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Pain Sensation

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181. Assessment of LTP-like Pain Amplification in Chronic Low Back Pain Patients

: Perception Features of conditioning electrical stimulation (CES) [ Time Frame: All subjects will rate the pain ratings during the 50 seconds stimulation. ] The subjects were asked to rate continuously the magnitude of pain induced by the 100 Hz CES using a hand-held visual analogue scale (VAS) device. These VAS ratings were sampled by a computer. The VAS ranges from "0"(no sensation") to "100" (most imaginable pain) where "30" means pain threshold. Change of pain intensity to light-stroking stimuli (...) [ Time Frame: The light-touch sensation will be measured three times before and six times after the conditioning electrical stimulation with 10 minutes interval throughout the experiment (90 minutes). ] A cotton swab was used for light stroking stimuli (~100mN) for assessing the tactile perception around the conditioned site. Change of pain intensity to single electrical stimulation (SES) [ Time Frame: The pain ratings to SES will be measured three times before and six times after the conditioning

2017 Clinical Trials

182. Conditioned Pain Modulation in Chronic Neck Pain Patients

PPT was recorded beginning 30 s after immersion of the leg with two PPT measures for each point. The PPT will be also measured again immediately after CPT. Secondary Outcome Measures : Numerical rating scale for pain (NRS) [ Time Frame: The patients used this scale to rate the pain intensity of the neck pain before the experiment. ] The NRS evaluates levels of pain intensity using an 100-point scale (range 0-100), with 0 being classified as "no sensation", 30 "pain threshold", 100 "pain as bad (...) Conditioned Pain Modulation in Chronic Neck Pain Patients Conditioned Pain Modulation in Chronic Neck Pain Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Conditioned Pain Modulation in Chronic

2017 Clinical Trials

183. Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity

Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Cortical Neuroplasticity (...) by Muscle Pain of Pain-induced Plasticity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03354624 Recruitment Status : Completed First Posted : November 28, 2017 Last Update Posted : March 5, 2018 Sponsor: Aalborg University Information provided by (Responsible Party): Enrico De Martino, Aalborg

2017 Clinical Trials

184. Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life

Adult patients with ocular neuropathic pain. Criteria Inclusion Criteria: Patient aged 18 years or older, Presenting at least one of the following symptoms: spontaneous pain, burning sensation in eye, dysesthesia, allodynia, hyperalgesia French language-skills Exclusion Criteria: Severe corneal or palpebral damage explaining current pain Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research (...) Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2017 Clinical Trials

185. Spread of Muscle Hyperalgesia and Pain in a Low Dose NGF-induced Pain Model

injections of low dose NGF into the muscle combined are able to course immediate pain sensation and spreading of muscle hypersensitivity. Condition or disease Intervention/treatment Phase Hyperalgesia Healthy Subjects Drug: NGF Early Phase 1 Detailed Description: Effects of pain responses, symptom development and pattern (time course and distribution) following 5 i.m low dose injections of NGF injected into the tibialis anterior muscle will be compared to a high dose i.m injection of NGF injected (...) predetermined sites within the tibialis anterior muscle, a constant pressure stimulation (120% of PPT) is evoked by use of the pressure algometer. Subjects color their perceived sensation of pain on an electronic schematic of the lower legs using Navigate Pain. Activity-induced muscle soreness [ Time Frame: Change from baseline at 3 weeks ] Subjects perform 10 dorsiflexions with each leg. The perceived muscle soreness is reported using a numeric rating scale (NRS) and the area of soreness is colored

2017 Clinical Trials

186. Effects of Hip and Knee Exercises on Knee Pain in Young Adult Females With Long-standing Patellofemoral Pain

exercise intervention (hip or knee). ] The cuff will inflate with 1 kPa per second and the participants are instructed to start rating their pain on the electronic VAS as soon as the sensation of pressure becomes painful (pain detection threshold). Change in pain tolerance threshold (PTT) measured with cuff pressure allometry at the lower leg of both limbs. [ Time Frame: This will be assessed at 1) baseline, 2) within 20 minutes after completing the first exercise intervention (hip or knee) and 3 (...) ) within 20 minutes after completing the second exercise intervention (hip or knee). ] The cuff will inflate with 1 kPa per second and the participants are instructed to start rating their pain on the electronic VAS as soon as the sensation of pressure becomes painful. Participants are instructed to press the release button when the pain becomes intolerable (pain tolerance threshold). Change in temporal summation of pain assessed by cuff pressure allometry at the lower leg of the test limb. [ Time

2017 Clinical Trials

187. Noninvasive experimental bladder pain assessment in painful bladder syndrome. (PubMed)

). Multivariate regression identified three independent components of bladder symptoms in PBS: bladder distension pain, bladder sensation, and somatic symptoms.Diuresis-induced bladder pain differentiates CPP from PBS. Experimental bladder pain is not predicted by pelvic floor sensitivity. Compared with patient-reported outcomes it appears less influenced by psychological factors. Further study is needed to determine whether screening for experimental bladder pain sensitivity could predict future risk (...) Noninvasive experimental bladder pain assessment in painful bladder syndrome. To compare bladder sensitivity between patients with pelvic pain and patients who were pain free, undergoing noninvasive, controlled bladder distension via diuresis. We also sought to measure potential mechanisms underlying bladder sensitivity.Prospective observational study.Community teaching hospital.Reproductive-age women with non-bladder chronic pelvic pain (CPP, n = 23), painful bladder syndrome (PBS, n = 23

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2017 BJOG

188. Chronic calf pain caused by fibroma-induced chronic inflammation around the tibial and peroneal nerves that was misdiagnosed as centralized neuropathic pain: A case report. (PubMed)

for the evaluation of calf pain. However, simple inflammation around the nerve should also be considered as a possible etiology. Here we describe a 35-year-old man with chronic pain in the right calf that was actually caused by fibroma-induced chronic inflammation around the tibial and peroneal nerves but misdiagnosed as centralized neuropathic pain.The patient presented with chronic pain and a tingling sensation in the right calf. He had a slowly growing tibial nerve neurilemmoma that was excised at 28 years (...) of age; however, the pain and tingling sensation persisted. He visited several hospitals for 7 years and was misdiagnosed with peripheral nerve injury-induced neuropathic pain. At 35 years of age, he visited our hospital for further evaluation. Ultrasonography revealed a mass in the popliteal region, which was excised and confirmed to be a fibroma via histopathological analysis. Severe inflammation was observed in the operative field. His symptoms finally ameliorated after this surgery.The findings

2017 Pain Practice

189. Ethnic Differences Identified by Pain Sensitivity Questionnaire Correlate With Clinical Pain Responses. (PubMed)

Ethnic Differences Identified by Pain Sensitivity Questionnaire Correlate With Clinical Pain Responses. The Pain Sensitivity Questionnaire, English version (PSQ-E), is predictive of pain-related responses to experimental stimuli. Ethnic differences have been noted in experimental measures of pain sensation using quantitative sensory testing. The present study sought to determine if the PSQ-E also identified similar ethnic differences.Fifty-seven subjects who self-identified as African Americans (...) (AAs) and who were scheduled to undergo a low-back interventional procedure completed the PSQ-E and other questionnaires. Their data were compared with an age-, sex-, and opioid usage-matched sample of 57 self-identified non-Hispanic white (NHW) subjects. Pain ratings on a visual analog scale (VAS) were obtained following 2 standardized injections of subcutaneous lidocaine (VAS1-infiltration in hand, VAS2-infiltration of procedural site). Correlations between PSQ-E scores, VAS measures, and other

2017 Regional Anesthesia and Pain Medicine

190. Brain structural alterations associated with dysfunctional cognitive control of pain in patients with low back pain. (PubMed)

to pain, which may also increase pain sensation, but thus far, the relationship between pain-related TS and structural brain alterations is unknown.In this study, we investigated a group of 30 patients 6 months after lumbar disc surgery by applying voxel-based morphometry (VBM) to identify brain regions correlated with TS scores.Since pain-related TS has been positively correlated with depression, all calculations were controlled for depression and age. VBM revealed a negative correlation between (...) Brain structural alterations associated with dysfunctional cognitive control of pain in patients with low back pain. Recent evidence has shown that chronic back pain (CBP) can lead to functional alterations in the circuitry underlying the cognitive control of pain. Thought suppression (TS) is a common type of cognitive control of pain. Previous research has shown that TS has paradoxical effects that may increase the awareness of pain. Pain-related TS may also increase individuals' attention

2017 European Journal of Pain

191. Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in Na<sub>V</sub> 1.7. (PubMed)

range suggesting that sensitized supra-threshold encoding is important for the clinical pain phenotype in EM in addition to lower activation threshold. Intracutaneous lidocaine dose-dependently blocked nociceptive sensations, but we did not identify EM patients with particular high lidocaine sensitivity that could have provided valuable therapeutic guidance.Acute pain thresholds and supra-threshold heat pain in controls and patients with erythromelalgia do not differ and have the same lidocaine (...) Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in NaV 1.7. Nociceptive thresholds and supra-threshold pain ratings as well as their reduction upon local injection with lidocaine were compared between healthy subjects and patients with erythromelalgia (EM).Lidocaine (0.25, 0.50, 1.0 or 10 mg/mL) or placebo (saline) was injected intradermally in non-painful areas of the lower arm, in a randomized, double

2017 European Journal of Pain Controlled trial quality: uncertain

192. Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain. (PubMed)

. Upon detailed characterization of ASO activity in individual cell populations in DRG, we observe robust target suppression in all neuronal populations, thereby establishing that ASOs are effective in the cell populations involved in pain propagation. Furthermore, we confirm that ASOs are selective and do not modulate basal pain sensation. We also demonstrate that ASOs targeting the sodium channel Nav1.7 induce sustained analgesia up to 4 weeks. Taken together, our findings support the idea (...) Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain. There is an urgent need for better treatments for chronic pain, which affects more than 1 billion people worldwide. Antisense oligonucleotides (ASOs) have proven successful in treating children with spinal muscular atrophy, a severe infantile neurological disorder, and several ASOs are currently being tested in clinical trials for various neurological

2017 Pain

193. Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations. (PubMed)

Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations. Forty subjects rated the magnitude of painful electrical stimulation of tooth pulp before and after the intravenous administration of either fentanyl, a short-acting narcotic, or a saline placebo. The responses were choices of verbal descriptors from randomized lists of either sensory intensity (that is, weak, mild, intense) or unpleasantness (annoying, unpleasant, distressing (...) ) descriptors. The fentanyl significantly reduced the sensory intensity without reducing the unpleasantness of the tooth pulp stimuli, indicating that the mechanisms of narcotic analgesia may include a significant attenuation in pain sensation in addition to effects on pain reaction. These results stress the importance of using multiple measures of pain.

1979 Science (New York, N.Y.) Controlled trial quality: uncertain

194. Pain sensation in man. (PubMed)

Pain sensation in man. 912320 1977 12 29 2018 11 13 0007-1447 2 6090 1977 Sep 24 British medical journal Br Med J Pain sensation in man. 783-4 eng Editorial England Br Med J 0372673 0007-1447 AIM IM Humans Nerve Fibers physiology Pain physiopathology Pain Management 1977 9 24 1977 9 24 0 1 1977 9 24 0 0 ppublish 912320 PMC1631998 Brain. 1964 Dec;87:609-18 14236006 Br Med Bull. 1977 May;33(2):157-61 193604 Br Med Bull. 1977 May;33(2):149-55 67868 Pain. 1976 Dec;2(4):379-404 195254 Brain. 1976 (...) Mar;99(1):123-58 183859 Pain. 1975 Dec;1(4):357-73 141644 Pain. 1977 Feb;3(1):57-68 876667 Pain. 1977 Feb;3(1):43-56 876666 Br Med Bull. 1977 May;33(2):97-102 861488 Pain. 1976 Sep;2(3):223-43 800250 Pain. 1975 Jun;1(2):147-65 1235979 Science. 1965 Nov 19;150(3699):971-9 5320816 Exp Brain Res. 1973 Jan 29;16(3):321-32 4686614 Exp Brain Res. 1973 Jan 29;16(3):309-20 4686613 Exp Neurol. 1968 Jul;21(3):270-89 5673644

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1977 British medical journal

195. Pain Sensation Related to Local Anesthesia Injected at Varying Temperatures (PubMed)

Pain Sensation Related to Local Anesthesia Injected at Varying Temperatures The purpose of the study was to determine whether local anesthetic solution warmed to body temperature (37° C) produced less pain on injection than an anesthetic solution injected at room temperature (21° C) and to determine which solution resulted in quicker anesthetic onset. It was found that the subjects experienced no difference in pain during injection of warm and cold anesthetic solution given respectively

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1978 Anesthesia progress

196. The effect of analgesic drugs on the sensation of thermal pain in man (PubMed)

The effect of analgesic drugs on the sensation of thermal pain in man 14954117 2004 02 15 2018 12 01 0366-0826 7 2 1952 Jun British journal of pharmacology and chemotherapy Br J Pharmacol Chemother The effect of analgesic drugs on the sensation of thermal pain in man. 203-14 JACKSON H H eng Journal Article England Br J Pharmacol Chemother 0154627 0366-0826 0 Analgesics OM Analgesics pharmacology Humans Male Pain Sensation 5222:40575:23:326 ANALGESICS/effects PAIN 1952 6 1 1952 6 1 0 1 1952 6 1

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1952 British journal of pharmacology and chemotherapy

197. SUBJECTIVE SYMPTOMS AND PAINFUL SENSATIONS IN HEART DISEASE (PubMed)

SUBJECTIVE SYMPTOMS AND PAINFUL SENSATIONS IN HEART DISEASE 18734281 2008 08 29 2008 11 20 0093-402X 6 2 1908 Feb California state journal of medicine Cal State J Med SUBJECTIVE SYMPTOMS AND PAINFUL SENSATIONS IN HEART DISEASE. 64-7 Schmoll E E eng Journal Article United States Cal State J Med 0414327 0093-402X 1908 2 1 0 0 1908 2 1 0 1 1908 2 1 0 0 ppublish 18734281 PMC1652367

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1908 California state journal of medicine

198. Experiments on visceral sensation: Part I. The relation of pain to activity in the Å“sophagus (PubMed)

Experiments on visceral sensation: Part I. The relation of pain to activity in the Å“sophagus 16993885 2007 02 05 2018 11 13 0022-3751 63 3 1927 Aug 08 The Journal of physiology J. Physiol. (Lond.) Experiments on visceral sensation: Part I. The relation of pain to activity in the oesophagus. 217-41 Payne W W WW Poulton E P EP eng Journal Article England J Physiol 0266262 0022-3751 1927 8 8 0 0 1927 8 8 0 1 1927 8 8 0 0 ppublish 16993885 PMC1514898 J Physiol. 1899 May 11;24(2):99-143 16992487 J

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1927 The Journal of physiology

199. Observations on sensation: The sensory functions of the skin for touch and pain (PubMed)

Observations on sensation: The sensory functions of the skin for touch and pain 16994388 2007 02 05 2008 11 20 0022-3751 77 3 1933 Feb 08 The Journal of physiology J. Physiol. (Lond.) Observations on sensation: The sensory functions of the skin for touch and pain. 251-7 Waterston D D eng Journal Article England J Physiol 0266262 0022-3751 1933 2 8 0 0 1933 2 8 0 1 1933 2 8 0 0 ppublish 16994388 PMC1394770

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1933 The Journal of physiology

200. Testicular Pain Sensation in Diabetic Autonomic Neuropathy (PubMed)

Testicular Pain Sensation in Diabetic Autonomic Neuropathy Testicular sensation was examined in 32 male diabetics with symptoms suggestive of autonomic neuropathy to evaluate its usefulness as a clinical sign in this condition. Vascular reflex responses to the Valsalva manoeuvre and sustained handgrip and blood pressure fall on standing were measured as objective tests of autonomic involvement. Absent or diminished testicular sensation correlated well both with the clinical features (...) of autonomic neuropathy, except where impotence occurred alone, and with abnormal vascular reflexes. Most patients with impotence alone had normal testicular sensation and normal vascular reflexes. It is concluded that this sign is useful in diabetics with impotence, the presence of intact testicular sensation indicating that the impotence is unlikely to be due to autonomic neuropathy.

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1974 British medical journal

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