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Pain Sensation

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361. Self-Compassion and Acute Pain

device to study pain sensation and analgesic effects. Experimental: Acceptance After pretreatment heat pain assessment, participants are introduced to the concept of acceptance. Participants practice the new strategy with heat pain stimuli three times. Next, the posttreatment pain assessment is conducted. For a one week period, participants receive daily acceptance audio-interventions. Afterwards, the follow-up pain assessment is conducted. Other: Acceptance Participants are introduced to the concept (...) of acceptance. Thoughts, Emotions and Reactions do not need to be related. Being aware of the present moment helps with accepting the present state and reacting contradictory to the thoughts and feelings. Participants are instructed to use this strategy to cope with the following heat stimulus. Other: Heat pain Participants receive heat pain stimuli using the Thermo Sensory Analyser (TSA-II), a commonly used device to study pain sensation and analgesic effects. Experimental: Distraction After pretreatment

2018 Clinical Trials

362. A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)

, docetaxel, or any combination of these. No ongoing pain in distal symmetric distribution (subjects with symptoms and signs such as mild numbness, or vibration sensation loss are eligible to be included in the control group). Able and willing to sign an IRB-approved written informed consent. * Subjects in the control group will be matched by the type of previous chemotherapy to the subjects in the Painful CIPN group. An additional attempt will be made to match controls by sex, age, cancer diagnosis (...) A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN) A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

363. Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain

Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain (INSTANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03674892 Recruitment Status : Recruiting First Posted : September 18, 2018

2018 Clinical Trials

364. The Effect of Barefoot Walking Plantar Chronic Heel Pain

walking (barefoot or with shoes) on a treadmill reduces pain in the heel and improves function. Condition or disease Intervention/treatment Phase Plantar Fascitis Other: walking on a treadmill Not Applicable Detailed Description: A bare foot functions differently than a foot in a shoe while walking, as there are differences in movement, muscle tone, pressure and sensation. Wearing shoes over the years can cause changes in walking and pain. In the examination of the feet of patients suffering from (...) sensation of pain (p1) is produced: Static standing on one leg: measuring the number of seconds (up to 20 sec) and the level of pain on a visual analog scale (VAS); Crouching on one leg: measuring the number of repetitions (up to10 rep) and the level of pain according to VAS; Ascension on fingertips: Measuring the number of repetitions (up to10 rep) and the level of pain according to VAS. It was found that when pain is produced in one of the above tests, the patient may be diagnosed with chronic heel

2018 Clinical Trials

365. Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Different Modes of Assessment on Acupuncture Effect on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

366. Exercise Dosing for Pain in Healthy Participants

defined threshold). Following the stimulus, subjects will rate the unpleasantness of the pain associated with the stimulus using a visual analog scale numbered at 0 and 10, where "0" represents "not unpleasant" and "10" represents "the most unpleasant sensation imaginable" (0=minimum score, 10 maximum score). This will be assessed on the forearm and calf. Percent change from baseline across days 1, 3 & 5 at 5 minutes and 30 minutes-post session will then be calculated. Eligibility Criteria Go (...) Exercise Dosing for Pain in Healthy Participants Exercise Dosing for Pain in Healthy Participants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Dosing for Pain in Healthy Participants The safety

2018 Clinical Trials

367. Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome

Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03671993

2018 Clinical Trials

368. Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI

Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03748290 Recruitment Status : Recruiting First Posted : November 20, 2018 Last Update Posted : November 20, 2018

2018 Clinical Trials

369. The Effect of Smartphone Use Duration in Patients With Chronic Mechanical Neck Pain.

months. Patients should have at least a one year experience in using touch-screen smartphone. Have a neck impairment of more than 8% on the neck disability index (NDI). Exclusion Criteria: Any history of upper extremity injury or surgery within the past year Visual problems, dizziness and vertigo Any deformity in the upper extremities or spine Previous history of spinal surgery. Neurological or systemic disorders that interfere with balance and sensation Low back pain or deformity. Patients with any (...) The Effect of Smartphone Use Duration in Patients With Chronic Mechanical Neck Pain. The Effect of Smartphone Use Duration in Patients With Chronic Mechanical Neck Pain. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2018 Clinical Trials

370. Characterization & Treatment of Chronic Pain After Moderate to Severe TBI

, ignoring pain sensations, increasing behavior, and using coping self-statements. Each item is scored from 0 to 6, with 0 representing 'no use' and 6 representing 'regular use' of the coping strategy. Scores for each domain are the mean score of the two items in that domain. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study (...) Characterization & Treatment of Chronic Pain After Moderate to Severe TBI Characterization & Treatment of Chronic Pain After Moderate to Severe TBI - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more

2018 Clinical Trials

371. Impact of TENS on Postoperative Pain and Quality of Life After Inguinal Hernia Repair

min before and 10 min after each TENS procedure, which occur 24, 26, 48 and 50 hours after surgery. ] Pressure pain threshold assessed using digital pressure algometer examination in inguinal region (hernia and contralateral side). Pressure in newtons (N) that evokes minimal sensation of pain is assessed. Change in pressure pain tolerance. [ Time Frame: 1 hour before surgery (baseline), 10 min before and 10 min after each TENS procedure, which occur 24, 26, 48 and 50 hours after surgery (...) . ] Pressure pain tolerance assessed using digital pressure algometer examination in inguinal region (hernia and contralateral side). Pressure in newtons (N) that evokes maximal tolerable sensation of pain is assessed. Change in hernia specific quality of life. [ Time Frame: 1 hour before surgery (baseline), 2 days, 1 week, 4 weeks and 6 month after surgery. ] Hernia specific quality of life is assessed using self reported questionnaire Carolina's comfort scale (CCS) application, providing a 0 to 115 score

2018 Clinical Trials

372. Exercise Protocol for Pilots With Back Pain.

of eccentric phase timing. No Intervention: Control group After the 8 weeks of intervention, the pilots will receive explanation and handbook demonstration of the same exercises. Outcome Measures Go to Primary Outcome Measures : Change in number on Visual Analog Scale (VAS) of pain sensation in areas of the body (neck, shoulder, thoracic, low back spine, lower limbs) [ Time Frame: Change from Baseline pain sensation at 8 weeks. ] Quantification in number on Visual Analog Scale (VAS) of pain sensation (...) Exercise Protocol for Pilots With Back Pain. Exercise Protocol for Pilots With Back Pain. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Protocol for Pilots With Back Pain. The safety

2018 Clinical Trials

373. Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls

system is examined using pressure algometry and cuff algometry. A pressure algometer is a pistol shaped device that elicits pressure through a rod and a cuff algometer is akin to a blood pressure cuff. Different thresholds will be measured, such as when the sensation of pressure becomes painful and when the painful pressure becomes unbearable. Participants will also get hand strength tested, have their joints examined and answer questionnaires regarding daily function and quality of life. Furthermore (...) Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

374. Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy

for eligibility information Ages Eligible for Study: 18 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Probability Sample Study Population Meet the diagnosis of diabetic peripheral neuropathy (at the same time meets the following three items, of which painful neuropathy patients have pain symptom): (1) neuropathy occurs not earlier than the diagnosis of diabetes; (2) having clinical manifestations of pain, numbness, and abnormal sensation; (3) any (...) abnormality in the following 5 examinations: ankle reflex, vibratory sensation, pressure sensation, temperature sensation, and acupuncture pain. Criteria Inclusion Criteria: Voluntary participation and signing informed consent 18 to 60 years old with junior high school education or above meeting the 1999 WHO type 2 diabetes diagnostic criteria: having symptoms of diabetes (polydipsia, polyphagia, polyuria and unexplained weight loss) plus one of the following 3 items: (1) random blood glucose more than

2018 Clinical Trials

375. Perfusion index as a reliable parameter of vasomotor disturbance in complex regional pain syndrome. Full Text available with Trip Pro

Perfusion index as a reliable parameter of vasomotor disturbance in complex regional pain syndrome. Discrepancy between a patient's subjective thermal symptoms and objective measured temperature value is common in complex regional pain syndrome (CRPS) in clinical settings. For that reason, the diagnostic validity of a single temperature measurement method has been criticised. Several studies showed that the perfusion index (PI), which is derived from pulse oximetry, is a more sensitive (...) and earlier indicator of sympathetic blockade than temperature measurement.Forty-six participants (CRPS group, n=23; healthy control group, n=23) were enrolled. CRPS patients with subjective sensation of coldness on the affected side were chosen for this study. Temperature and PI were measured at the affected and contralateral hands in the CRPS group, and right and left hands in the healthy control group. To evaluate each method's efficacy for detecting thermal symptoms, differences in the parameters

2018 British Journal of Anaesthesia

376. Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. (Abstract)

and repeated up to 10 h postdose.Paracetamol did not show a significant reduction in pain sensation or subjective cognitive functioning compared to placebo. Promethazine induced a statistically significant reduction in PTT for cold pressor and pressure stimulation. Furthermore, reduced subjective alertness was observed. Δ9-THC showed a statistically significant decrease in PTT for electrical and pressure stimulation. Δ9-THC also demonstrated subjective effects, including changes in alertness and calmness (...) Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects. A battery of evoked pain tasks (PainCart) was developed to investigate the pharmacodynamic properties of novel analgesics in early-phase clinical research. As part of its clinical validation, compounds with different pharmacological mechanisms of actions are investigated. The aim was to investigate the analgesic effects of classic and nonclassic analgesics compared to a sedating

2018 European Journal of Pain Controlled trial quality: uncertain

377. Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain. Full Text available with Trip Pro

evaluations, patients were selected asking if they had ever experienced neural pain. Data analyses of their pain characteristics, clinical examination results, and both the Douleur Neuropathique 4 Questionnaire and Hamilton Depression Scale scores were used to classify these patients. The most common word they used to describe the sensation of pain for 25 (60%) of these patients was "burning." In the early stages of the disease and before leprosy diagnosis, 19 (45%) had already complained about NP (...) Clinical and Neurophysiological Features of Leprosy Patients with Neuropathic Pain. Neural pain is a frequent symptom in leprosy disease. There is a paucity of data regarding neural pain diagnostics resulting in common prescriptive errors when neuritis is confused with neuropathic or mixed nociceptive-neuropathic pain. The present study identified important demographic, clinical, and neurophysiological features of 42 leprosy neuropathy patients presenting neuropathic pain (NP). During routine

2018 American Journal of Tropical Medicine & Hygiene

378. Lumbar Sympathetic Plexus Block as a Treatment for Postamputation Pain: Methodology for a Randomized Controlled Trial. Full Text available with Trip Pro

was also performed, which included vibration sensation testing, pinprick sensation testing, brush sensation testing, Von Frey repeated weighted pinprick sensation, and thermal quantitative sensory testing.In the four described cases, treatment of PAP with a single lumbar sympathetic block but not sham intervention resulted in reduction of both residual limb pain and phantom limb pain as well as perceived disability on the PDI at three-month follow-up.An appropriately powered randomized controlled study (...) Lumbar Sympathetic Plexus Block as a Treatment for Postamputation Pain: Methodology for a Randomized Controlled Trial. We present a technical protocol for rigorous assessment of patient-reported outcomes and psychophysical testing relevant to lumbar sympathetic blocks for the treatment of postamputation pain (PAP). This description is intended to inform future prospective investigation.Series of four participants from a blinded randomized sham-controlled trial.Tertiary, urban, academic pain

2018 Pain Medicine Controlled trial quality: uncertain

379. Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity Full Text available with Trip Pro

(DRGs) and spinal cord nor the function determination by NECAB2 has been defined. A combination of histochemical analyses and single-cell RNA-sequencing showed NECAB2 in small- and medium-sized C- and Aδ D-hair low-threshold mechanoreceptors in DRGs, as well as in protein kinase C γ excitatory spinal interneurons. NECAB2 was downregulated by peripheral nerve injury, leading to the hypothesis that NECAB2 loss of function could limit pain sensation. Indeed, Necab2-/- mice reached a pain-free state (...) Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity Pain signals are transmitted by multisynaptic glutamatergic pathways. Their first synapse between primary nociceptors and excitatory spinal interneurons gates the sensory load. In this pathway, glutamate release is orchestrated by Ca2+-sensor proteins, with N-terminal EF-hand Ca2+-binding protein 2 (NECAB2) being particular abundant. However, neither the importance of NECAB2+ neuronal contingents in dorsal root ganglia

2018 The Journal of clinical investigation

380. Quantitative SSEP and EEG as Objective Pain Biomarker

of a person's electrical brain activity do reflect pain sensation. Condition or disease Intervention/treatment Phase Pain Other: Standard EEG or SSEP Not Applicable Detailed Description: Over the past few years, significant advances have begun to be made in the development of particular measures as valid biomarkers or surrogate markers for the presence of acute and/or chronic pain. Many of these advances have been made because of the development of new and improved technologies, for example in the fields (...) Quantitative SSEP and EEG as Objective Pain Biomarker Quantitative SSEP and EEG as Objective Pain Biomarker - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Quantitative SSEP and EEG as Objective Pain

2018 Clinical Trials

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