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Pain Sensation

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241. The effect of a single irradiation of low-level laser on nipple pain in breastfeeding women: a randomized controlled trial. (Abstract)

in the laser group (11/36) reported secondary effects, such as tingling (10/36) and pricking (2/36). The laser protocol of a single application was not effective in reducing pain in women with damaged nipples. Tingling sensation may be experienced by women receiving laser treatment for nipple damage. (...) The effect of a single irradiation of low-level laser on nipple pain in breastfeeding women: a randomized controlled trial. Photobiomodulation with low-level laser therapy (PBM-LLLT) has been introduced as a new tool to relieve nipple pain and repair nipple damage in breastfeeding women; however, evidence is needed to assess its effectiveness. The aim was to evaluate the effect of a single application of PBM-LLLT for breastfeeding women with nipple pain and damage; side effects were also

2019 Lasers in medical science Controlled trial quality: predicted high

242. A randomized comparative study assessing efficacy of pain versus comfort scores. Full Text available with Trip Pro

was associated with injury or healing.Data were analyzed using Student's t-test and nonparametric Mann-Whitney U-test, performed at a significance level of α =0.05.In Group P, 62 women (68.9%) reported pain compared with only 49 women (54.4%) in Group C (P < 0.05). There were no significant differences between groups for VNRS at rest and on movement. In Group P, thirty women (33.33%) reported sensations as injury compared with only 11 women (12.22%) in Group C (P < 0.001).Assessment of pain using positive (...) A randomized comparative study assessing efficacy of pain versus comfort scores. Use of language with negative emotional content is likely to increase patient's pain and anxiety.We designed a single-blinded randomized study to compare pain scores with comfort scores and to determine whether the technique of pain assessment affects patient's perceptions and experience.After cesarean section, 180 women were randomized before postanaesthesia interview into two groups. Group P women were asked

2019 Saudi journal of anaesthesia Controlled trial quality: uncertain

243. A Randomized Controlled Trial to Assess the Effectiveness of Muscle Strengthening and Balancing Exercises on Chemotherapy-Induced Peripheral Neuropathic Pain and Quality of Life Among Cancer Patients. (Abstract)

A Randomized Controlled Trial to Assess the Effectiveness of Muscle Strengthening and Balancing Exercises on Chemotherapy-Induced Peripheral Neuropathic Pain and Quality of Life Among Cancer Patients. Chemotherapy-induced peripheral neuropathy (CIPN) is the presence of tingling, burning, itching, and unpleasant sensations in hands and feet due to nerve damage by chemotherapy. Exercise rehabilitation has potential to prevent or alleviate CIPN.The aim of this study was to assess the effectiveness (...) of muscle strengthening and balancing exercises on CIPN pain and quality of life (QOL) among cancer patients.The randomized controlled trial included 45 cancer patients from a tertiary care hospital in India receiving chemotherapeutic drugs paclitaxel and carboplatin and found to have CIPN. Subjects were randomly allocated to exercise (n1 = 22) and usual care (n2 = 23) groups. The exercise group received home-based muscle strengthening and balancing exercise for 10 weeks. Data regarding demographic

2019 Cancer nursing Controlled trial quality: uncertain

244. Pelvic floor myofascial pain severity and pelvic floor disorder symptom bother: is there a correlation? (Abstract)

. Severity of myofascial pain at several individual pelvic floor sites was also independently correlated with lower urinary tract symptoms, including pain in the lower abdomen (myofascial pain at all sites) and difficulty emptying the bladder (right obturator internus and left levator ani); and with defecatory dysfunction, including sensation of incomplete rectal emptying (pain at all sites combined and the right obturator internus), anal incontinence to flatus (pain at all sites combined), and pain (...) Pelvic floor myofascial pain severity and pelvic floor disorder symptom bother: is there a correlation? Pelvic floor myofascial pain, which is predominantly identified in the muscles of the levator ani and obturator internus, has been observed in women with chronic pelvic pain and other pelvic floor disorder symptoms, and is hypothesized to contribute to their symptoms.To describe the prevalence of pelvic floor myofascial pain in patients presenting with pelvic floor disorder symptoms

2019 American Journal of Obstetrics and Gynecology

245. Pain Neurology. Full Text available with Trip Pro

Pain Neurology. Pain is often the initial complaint for which patients seek medical care presenting both a diagnostic and therapeutic challenge to the primary care provider. The appreciation of pain is not merely the result of abnormal sensory stimulation causing an unpleasant sensation but rather a combination of the recognition of the somatic discomfort in association with an emotional response to that discomfort. The perception of pain and the extent of distress and disability can vary (...) depending on previous experience, cultural background, situational factors, and comorbid psychiatric disease. While acute pain is usually the result of tissue damage, that is not always the case as evidenced by the primary headache disorders. Chronic pain may be the result of an injury, irreversible underlying disease or clinical conditions such as fibromyalgia for which the mechanism remains unclear. Treatment of the underlying cause will usually effect a resolution or improvement in the pain but when

2019 American Journal of Medicine

246. A Human TRPA1-Specific Pain Model. Full Text available with Trip Pro

A Human TRPA1-Specific Pain Model. The cation channel transient receptor potential ankyrin 1 (TRPA1) plays an important role in sensing potentially hazardous substances. However, TRPA1 species differences are substantial and limit translational research. TRPA1 agonists tested previously in humans also have other targets. Therefore, the sensation generated by isolated TRPA1 activation in humans is unknown. The availability of 2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl (...) to be involved in pain generation. The newly established TRPA1-specific pain model allows different applications. First, it can be tested whether diseases are associated with compromised or exaggerated TRPA1-dependent painful sensations in the skin. Second, it can be investigated whether a new, possibly systemically applied drug directed against TRPA1 engages its target in humans. Further, the general possibility of quantitative inhibition of TRPA1 allows identification of the TRPA1-dependent disease

2019 The Journal of neuroscience : the official journal of the Society for Neuroscience Controlled trial quality: uncertain

247. Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients (Abstract)

. Supplementation with CoQ10 effectively reduced greater pain, anxiety and brain activity, mitochondrial oxidative stress, and inflammation. CoQ10 also increased a reduced glutathione levels and superoxide dismutase (SOD) levels in FM patients. These findings provide new evidence that CoQ10 supplementation provides further benefit for relieving pain sensation in pregabalin-treated FM patients, possibly via improving mitochondrial function, reducing inflammation, and decreasing brain activity. (...) Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients Although coenzyme Q10 (CoQ10) supplementation has shown to reduce pain levels in chronic pain, the effects of CoQ10 supplementation on pain, anxiety, brain activity, mitochondrial oxidative stress, antioxidants, and inflammation in pregabalin-treated fibromyalgia (FM) patients have not clearly elucidated. We hypothesised that CoQ10 supplementation reduced pain better than pregabalin alone via reducing brain

2019 Free Radical Research Controlled trial quality: predicted high

248. Pain and Pruritus: a study of their similarities and differences. (Abstract)

subset of this general fiber. Overall, pain and pruritus share many integral similarities. Although these sensations both initiate the body's awareness to injury, pain and itch may have evolved for sensing different damages such as a burrowing parasite or a noxious stimulus, respectively. This seems to have been validated through analyses of their pathophysiology, acute and chronic conditions, and treatment modalities. However, their symptoms and intrinsic mechanisms vary considerably (...) Pain and Pruritus: a study of their similarities and differences. Pruritus is one of the most common dermatologic complaints and, as the most common dermatologic symptom, is a major contributor to frequent dermatology visits. Chronic pruritus mirrors another major medical condition faced by millions of Americans each year - chronic pain. In older literature, pain and pruritus were thought to have been conveyed by the same C fiber, and the proportion contributing to pruritus was just a small

2019 International Journal of Dermatology

249. <i>Salvia officinalis</i>, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. Full Text available with Trip Pro

) was induced in mice, and neuropathic pain behaviors tests were evaluated by mechanical, chemical, thermal sensation tests and functional recovery of the sciatic nerve at different time intervals, i.e., (day 0, 1, 7, 14, and 21). Ethanolic extract of SO (100 and 200 mg/kg, p.o.), ROS (10 and 20 mg/kg, i.p.), CAF (30 and 40 mg/kg, i.p.), and CLOM (5 mg/kg, i.p., a positive control) was given for 21 days after surgery. Hematological and biochemical parameters were also measured as well as histopathological (...) Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. The leaves of Salvia officinalis L. have a traditional reputation for the management of pain in Morocco. This study was conducted to investigate the curative effects of Salvia officinalis (SO) and its major constituents Rosmarinic (ROS) and Caffeic acids (CAF) on peripheral neuropathic pain in mice. Chronic constriction injury (CCI

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

250. Effects of Multiple Waveforms on Patient Preferences and Clinical Outcomes in Patients Treated With Spinal Cord Stimulation for Leg and/or Back Pain. (Abstract)

to a SP-SCS waveform only for having higher pain relief.There was a high heterogeneity regarding waveform preference, with patients who preferred to feel the tingling sensation and those who chose a SP-SCS option, mainly for greater pain relief. In general, SCS is successful, resulting in high pain relief, improvements in quality of life, and little depression. Overall, 42% patients benefited from the novel SP-SCS stimulation waveforms.© 2018 International Neuromodulation Society. (...) Effects of Multiple Waveforms on Patient Preferences and Clinical Outcomes in Patients Treated With Spinal Cord Stimulation for Leg and/or Back Pain. We present the results of a prospective, randomized, crossover, single-blind, study in which each patient is in control of himself. The aim was to evaluate subperception-based (SP-SCS) waveforms in previously implanted spinal cord stimulation (SCS) patients with leg and/or back pain due to failed back surgery syndrome, who experienced only

2019 Neuromodulation : journal of the International Neuromodulation Society Controlled trial quality: uncertain

251. The clinical features of painful small-fibre neuropathy suggesting an origin linked to a primary Sjögren's syndrome. (Abstract)

with idio-SFN had more frequent severe burning sensations and higher mean anxiety scores and daily pain intensity compared to patients with pSSSFN. Conversely, patients with pSS-SFN had reduced electrochemical skin conductance measured by Sudoscan_, and almost half of them had the sensation of walking on cotton wool.Our results suggest that idio-SFN more specifically involved small sensory fibers than pSS-SFN, in which subtle dysfunction of larger sensory fibers and damage of distal autonomic sudomotor (...) The clinical features of painful small-fibre neuropathy suggesting an origin linked to a primary Sjögren's syndrome. We attempted to determine whether clinical features could differentiate painful small-fiber neuropathy related to primary Sj€ogren's syndrome (pSS-SFN) from idiopathic SFN (idio-SFN).Validated clinical questionnaires and neurophysiological investigations specific for pain and SFN assessment were performed in 25 patients with pSS-SFN and 25 patients with idio-SFN.Patients

2019 Pain Practice

252. An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain: A case report. Full Text available with Trip Pro

An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain: A case report. We present a case of high spinal anesthesia after inadvertent injection of local anesthetics and corticosteroids into the subarachnoid space during attempted epidural injection. Cerebrospinal fluid (CSF) lavage is a suitable method for treatment.A 45-year-old woman presented with posterior thigh, leg, and ankle pain for >6 months and was treated with epidural (...) injection. Five minutes after the third time of epidural injection, the patient complained loss of sensation and muscle strength in the lower extremities and abdominal area.A high spinal anesthesia was confirmed by the patient loss of sensation and muscle strength in the lower extremities and abdominal area.CSF lavage was performed for treatment.After CSF lavage, the patient gradually returns to normal sensory and motor functions of lower limbs. On the fourth day, the patient sensed her physical

2019 Medicine

253. Adaptation of an Ultrasound-Guided Technique for Pulsed Radiofrequency on Axillary and Suprascapular Nerves in the Treatment of Shoulder Pain. (Abstract)

Adaptation of an Ultrasound-Guided Technique for Pulsed Radiofrequency on Axillary and Suprascapular Nerves in the Treatment of Shoulder Pain. It has been estimated that 20% of the general population will suffer shoulder pain throughout their lives, with a prevalence that can reach up to 50%. The suprascapular nerve (SSN) provides sensation for the posterior and superior regions of the glenohumeral joint, whereas the anterior and inferior zones and the skin are innervated mostly by the axillary (...) nerve. Pulsed radiofrequency on the SSN has been proposed as a therapeutic option in chronic shoulder pain. Axillary nerve block has been proposed in the context of surgical analgesia as an adjuvant to SSN block.Ultrasound (US)-guided techniques target the nerve selectively, minimizing patients' and physicians' exposure to harmful radiation while increasing success rates by better needle placement. We perform both US-guided techniques with the patient in a lateral decubitus position

2019 Pain Medicine

254. Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting Full Text available with Trip Pro

Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting Medical management of acute pain among hospital inpatients may be enhanced by mind-body interventions.We hypothesized that a single, scripted session of mindfulness training focused on acceptance of pain or hypnotic suggestion focused on changing pain sensations through imagery would significantly reduce acute pain intensity and unpleasantness compared (...) to a psychoeducation pain coping control. We also hypothesized that mindfulness and suggestion would produce significant improvements in secondary outcomes including relaxation, pleasant body sensations, anxiety, and desire for opioids, compared to the control condition.This three-arm, parallel-group randomized controlled trial conducted at a university-based hospital examined the acute effects of 15-min psychosocial interventions (mindfulness, hypnotic suggestion, psychoeducation) on adult inpatients reporting

2017 EvidenceUpdates

255. A novel player in the field: Merkel disk in touch, itch, and pain. Full Text available with Trip Pro

A novel player in the field: Merkel disk in touch, itch, and pain. Mammalian skin, comprising both hairy and glabrous skin, is innervated by various types of low-threshold mechanoreceptors (LTMRs), which renders skin into a mechanosensitive organ [1]. Based on the degree of axonal myelination and conduction velocity, LTMRs are further divided into C-, Aδ- and Aβ-LTMRs. Electrophysiological recordings from those LTMRs have revealed unique action potential firing patterns upon discriminative (...) mechanical stimuli. Although great strides have been made in the past decades to identify LTMRs that are specifically involved in the genesis of tactile sensations [2, 3], their anatomical and physiological properties remain largely unknown. Light touch sensation is encoded by Merkel cell-neurite complex which is composed of slowly adapting type I (SAI) cutaneous Aβ-LTMRs and skin-derived Merkel cells. Recent exciting studies have begun to understand how Merkel cell-neurite complex is involved

2019 Experimental Dermatology

256. Chronic continuous abdominal pain: evaluation of diagnostic features, iatrogenesis and drug treatments in a cohort of 103 patients. Full Text available with Trip Pro

differences between patients who satisfied Rome IV criteria and those who did not. Overall, 81% had allodynia (a nonpainful stimulus evoking pain sensation). Opioid use was associated with allodynia (P = 0.003). Prior surgery was associated with further operations post CCAP onset (P < 0.001). Although 68% had undergone surgical interventions, surgery did not resolve pain in any patient and worsened pain in 35%. Whilst duloxetine was the most effective neuromodulator (P = 0.003), combination therapy (...) Chronic continuous abdominal pain: evaluation of diagnostic features, iatrogenesis and drug treatments in a cohort of 103 patients. Chronic continuous abdominal pain (CCAP) is characteristic of centrally mediated gastrointestinal pain disorders. It consumes significant healthcare resources yet is poorly understood, with minimal cohort-specific data in the literature.To examine in a large cohort of CCAP patients, (a) diagnostic features, (b) iatrogenic impact of opioids and surgery, (c) drug

2019 Alimentary Pharmacology & Therapeutics

257. Methylglyoxal causes pain and hyperalgesia in human through C-fiber activation. (Abstract)

was assessed via selective A-fiber nerve block, axon-reflex-erythema and via single nerve fiber recordings in humans (microneurography). Involvement of the transduction channels TRPA1 and TRPV1 in MG-induced pain sensation was investigated with specific ion channel blockers. We showed for the first time in healthy humans that MG induces pain, axon-reflex-erythema and long-lasting hyperalgesia via the activation of C-nociceptors. Predominantly the subclass of mechano-insensitive C-fibers is activated by MG (...) . A-fibers contribute only negligibly to the burning pain sensation. Selective harmacological blockade of TRPA1 or TRPV1 showed that TRPA1 is crucially involved in MG-induced chemical pain sensation and heat hyperalgesia. In conclusion, the ctions of MG via TRPA1 activation on predominantly mechanoinsensitive C-fibers might be involved in spontaneously perceived pain in diabetic neuropathy and hyperalgesia as well as allodynia.

2019 Pain

258. Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine. (Abstract)

interventional target for pain control. Since DRG ectopia is selectively suppressed with lidocaine at concentrations too low to block axonal impulse propagation, we asked whether targeted delivery of dilute lidocaine to the L5 DRG can relieve L5 SNL-induced tactile allodynia without blocking normal sensation or motor function. Results showed that intraforaminal injection of 10 µL bolus doses of 0.2% lidocaine suppressed allodynia transiently, while sustained infusion over 2 weeks using osmotic minipumps (...) Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine. Neuropathic pain is frequently driven by ectopic impulse discharge (ectopia) generated in injured peripheral afferent neurons. Observations in the spinal nerve ligation (SNL) model in rats suggest that cell bodies in the dorsal root ganglion (DRG) contribute three times more to the ectopic barrage than the site of nerve injury (neuroma). The DRG is therefore a prime

2019 Pain

259. AMPK Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signalling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. (Abstract)

of radicular pain. AMPK is recognized as a cellular energy sensor, as well as a pain sensation modulator, but its function in LDH-induced pain hypersensitivity remains largely unknown.The LDH rat model was established by autologous nucleus pulposus transplantation into the right lumbar 5 (L5) nerve root. At different time points after AMPK agonist metformin (250 mg/kg/d) or mTOR inhibitor rapamycin (5 mg/kg) intraperitoneal administration, thermal and mechanical sensitivity were evaluated by measuring paw (...) AMPK Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signalling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. Animal experiment: a rat model of lumbar disc herniation (LDH) induced painful radiculopathies.To investigate the role and mechanism of AMP-activated protein kinase (AMPK) in dorsal root ganglia (DRG) neurons in LDH-induced painful radiculopathies.Overactivation of multiple pain signals in DRG neurons triggered by LDH is crucial to the development

2019 Spine

260. Knee Pain and Mobility Impairments: Meniscal and Articular Cartilage Lesions

Knee Pain and Mobility Impairments: Meniscal and Articular Cartilage Lesions Clinical Practice Guidelines DAVID S. LOGERSTEDT , PT , PhD • DAVID A. SCALZITTI, PT , PhD • KIM L. BENNELL, PT , PhD • RANA S. HINMAN, PT , PhD HOLLY SILVERS-GRANELLI, PT , PhD • JAY EBERT , PhD • KAREN HAMBLY, PT , PhD • JAMES L. CAREY, MD, MPH LYNN SNYDER-MACKLER, PT , ScD, FAPTA • MICHAEL J. AXE, MD • CHRISTINE M. MCDONOUGH, PT , PhD Knee Pain and Mobility Impairments: Meniscal and Articular Cartilage Lesions (...) permission. Copyright © 2018 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.Knee Pain and Mobility Impairments: Clinical Practice Guidelines Revision 2018 a2 | february 2018 | volume 48 | number 2 | journal of orthopaedic & sports physical therapy EXAMINATION – OUTCOME MEASURES: ACTIVITY LIMITATIONS/ SELF-REPORTED MEASURES 2018 Recommendation B For knee-speci?c outcomes, clinicians should use the Interna- tional Knee Documentation Committee 2000 Subjective Knee Evaluation Form

2018 The Orthopaedic Section of the American Physical Therapy Association (APTA), Inc.

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