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Pain Sensation

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221. Surface electrical stimulation to evoke referred sensation. (PubMed)

Surface electrical stimulation to evoke referred sensation. Surface electrical stimulation (SES) is being investigated as a noninvasive method to evoke natural sensations distal to electrode location. This may improve treatment for phantom limb pain as well as provide an alternative method to deliver sensory feedback. The median and/or ulnar nerves of 35 subjects were stimulated at the elbow using surface electrodes. Strength-duration curves of hand sensation were found for each subject. All (...) subjects experienced sensation in their hand, which was mostly described as a paresthesia-like sensation. The rheobase and chronaxie values were found to be lower for the median nerve than the ulnar nerve, with no significant difference between sexes. Repeated sessions with the same subject resulted in sufficient variability to suggest that recalculating the strength-duration curve for each electrode placement is necessary. Most of the recruitment curves in this study were generated with 28 to 36 data

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2015 Journal of rehabilitation research and development Controlled trial quality: uncertain

222. A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome. (PubMed)

and postprandial), bowel pattern, abdominal pain (average and worst severity) and bloating scores, IBS quality of life and safety profile.Rectal sensation ratings post-treatment were significantly associated with baseline (pre-treatment) ratings and with level of anxiety or stress recorded at the time of the sensation testing. There were no effects of TU-100 treatment on rectal sensation ratings, sensation thresholds, rectal fasting or postprandial tone, rectal compliance, bowel function, abdominal pain (...) A Pilot Study of the Effect of Daikenchuto on Rectal Sensation in Patients with Irritable Bowel Syndrome. Daikenchuto (TU 100), a botanical agent that modulates gastrointestinal nerves, is used in the treatment of motility and functional disorders. Our aim was to study the effects of TU-100 on rectal compliance and sensation in patients with irritable bowel syndrome (IBS).In 20 patients per treatment arm, we conducted a single-center, randomized, parallel-group, double-blind, placebo-controlled

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2015 Journal of neurogastroenterology and motility Controlled trial quality: uncertain

223. Neck pain - whiplash injury

, regardless of pain, do not require cervical spine radiography. Suspect a serious neck injury if the person cannot laterally rotate the neck more than 45 degrees. Assess disability using the Neck Disability Index (NDI). Evaluate for evidence of neurological involvement (for example, decrease in sensation, or strength, or abnormal reflexes). For more information, see the section on in the CKS topic on . Consider examining for Kernig's sign (painful/resisted extension of leg bent at hip and knee (...) of objective physical signs. II — neck pain and associated symptoms in the presence of objective physical signs and without evidence of neurological involvement. III — neck pain and associated symptoms with evidence of neurological involvement including decreased or absent reflexes, decreased or limited sensation, or muscular weakness. IV — neck pain and associated symptoms with evidence of fracture or dislocation. [ ] Basis for recommendation Basis for recommendation These recommendations are based

2018 NICE Clinical Knowledge Summaries

224. Neck pain - acute torticollis

of cancer — in these people, aetiology of pain should be assumed to be cancer, until it is excluded. Presence of fever — in these people, neck pain should be assumed to be secondary to an infection until proven otherwise. Assess the appearance of the neck and the range of motion. Palpate the neck for tenderness. Evaluate for evidence of neurological involvement (for example, decrease in sensation, or strength, or abnormal reflexes). Inspect the skin — for example, for papulovesicular rash in a prodromal (...) Neck pain - acute torticollis Neck pain - acute torticollis - NICE CKS Share Neck pain - acute torticollis: Summary Torticollis, or wry neck, is a painful neck. Acute torticollis (less than six weeks duration) is thought to be due to minor local musculoskeletal irritation causing pain and spasm in neck muscles. The cause of torticollis is often not known, but it may be due to issues with posture — for example, poor positioning at a computer screen, inappropriate seating, sleeping without

2018 NICE Clinical Knowledge Summaries

225. Neck pain - cervical radiculopathy

and disease is very difficult to define [ ]. Signs and symptoms What are the signs and symptoms of cervical radiculopathy? Symptoms of cervical radiculopathy include: Pain in the neck, shoulder and/or arm that approximates to that of a dermatome. It is usually unilateral, but may be bilateral. The pain may be severe enough to wake the person at night. Sensory symptoms, such as absent or altered sensation (for example, shooting pains, numbness, and hyperaesthesia). Sensory symptoms are more common than (...) persistent or debilitating pain combined with loss of power or sensation [ ]. Prescribing information Prescribing information For prescribing information on nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol, and codeine, see the CKS topics on and . For further information on prescribing amitriptyline, pregabalin and gabapentin, see the CKS topic on . Supporting evidence Supporting evidence This CKS topic is largely based on the British Medical Journal (BMJ) best practice guide Assessment of neck

2018 NICE Clinical Knowledge Summaries

226. Back pain - low (without radiculopathy)

or swelling of the back. Perform a neurological examination looking for loss of sensation, changes to reflexes, limitation of range of movement including straight leg raising, tenderness, fever and loss of anal tone. Assess for the presence of that may suggest a serious underlying cause, such as: Cauda equina syndrome. Cancer of the spine. Spinal fracture due to trauma or osteoporotic collapse. Spinal infection. Be aware that low back pain can be caused by intra-abdominal p athol ogy, including (...) Back pain - low (without radiculopathy) Back pain - low (without radiculopathy) - NICE CKS Share Back pain - low (without radiculopathy): Summary Low back pain affects the lumbosacral area of the back, between the bottom of the ribs and the top of the legs. It affects around one third of the adult population each month. In most people, low back pain is non-specific and serious specific causes are rare. Complications include: Development of chronicity and depression. Disability and loss

2018 NICE Clinical Knowledge Summaries

227. Neck pain - non-specific

. Assess the appearance of the neck and the range of motion. Palpate the neck for tenderness. Inspect the skin — for example, for papulovesicular rash, petechiae or purpura. Evaluate for evidence of neurological involvement (for example, decrease in sensation, or strength, or abnormal reflexes). A combination of tests can be used to help identify cervical radiculopathy, including the Spurling test. For more information, see the CKS topic on . Consider examining for Kernig's sign (painful/resisted (...) , into the shoulder, or across the scapulae. Pain associated with paraesthesia or hyperaesthesia, but with no objective loss of sensation or muscle strength. Positional asymmetry, limited range of movements often asymmetrically. Tenderness in intervertebral joints and/or hypertonic muscles that may be palpable as nodules or tender bands. Red flags What signs and symptoms may indicate a more serious pathology? Signs and symptoms that may indicate a more serious pathology (for example, spinal cord compression

2018 NICE Clinical Knowledge Summaries

228. Percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica

0.2% to 1.4%). Adverse events included: A burning sensation in the leg of 1 patient; this resolved. Paraesthesia and numbness in the thighs of 2 patients; both resolved. Foot drop in 1 patient; this resolved. Increasing lower leg pain in 1 patient; the patient was subsequently lost to follow-up. Increasing back and thigh pain in 1 patient; this was treated by spinal fusion. Percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica (IPG544) © NICE 2018 (...) Percutaneous electrothermal treatment of the intervertebral disc annulus for low back pain and sciatica P Percutaneous electrothermal treatment of the ercutaneous electrothermal treatment of the interv intervertebr ertebral disc annulus for low back pain and al disc annulus for low back pain and sciatica sciatica Interventional procedures guidance Published: 27 January 2016 nice.org.uk/guidance/ipg544 Y Y our responsibility our responsibility This guidance represents the view of NICE, arrived

2016 National Institute for Health and Clinical Excellence - Interventional Procedures

229. Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid

Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved (...) studies (100). Please remove one or more studies before adding more. Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01449487 Recruitment Status : Completed First Posted : October 10, 2011

2011 Clinical Trials

230. Therapeutic mechanisms of a mindfulness-based treatment for IBS: Effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations (PubMed)

Therapeutic mechanisms of a mindfulness-based treatment for IBS: Effects on visceral sensitivity, catastrophizing, and affective processing of pain sensations Irritable bowel syndrome (IBS) is a prevalent functional disorder characterized by abdominal pain and hypervigilance to gastrointestinal sensations. We hypothesized that mindfulness training (MT), which promotes nonreactive awareness of emotional and sensory experience, may target underlying mechanisms of IBS including affective pain (...) processing and catastrophic appraisals of gastrointestinal sensations. Seventy five female IBS patients were randomly assigned to participate in either 8 weeks of MT or a social support group. A theoretically grounded, multivariate path model tested therapeutic mediators of the effect of MT on IBS severity and quality of life. Results suggest that MT exerts significant therapeutic effects on IBS symptoms by promoting nonreactivity to gut-focused anxiety and catastrophic appraisals of the significance

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2011 Journal of behavioral medicine Controlled trial quality: uncertain

231. Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome. (PubMed)

Visceral sensation and irritable bowel syndrome; with special reference to comparison with functional abdominal pain syndrome. Stress-induced visceral hypersensitivity may play an important role in the pathogenesis of irritable bowel syndrome (IBS) but not in functional abdominal pain syndrome (FAPS). We examined rectal sensation in those patients.Experiment 1: Rectal thresholds of pain (PT) and maximum tolerance were assessed by barostat with ramp distention before and after repetitive rectal (...) painful distention (RRD). Experiment 2, PT was measured in basal state and after intravenous CRF (100 µg) or vehicle, together with or without RRD. Experiment 3: Three phasic distentions at physiological range were randomly loaded. The subjects were asked to mark the visual analogue scale (VAS) in reference to subjective intensity of sensation.Experiment 1: Majority of IBS patients showed rectal hypersensitivity before RRD in contrast to FAPS. All IBS patients developed hypersensitivity after RRD

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2011 Journal of gastroenterology and hepatology Controlled trial quality: uncertain

232. Poor functional outcomes in pediatric chronic pain – what’s catastrophizing got to do with it?

will be paid for their time. It’s impossible to slip your disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic pain How do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS researcher Janet Bultitude find out by responding to her . The survey is aimed at people with CRPS, people with chronic pain conditions other than CRPS (...) Poor functional outcomes in pediatric chronic pain – what’s catastrophizing got to do with it? Poor functional outcomes in pediatric chronic pain Research into the role of the brain and mind in chronic pain Poor functional outcomes in pediatric chronic pain – what’s catastrophizing got to do with it? January 31, 2019 by Catastrophizing has long been implicated in many poor outcomes in chronic pain-related conditions in both adults and children [3,4,11,12,14,15,18,20,22,24,29]. Scholars have

2019 Body in Mind blog

233. Adaptation of an Ultrasound-Guided Technique for Pulsed Radiofrequency on Axillary and Suprascapular Nerves in the Treatment of Shoulder Pain. (PubMed)

Adaptation of an Ultrasound-Guided Technique for Pulsed Radiofrequency on Axillary and Suprascapular Nerves in the Treatment of Shoulder Pain. It has been estimated that 20% of the general population will suffer shoulder pain throughout their lives, with a prevalence that can reach up to 50%. The suprascapular nerve (SSN) provides sensation for the posterior and superior regions of the glenohumeral joint, whereas the anterior and inferior zones and the skin are innervated mostly by the axillary (...) nerve. Pulsed radiofrequency on the SSN has been proposed as a therapeutic option in chronic shoulder pain. Axillary nerve block has been proposed in the context of surgical analgesia as an adjuvant to SSN block.Ultrasound (US)-guided techniques target the nerve selectively, minimizing patients' and physicians' exposure to harmful radiation while increasing success rates by better needle placement. We perform both US-guided techniques with the patient in a lateral decubitus position

2019 Pain Medicine

234. Extending scope of practice – physiotherapists’ perceptions of managing non-specific low back pain

of young people with CRPS to complete a 20-25 online survey which asks them to think about their future. Study recruitment is being conducted separately for both young people and parents. Please email if you would like to take part. Participants will be paid for their time. It’s impossible to slip your disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic pain How (...) do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS researcher Janet Bultitude find out by responding to her . The survey is aimed at people with CRPS, people with chronic pain conditions other than CRPS, and people without any chronic pain condition. The survey takes approximately 20 minutes and the responses are anonymous. Prof Paul Hodges on pain and altered movement Am I safe to move? Listen to Lorimer Moseley talk to Karim Khan on new

2019 Body in Mind blog

235. Do kids once in chronic pain break free?

disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic pain How do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS researcher Janet Bultitude find out by responding to her . The survey is aimed at people with CRPS, people with chronic pain conditions other than CRPS, and people without any chronic pain condition (...) Do kids once in chronic pain break free? Do kids once in chronic pain break free? • Body in Mind Research into the role of the brain and mind in chronic pain Do kids once in chronic pain break free? January 18, 2019 by After the long and winding road towards diagnosis, many children with chronic pain conditions improve with standard outpatient therapy approaches such as a combination of physical and cognitive behavioral therapies with or without medications. However a subset of children

2019 Body in Mind blog

236. Vision and pain – evidence of safety or evidence of danger?

and parents of young people with CRPS to complete a 20-25 online survey which asks them to think about their future. Study recruitment is being conducted separately for both young people and parents. Please email if you would like to take part. Participants will be paid for their time. It’s impossible to slip your disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic (...) pain How do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS researcher Janet Bultitude find out by responding to her . The survey is aimed at people with CRPS, people with chronic pain conditions other than CRPS, and people without any chronic pain condition. The survey takes approximately 20 minutes and the responses are anonymous. Prof Paul Hodges on pain and altered movement Am I safe to move? Listen to Lorimer Moseley talk to Karim Khan on new

2019 Body in Mind blog

237. The clinical features of painful small-fibre neuropathy suggesting an origin linked to a primary Sjögren's syndrome. (PubMed)

with idio-SFN had more frequent severe burning sensations and higher mean anxiety scores and daily pain intensity compared to patients with pSSSFN. Conversely, patients with pSS-SFN had reduced electrochemical skin conductance measured by Sudoscan_, and almost half of them had the sensation of walking on cotton wool.Our results suggest that idio-SFN more specifically involved small sensory fibers than pSS-SFN, in which subtle dysfunction of larger sensory fibers and damage of distal autonomic sudomotor (...) The clinical features of painful small-fibre neuropathy suggesting an origin linked to a primary Sjögren's syndrome. We attempted to determine whether clinical features could differentiate painful small-fiber neuropathy related to primary Sj€ogren's syndrome (pSS-SFN) from idiopathic SFN (idio-SFN).Validated clinical questionnaires and neurophysiological investigations specific for pain and SFN assessment were performed in 25 patients with pSS-SFN and 25 patients with idio-SFN.Patients

2019 Pain Practice

238. Can video games help older people with back pain?

if you would like to take part. Participants will be paid for their time. It’s impossible to slip your disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic pain How do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS researcher Janet Bultitude find out by responding to her . The survey is aimed at people with CRPS (...) Can video games help older people with back pain? Can video games help older people with back pain? • Body in Mind Research into the role of the brain and mind in chronic pain Can video games help older people with back pain? January 11, 2019 by Low back pain is the leading cause of disability worldwide [1] and up to 90% of people will experience low back pain at some point in their life [2]. The small percentage of people who develop chronic and disabling symptoms account for most

2019 Body in Mind blog

239. AMPK Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signalling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. (PubMed)

of radicular pain. AMPK is recognized as a cellular energy sensor, as well as a pain sensation modulator, but its function in LDH-induced pain hypersensitivity remains largely unknown.The LDH rat model was established by autologous nucleus pulposus transplantation into the right lumbar 5 (L5) nerve root. At different time points after AMPK agonist metformin (250 mg/kg/d) or mTOR inhibitor rapamycin (5 mg/kg) intraperitoneal administration, thermal and mechanical sensitivity were evaluated by measuring paw (...) AMPK Activation in Dorsal Root Ganglion Suppresses mTOR/p70S6K Signalling and Alleviates Painful Radiculopathies in Lumbar Disc Herniation Rat Model. Animal experiment: a rat model of lumbar disc herniation (LDH) induced painful radiculopathies.To investigate the role and mechanism of AMP-activated protein kinase (AMPK) in dorsal root ganglia (DRG) neurons in LDH-induced painful radiculopathies.Overactivation of multiple pain signals in DRG neurons triggered by LDH is crucial to the development

2019 Spine

240. What does high value care for musculoskeletal pain look like?

. Study recruitment is being conducted separately for both young people and parents. Please email if you would like to take part. Participants will be paid for their time. It’s impossible to slip your disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic pain How do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS (...) What does high value care for musculoskeletal pain look like? What does high value care for musculoskeletal pain look like? • Research into the role of the brain and mind in chronic pain What does high value care for musculoskeletal pain look like? March 14, 2019 by A middle aged patient with slow onset shoulder pain was concerned about the results of a left shoulder ultrasound that showed a partial tear in her rotator cuff. Since the result she had taken to wearing a sling to protect

2019 Body in Mind blog

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