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Pain Sensation

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361. Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Full Text available with Trip Pro

pain sensation and depression. Here we report that spinal nerve ligation (SNL) induced upregulation of chemokine CCL2 and its major receptor CCR2 in both dopamine D1 and D2 receptor (D1R and D2R)-containing neurons in the NAc. Inhibition of CCR2 by shRNA lentivirus in the NAc shell attenuated SNL-induced pain hypersensitivity and depressive behaviors. Conversely, intra-NAc injection of CCL2-expressing lentivirus-induced nociceptive and depressive behaviors in naïve mice. Whole-cell patch clamp (...) Chemokine receptor CCR2 contributes to neuropathic pain and the associated depression via increasing NR2B-mediated currents in both D1 and D2 dopamine receptor-containing medium spiny neurons in the nucleus accumbens shell. Patients with neuropathic pain are usually accompanied by depression. Chemokine-mediated neuroinflammation is involved in a variety of diseases, including neurodegenerative diseases, depression, and chronic pain. The nucleus accumbens (NAc) is an important area in mediating

2018 Neuropsychopharmacology

362. Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease. Full Text available with Trip Pro

Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease. Chronic pain conditions, especially osteoarthritis (OA), are as common in individuals with Alzheimer's disease (AD) as in the general elderly population, which results in detrimental impact on patient's quality of life. However, alteration in perception of pain in AD coupled with deteriorating ability to communicate pain sensations often result in under-diagnosis (...) and inappropriate management of pain. Therefore, a better understanding of mechanisms in chronic pain processing in AD is needed. Here, we explored the development and progression of OA pain and the effect of analgesics in a transgenic mouse model of AD.Unilateral OA pain was induced chemically, via an intra-articular injection of monosodium iodoacetate (MIA) in the left knee joint of AD-mice (TASTPM) and age- and gender-matched C57BL/6J (WT). Pharmacological and biochemical assessments were conducted in plasma

2018 European Journal of Pain

363. Parents' experience when their child has chronic abdominal pain: a qualitative study in Norway. Full Text available with Trip Pro

sensations like anxiety and 'butterfly' tensions from physical pain. The parents and children needed professional guidance on how to manage the pain .The doctor's consultation should not end at the diagnosis of functional abdominal pain. Doctors may help these families further by focusing on pain management strategies.© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. (...) Parents' experience when their child has chronic abdominal pain: a qualitative study in Norway. Functional abdominal pain occurs frequently in children and adolescents. It is an exclusion diagnosis; somatic diseases have to be ruled out. However little explanation is given for why the child is experiencing pain. The aim was to explore the experiences of parents of children with chronic abdominal pain discharged from hospital without a somatic explanation.The study has a qualitative design

2018 BMJ open

364. Pain processing in functional and idiopathic dystonia: An exploratory study. Full Text available with Trip Pro

-matched healthy controls underwent psychophysical testing of tactile and pain thresholds and pain tolerance. We delivered electrical pulses of increasing intensity to the index finger of each hand and the halluces of each foot. Pain threshold and pain tolerance were respectively defined as the (1) intensity at which sensation changed from unpainful to faintly painful and (2) intensity at which painful sensation was intolerable.No differences were found between the three groups for tactile and pain (...) Pain processing in functional and idiopathic dystonia: An exploratory study. Pain is often experienced by patients with functional dystonia and idiopathic cervical dystonia and is likely to be determined by different neural mechanisms.In this exploratory study, we tested the sensory-discriminative and cognitive-emotional component of pain in patients with functional and idiopathic dystonia.Ten patients with idiopathic cervical dystonia, 12 patients with functional dystonia, and 16 age- and sex

2018 Movement Disorders

365. Cortical astrocytes prime the induction of spine plasticity and mirror image pain. (Abstract)

Cortical astrocytes prime the induction of spine plasticity and mirror image pain. Peripheral nerve injury causes maladaptive plasticity in the central nervous system and induces chronic pain. In addition to the injured limb, abnormal pain sensation can appear in the limb contralateral to the injury, called mirror image pain. Because synaptic remodeling in the primary somatosensory cortex (S1) has critical roles in the induction of chronic pain, cortical reorganization in the S1 ipsilateral (...) to the injured limb may also accompany mirror image pain. To elucidate this, we conducted in vivo 2-photon calcium imaging of neuron and astrocyte activity in the ipsilateral S1 after a peripheral nerve injury. We found that cross-callosal inputs enhanced the activity of both S1 astrocytes and inhibitory neurons, whereas activity of excitatory neurons decreased. When local inhibitory circuits were blocked, astrocyte-dependent spine plasticity and allodynia were revealed. Thus, we propose that cortical

2018 Pain

366. Getting pain on the table in primary care physical exams. (Abstract)

practices to implicitly account for unsolicited pain informings as motivated by a virtual solicitation and/or a sudden pain sensation. With these practices, patients manage to share potentially relevant pain information without accountably being heard to assert its relevance to the doctor's diagnostic inquiry. This achievement demonstrates how asymmetries in doctor-patient communication are a joint accomplishment of both doctors and patients, and are incarnate in the details of everyday clinical (...) Getting pain on the table in primary care physical exams. Using conversation analysis and a dataset of 171 video recordings of US primary care encounters (2003-2005), this paper examines patients' unsolicited pain informings - e.g. "that hurts" - during the physical examination phase of acute care visits. I argue that when patients experience pain in a physical exam but have not been asked a question like "does that hurt?", they face an interactional dilemma. Having presented their health

2018 Social Science & Medicine

367. Enso Pilot Study for Chronic Low Back Pain

Enso Pilot Study for Chronic Low Back Pain Enso Pilot Study for Chronic Low Back Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Enso Pilot Study for Chronic Low Back Pain The safety and scientific (...) Information provided by (Responsible Party): Thimble Bioelectronics, Inc. Study Details Study Description Go to Brief Summary: Enso is a portable device for the treatment of chronic and acute types of musculoskeletal pain. This study is being designed as a single blind, sham-controlled randomized clinical trial. Condition or disease Intervention/treatment Phase Chronic Low Back Pain Device: ENSO Device Device: Sham Device Not Applicable Detailed Description: Fifty subjects will be selected based

2018 Clinical Trials

368. Comparison of the Efficacy of Nepafenac 0.1% and Nepafenac 0.3 % on Pain Associated With Intravitreal Injections

. The PPI index is a numerical verbal rating scale consisting of 6 adjectives of gradually increasing pain sensation (0, none; 1, mild; 2, discomforting; 3, distressing; 4, horrible; and 5, excruciating). The patient is instructed to choose the adjective indicating their pain state. The score for the PPI is derived from the number next to the patients' adjective of choice, ranging from 0 to 5. Higher scores indicate more intense pain. Assessment of topical Nepafenac 0.1% and Nepafenac 0.3% analgesic (...) effect in patients undergoing intravitreal injections of anti-VEGFs [ Time Frame: Six hours after injection ] As measured by the Present Pain Intensity score. The Present Pain Intensity (abbreviation PPI) index is a numerical verbal rating scale consisting of 6 adjectives of gradually increasing pain sensation (0, none; 1, mild; 2, discomforting; 3, distressing; 4, horrible; and 5, excruciating). The patient is instructed to choose the adjective indicating their pain state. The score for the PPI

2018 Clinical Trials

369. Self-Compassion and Acute Pain

device to study pain sensation and analgesic effects. Experimental: Acceptance After pretreatment heat pain assessment, participants are introduced to the concept of acceptance. Participants practice the new strategy with heat pain stimuli three times. Next, the posttreatment pain assessment is conducted. For a one week period, participants receive daily acceptance audio-interventions. Afterwards, the follow-up pain assessment is conducted. Other: Acceptance Participants are introduced to the concept (...) of acceptance. Thoughts, Emotions and Reactions do not need to be related. Being aware of the present moment helps with accepting the present state and reacting contradictory to the thoughts and feelings. Participants are instructed to use this strategy to cope with the following heat stimulus. Other: Heat pain Participants receive heat pain stimuli using the Thermo Sensory Analyser (TSA-II), a commonly used device to study pain sensation and analgesic effects. Experimental: Distraction After pretreatment

2018 Clinical Trials

370. A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)

, docetaxel, or any combination of these. No ongoing pain in distal symmetric distribution (subjects with symptoms and signs such as mild numbness, or vibration sensation loss are eligible to be included in the control group). Able and willing to sign an IRB-approved written informed consent. * Subjects in the control group will be matched by the type of previous chemotherapy to the subjects in the Painful CIPN group. An additional attempt will be made to match controls by sex, age, cancer diagnosis (...) A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN) A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

371. Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain

Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain (INSTANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03674892 Recruitment Status : Recruiting First Posted : September 18, 2018

2018 Clinical Trials

372. The Effect of Barefoot Walking Plantar Chronic Heel Pain

walking (barefoot or with shoes) on a treadmill reduces pain in the heel and improves function. Condition or disease Intervention/treatment Phase Plantar Fascitis Other: walking on a treadmill Not Applicable Detailed Description: A bare foot functions differently than a foot in a shoe while walking, as there are differences in movement, muscle tone, pressure and sensation. Wearing shoes over the years can cause changes in walking and pain. In the examination of the feet of patients suffering from (...) sensation of pain (p1) is produced: Static standing on one leg: measuring the number of seconds (up to 20 sec) and the level of pain on a visual analog scale (VAS); Crouching on one leg: measuring the number of repetitions (up to10 rep) and the level of pain according to VAS; Ascension on fingertips: Measuring the number of repetitions (up to10 rep) and the level of pain according to VAS. It was found that when pain is produced in one of the above tests, the patient may be diagnosed with chronic heel

2018 Clinical Trials

373. Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

374. Exercise Dosing for Pain in Healthy Participants

defined threshold). Following the stimulus, subjects will rate the unpleasantness of the pain associated with the stimulus using a visual analog scale numbered at 0 and 10, where "0" represents "not unpleasant" and "10" represents "the most unpleasant sensation imaginable" (0=minimum score, 10 maximum score). This will be assessed on the forearm and calf. Percent change from baseline across days 1, 3 & 5 at 5 minutes and 30 minutes-post session will then be calculated. Eligibility Criteria Go (...) Exercise Dosing for Pain in Healthy Participants Exercise Dosing for Pain in Healthy Participants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Dosing for Pain in Healthy Participants The safety

2018 Clinical Trials

375. Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome

Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03671993

2018 Clinical Trials

376. Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI

Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03748290 Recruitment Status : Recruiting First Posted : November 20, 2018 Last Update Posted : November 20, 2018

2018 Clinical Trials

377. The Effect of Smartphone Use Duration in Patients With Chronic Mechanical Neck Pain.

months. Patients should have at least a one year experience in using touch-screen smartphone. Have a neck impairment of more than 8% on the neck disability index (NDI). Exclusion Criteria: Any history of upper extremity injury or surgery within the past year Visual problems, dizziness and vertigo Any deformity in the upper extremities or spine Previous history of spinal surgery. Neurological or systemic disorders that interfere with balance and sensation Low back pain or deformity. Patients with any (...) The Effect of Smartphone Use Duration in Patients With Chronic Mechanical Neck Pain. The Effect of Smartphone Use Duration in Patients With Chronic Mechanical Neck Pain. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

378. Characterization & Treatment of Chronic Pain After Moderate to Severe TBI

, ignoring pain sensations, increasing behavior, and using coping self-statements. Each item is scored from 0 to 6, with 0 representing 'no use' and 6 representing 'regular use' of the coping strategy. Scores for each domain are the mean score of the two items in that domain. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study (...) Characterization & Treatment of Chronic Pain After Moderate to Severe TBI Characterization & Treatment of Chronic Pain After Moderate to Severe TBI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

379. Impact of TENS on Postoperative Pain and Quality of Life After Inguinal Hernia Repair

min before and 10 min after each TENS procedure, which occur 24, 26, 48 and 50 hours after surgery. ] Pressure pain threshold assessed using digital pressure algometer examination in inguinal region (hernia and contralateral side). Pressure in newtons (N) that evokes minimal sensation of pain is assessed. Change in pressure pain tolerance. [ Time Frame: 1 hour before surgery (baseline), 10 min before and 10 min after each TENS procedure, which occur 24, 26, 48 and 50 hours after surgery (...) . ] Pressure pain tolerance assessed using digital pressure algometer examination in inguinal region (hernia and contralateral side). Pressure in newtons (N) that evokes maximal tolerable sensation of pain is assessed. Change in hernia specific quality of life. [ Time Frame: 1 hour before surgery (baseline), 2 days, 1 week, 4 weeks and 6 month after surgery. ] Hernia specific quality of life is assessed using self reported questionnaire Carolina's comfort scale (CCS) application, providing a 0 to 115 score

2018 Clinical Trials

380. Exercise Protocol for Pilots With Back Pain.

of eccentric phase timing. No Intervention: Control group After the 8 weeks of intervention, the pilots will receive explanation and handbook demonstration of the same exercises. Outcome Measures Go to Primary Outcome Measures : Change in number on Visual Analog Scale (VAS) of pain sensation in areas of the body (neck, shoulder, thoracic, low back spine, lower limbs) [ Time Frame: Change from Baseline pain sensation at 8 weeks. ] Quantification in number on Visual Analog Scale (VAS) of pain sensation (...) Exercise Protocol for Pilots With Back Pain. Exercise Protocol for Pilots With Back Pain. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Protocol for Pilots With Back Pain. The safety

2018 Clinical Trials

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