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Pain Sensation

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281. Chronic Pelvic Pain, Initial Management

after the original tissue injury or exist in the absence of any such injury. Major changes are seen in both afferent and efferent nerve pathways in the central and peripheral nervous systems. Local factors, such as tumour necrosis factor alpha (TNF-) and chemokines, may change peripheral nerve function and/or stimulate normally quiescent fibres, resulting in altered sensation over a wider area than that originally affected. A persistent barrage of pain may lead to changes within the central nervous (...) system, which magnify the original signal. 7 Descending information from the central nervous system, possibly influenced by previous experiences and current circumstances, may modify pain perception and visceral function. Alteration in visceral sensation and function, provoked by a variety of neurological factors, has been termed ‘visceral hyperalgesia’. Nerve damage following surgery, trauma, inflammation, fibrosis or infection may play a part in this process. 8,9 Pain as a result of changes

2012 Royal College of Obstetricians and Gynaecologists

282. Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity (Full text)

(DRGs) and spinal cord nor the function determination by NECAB2 has been defined. A combination of histochemical analyses and single-cell RNA-sequencing showed NECAB2 in small- and medium-sized C- and Aδ D-hair low-threshold mechanoreceptors in DRGs, as well as in protein kinase C γ excitatory spinal interneurons. NECAB2 was downregulated by peripheral nerve injury, leading to the hypothesis that NECAB2 loss of function could limit pain sensation. Indeed, Necab2-/- mice reached a pain-free state (...) Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity Pain signals are transmitted by multisynaptic glutamatergic pathways. Their first synapse between primary nociceptors and excitatory spinal interneurons gates the sensory load. In this pathway, glutamate release is orchestrated by Ca2+-sensor proteins, with N-terminal EF-hand Ca2+-binding protein 2 (NECAB2) being particular abundant. However, neither the importance of NECAB2+ neuronal contingents in dorsal root ganglia

2018 The Journal of clinical investigation PubMed abstract

283. Atypical changes in DRG neuron excitability and complex pain phenotype associated with a Nav1.7 mutation that massively hyperpolarizes activation (Full text)

by I234T, and confirmed that the I234T conductance could drastically depolarize DRG neurons, resulting in loss of excitability. We conclude that attenuation of pain sensation by I234T is caused by massively depolarized membrane potential of some DRG neurons which is partly due to enhanced overlap between activation and fast-inactivation, impairing their ability to fire. Our results demonstrate how a Nav1.7 mutation that produces channel gain-of-function can contribute to a dual clinical presentation (...) that includes loss of pain sensation at the clinical level.

2018 Scientific reports PubMed abstract

284. Neurological Assessment Using a Quantitative Sensory Test in Patients with Chronic Unilateral Orofacial Pain (Full text)

using QST.A total of 60 participants (5o females: 28-83 years; 10 males: 44-81 years) with unilateral orofacial pain were recruited from the Orofacial Pain Clinic at the Pain Management and Research Centre, Royal North Shore Hospital, Sydney, Australia. The study followed the methods of limits of the German Research Network testing four modalities of thermal thresholds, the Warm Sensation, the Cold Sensation, the Heat Pain and the Cold Pain using a TSA-II Neurosensory Analyser. The results were (...) compared to the results from the unaffected side of the same patient on the same area and a single t test statistical analysis was performed, where a p value of less than 0.05 was considered significant.The Mean Difference for Cold Sensation between the pain side and the non-pain side was 0.48 °C ± 1.5 (t= 2.466, p=0.017), 0.68 °C ± 2.04 for Warm Sensation (t= -2.573, p= 0.013), 2.56 °C ± 2.74 for Cold Pain (t= 7.238, p<0.001) and -1.21 °C ± 2.59 for Hot Pain (t= -3.639, p=0.001).The study showed

2018 The open dentistry journal PubMed abstract

285. Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex (Full text)

Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex Background Chronic pain is a persistent unpleasant sensation that produces pathological synaptic plasticity in the central nervous system. Both human imaging study and animal studies consistently demonstrate that the anterior cingulate cortex is a critical cortical area for nociceptive and chronic pain processing. Thus far, the mechanisms of excitatory synaptic transmission (...) and plasticity have been well characterized in the anterior cingulate cortex for various models of chronic pain. By contrast, the potential contribution of inhibitory synaptic transmission in the anterior cingulate cortex, in models of chronic pain, is not fully understood. Methods Chronic inflammation was induced by complete Freund adjuvant into the adult mice left hindpaw. We performed in vitro whole-cell patch-clamp recordings from layer II/III pyramidal neurons in two to three days after the complete

2018 Molecular pain PubMed abstract

286. Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome

Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Clinical Effect Observation for Electrical Pudendal Nerve Stimulation in Treating Urethral Pain Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03671993

2018 Clinical Trials

287. Lidocaine Infusion for Postthoracotomy Pain Syndrome

: Postthoracotomy pain syndrome (PPS) is defined as a persistent and/or recurrent pain or burning sensation along the thoracotomy scar at 3 months after surgery. The pain is very significant, given that 3 to 5% of postthoractomy patients report it as being severe, and approximately 50% of patients report limitations in their activities of daily living. Little is known about the origin of this pain, but it seems that the intensity of acute postoperative pain is the best predictor of it. Lidocaine infusion could (...) Lidocaine Infusion for Postthoracotomy Pain Syndrome Lidocaine Infusion for Postthoracotomy Pain Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Lidocaine Infusion for Postthoracotomy Pain Syndrome

2018 Clinical Trials

288. Exercise Dosing for Pain in Healthy Participants

defined threshold). Following the stimulus, subjects will rate the unpleasantness of the pain associated with the stimulus using a visual analog scale numbered at 0 and 10, where "0" represents "not unpleasant" and "10" represents "the most unpleasant sensation imaginable" (0=minimum score, 10 maximum score). This will be assessed on the forearm and calf. Percent change from baseline across days 1, 3 & 5 at 5 minutes and 30 minutes-post session will then be calculated. Eligibility Criteria Go (...) Exercise Dosing for Pain in Healthy Participants Exercise Dosing for Pain in Healthy Participants - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Dosing for Pain in Healthy Participants The safety

2018 Clinical Trials

289. Assessment of Musculoskeletal Pain and Psychosocial Status of Athletes

consists of 11 questions asked from the 9 body regions. The questionnaire firstly questions the pain-pain sensation in the 9 body areas in the form of a yes / no response. severity of pain perception [ Time Frame: 14 days ] Visual Analogue Scale (VAS); This study will be used to understand how the athlete expresses pain on a 10 cm scale before, during and after training. Using a ruler, the score is about 10-cm in length. It have been recommended: no pain (0 and4 mm), mild pain (5-44 mm), moderate pain (...) Assessment of Musculoskeletal Pain and Psychosocial Status of Athletes Assessment of Musculoskeletal Pain and Psychosocial Status of Athletes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Assessment

2018 Clinical Trials

290. Psychosocial Support for Pre-operative Pain and Distress

-judgmental fashion. Experimental: Suggestion 15 minute therapeutic suggestion session Behavioral: Suggestion The 15 minute suggestion session is a scripted suggestion exercise that incorporates imagery and suggestions for changes in cognition, emotion, and body sensations. Active Comparator: Psychoeducation 15 minute psychoeducation session Behavioral: Psychoeducation The 15 minute psychoeducation session is a supportive session in which behavioral coping strategies for pain management are discussed (...) Psychosocial Support for Pre-operative Pain and Distress Psychosocial Support for Pre-operative Pain and Distress - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Psychosocial Support for Pre-operative Pain

2018 Clinical Trials

291. Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent

treatment (Real DLPFC of MPFC TMS vs. Sham) and time (Before vs. After rTMS) on reported painfulness using a quantitative sensory testing technique determines the sensation and pain thresholds of warm temperatures. Painfulness ratings will be assessed and reported through the duration of the study. Secondary Outcome Measures : Reductions in Patient Reported Pain and Discomfort [ Time Frame: Throughout the duration of the study, approximately 16 weeks ] The investigators expect reductions in self (...) Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2018 Clinical Trials

292. A Decision Support System for Self-management of Low Back Pain

A Decision Support System for Self-management of Low Back Pain A Decision Support System for Self-management of Low Back Pain - PILOTSTUDY - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. A Decision Support (...) System for Self-management of Low Back Pain - PILOTSTUDY (selfBACK) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03697759 Recruitment Status : Completed First Posted : October 5, 2018 Last Update Posted : February 28, 2019 Sponsor: University of Southern Denmark Collaborators: Norwegian University

2018 Clinical Trials

293. Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy

for eligibility information Ages Eligible for Study: 18 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Probability Sample Study Population Meet the diagnosis of diabetic peripheral neuropathy (at the same time meets the following three items, of which painful neuropathy patients have pain symptom): (1) neuropathy occurs not earlier than the diagnosis of diabetes; (2) having clinical manifestations of pain, numbness, and abnormal sensation; (3) any (...) abnormality in the following 5 examinations: ankle reflex, vibratory sensation, pressure sensation, temperature sensation, and acupuncture pain. Criteria Inclusion Criteria: Voluntary participation and signing informed consent 18 to 60 years old with junior high school education or above meeting the 1999 WHO type 2 diabetes diagnostic criteria: having symptoms of diabetes (polydipsia, polyphagia, polyuria and unexplained weight loss) plus one of the following 3 items: (1) random blood glucose more than

2018 Clinical Trials

294. Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls

system is examined using pressure algometry and cuff algometry. A pressure algometer is a pistol shaped device that elicits pressure through a rod and a cuff algometer is akin to a blood pressure cuff. Different thresholds will be measured, such as when the sensation of pressure becomes painful and when the painful pressure becomes unbearable. Participants will also get hand strength tested, have their joints examined and answer questionnaires regarding daily function and quality of life. Furthermore (...) Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls Central Pain Mechanisms in Patients With Hand-Osteoarthritis, Psoriatic Arthritis and Healthy Controls - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

295. Effectiveness of Dry Needling as a Treatment of Shoulder Myofascial Pain Syndrome in Spinal Cord Injury Patients

the patient can only choose one word from each of the 20 groups, choosing only those adjectives that best suit his pain sensation. It also includes a category on the changes that experimental pain, and another with a rate of pain intensity (Present Pain Index = PPI). Visual Analog Scale (VAS) [ Time Frame: Change from baseline and one week later. ] This scale is a line of 10 centimeters without marks between the parameters without pain and unbearable pain, where the patient has to mark between those (...) Effectiveness of Dry Needling as a Treatment of Shoulder Myofascial Pain Syndrome in Spinal Cord Injury Patients Effectiveness of Dry Needling as a Treatment of Shoulder Myofascial Pain Syndrome in Spinal Cord Injury Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

296. The Effect of Barefoot Walking Plantar Chronic Heel Pain

walking (barefoot or with shoes) on a treadmill reduces pain in the heel and improves function. Condition or disease Intervention/treatment Phase Plantar Fascitis Other: walking on a treadmill Not Applicable Detailed Description: A bare foot functions differently than a foot in a shoe while walking, as there are differences in movement, muscle tone, pressure and sensation. Wearing shoes over the years can cause changes in walking and pain. In the examination of the feet of patients suffering from (...) sensation of pain (p1) is produced: Static standing on one leg: measuring the number of seconds (up to 20 sec) and the level of pain on a visual analog scale (VAS); Crouching on one leg: measuring the number of repetitions (up to10 rep) and the level of pain according to VAS; Ascension on fingertips: Measuring the number of repetitions (up to10 rep) and the level of pain according to VAS. It was found that when pain is produced in one of the above tests, the patient may be diagnosed with chronic heel

2018 Clinical Trials

297. Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain

Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding (...) more. Intranasal Neurostimulation in Ameliorating Symptoms of Neuropathic Corneal Pain (INSTANT) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03674892 Recruitment Status : Recruiting First Posted : September 18, 2018

2018 Clinical Trials

298. Investigation of the Effects of CGF and A-PRF on Pain, Edema and Trismus After Impacted Lower Third Molar Surgery

)--------------------------------------------------------------------------------10 (unbearable pain) Higher values of the scale represent worse outcome. Post-operative symptom severity (PoSSe) scale [ Time Frame: Post operative 7th day ] The evaluation of the change in postoperative quality of life will be done with a scale of post-operative symptom severity (PoSSe) consisting of 15-item questionnaire in which the effect of operation on eating, speech, sensation, appearance, pain, disease and daily activities is evaluated. This questionnaire was divided into subscales (...) Investigation of the Effects of CGF and A-PRF on Pain, Edema and Trismus After Impacted Lower Third Molar Surgery Investigation of the Effects of CGF and A-PRF on Pain, Edema and Trismus After Impacted Lower Third Molar Surgery - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2018 Clinical Trials

299. Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification

Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Clinical Study of the Efficacy of the Ophthalmic Emulsion PRO-145 for Inflammation and Pain After Phacoemulsification (PRO-145/III) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2018 Clinical Trials

300. Exercise Protocol for Pilots With Back Pain.

of eccentric phase timing. No Intervention: Control group After the 8 weeks of intervention, the pilots will receive explanation and handbook demonstration of the same exercises. Outcome Measures Go to Primary Outcome Measures : Change in number on Visual Analog Scale (VAS) of pain sensation in areas of the body (neck, shoulder, thoracic, low back spine, lower limbs) [ Time Frame: Change from Baseline pain sensation at 8 weeks. ] Quantification in number on Visual Analog Scale (VAS) of pain sensation (...) Exercise Protocol for Pilots With Back Pain. Exercise Protocol for Pilots With Back Pain. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise Protocol for Pilots With Back Pain. The safety

2018 Clinical Trials

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