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Pain Sensation

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181. No Pain and Extreme Pain From One Gene

an urban legend. Then a study in this week’s led me back to the Pakistani boy. He was real. And it turns out that different mutations in the same gene can cause complete absence of pain, or attacks of pain so severe that sufferers compare the sensation to dipping one’s feet into hot lava. In these extremes lie clues to developing new painkillers. From Hot Coals to a Channelopathy sodium channels In 2006, James Cox at University College London and Frank Reimann of the University of Cambridge (...) from the body’s periphery. The sodium channel is one of ten types, distinguished by its binding tetrodotoxin. That’s the stuff in pufferfish, a delicacy that makes one’s lips tingle when one eats it, and which I wrote about in 2002 when its was sequenced. Burning People Syndrome The mutations in the children who couldn’t feel pain are “loss-of-function” – their nociceptors can’t generate the action potentials that provoke the sensation. Mutations in the same gene that introduce a “gain-of-function

2016 PLOS Blogs Network

182. Pain Education for Patients With Low Back Pain in Nepal: A Feasibility Study

Pain Education for Patients With Low Back Pain in Nepal: A Feasibility Study Pain Education for Patients With Low Back Pain in Nepal: A Feasibility Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain (...) Education for Patients With Low Back Pain in Nepal: A Feasibility Study (PEN-LBP) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03387228 Recruitment Status : Completed First Posted : January 2, 2018 Last Update Posted : May 31, 2018 Sponsor: Kathmandu University School of Medical Sciences Collaborators

2017 Clinical Trials

183. Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity

Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cortical Neuroplasticity (...) by Muscle Pain of Pain-induced Plasticity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03354624 Recruitment Status : Completed First Posted : November 28, 2017 Last Update Posted : March 5, 2018 Sponsor: Aalborg University Information provided by (Responsible Party): Enrico De Martino, Aalborg

2017 Clinical Trials

184. Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults

for Study: 18 Years and older (Adult, Older Adult) Sexes Eligible for Study: Male Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Healthy male volunteers (American Society of Anaesthesiologist's Class I or II) Body mass index between 18 and 25kg/m2 Able to understand the study and the NRS scale Able to give informed consent Exclusion Criteria: Recreational drug abuse Regularly taking medication potentially interfere with pain sensation (analgesics, antihistamines and calcium and potassium (...) Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding

2017 Clinical Trials

185. Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life

Adult patients with ocular neuropathic pain. Criteria Inclusion Criteria: Patient aged 18 years or older, Presenting at least one of the following symptoms: spontaneous pain, burning sensation in eye, dysesthesia, allodynia, hyperalgesia French language-skills Exclusion Criteria: Severe corneal or palpebral damage explaining current pain Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research (...) Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

186. Evaluation of Pain Regression in Patients With Myofascial Facial Pain Using Dextrose, Local Anaesthesia and Saline.

of dextrose and water. Active Comparator: Local Anaesthetic Other: Local Anaesthesia A local anaesthetic is a medication that causes reversible absence of pain sensation Placebo Comparator: Saline Other: Saline Saline is a control group Outcome Measures Go to Primary Outcome Measures : Patients' subjective pain experience [ Time Frame: one year ] Pressure pain threshold (PPT): An algometer will be used to assess PPT. The algometer consists of a 1 cm2 rubber tipped plunger mounted on a force transducer (...) . The pressure will be applied over the examined trigger point. The participants will be instructed to point when the sensation changed from pressure to pain. The mean of three trials will be calculated and used for analysis. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may

2017 Clinical Trials

187. Spread of Muscle Hyperalgesia and Pain in a Low Dose NGF-induced Pain Model

injections of low dose NGF into the muscle combined are able to course immediate pain sensation and spreading of muscle hypersensitivity. Condition or disease Intervention/treatment Phase Hyperalgesia Healthy Subjects Drug: NGF Early Phase 1 Detailed Description: Effects of pain responses, symptom development and pattern (time course and distribution) following 5 i.m low dose injections of NGF injected into the tibialis anterior muscle will be compared to a high dose i.m injection of NGF injected (...) predetermined sites within the tibialis anterior muscle, a constant pressure stimulation (120% of PPT) is evoked by use of the pressure algometer. Subjects color their perceived sensation of pain on an electronic schematic of the lower legs using Navigate Pain. Activity-induced muscle soreness [ Time Frame: Change from baseline at 3 weeks ] Subjects perform 10 dorsiflexions with each leg. The perceived muscle soreness is reported using a numeric rating scale (NRS) and the area of soreness is colored

2017 Clinical Trials

188. Consciously Feeling the Pain of Others Reflects Atypical Functional Connectivity between the Pain Matrix and Frontal-Parietal Regions (PubMed)

Consciously Feeling the Pain of Others Reflects Atypical Functional Connectivity between the Pain Matrix and Frontal-Parietal Regions Around a quarter of the population report "mirror pain" experiences in which bodily sensations of pain are elicited in response to viewing another person in pain. We have shown that this population of responders further fractionates into two distinct subsets (Sensory/localized and Affective/General), which presents an important opportunity to investigate (...) the neural underpinnings of individual differences in empathic responses. Our study uses fMRI to determine how regions involved in the perception of pain interact with regions implicated in empathic regulation in these two groups, relative to controls. When observing pain in others (minor injuries to the hands and feet), the two responder groups show activation in both the sensory/discriminative and affective/motivational components of the pain matrix. The control group only showed activation

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2017 Frontiers in human neuroscience

189. Test-retest Reliability in Reporting the Pain Induced by a Pain Provocation Test: Further Validation of a Novel Approach for Pain Drawing Acquisition and Analysis. (PubMed)

Test-retest Reliability in Reporting the Pain Induced by a Pain Provocation Test: Further Validation of a Novel Approach for Pain Drawing Acquisition and Analysis. Pain drawings (PD) are frequently used in research to illustrate the pain response to pain provocation tests. However, there is a lack of data on the reliability in defining the extent and location of pain. We investigated the test-retest reliability in reporting an acute painful sensation induced by a pain provocation test using (...) is a reliable instrument to investigate pain extent and pain location in healthy individuals experiencing an acute painful sensation induced by a pain provocation test.© 2016 World Institute of Pain.

2016 Pain Practice

190. Differences in central pain modulation between patients with chronic pain are important determinants of clinical pain status

and parents of young people with CRPS to complete a 20-25 online survey which asks them to think about their future. Study recruitment is being conducted separately for both young people and parents. Please email if you would like to take part. Participants will be paid for their time. It’s impossible to slip your disc! Lorimer Moseley answering the question “What is the thing that annoys you most when we talk about back pain?” Online survey on bodily changes, sensations, and mood in people with chronic (...) pain How do CRPS and other chronic pain conditions affect bodily functions, sensations, and mood? Help CRPS researcher Janet Bultitude find out by responding to her . The survey is aimed at people with CRPS, people with chronic pain conditions other than CRPS, and people without any chronic pain condition. The survey takes approximately 20 minutes and the responses are anonymous. Prof Paul Hodges on pain and altered movement Am I safe to move? Listen to Lorimer Moseley talk to Karim Khan on new

2016 Body in Mind blog

191. STUDIES ON PAIN: QUANTITATIVE MEASUREMENTS OF TWO PAIN SENSATIONS OF THE SKIN, WITH REFERENCE TO THE NATURE OF THE “HYPERALGESIA OF PERIPHERAL NEURITIS” (PubMed)

STUDIES ON PAIN: QUANTITATIVE MEASUREMENTS OF TWO PAIN SENSATIONS OF THE SKIN, WITH REFERENCE TO THE NATURE OF THE “HYPERALGESIA OF PERIPHERAL NEURITIS” 16695239 2006 05 31 2018 11 13 0021-9738 24 4 1945 Jul The Journal of clinical investigation J. Clin. Invest. STUDIES ON PAIN: QUANTITATIVE MEASUREMENTS OF TWO PAIN SENSATIONS OF THE SKIN, WITH REFERENCE TO THE NATURE OF THE "HYPERALGESIA OF PERIPHERAL NEURITIS". 503-12 Bigelow N N New York Hospital, New York City. Harrison I I Goodell H H

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1945 Journal of Clinical Investigation

192. Buffering local anaesthetics to reduce dental injection pain?

sensations during injection of anaesthetics. A potential cause of this is the acidic nature of the local anaesthetic solution. It has been suggested that alkalisation of local anaesthesia with buffering agents hey reduce pain and speed anaesthesia onsets period The aim of this review is to investigate the efficacy of buffering local anaesthetics in reducing infiltration pain and anaesthesia onset time in dentistry. Methods Searches were conducted in the Medline, Embase, Scopus and SCIELO databases (...) Buffering local anaesthetics to reduce dental injection pain? Buffering local anaesthetics to reduce dental injection pain? - National Elf Service Search National Elf Service Search National Elf Service » » » » Buffering local anaesthetics to reduce dental injection pain? Feb 28 2018 Posted by Local anaesthesia is essential in order to perform the wide range of dental procedures carried out daily in dental practices. While they help to control pain patients often report burning and stinging

2018 The Dental Elf

193. Neuropathic pain in adults: pharmacological management in non-specialist settings

secondary to tumour antigens, or caused by direct invasion or compression of neural structures). Examples of conditions that can cause central neuropathic pain include stroke, spinal cord injury and multiple sclerosis. Neuropathic pain can be intermittent or constant, and spontaneous or provoked. Typical descriptions of the pain include terms such as shooting, stabbing, like an electric shock, burning, tingling, tight, numb, prickling, itching and a sensation of pins and needles. People may also (...) Neuropathic pain in adults: pharmacological management in non-specialist settings Neuropathic pain in adults: Neuropathic pain in adults: pharmacological management in non- pharmacological management in non- specialist settings specialist settings Clinical guideline Published: 20 November 2013 nice.org.uk/guidance/cg173 © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of- rights).Y Y our responsibility our responsibility

2013 National Institute for Health and Clinical Excellence - Clinical Guidelines

194. How can we assess the intensity of non-painful events as well as painful events?

be frustrating. At the same time, the researcher loses potentially valuable information by restricting the participant’s response options. What about putting both non-painful and painful experiences onto a single scale? OK sure, it would violate the age-old traditions of psychophysiology, but it could be useful. We tentatively developed this ‘Sensation and Pain Rating Scale’ (SPARS) (Figure 1). Figure 1: The Sensation and Pain Rating Scale (SPARS) We piloted it to determine whether people intuitively (...) presented separately. We chose a conventional NRS (0 = no pain; 100 = worst pain you can imagine) to represent the ‘painful’ end of the SPARS, and an invented ‘Sensation Rating Scale’ (SRS) (0 = no sensation; 100 = pain) to represent the non-painful end of the SPARS. In this Experiment 2, our participants rated a range of intensities of laser stimulation. In each block, they used only the SPARS, only the NRS, or only the SRS. We asked participants a whole heap of questions and we [1] Here’s what we

2019 Body in Mind blog

195. CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch (PubMed)

CGRPα-Expressing Sensory Neurons Respond to Stimuli that Evoke Sensations of Pain and Itch Calcitonin gene-related peptide (CGRPα, encoded by Calca) is a classic marker of nociceptive dorsal root ganglia (DRG) neurons. Despite years of research, it is unclear what stimuli these neurons detect in vitro or in vivo. To facilitate functional studies of these neurons, we genetically targeted an axonal tracer (farnesylated enhanced green fluorescent protein; GFP) and a LoxP-stopped cell ablation (...) study provides direct evidence that CGRPα(+) DRG neurons respond to agonists that evoke pain and itch and constitute a sensory circuit that is largely distinct from nonpeptidergic circuits and TRPM8(+)/cool temperature circuits. In future studies, it should be possible to conditionally ablate CGRPα-expressing neurons to evaluate sensory and non-sensory functions for these neurons.

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2012 PloS one

196. Sensation of Abdominal Pain Induced by Peritoneal Carcinomatosis Is Accompanied by Changes in the Expression of Substance P and μ -Opioid Receptors in the Spinal Cord of Mice. (PubMed)

Sensation of Abdominal Pain Induced by Peritoneal Carcinomatosis Is Accompanied by Changes in the Expression of Substance P and μ -Opioid Receptors in the Spinal Cord of Mice. Patients with peritoneal carcinomatosis often report abdominal pain, which is relatively refractory to morphine. It has been considered that a new animal model is required to investigate the mechanism of abdominal pain for the development of optimal treatments for this type of pain.To prepare a peritoneal carcinomatosis (...) model, highly peritoneal-seeding gastric cancer cells, 60As6, were implanted into the abdominal cavity. The nociceptive modality for pain-related behavior was assessed in terms of withdrawal behavior in response to mechanical stimuli and hunching behavior. Tissue samples from mouse dorsal root ganglia and spinal cord were subject to immunohistochemistry and real-time reverse transcription polymerase chain reaction.Mice with peritoneal dissemination showed significant hypersensitivity of the abdomen

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2012 Anesthesiology

197. Modulation of pain sensation by stress-related testosterone and cortisol. (PubMed)

Modulation of pain sensation by stress-related testosterone and cortisol. Stress increases cortisol and decreases testosterone. It is not known whether pain is affected by stress-related testosterone. Therefore, we investigated whether stress can affect pain perception by decreasing testosterone and increasing cortisol. Pain thresholds, pain and anxiety ratings and salivary testosterone and cortisol levels were measured in 46 healthy men during resting and stressful conditions. Pain was induced (...) by electrical stimulation. Stress was induced by having participants perform a medical test. Stress significantly increased anxiety ratings and salivary cortisol levels, but decreased salivary testosterone levels. Stress also increased pain ratings and decreased pain thresholds. During stress, cortisol levels were negatively correlated with pain thresholds and testosterone levels were positively correlated with pain thresholds. Results indicated that testosterone can decrease and cortisol can increase pain

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2012 Anaesthesia

198. Thermal grill-evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde. (PubMed)

Thermal grill-evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde. Thunberg's thermal grill produces a sensation of strong heat upon skin contact with spatially interlaced innocuous warm and cool stimuli.To examine the classes of peripheral axons that might contribute to this illusion, the effects of topical l-menthol, an activator of TRPM8, and cinnamaldehyde, a TRPA1 agonist, on the magnitude of thermal sensations were examined during (...) grill stimulation in healthy volunteers.Under control conditions, cutaneous grill stimulation (interlaced 20/40 °C) evoked a sensation of heat, and for individual subjects, the magnitude of this heat sensation was positively correlated with cold pain threshold (CPT). Menthol increased the CPT and enhanced the magnitude of grill-evoked heat. Cinnamaldehyde intensified warm sensations, reduced heat pain threshold and also enhanced grill-evoked heat.Both TRPM8-expressing and TRPA1-expressing afferent

2012 European Journal of Pain

199. Ranking of dental and somatic pain sensations among paediatric dental patients. (PubMed)

Ranking of dental and somatic pain sensations among paediatric dental patients. Children suffer from somatic and dental pain, which may interfere with their everyday life. Pain self-report tools are available for children. Research is needed to better understand the perception of dental pain in comparison with pain in other organs.To investigate relations between the perceptions of dental and somatic pain complaints among school-age children.One hundred and two children, aged 7-17 years (mean (...) age, 11.5 ± 2.65 years), completed questioners regarding their somatic and dental: 1. Memory pain rank (MPR) and 2. Wong-Baker FACES Pain Rating Scale (FRS).Children reported increased dental pain after school in both scales (P = 0.015 in MPR). In both MPR and FRS, the pattern of pain ranking was similar: Abdominal pain was scored highest (2.75 ± 1.4 and 1.56 ± 1.63, respectively), followed by headache, ear, dental and TMJ (Temporomandibular joint).There was a strong correlation between pain

2012 International Journal of Paediatric Dentistry

200. BOLD responses in somatosensory cortices better reflect heat sensation than pain (PubMed)

BOLD responses in somatosensory cortices better reflect heat sensation than pain The discovery of cortical networks that participate in pain processing has led to the common generalization that blood oxygen level-dependent (BOLD) responses in these areas indicate the processing of pain. Physical stimuli have fundamental properties that elicit sensations distinguishable from pain, such as heat. We hypothesized that pain intensity coding may reflect the intensity coding of heat sensation during (...) the presentation of thermal stimuli during fMRI. Six 3T fMRI heat scans were collected for 16 healthy subjects, corresponding to perceptual levels of "low innocuous heat," "moderate innocuous heat," "high innocuous heat," "low painful heat," "moderate painful heat," and "high painful heat" delivered by a contact thermode to the face. Subjects rated pain and heat intensity separately after each scan. A general linear model analysis detected different patterns of brain activation for the different phases

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2012 The Journal of Neuroscience

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