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Pain Sensation

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221. Persistent Pain with Breastfeeding

for vasospasm of the nipple. Allodynia/functional pain Allodynia is de?ned as sensation of pain in response to a stimulus,suchaslighttouch,whichwouldnotnormallyelicit pain.Breastallodyniacanoccurinisolationorinthecontext of other pain disorders, such as irritable bowel syndrome, ?bromyalgia, interstitial cystitis, migraines, temporoman- dibular joint disorders (TMJ), and pain with intercourse. Taking a careful history to assess for other pain disorders is important for informing treatment (...) Persistent Pain with Breastfeeding ABM Protocol ABM Clinical Protocol #26: Persistent Pain with Breastfeeding Pamela Berens, 1 Anne Eglash, 2 Michele Malloy, 2 Alison M. Steube, 3,4 and the Academy of Breastfeeding Medicine A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for man- aging common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do

2016 Academy of Breastfeeding Medicine

222. Chronic Pelvic Pain

and muscle hyperalgesia is common, as is involvement of other visceral organs. Hyperalgesia tends to be localised. Innervation Low density, unmyelinated C fibres and thinly myelinated A? fibres. Dense innervation with a wide range of nerve fibres. Primary afferent physiology Intensity coding. As stimulation increases, afferent firing increases with an increase in sensation and ultimately pain. Two fibre coding. Separate fibres for pain and normal sensation. Silent afferents 50-90% of visceral afferents (...) are silent until the time they are switched on. These fibres are very important in the central sensitisation process. Silent afferents present, but form a lower percentage.CHRONIC PELVIC PAIN - UPDATE APRIL 2014 9 Central mechanisms Play an important part in the hyperalgesia, viscero-visceral, visceromuscular and musculo- visceral hyperalgesia. Sensations not normally perceived become perceived and non-noxious sensations become painful. Responsible for the allodynia and hyperalgesia of chronic somatic

2015 European Association of Urology

223. Acute Pain Management: Scientific Evidence

Acute Pain Management: Scientific Evidence ACUTE PAIN MANAGEMENT: SCIENTIFIC EVIDENCE Fourth Edition 2015 Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine Edited by: Stephan A Schug Greta M Palmer David A Scott Richard Halliwell Jane T rinca© Australian and New Zealand College of Anaesthetists 2015 ISBN Print: 978-0-9873236-7-5 Online: 978-0-9873236-6-8 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced (...) and Faculty of Pain Medicine (2015), Acute Pain Management: Scientific Evidence (4th edition), ANZCA & FPM, Melbourne. Copyright information for Tables 10.1 and 10.2 The material presented in Table 10.1 and Table 10.2 of this document has been reproduced with permission from Prescribing Medicines in Pregnancy, 2015, Therapeutic Goods Administration. It does not purport to be the official or authorised version. © Commonwealth of Australia 2015 This work is copyright. You may download, display, print

2015 Clinical Practice Guidelines Portal

224. Nerve blocks for initial pain management of femoral fractures in children. (Full text)

to stretcher/imaging/operating-suite table or hospital bed within the first few hours, so prompt pain relief is essential. Systemic analgesia can be provided orally or parenterally. Alternatively, a nerve block may be used where local anaesthetic is injected around a nerve to block sensation or freeze the involved area.To assess the effects (benefits and harms) of femoral nerve block (FNB) or fascia iliaca compartment block (FICB) for initial pain management of children with fractures of the femur (thigh (...) Nerve blocks for initial pain management of femoral fractures in children. Children and adolescents with femoral fractures are almost always admitted to hospital. They invariably start their hospital experience in the Emergency Department, often requiring transfer to a specialist children's hospital. They require analgesia or anaesthesia so that radiographs can be obtained and for management of their fractures. The initial care process involves from two to six transfers from stretcher

2013 Cochrane PubMed abstract

225. Use of Topical Tetracycline-Class Antibiotics Can Reduce Pain and Formation of New Ulcers and Increase Speed of Recovery in Patients with Recurrent Aphthous Stomatitis

Use of Topical Tetracycline-Class Antibiotics Can Reduce Pain and Formation of New Ulcers and Increase Speed of Recovery in Patients with Recurrent Aphthous Stomatitis UTCAT2830, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Use of Topical Tetracycline-Class Antibiotics Can Reduce Pain and Formation of New Ulcers and Increase Speed of Recovery in Patients with Recurrent Aphthous Stomatitis Clinical Question (...) In an adult patient with recurrent aphthous stomatitis, does use of tetracycline-class drugs significantly reduce pain and increase speed of recovery when compared to placebo? Clinical Bottom Line For patients with recurrent aphthous stomatitis, treatment with tetracycline is more effective than placebo in reducing pain and increasing speed of recovery. This is supported by three randomized controlled trials in which various doxycycline formulations showed significantly better healing, pain reduction

2015 UTHSCSA Dental School CAT Library

226. Management of chronic pain

Management of chronic pain SIGN 136 • Management of chronic pain A national clinical guideline December 2013 Evidence Help us to improve SIGN guidelines - click here to complete our survey KEY TO EVIDENCE STATEMENTS AND GRADES OF RECOMMENDATIONS LEVELS OF EVIDENCE 1 ++ High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 - Meta-analyses, systematic reviews, or RCTs (...) in the web version of this document, which is the definitive version at all times. This version can be found on our web site www.sign.ac.uk. This document is produced from elemental chlorine-free material and is sourced from sustainable forests.Scottish Intercollegiate Guidelines Network Management of chronic pain A national clinical guideline December 2013Scottish Intercollegiate Guidelines Network Gyle Square, 1 South Gyle Crescent Edinburgh EH12 9EB www.sign.ac.uk First published December 2013 ISBN

2013 SIGN

227. Acute Pain Medicine in the United States: A Status Report (Full text)

The insight that the experience of pain is not simply a sensation but an experience more akin to hunger or nausea was a seminal event that inaugurated modern pain research . Unraveling this observation gave rise to the research discipline of psychophysics research and coincided with, in Beecher's words, “a common tide of interest at that time in the pain problem .” Similarly, the current upsurge of professional and regulatory interest in pain control can be seen as an offshoot of broader societal trends (...) Acute Pain Medicine in the United States: A Status Report Acute Pain Medicine in the United States: A Status Report | Pain Medicine | Oxford Academic ') We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article

2015 American Academy of Pain Medicine PubMed abstract

228. Pharmacological Management of Cancer Pain in Adults

Pharmacological Management of Cancer Pain in Adults Pharmacological Management of Cancer Pain in Adults National Clinical Guideline No. 9 November 2015Guideline Development Group The Pharmacological Management of Cancer Pain in Adults Guideline was developed by a subgroup of the Health Service Executive (HSE)/Royal College of Physicians (RCPI) National Clinical Programme for Palliative Care. The Core Guideline Development Group was supported by a group of senior multidisciplinary service leads (...) assembled by the National Clinical Programme for Palliative Care who evaluated the quality of the development process and documentation at key timepoints. This group was called the Guideline Steering Group. Using this National Clinical Guideline This guideline applies to healthcare professionals involved in the management of cancer pain. This includes Palliative Care staff, Physicians, Surgeons, General Practitioners, Pharmacists and Nursing staff in hospital, hospice and community-based settings

2015 National Clinical Guidelines (Ireland)

229. A randomized comparative study assessing efficacy of pain versus comfort scores. (Full text)

was associated with injury or healing.Data were analyzed using Student's t-test and nonparametric Mann-Whitney U-test, performed at a significance level of α =0.05.In Group P, 62 women (68.9%) reported pain compared with only 49 women (54.4%) in Group C (P < 0.05). There were no significant differences between groups for VNRS at rest and on movement. In Group P, thirty women (33.33%) reported sensations as injury compared with only 11 women (12.22%) in Group C (P < 0.001).Assessment of pain using positive (...) A randomized comparative study assessing efficacy of pain versus comfort scores. Use of language with negative emotional content is likely to increase patient's pain and anxiety.We designed a single-blinded randomized study to compare pain scores with comfort scores and to determine whether the technique of pain assessment affects patient's perceptions and experience.After cesarean section, 180 women were randomized before postanaesthesia interview into two groups. Group P women were asked

2019 Saudi journal of anaesthesia Controlled trial quality: uncertain PubMed abstract

230. The effect of a single irradiation of low-level laser on nipple pain in breastfeeding women: a randomized controlled trial. (Abstract)

in the laser group (11/36) reported secondary effects, such as tingling (10/36) and pricking (2/36). The laser protocol of a single application was not effective in reducing pain in women with damaged nipples. Tingling sensation may be experienced by women receiving laser treatment for nipple damage. (...) The effect of a single irradiation of low-level laser on nipple pain in breastfeeding women: a randomized controlled trial. Photobiomodulation with low-level laser therapy (PBM-LLLT) has been introduced as a new tool to relieve nipple pain and repair nipple damage in breastfeeding women; however, evidence is needed to assess its effectiveness. The aim was to evaluate the effect of a single application of PBM-LLLT for breastfeeding women with nipple pain and damage; side effects were also

2019 Lasers in medical science Controlled trial quality: predicted high

231. Comparative Study between Preemptive and Postoperative Intra-Articular Injection of Levobupivacaine and Tramadol for Control of Postoperative Pain. (Full text)

received IAI of 20 mL (0.5%) levobupivacaine preoperative, meanwhile patients in Group PE received IAI of 18 mL (0.5%) levobupivacaine with 100 mg tramadol (2 mL). Patients in Group PO received IAI of 18 mL (0.5%) levobupivacaine with 100 mg tramadol (2 mL) postoperatively, whereas patients in Group PE/PO received IAI of 19 mL (0.25%) levobupivacaine with 50 mg tramadol (1 mL) preoperatively and postoperatively. Numeric rating scale (NRS) had been used to assess pain sensation. Duration till the first (...) Comparative Study between Preemptive and Postoperative Intra-Articular Injection of Levobupivacaine and Tramadol for Control of Postoperative Pain. This study had been formulated to evaluate and compare the analgesic effect of preemptive (PE), postoperative (PO), and combined knee intra-articular injection (IAI) of levobupivacaine and tramadol after knee arthroscopy.A total of 220 patients assigned for therapeutic knee arthroscopy were divided into four equal groups. Patients in Group C

2019 Anesthesia, essays and researches Controlled trial quality: uncertain PubMed abstract

232. A Randomized Controlled Trial to Assess the Effectiveness of Muscle Strengthening and Balancing Exercises on Chemotherapy-Induced Peripheral Neuropathic Pain and Quality of Life Among Cancer Patients. (Abstract)

A Randomized Controlled Trial to Assess the Effectiveness of Muscle Strengthening and Balancing Exercises on Chemotherapy-Induced Peripheral Neuropathic Pain and Quality of Life Among Cancer Patients. Chemotherapy-induced peripheral neuropathy (CIPN) is the presence of tingling, burning, itching, and unpleasant sensations in hands and feet due to nerve damage by chemotherapy. Exercise rehabilitation has potential to prevent or alleviate CIPN.The aim of this study was to assess the effectiveness (...) of muscle strengthening and balancing exercises on CIPN pain and quality of life (QOL) among cancer patients.The randomized controlled trial included 45 cancer patients from a tertiary care hospital in India receiving chemotherapeutic drugs paclitaxel and carboplatin and found to have CIPN. Subjects were randomly allocated to exercise (n1 = 22) and usual care (n2 = 23) groups. The exercise group received home-based muscle strengthening and balancing exercise for 10 weeks. Data regarding demographic

2019 Cancer nursing Controlled trial quality: uncertain

233. Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine. (Abstract)

interventional target for pain control. Since DRG ectopia is selectively suppressed with lidocaine at concentrations too low to block axonal impulse propagation, we asked whether targeted delivery of dilute lidocaine to the L5 DRG can relieve L5 SNL-induced tactile allodynia without blocking normal sensation or motor function. Results showed that intraforaminal injection of 10 µL bolus doses of 0.2% lidocaine suppressed allodynia transiently, while sustained infusion over 2 weeks using osmotic minipumps (...) Suppression of neuropathic pain by selective silencing of DRG ectopia using non-blocking concentrations of lidocaine. Neuropathic pain is frequently driven by ectopic impulse discharge (ectopia) generated in injured peripheral afferent neurons. Observations in the spinal nerve ligation (SNL) model in rats suggest that cell bodies in the dorsal root ganglion (DRG) contribute three times more to the ectopic barrage than the site of nerve injury (neuroma). The DRG is therefore a prime

2019 Pain

234. Pelvic floor myofascial pain severity and pelvic floor disorder symptom bother: is there a correlation? (Abstract)

. Severity of myofascial pain at several individual pelvic floor sites was also independently correlated with lower urinary tract symptoms, including pain in the lower abdomen (myofascial pain at all sites) and difficulty emptying the bladder (right obturator internus and left levator ani); and with defecatory dysfunction, including sensation of incomplete rectal emptying (pain at all sites combined and the right obturator internus), anal incontinence to flatus (pain at all sites combined), and pain (...) Pelvic floor myofascial pain severity and pelvic floor disorder symptom bother: is there a correlation? Pelvic floor myofascial pain, which is predominantly identified in the muscles of the levator ani and obturator internus, has been observed in women with chronic pelvic pain and other pelvic floor disorder symptoms, and is hypothesized to contribute to their symptoms.To describe the prevalence of pelvic floor myofascial pain in patients presenting with pelvic floor disorder symptoms

2019 American Journal of Obstetrics and Gynecology

235. <i>Salvia officinalis</i>, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. (Full text)

) was induced in mice, and neuropathic pain behaviors tests were evaluated by mechanical, chemical, thermal sensation tests and functional recovery of the sciatic nerve at different time intervals, i.e., (day 0, 1, 7, 14, and 21). Ethanolic extract of SO (100 and 200 mg/kg, p.o.), ROS (10 and 20 mg/kg, i.p.), CAF (30 and 40 mg/kg, i.p.), and CLOM (5 mg/kg, i.p., a positive control) was given for 21 days after surgery. Hematological and biochemical parameters were also measured as well as histopathological (...) Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. The leaves of Salvia officinalis L. have a traditional reputation for the management of pain in Morocco. This study was conducted to investigate the curative effects of Salvia officinalis (SO) and its major constituents Rosmarinic (ROS) and Caffeic acids (CAF) on peripheral neuropathic pain in mice. Chronic constriction injury (CCI

2019 Evidence-based Complementary and Alternative Medicine (eCAM) PubMed abstract

236. Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives. (Abstract)

and/or via membrane receptors of neurotransmitters that pivotally modulate pain sensation. Basic studies which uncovered a direct link between neuropathic pain symptoms and endogenous neurosteroid production/regulation, paved the way for the investigations of neurosteroid therapeutic potential against pathological pain. Concordantly, antinociceptive properties of synthetic neurosteroids were evidenced in humans and animals. Neurosteroids promote peripheral analgesia mediated by T-type calcium and gamma (...) Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives. Complex mechanisms involved in neuropathic pain that represents a major health concern make its management complicated. Because neurosteroids are bioactive steroids endogenously synthesized in the nervous system, including in pain pathways, they appear relevant to develop effective treatments against neuropathic pain. Neurosteroids act in paracrine or autocrine manner through genomic mechanisms

2019 Frontiers in Neuroendocrinology

237. Pain and Pruritus: a study of their similarities and differences. (Abstract)

subset of this general fiber. Overall, pain and pruritus share many integral similarities. Although these sensations both initiate the body's awareness to injury, pain and itch may have evolved for sensing different damages such as a burrowing parasite or a noxious stimulus, respectively. This seems to have been validated through analyses of their pathophysiology, acute and chronic conditions, and treatment modalities. However, their symptoms and intrinsic mechanisms vary considerably (...) Pain and Pruritus: a study of their similarities and differences. Pruritus is one of the most common dermatologic complaints and, as the most common dermatologic symptom, is a major contributor to frequent dermatology visits. Chronic pruritus mirrors another major medical condition faced by millions of Americans each year - chronic pain. In older literature, pain and pruritus were thought to have been conveyed by the same C fiber, and the proportion contributing to pruritus was just a small

2019 International Journal of Dermatology

238. A Human TRPA1-Specific Pain Model. (Full text)

A Human TRPA1-Specific Pain Model. The cation channel transient receptor potential ankyrin 1 (TRPA1) plays an important role in sensing potentially hazardous substances. However, TRPA1 species differences are substantial and limit translational research. TRPA1 agonists tested previously in humans also have other targets. Therefore, the sensation generated by isolated TRPA1 activation in humans is unknown. The availability of 2-chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl (...) to be involved in pain generation. The newly established TRPA1-specific pain model allows different applications. First, it can be tested whether diseases are associated with compromised or exaggerated TRPA1-dependent painful sensations in the skin. Second, it can be investigated whether a new, possibly systemically applied drug directed against TRPA1 engages its target in humans. Further, the general possibility of quantitative inhibition of TRPA1 allows identification of the TRPA1-dependent disease

2019 The Journal of neuroscience : the official journal of the Society for Neuroscience Controlled trial quality: uncertain PubMed abstract

239. Pain Neurology. (Abstract)

Pain Neurology. Pain is often the initial complaint for which patients seek medical care presenting both a diagnostic and therapeutic challenge to the primary care provider. The appreciation of pain is not merely the result of abnormal sensory stimulation causing an unpleasant sensation but rather a combination of the recognition of the somatic discomfort in association with an emotional response to that discomfort. The perception of pain and the extent of distress and disability can vary (...) depending on previous experience, cultural background, situational factors, and comorbid psychiatric disease. While acute pain is usually the result of tissue damage, that is not always the case as evidenced by the primary headache disorders. Chronic pain may be the result of an injury, irreversible underlying disease or clinical conditions such as fibromyalgia for which the mechanism remains unclear. Treatment of the underlying cause will usually effect a resolution or improvement in the pain but when

2019 American Journal of Medicine

240. Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain. (Abstract)

assessed pain sensation and perception subsequent to specific targeting of brain-TNF (via TNF antibody) administered through a novel subcutaneous perispinal route. Neuropathic pain was induced in Sprague-Dawley rats via chronic constriction injury (CCI), and thermal hyperalgesia was monitored for 10 days post-surgery. On day 8 following CCI and sensory pain behavior testing, rats were randomized to receive perispinal injection of TNF antibody or control IgG isotype antibody. Pain perception (...) Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain. Neuropathic pain is chronic pain that follows nerve injury, mediated in the brain by elevated levels of the inflammatory protein tumor necrosis factor-alpha (TNF). We have shown that peripheral nerve injury increases TNF in the hippocampus/pain perception region, which regulates neuropathic pain symptoms. In this study we

2019 Brain, behavior, and immunity

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