, 2, and 4 kg), and glutamate (1 mol/L or 0.25 mol/L) was injected into the same area. Participants rated their perceived masseter sensations and rated and drew any RS

2018 Pain Controlled trial quality: uncertain

40. TRPM2 and warmth sensation Full Text available with Trip Pro

TRPM2 and warmth sensation The abilities to detect warmth and heat are critical for the survival of all animals, both in order to be able to identify suitable thermal environments for the many different activities essential for life and to avoid damage caused by extremes of temperature. Several ion channels belonging to the TRP family are activated by non-noxious warmth or by heat and are therefore plausible candidates for thermal detectors, but identifying those that actually regulate warmth (...) , in pain and in insulin secretion, but the mechanisms are unclear. TRPM2 has to date received less attention than many other members of the TRP family but is rapidly assuming importance both in normal physiology and as a key target in disease pathology.

2018 Pflugers Archiv

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