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Pain Sensation

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1. Pain behavior without pain sensation: an epileptic syndrome of "symbolism for pain"? (Abstract)

Pain behavior without pain sensation: an epileptic syndrome of "symbolism for pain"? "Asymbolia for pain" has shown the potentiality of diseased insular networks to dissociate sensory from affective-behavioral dimensions of pain, resulting in the lack of appropriate motor and affective responses despite preserved sensory aspect of pain. Here, we describe 4 patients with an inverse phenomenon of asymbolia for pain, namely an isolated "symbolism for pain" triggered by epileptic seizures (...) , characterized by pain behavior without declarative pain sensation despite fully preserved contact and vigilance. Stereoelectroencephalography demonstrated in each case focal seizure discharges within the posterior insulo-opercular cortex, with little or no propagation to other cortical structures, especially those considered to drive subjective pain experiences. The pain behavior might reflect seizure propagation from the insula to brain networks serving for behavioral responses associated with pain

2020 Pain

2. Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial

Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine (...) Obstet Gynecol Actions . 2020 Mar;135(3):609-614. doi: 10.1097/AOG.0000000000003710. Sensation of Pain Using Buffered Lidocaine for Infiltration Before Vulvar Biopsy: A Randomized Controlled Trial , , , , , , Affiliations Expand Affiliation 1 Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan; and the Department of Obstetrics and Gynecology, the Program in Women's Oncology, Division of Research, Department of Obstetrics and Gynecology, and the Program in Women's

2020 EvidenceUpdates

3. Attention to breath sensations does not engage endogenous opioids to reduce pain. (Abstract)

Attention to breath sensations does not engage endogenous opioids to reduce pain. The endogenous opioidergic system is critically involved in the cognitive modulation of pain. Slow-breathing-based techniques are widely used nonpharmacological approaches to reduce pain. Yet, the active mechanisms of actions supporting these practices are poorly characterized. Growing evidence suggest that mindfulness-meditation, a slow-breathing technique practiced by nonreactively attending to breathing (...) sensations, engages multiple unique neural mechanisms that bypass opioidergically mediated descending pathways to reduce pain. However, it is unknown whether endogenous opioids contribute to pain reductions produced by slow breathing. The present double-blind, placebo-controlled crossover study examined behavioral pain responses during mindfulness-meditation (n = 19), sham-mindfulness meditation (n = 20), and slow-paced breathing (n = 20) in response to noxious heat (49°C) and intravenous administration

2020 Pain

4. General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation Full Text available with Trip Pro

General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm's way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the healthcare system with continuous rehabilitation of patients with adverse pain sensations, which might (...) reduce not only their quality of life but also their productivity at work setting back the pace of our economy. It may not look like a huge deal but factor in pain as an issue for majority of us, it becomes an economical burden. Although pain has been researched into and understood by numerous researches, from its definition, mechanism of action to its inhibition in hopes of finding an absolute solution for victims of pain, the pathways of pain sensation, neurotransmitters involved in producing

2018 International journal of molecular sciences

5. Touch and Pain Sensations in Diadynamic Current (DD) and Transcutaneous Electrical Nerve Stimulation (TENS): A Randomized Study. Full Text available with Trip Pro

Touch and Pain Sensations in Diadynamic Current (DD) and Transcutaneous Electrical Nerve Stimulation (TENS): A Randomized Study. The study investigated touch and pain sensations and the correlation between them in diadynamic current (DD) and transcutaneous electrical nerve stimulation (TENS), electrotherapies commonly applied in musculoskeletal disorders and occupational rehabilitation medicine. Forty healthy subjects were treated with either DD (n=20) or TENS (n=20). Each treatment consisted (...) of three sessions with one-week interval. Touch sensation was determined with the JVP Domes esthesiometer, pain sensation with pressure pain threshold (PPT), and pressure pain tolerance threshold (PPTO) by an algometer. During each session the measurements were performed before the application of the procedure (T0), immediately after it (T1), and 30 minutes after the end of the procedure (T2). Both DD and TENS increased touch sensation (p<0.01) and did not significantly alter PPT and PPTO (p>0.05

2019 BioMed research international Controlled trial quality: uncertain

6. Mapping the Affective Dimension of Embodiment with the Sensation Manikin: Validation Among Chronic Pain Patients and Modification by Mindfulness-Oriented Recovery Enhancement. (Abstract)

Mapping the Affective Dimension of Embodiment with the Sensation Manikin: Validation Among Chronic Pain Patients and Modification by Mindfulness-Oriented Recovery Enhancement. Mindfulness-based interventions (MBIs) target novel pain relief mechanisms not captured by legacy pain scales, including 1) cultivating awareness of pleasant and neutral sensations proximal to unpleasant sensations and 2) interoceptively mapping sensation locations and spatial distributions.We created a digital sensation (...) manikin (SM), by overlaying a human figure silhouette with a grid of 469 "sensation" pixels. A series of five research questions examined the SM's discriminant validity, construct validity, incremental validity, convergence with an objective measure of pain attentional bias, and sensitivity to a mindfulness-based psychological treatment. A sample of opioid treated chronic pain patients (n=108, Age=53.79±12.94, Female=65%) was recruited to answer research questions 1-5, and a sample of healthy controls

2019 Psychosomatic Medicine

7. Defence response mobilization in response to provocation or imagery of interoceptive sensations in adolescents with chronic pain: a study protocol Full Text available with Trip Pro

Defence response mobilization in response to provocation or imagery of interoceptive sensations in adolescents with chronic pain: a study protocol Fear of pain seems to be a key factor in the development and maintenance of chronic pain and pain-related disability. Interoceptive fear conditioning is assumed to constitute an important mechanism in the origins and maintenance of fear of pain. If conditioned stimuli such as internal bodily sensations are repeatedly paired with pain (unconditioned (...) stimulus), they in turn elicit a conditioned fear response, including defence mobilization such as startle modulation and changes in heart rate and electrodermal activity. Research into emotional imagery suggests that defensive responses can also be elicited through imagery of fear scripts.We present 2 novel paradigms adapted from research on anxiety disorders, which allow to test, if perceived or imagined sensations locally proximal to the main pain location trigger heightened defence response

2018 Pain Reports

8. Disrupted physical pain sensation by social exclusion in women with dysmenorrhea Full Text available with Trip Pro

Disrupted physical pain sensation by social exclusion in women with dysmenorrhea Dysmenorrhea (DM), which involves both acute and chronic pain, is associated with abnormalities in pain modulation. Previous studies have shown that social pain relies on some of the same neural regions that process physical pain, highlighting a possible physical-social pain overlap. However, evidence suggesting that social pain modulates the sensitivity to physical pain remains controversial. The present study (...) more fearful of being evaluated unfavorably. No significant differences were observed in self-esteem scores between DM and HC after both inclusion and exclusion.We observed altered pain sensation in DM participants in response to social pain manipulation, suggesting that DM not only impacts menstruation but also modulates the perception of pain more generally, especially its affective processes. The present study suggests that the effect of social pain on pain sensation and certain psychometric

2018 Journal of pain research Controlled trial quality: uncertain

9. Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system Full Text available with Trip Pro

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system Various small molecules act as neurotransmitters and orchestrate neural communication. Growing evidence suggests that not only classical neurotransmitters but also several small molecules, including amino acid derivatives, modulate synaptic transmission. As conditions of acute and chronic pain alter neuronal excitability (...) in the nucleus accumbens, we hypothesized that small molecules released in the nucleus accumbens might play important roles in modulating the pain sensation. However, it is not easy to identify possible pain modulators owing to the absence of a method for comprehensively measuring extracellular small molecules in the brain. In this study, through the use of an emerging metabolomics technique, namely ion chromatography coupled with high-resolution mass spectrometry, we simultaneously analyzed the dynamics

2018 Molecular pain

10. Beyond Sensation: Exploring the Molecular and Genetic Basis for Pain: An Interview with Stephen Waxman, MD, PhD
 Full Text available with Trip Pro

Beyond Sensation: Exploring the Molecular and Genetic Basis for Pain: An Interview with Stephen Waxman, MD, PhD
 29599659 2018 09 24 2018 12 02 1551-4056 91 1 2018 03 The Yale journal of biology and medicine Yale J Biol Med Beyond Sensation: Exploring the Molecular and Genetic Basis for Pain: An Interview with Stephen Waxman, MD, PhD. 63-66 DeNardo Erin K EK Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT. eng Autobiography Historical Article (...) Interview Portrait 2018 03 28 United States Yale J Biol Med 0417414 0044-0086 IM History, 20th Century History, 21st Century Humans Models, Biological Pain genetics Pain Management Physicians Sensation genetics Waxman Stephen S inherited erythromelalgia ion channels neuralgia precision medicine 2018 3 31 6 0 2018 3 31 6 0 2018 9 25 6 0 epublish 29599659 PMC5872643 Pharmacol Rev. 2005 Dec;57(4):397-409 16382098 Nat Rev Neurosci. 2013 Jan;14(1):49-62 23232607

2018 The Yale journal of biology and medicine

11. Examining Effects of Aerobic Exercise on Pain Sensation

Examining Effects of Aerobic Exercise on Pain Sensation Examining Effects of Aerobic Exercise on Pain Sensation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Examining Effects of Aerobic Exercise on Pain (...) in sensation in the areas for the pain sensitivity tests as reported by the subject cervical or thoracic pain as a main complaint spinal pathologies such as fracture, tumor, infection, and severe inflammation severe spinal deformity severe cardiovascular and neurological diseases cancer history of spinal surgery currently seeking active treatments for LBP other than medications resting blood pressure more than 160/90 mmHg 49 currently taking blood thinning medications uncontrolled diabetes cannot have

2018 Clinical Trials

12. Pain and Sensation After Regional Anesthesia

Pain and Sensation After Regional Anesthesia Pain and Sensation After Regional Anesthesia - Pilot Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pain and Sensation After Regional Anesthesia - Pilot (...) the presence of pin prick sensation at these levels. This will help determine if pain scores collected at 6hrs reflect analgesia provided by the preoperative LPB alone or if the data is confounded by the presence of spinal anesthesia. This data will help us determine if 6hrs is a feasible primary endpoint to assess pain scores. Additionally, assuming that spinal regression is complete by 6hrs, the VAS pain scores obtained will then be used to perform a power analysis to determine the necessary study size

2018 Clinical Trials

13. Phantom Acupuncture Induces Placebo Credibility and Vicarious Sensations: A Parallel fMRI Study of Low Back Pain Patients Full Text available with Trip Pro

Phantom Acupuncture Induces Placebo Credibility and Vicarious Sensations: A Parallel fMRI Study of Low Back Pain Patients Although acupuncture is an effective therapeutic intervention for pain reduction, the exact difference between real and sham acupuncture has not been clearly understood because a somatosensory tactile component is commonly included in the existing sham acupuncture protocols. In an event-related fMRI experiment, we implemented a novel form of sham acupuncture, phantom (...) could be delivered credibly. Interestingly, the PHNT-credible group exhibited bilateral activation in SI/SII and also reported vicarious acupuncture sensations without needling stimulation. The PHNT group showed greater activation in the bilateral dorsolateral/ventrolateral prefrontal cortex (dlPFC/vlPFC). Moreover, the PHNT group exhibited significant pain reduction, with a significant correlation between the subjective fMRI signal in the right dlPFC/vlPFC and a score assessing belief

2018 Scientific reports

14. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice Full Text available with Trip Pro

TRPV1 gain-of-function mutation impairs pain and itch sensations in mice Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel, which can detect various noxious stimuli that cause pain, inflammation, hyperalgesia, and itch. TRPV1 knock-out mice show deficiency in nociception, but the in vivo effects of persistent activation of TRPV1 are not completely understood. Here, we generated TRPV1 knock-in mice with a G564S mutation. In the heterologous expression system (...) decreased capsaicin sensitivity. Western blot analysis revealed that the G564S mutant reduced TRPV1 phosphorylation and cell membrane trafficking. Together, we have generated a mouse model with a gain-of-function mutation in Trpv1 gene and demonstrated that the pain and histamine-dependent itch sensations in these mice are impaired due to a decreased phosphorylation level and reduced membrane localization of TRPV1.

2018 Molecular pain

15. Is the Organisation of the Primary Motor Cortex in Low Back Pain Related to Pain, Movement and/or Sensation? (Abstract)

Is the Organisation of the Primary Motor Cortex in Low Back Pain Related to Pain, Movement and/or Sensation? Primary motor cortex (M1) organization differs between individuals with and without chronic low back pain (CLBP), in parallel with motor and sensory impairments. This study investigated whether movement behaviour and tactile/pain sensation are related to M1 organisation in CLBP.Transcranial magnetic stimulation (TMS) was used to map the M1 representation of the erector spinae (...) and multifidus muscles in 20 participants with and without CLBP. Cortical organisation was quantified by: map volume; center of gravity (CoG); number of peaks; and primary and secondary peak location. Movement behaviour was assessed as the ability to dissociate lumbar from thorax motion and sensory function as two-point discrimination, pressure pain thresholds, and pain intensity (visual analogue scale).People with CLBP showed more anterior location of the CoG than controls. Map peaks were more numerous

2017 Clinical Journal of Pain

16. Painful decisions: How classifying sensations can change the experience of pain. (Abstract)

Painful decisions: How classifying sensations can change the experience of pain. Categorizing perceptual stimuli is a mechanism for facilitating the processing of sensory input from our environment. This facilitation of perception is achieved through generalization (assimilation) of stimulus characteristics within categories and accentuation between categories. These categorization processes have been demonstrated in visual, auditory, tactile and social perception, but never in pain (...) perception.We presented participants with six thermal noxious stimuli, increasing in steps of 0.5 °C. In an experimental group, stimuli were assigned to two categories labelled A and B containing the three lower (A1, A2, A3) and three higher (B1, B2, B3) stimuli. A control group did not receive such category information (stimuli were labelled S1-S6). In a first part of the experiment, participants simply rated pain intensity and unpleasantness for all stimuli. In a second part, we presented stimuli without

2017 European Journal of Pain Controlled trial quality: uncertain

17. γ-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects. Full Text available with Trip Pro

γ-Aminobutyric acid (GABA) oral rinse reduces capsaicin-induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects. In burning mouth patients, analgesia after oral administration of clonazepam may result from modulation of peripheral γ-aminobutyric acid (GABA) receptors.The effect of oral administration of test solutions (water, 0.5 mol/L or 0.05 mol/L GABA, 1% lidocaine) was investigated for the amelioration of pain and sensitivity induced (...) by application of capsaicin (1%, 2 min) to the tongue of thirty healthy male and female subjects in this four-session, randomized, placebo-controlled, double-blinded, cross-over study. Intra-oral quantitative sensory testing was used to assess cold (CDT), warm (WDT) and mechanical (MDT) detection thresholds as well as mechanical (MPT) and heat (HPT) pain thresholds. Capsaicin-induced pain intensity was continuously rated on a 0-10 electronic visual analogue scale (VAS). The area under the VAS curve (VASAUC

2017 European Journal of Pain Controlled trial quality: uncertain

18. Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe Full Text available with Trip Pro

Painful After-Sensations in Fibromyalgia are Linked to Catastrophizing and Differences in Brain Response in the Medial Temporal Lobe Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain, hyperalgesia, and other disabling symptoms. Although the brain response to experimental pain in FM patients has been the object of intense investigation, the biological underpinnings of painful after-sensations (PAS), and their relation to negative affect have received little (...) . These results suggest that the MTL plays a role in PAS in FM patients.PAS are more common and severe in FM, and are associated with clinical pain and catastrophizing. PAS severity is also associated with less MTL deactivation, suggesting that the MTL, a core node of the default mode network, may be important in the prolongation of pain sensation in FM.Copyright © 2017 American Pain Society. Published by Elsevier Inc. All rights reserved.

2017 The journal of pain : official journal of the American Pain Society

19. Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test Full Text available with Trip Pro

Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test The Hargreaves test is specifically designed to assess thermal pain sensation in rodents such as rats and mice. This test has been used in experiments involving pain sensitization or recovery of thermal pain response following neural injury and regeneration. We present here a step-by-step protocol highlighted with important notes to guide first-time users through the learning process. Additionally, we have also

2017 Bio-protocol

20. Peripheral and orofacial pain sensation is unaffected by the loss of p39 Full Text available with Trip Pro

Peripheral and orofacial pain sensation is unaffected by the loss of p39 Cdk5 is a key neuronal kinase necessary for proper brain development, which has recently been implicated in modulating nociception. Conditional deletion of Cdk5 in pain-sensing neurons attenuates pain responses to heat in both the periphery and orofacial regions. Cdk5 activity is regulated by binding to the activators p35 and p39, both of which possess a cyclin box. Our previous examination of the nociceptive role (...) effects that result from the deletion of p35. Our data demonstrate different and nonoverlapping roles of Cdk5 activators in the regulation of orofacial as well as peripheral nociception with a crucial role for Cdk5/p35 in pain signaling.

2017 Molecular pain

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