How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

9,674 results for

Pain Sensation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

221. Use of Topical Tetracycline-Class Antibiotics Can Reduce Pain and Formation of New Ulcers and Increase Speed of Recovery in Patients with Recurrent Aphthous Stomatitis

Use of Topical Tetracycline-Class Antibiotics Can Reduce Pain and Formation of New Ulcers and Increase Speed of Recovery in Patients with Recurrent Aphthous Stomatitis UTCAT2830, Found CAT view, CRITICALLY APPRAISED TOPICs University: | | ORAL HEALTH EVIDENCE-BASED PRACTICE PROGRAM View the CAT / Title Use of Topical Tetracycline-Class Antibiotics Can Reduce Pain and Formation of New Ulcers and Increase Speed of Recovery in Patients with Recurrent Aphthous Stomatitis Clinical Question (...) In an adult patient with recurrent aphthous stomatitis, does use of tetracycline-class drugs significantly reduce pain and increase speed of recovery when compared to placebo? Clinical Bottom Line For patients with recurrent aphthous stomatitis, treatment with tetracycline is more effective than placebo in reducing pain and increasing speed of recovery. This is supported by three randomized controlled trials in which various doxycycline formulations showed significantly better healing, pain reduction

2015 UTHSCSA Dental School CAT Library

222. Pharmacological Management of Cancer Pain in Adults

Pharmacological Management of Cancer Pain in Adults Pharmacological Management of Cancer Pain in Adults National Clinical Guideline No. 9 November 2015Guideline Development Group The Pharmacological Management of Cancer Pain in Adults Guideline was developed by a subgroup of the Health Service Executive (HSE)/Royal College of Physicians (RCPI) National Clinical Programme for Palliative Care. The Core Guideline Development Group was supported by a group of senior multidisciplinary service leads (...) assembled by the National Clinical Programme for Palliative Care who evaluated the quality of the development process and documentation at key timepoints. This group was called the Guideline Steering Group. Using this National Clinical Guideline This guideline applies to healthcare professionals involved in the management of cancer pain. This includes Palliative Care staff, Physicians, Surgeons, General Practitioners, Pharmacists and Nursing staff in hospital, hospice and community-based settings

2015 National Clinical Guidelines (Ireland)

223. Acute Pain Medicine in the United States: A Status Report Full Text available with Trip Pro

The insight that the experience of pain is not simply a sensation but an experience more akin to hunger or nausea was a seminal event that inaugurated modern pain research . Unraveling this observation gave rise to the research discipline of psychophysics research and coincided with, in Beecher's words, “a common tide of interest at that time in the pain problem .” Similarly, the current upsurge of professional and regulatory interest in pain control can be seen as an offshoot of broader societal trends (...) Acute Pain Medicine in the United States: A Status Report Acute Pain Medicine in the United States: A Status Report | Pain Medicine | Oxford Academic ') We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Search Account Menu Menu Navbar Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article

2015 American Academy of Pain Medicine

224. Management of chronic pain

Management of chronic pain SIGN 136 • Management of chronic pain A national clinical guideline December 2013 Evidence Help us to improve SIGN guidelines - click here to complete our survey KEY TO EVIDENCE STATEMENTS AND GRADES OF RECOMMENDATIONS LEVELS OF EVIDENCE 1 ++ High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 - Meta-analyses, systematic reviews, or RCTs (...) in the web version of this document, which is the definitive version at all times. This version can be found on our web site www.sign.ac.uk. This document is produced from elemental chlorine-free material and is sourced from sustainable forests.Scottish Intercollegiate Guidelines Network Management of chronic pain A national clinical guideline December 2013Scottish Intercollegiate Guidelines Network Gyle Square, 1 South Gyle Crescent Edinburgh EH12 9EB www.sign.ac.uk First published December 2013 ISBN

2013 SIGN

225. Chronic Pelvic Pain

and muscle hyperalgesia is common, as is involvement of other visceral organs. Hyperalgesia tends to be localised. Innervation Low density, unmyelinated C fibres and thinly myelinated A? fibres. Dense innervation with a wide range of nerve fibres. Primary afferent physiology Intensity coding. As stimulation increases, afferent firing increases with an increase in sensation and ultimately pain. Two fibre coding. Separate fibres for pain and normal sensation. Silent afferents 50-90% of visceral afferents (...) are silent until the time they are switched on. These fibres are very important in the central sensitisation process. Silent afferents present, but form a lower percentage.CHRONIC PELVIC PAIN - UPDATE APRIL 2014 9 Central mechanisms Play an important part in the hyperalgesia, viscero-visceral, visceromuscular and musculo- visceral hyperalgesia. Sensations not normally perceived become perceived and non-noxious sensations become painful. Responsible for the allodynia and hyperalgesia of chronic somatic

2015 European Association of Urology

226. Acute Pain Management: Scientific Evidence

Acute Pain Management: Scientific Evidence ACUTE PAIN MANAGEMENT: SCIENTIFIC EVIDENCE Fourth Edition 2015 Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine Edited by: Stephan A Schug Greta M Palmer David A Scott Richard Halliwell Jane T rinca© Australian and New Zealand College of Anaesthetists 2015 ISBN Print: 978-0-9873236-7-5 Online: 978-0-9873236-6-8 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced (...) and Faculty of Pain Medicine (2015), Acute Pain Management: Scientific Evidence (4th edition), ANZCA & FPM, Melbourne. Copyright information for Tables 10.1 and 10.2 The material presented in Table 10.1 and Table 10.2 of this document has been reproduced with permission from Prescribing Medicines in Pregnancy, 2015, Therapeutic Goods Administration. It does not purport to be the official or authorised version. © Commonwealth of Australia 2015 This work is copyright. You may download, display, print

2015 Clinical Practice Guidelines Portal

227. Nerve blocks for initial pain management of femoral fractures in children. (Abstract)

to stretcher/imaging/operating-suite table or hospital bed within the first few hours, so prompt pain relief is essential. Systemic analgesia can be provided orally or parenterally. Alternatively, a nerve block may be used where local anaesthetic is injected around a nerve to block sensation or freeze the involved area.To assess the effects (benefits and harms) of femoral nerve block (FNB) or fascia iliaca compartment block (FICB) for initial pain management of children with fractures of the femur (thigh (...) Nerve blocks for initial pain management of femoral fractures in children. Children and adolescents with femoral fractures are almost always admitted to hospital. They invariably start their hospital experience in the Emergency Department, often requiring transfer to a specialist children's hospital. They require analgesia or anaesthesia so that radiographs can be obtained and for management of their fractures. The initial care process involves from two to six transfers from stretcher

2013 Cochrane

228. Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives. (Abstract)

and/or via membrane receptors of neurotransmitters that pivotally modulate pain sensation. Basic studies which uncovered a direct link between neuropathic pain symptoms and endogenous neurosteroid production/regulation, paved the way for the investigations of neurosteroid therapeutic potential against pathological pain. Concordantly, antinociceptive properties of synthetic neurosteroids were evidenced in humans and animals. Neurosteroids promote peripheral analgesia mediated by T-type calcium and gamma (...) Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives. Complex mechanisms involved in neuropathic pain that represents a major health concern make its management complicated. Because neurosteroids are bioactive steroids endogenously synthesized in the nervous system, including in pain pathways, they appear relevant to develop effective treatments against neuropathic pain. Neurosteroids act in paracrine or autocrine manner through genomic mechanisms

2019 Frontiers in Neuroendocrinology

229. Endogenous cortisol and conditioned placebo effects on pain - A randomized trial. (Abstract)

between groups as an indicator of glucocorticoid modulation on the placebo learning. Results indicated a significant conditioned placebo-induced analgesia, resulting in a placebo effect of small to medium size. Cortisol levels on conditioning day significantly differed between groups and cortisol levels were similar during assessment of placebo effects. Groups did not differ in their mean reduction in pain sensation, thus the placebo effect was not affected by differences in cortisol levels during (...) Endogenous cortisol and conditioned placebo effects on pain - A randomized trial. Placebo effects can be induced by learning and conditioning processes, which in turn are influenced and modulated by glucocorticoids. Accordingly, previous research has shown that intervention-related associative learning can be modulated through exogenous as well as endogenous glucocorticoids. Thus, the aim of this study was to elucidate whether placebo effects induced by conditioning is modulated by daily

2019 Journal of psychosomatic research Controlled trial quality: uncertain

230. CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. (Abstract)

that CHS upregulates CCL2/CCR2 signaling in a subpopulation of cutaneous small diameter DRG neurons and that CCL2 can activate these neurons through neuronal CCR2 to elicit itch- and pain-behavior. Targeting the CCL2/CCR2 signaling might be beneficial for the treatment of the itch and pain sensations accompanying ACD in humans.Copyright © 2019 Elsevier Inc. All rights reserved. (...) CCL2/CCR2 signaling elicits itch- and pain-like behavior in a murine model of allergic contact dermatitis. Spontaneous itch and pain are the most common symptoms in various skin diseases, including allergic contact dermatitis (ACD). The chemokine (C-C motif) ligand 2 (CCL2, also referred to as monocyte chemoattractant protein 1 (MCP-1)) and its receptor CCR2 are involved in the pathophysiology of ACD, but little is known of the role of CCL2/CCR2 for the itch- and pain-behaviors accompanying

2019 Brain, behavior, and immunity

231. Administration of ONO-2506 suppresses neuropathic pain after spinal cord injury by inhibition of astrocytic activation. (Abstract)

Administration of ONO-2506 suppresses neuropathic pain after spinal cord injury by inhibition of astrocytic activation. Spinal cord injury (SCI) results in not only motor dysfunction but also chronic neuropathic pain. Allodynia, an abnormal sensation that evokes pain against non-noxious stimuli, is a major symptom of post-SCI neuropathic pain. Astrocytic activation is a cause of post-SCI neuropathic pain and is considered a key treatment target. However, no effective treatment (...) . The histologic assessments at the injured site demonstrated a significant reduction in the cross-sectional area of the cysts and a high fluorescence intensity area of S100B and GFAP in the ONO-2506 group. By correlation analysis, a high absolute value of the correlation coefficient was confirmed between the intensity of S100B expression at the injured site and the allodynia severity.Administration of ONO-2506 attenuated post-SCI neuropathic pain in a rat model of incomplete SCI. Histologic results support

2019 The Spine Journal

232. Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis: an event-related fmri study. Full Text available with Trip Pro

with subjectively calibrated painful pressures corresponding to a pain sensation of 50 mm on a 100 mm VAS scale (P50) at disease-affected finger joint and thumbnail (left hand), and corresponding sites in HC.Compared to controls, RA patients had significantly increased pain sensitivity (lower P50) at the inflamed joints but not at the thumbnail. RA patients exhibited significantly less activation in regions related to pain- and somatosensory processing (S1, M1, anterior insula, S2, SMG and MCC) during painful (...) Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis: an event-related fmri study. To our knowledge, this is the first study assessing brain activation in response to painful stimulation over disease-relevant (finger joint) vs. neutral area (thumb nail) in patients suffering from rheumatoid arthritis (RA) compared to healthy controls (HC).Thirty-one RA patients and 23 HC underwent functional magnetic resonance imaging (fMRI) while stimulated

2019 Brain, behavior, and immunity

233. A Virtual Reality Intervention for the Treatment of Phantom Limb Pain: Development and Feasibility Results. Full Text available with Trip Pro

A Virtual Reality Intervention for the Treatment of Phantom Limb Pain: Development and Feasibility Results. To describe the development of a virtual reality (VR) treatment for phantom limb pain (PLP) and phantom sensations and provide feasibility data from testing the treatment in a population of veterans.Fourteen participants completed a baseline visit evaluating their amputation, PLP, and phantom sensations. Subsequently, participants completed a VR treatment modeled after mirror therapy (...) sensations and high user ratings.This feasibility study of a novel VR intervention for PLP was practical and was associated with significant reductions in PLP intensity and phantom sensations. Our findings support continued research in VR-based treatments in PLP, with a need for direct comparisons between VR and more established PLP treatments.2019 American Academy of Pain Medicine. This work is written by US Government employees and is in the public domain in the US.

2019 Pain Medicine

234. Neuropathic-Like Pain Symptoms in a Community-Dwelling Sample with or at Risk for Knee Osteoarthritis. (Abstract)

for disability and lower extremity function. The neuropathic-like pain group also reported greater overall heat pain ratings during the heat pain threshold and increased temporal summation of heat pain in the fully adjusted model. Additionally, those with neuropathic-like pain symptoms reported greater painful after-sensations following heat pain temporal summation in all analyses. No significant group differences in pressure pain threshold emerged at any of the testing sites. In contrast, temporal summation (...) Neuropathic-Like Pain Symptoms in a Community-Dwelling Sample with or at Risk for Knee Osteoarthritis. To characterize neuropathic-like pain among individuals with or at risk for knee osteoarthritis.One hundred eighty-four individuals who self-identified as non-Hispanic black or non-Hispanic white and presented with unilateral or bilateral knee pain.Neuropathic-like pain was assessed using the painDETECT, and those with high vs low neuropathic-like pain were compared on clinical pain

2019 Pain Medicine

235. There might be a distinctive clinical phenotype of constipation with non-cardiac chest pain which responds to combination laxatives: A retrospective, longitudinal symptom analysis. Full Text available with Trip Pro

There might be a distinctive clinical phenotype of constipation with non-cardiac chest pain which responds to combination laxatives: A retrospective, longitudinal symptom analysis. Proton pump inhibitor (PPI)-refractory non-cardiac chest pain (NCCP) is often resolved when constipation was relieved. This study aimed to investigate the clinical features of patients with both NCCP and constipated functional bowel disorders (FBD).Among 692 consecutive patients diagnosed with functional constipation (...) or irritable bowel syndrome with constipation and underwent anorectal manometry (ARM) in our hospital, PPI-refractory NCCP was present in 37. The clinical course of various torso symptoms including NCCP and ARM findings were retrospectively evaluated.The mean age was lower in the NCCP than in the non-NCCP group (57.4 vs 61.3 years, respectively, P = .042). Back pain (16.2% vs 2.0%, P < .001) and sharp abdominal pain (13.5% vs 0.9%, P < .001) were more common in the NCCP group. Increased resting pressure

2019 Medicine

236. Assessment of experimental orofacial pain, pleasantness and unpleasantness via standardised psychophysical testing. (Abstract)

experience. Therefore, the primary aim was to apply standardised QST stimuli as well as standardised pleasant stimuli and evaluate their potential capacity for evocation of perceived pain, pleasant and unpleasant sensations in the facial region.Twenty-one female participants underwent QST as per the protocol derived from the German Research Network on Neuropathic Pain. For the first time, two modified protocols were used to investigate stimuli for perceived pleasantness and unpleasantness.Thermal stimuli (...) provided separate thresholds for each sensation. From certain mechanical stimuli (e.g. vibration), overlap between the perceived sensations of pleasantness and unpleasantness were identified. It was not possible to evoke only an unpleasant sensation without a painful contribution, and both these sensations increased significantly when utilising an increasing pinprick force (p < 0.011). Between dynamic stimuli, the brush was rated as significantly more pleasant than the cotton wool tip (p = 0.015

2019 European Journal of Pain

237. Aqueous and methanol extracts of Paullinia pinnata L. (Sapindaceae) improve inflammation, pain and histological features in CFA-induced mono-arthritis: Evidence from in vivo and in vitro studies. (Abstract)

significantly reduced by 20-98% (p < 0.001) the inflammation and pain sensation in both the ankle and paw. AEPP significantly increased glutathione levels (p < 0.05) in serum. Both extracts reduced MDA production in serum and spinal cord (p < 0.001), and significantly improved tissue reorganization in treated arthritic rats. P. pinnata extracts did not affect NO production in non-stimulated macrophages but significantly reduced it by 47-88% in stimulated macrophages. AEPP and MEPP also significantly (...) Aqueous and methanol extracts of Paullinia pinnata L. (Sapindaceae) improve inflammation, pain and histological features in CFA-induced mono-arthritis: Evidence from in vivo and in vitro studies. Paullinia pinnata L. (Sapindaceae) is an African woody vine, traditionally used for the treatment of itch and pain-related conditions such as rheumatoid arthritis.This work evaluates, in vitro and in vivo, the anti-inflammatory and analgesic effects of aqueous (AEPP) and methanol (MEPP) extracts from

2019 Journal of Ethnopharmacology

238. A QST-based Pain Phenotype in Adults with Sickle Cell Disease: Sensitivity and Specificity of Quality Descriptors. (Abstract)

A QST-based Pain Phenotype in Adults with Sickle Cell Disease: Sensitivity and Specificity of Quality Descriptors. We sought to refine a screening measure for discriminating a sensitized or normal sensation pain phenotype among African American adults with sickle cell disease (SCD).To develop scoring schemes based on sensory pain quality descriptors; evaluate their performance on classifying patients with SCD who had sensitization or normal sensation, and compare with scores on the Self-report (...) Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) and the Neuropathic Pain Symptom Inventory (NPSI).Participants completed PAINReportIt® , quantitative sensory testing (QST), S-LANSS, and NPSI. Conventional binary logistic regression and lasso (least absolute shrinkage and selection operator) regression were used to obtain two sets of weights resulting in two scores: PR-Logistic and PR-Lasso. Performance of the proposed scores and the existing scores were evaluated.Lasso regression

2019 Pain Practice

239. Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain. (Abstract)

assessed pain sensation and perception subsequent to specific targeting of brain-TNF (via TNF antibody) administered through a novel subcutaneous perispinal route. Neuropathic pain was induced in Sprague-Dawley rats via chronic constriction injury (CCI), and thermal hyperalgesia was monitored for 10 days post-surgery. On day 8 following CCI and sensory pain behavior testing, rats were randomized to receive perispinal injection of TNF antibody or control IgG isotype antibody. Pain perception (...) Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain. Neuropathic pain is chronic pain that follows nerve injury, mediated in the brain by elevated levels of the inflammatory protein tumor necrosis factor-alpha (TNF). We have shown that peripheral nerve injury increases TNF in the hippocampus/pain perception region, which regulates neuropathic pain symptoms. In this study we

2019 Brain, behavior, and immunity

240. Comparative Study between Preemptive and Postoperative Intra-Articular Injection of Levobupivacaine and Tramadol for Control of Postoperative Pain. Full Text available with Trip Pro

received IAI of 20 mL (0.5%) levobupivacaine preoperative, meanwhile patients in Group PE received IAI of 18 mL (0.5%) levobupivacaine with 100 mg tramadol (2 mL). Patients in Group PO received IAI of 18 mL (0.5%) levobupivacaine with 100 mg tramadol (2 mL) postoperatively, whereas patients in Group PE/PO received IAI of 19 mL (0.25%) levobupivacaine with 50 mg tramadol (1 mL) preoperatively and postoperatively. Numeric rating scale (NRS) had been used to assess pain sensation. Duration till the first (...) Comparative Study between Preemptive and Postoperative Intra-Articular Injection of Levobupivacaine and Tramadol for Control of Postoperative Pain. This study had been formulated to evaluate and compare the analgesic effect of preemptive (PE), postoperative (PO), and combined knee intra-articular injection (IAI) of levobupivacaine and tramadol after knee arthroscopy.A total of 220 patients assigned for therapeutic knee arthroscopy were divided into four equal groups. Patients in Group C

2019 Anesthesia, essays and researches Controlled trial quality: uncertain

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>