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Pacemaker

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141. HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node (PubMed)

HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node The contribution of HCN4 pacemaker channels in the autonomic regulation of the sino-atrial node (SAN) has been a matter of debate. The transgenic overexpression of HCN4 did not induce tachycardia, but reduced heart rate variability, while the conditional knockdown of HCN4 gave rise to sinus arrhythmia. The response of the SAN to β-adrenergic stimulation was not affected (...) by overexpression or knockdown of HCN4 channels. When HCN4 channels were knocked down, the parasympathetic response examined by cervical vagus nerve stimulation (CVNS) was enhanced; the CVNS induced complete sinus pause. The overexpression of HCN4 attenuated bradycardia induced by CVNS only during β-adrenergic stimulation. We concluded that HCN4 pacemaker channels stabilize the spontaneous firing by attenuating the parasympathetic response of the SAN.The heart rate is dynamically controlled by the sympathetic

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2018 The Journal of physiology

142. Transcatheter Aortic Valve Replacement After Coronary Artery Bypass Graft Is Associated With Increased Pacemaker Implantation but Not Reduced Overall Survival (PubMed)

Transcatheter Aortic Valve Replacement After Coronary Artery Bypass Graft Is Associated With Increased Pacemaker Implantation but Not Reduced Overall Survival A history of coronary artery bypass graft (CABG) is a common compelling indication for transcatheter aortic valve replacement (TAVR). However, there is little data on how these patients compare to other TAVR patients. In this study, the short and long-term outcomes of these TAVR patients after CABG are defined.A retrospective chart review (...) ) or 2 years (70% vs. 57%, P = 0.135) post-TAVR. However, a history of CABG was associated with an increase in post-TAVR permanent pacemaker (PPM) implantation (15% vs. 6%, P = 0.015).This study gives evidence to suggest that patients with a history of prior CABG do not have any difference in overall survival as other TAVR patients, despite higher predicted surgical risk and differences in preprocedural comorbidities. Our study also confirms the safety of TAVR in this specific population in lower

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2018 Cardiology Research

143. A Leadless Pacemaker Which Became Encapsulated Only Two Months after Placement (PubMed)

A Leadless Pacemaker Which Became Encapsulated Only Two Months after Placement 29780151 2018 12 07 1349-7235 57 20 2018 Oct 15 Internal medicine (Tokyo, Japan) Intern. Med. A Leadless Pacemaker Which Became Encapsulated Only Two Months after Placement. 3053-3054 10.2169/internalmedicine.1066-18 Satoh Taijyu T Department of Cardiovascular Medicine, Yamagata Prefectural Central Hospital, Japan. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan. Fukui Akio (...) A Department of Cardiovascular Medicine, Yamagata Prefectural Central Hospital, Japan. Katoh Shigehiko S Department of Cardiovascular Medicine, Yamagata Prefectural Central Hospital, Japan. Matsui Motoyuki M Department of Cardiovascular Medicine, Yamagata Prefectural Central Hospital, Japan. eng Journal Article 2018 05 18 Japan Intern Med 9204241 0918-2918 autopsy leadless pacemaker 2018 5 22 6 0 2018 5 22 6 1 2018 5 22 6 0 ppublish 29780151 10.2169/internalmedicine.1066-18 PMC6232027 J Am Coll Cardiol

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2018 Internal Medicine

144. Alteplase Causing Cardiac Tamponade after Recent Cardiac Pacemaker Placement (PubMed)

Alteplase Causing Cardiac Tamponade after Recent Cardiac Pacemaker Placement A 56-year-old female presented to the emergency department with evolving cardiac tamponade after receiving alteplase for acute ischemic stroke. This is the first case report of cardiac tamponade from thrombolytics in the setting of recent pacemaker placement. Point-of-care ultrasound was used to make the diagnosis quickly and expedite the patient to the operating room where a pericardial window was performed.

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2018 Clinical Practice and Cases in Emergency Medicine

145. An incomplete pacemaker lead fracture causing inappropriate pacing inhibition due to oversensing of the minute ventilation sensor pulses (PubMed)

An incomplete pacemaker lead fracture causing inappropriate pacing inhibition due to oversensing of the minute ventilation sensor pulses Cardiac pacemakers using rate response technologies represent the effectiveness of increasing the heart rate and cardiac output during exercise. Minute ventilation (MV) sensors are popular and estimate rates using transthoracic impedance by emitting very low amperage short electrical current pulses between the pacemaker lead tip and pulse generator. We present (...) a case of an incomplete pacemaker lead fracture developing inappropriate pacing inhibition due to oversensing caused by the electrical current emitted by the MV sensor. A permanent pacemaker replacement was performed, resulting in no further abnormal findings such as inappropriate pacing inhibition. pacemaker lead tip

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2018 Journal of cardiology cases

146. The Effect of Astragaloside on Pacemaker Current and the Cytoskeleton in Rabbit Sinoatrial Node Cells Under the Ischemia and Reperfusion Condition (PubMed)

The Effect of Astragaloside on Pacemaker Current and the Cytoskeleton in Rabbit Sinoatrial Node Cells Under the Ischemia and Reperfusion Condition Objective: We investigated the role of astragaloside in the treatment of sick sinus syndrome (SSS). Methods: Neonatal New Zealand rabbits were selected for the study. Rabbit sinoatrial node (SAN) cells were isolated by the method of dual enzymatic digestion and differential adherence. The injury model was prepared through simulated ischemia (...) and reperfusion (I/R), and changes in the pacemaker current (If) were recorded using the whole-cell patch-clamp technique. The proteins F-actin and vinculin were examined between various groups of SAN cells using a microplate reader and laser scanning confocal microscopy. The mRNA level and protein expression of hyperpolarization-activated cyclic nucleotide gated potassium channel 4 (HCN4) were assessed by q-PCR and western blot method. Results: The peak current density of If was decreased to -19.64 ± 2.14 pA

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2018 Frontiers in pharmacology

147. Identification of uterine pacemaker regions at the myometrial–placental interface in the rat (PubMed)

Identification of uterine pacemaker regions at the myometrial–placental interface in the rat Coordinated contraction of the uterine smooth muscle is essential to parturition. Histologically and physiologically defined pacemaker structures have not been identified in uterine smooth muscle. Here we report combined electrophysiological and histological evidence of zones associated with pacemaker activity in the rat myometrium. Our method relies crucially on the integration of histological (...) and electrophysiological data in an in silico three-dimensional reconstruction of the rat myometrium at 10 μm resolution. We find that myometrial/placental pacemaking zones are closely related with placental sites and the area of disruptive myometrial remodelling surrounding such sites. If analogues of the myometrial/placental pacemaking zone are present in the human, defining their histology and physiology will be important steps towards treatment of pre-term birth, pre-eclampsia, and postpartum

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2018 The Journal of physiology

148. Visualization and appearance of artifacts of leadless pacemaker systems in cardiac MRI: An experimental ex vivo study (PubMed)

Visualization and appearance of artifacts of leadless pacemaker systems in cardiac MRI: An experimental ex vivo study Leadless pacemaker systems are an important upcoming device in clinical rhythmology. Currently two different products are available with the Micra system (Medtronic) being the most used in the clinical setting to date. The possibility to perform magnetic resonance imaging (MRI) is an important feature of modern pacemaker devices. Even though the Micra system is suitable for MRI (...) , little is yet known about its impact on artifacts within the images.The aim of our ex vivo study was to perform cardiac MRI to quantify the artifacts and to evaluate if artifacts limit or inhibit the assessment of the surrounding myocardium.After ex vivo implantation of the leadless pacemaker (LP) in a porcine model, hearts were filled with saline solution and fixed on wooden sticks on a plastic container. The model was examined at 1.5 T and at 3 T using conventional sequences and T2 mapping

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2018 Wiener klinische Wochenschrift

149. Dynamic Cellular Integration Drives Functional Assembly of the Heart’s Pacemaker Complex (PubMed)

Dynamic Cellular Integration Drives Functional Assembly of the Heart’s Pacemaker Complex Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular composition of the SAN has been a point of interest for more than a century, the biological (...) processes that drive the tissue-level assembly of the cells within the SAN are unknown. Here, we demonstrate that the SAN's structural features result from a developmental process during which mesenchymal cells derived from a multipotent progenitor structure, the proepicardium, integrate with and surround pacemaker myocardium. This process actively remodels the forming SAN and is necessary for sustained electrogenic signal generation and propagation. Collectively, these findings provide experimental

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2018 Cell reports

150. Mid-axillary pacemaker re-implantation after contralateral pocket infection in an emaciated elderly case (PubMed)

Mid-axillary pacemaker re-implantation after contralateral pocket infection in an emaciated elderly case The number of implantations of cardiac implantable electrophysiological devices (CIEDs) has increased over the past several years. However, the aging population and expansion of indications for CIEDs have led to an increase in associated infections. We experienced a case of a 99-year-old man presenting with skin erosion at the pocket site, where a 6-month-old implantable pacemaker (...) was replaced. He was referred for pacemaker pocket infection and presented with fever accompanied by pain and swelling around pacemaker generator. We could not explant 7-year-old pacemaker leads and the patient refused to undergo either laser lead extraction or surgical removal. We planned to re-implant in the contralateral chest. However, the patient was emaciated with low body-mass-index (15.2 kg/m2), thus concerns arose about the possibility of tissue disruption and re-infection owing to thin skin

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2018 Journal of cardiology cases

151. Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System (PubMed)

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System The regenerative medicine field has been revolutionized by the direct conversion of one cell type to another by ectopic expression of lineage-specific transcription factors. The direct reprogramming of fibroblasts to induced cardiac myocytes (iCMs) by core cardiac transcription factors (Gata4, Mef2c, Tbx5) both in vitro and in vivo has paved the way in cardiac regeneration and repair. Several independent (...) research groups have successfully reported the direct reprogramming of fibroblasts in injured myocardium to cardiac myocytes employing a variety of approaches that rely on transcription factors, small molecules, and micro RNAs (miRNAs). Recently, this technology has been considered for local repair of the pacemaker and the cardiac conduction system. To address this, we will first discuss the direct reprograming advancements in the setting of working myocardium regeneration, and then elaborate on how

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2018 Medicines

152. A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells (PubMed)

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that pump blood around the body. Although the heart rate of humans is substantially slower than that of smaller experimental animals, current perspectives on the biophysical mechanisms underlying the automaticity of sinoatrial nodal (...) pacemaker cells (SANCs) have been gleaned largely from studies of animal hearts. Using human SANCs, we demonstrated that spontaneous rhythmic local Ca2+ releases generated by a Ca2+ clock were coupled to electrogenic surface membrane molecules (the M clock) to trigger rhythmic action potentials, and that Ca2+-cAMP-protein kinase A (PKA) signaling regulated clock coupling. When these clocks became uncoupled, SANCs failed to generate spontaneous action potentials, showing a depolarized membrane potential

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2018 Science signaling

153. Cardiac pacemaker channel (HCN4) inhibition and atrial arrhythmogenesis after releasing cardiac sympathetic activation (PubMed)

Cardiac pacemaker channel (HCN4) inhibition and atrial arrhythmogenesis after releasing cardiac sympathetic activation Clinical trials and studies with ivabradine implicate cardiac pacemaker channels (HCN4) in the pathogenesis of atrial arrhythmias. Because acute changes in cardiac autonomic tone predispose to atrial arrhythmias, we studied humans in whom profound cardiac sympathetic activation was rapidly relieved to test influences of HCN4 inhibition with ivabradine on atrial arrhythmias. We

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2018 Scientific reports

154. Subvalvular His bundle pacing for pseudo-pacemaker syndrome and mitral regurgitation (PubMed)

Subvalvular His bundle pacing for pseudo-pacemaker syndrome and mitral regurgitation 30228970 2019 02 26 2214-0271 4 9 2018 Sep HeartRhythm case reports HeartRhythm Case Rep Subvalvular His bundle pacing for pseudo-pacemaker syndrome and mitral regurgitation. 425-428 10.1016/j.hrcr.2018.06.008 Shah Ruchit R Department of Cardiac Electrophysiology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama. Kumar Vineet V Department of Cardiac Electrophysiology, University (...) of Alabama at Birmingham School of Medicine, Birmingham, Alabama. eng Case Reports 2018 06 26 United States HeartRhythm Case Rep 101656239 2214-0271 AV dyssynchrony Diastolic mitral regurgitation His bundle pacing Pacemaker Pseudo-pacemaker syndrome 2018 9 20 6 0 2018 9 20 6 0 2018 9 20 6 1 epublish 30228970 10.1016/j.hrcr.2018.06.008 S2214-0271(18)30143-X PMC6140799 J Am Coll Cardiol. 1986 Apr;7(4):768-74 3958334 Pacing Clin Electrophysiol. 2016 Dec;39(12):1298-1304 27273200 Europace. 2010 Apr;12(4):594

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2018 HeartRhythm Case Reports

155. Massive transient pulmonary air embolism during permanent cardiac pacemaker implantation (PubMed)

Massive transient pulmonary air embolism during permanent cardiac pacemaker implantation Pulmonary air embolism is a rare complication with a high probability of death. We present an air embolism case during permanent cardiac pacemaker implantation procedure. When the patient worsened hemodynamically, we saw a large air embolism in the main pulmonary trunk. Air embolism can be fatal, it is always iatrogenic, but is an avoidable complication.

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2018 Global cardiology science & practice

156. Primary Cardiac B-Non-Hodgkin Lymphoma Disguised as a Pacemaker Endocarditis (PubMed)

Primary Cardiac B-Non-Hodgkin Lymphoma Disguised as a Pacemaker Endocarditis Background  Pacemaker infections rates are high compared with the incidence of primary malignant cardiac tumors. However, they can look alike in diagnostics and patient presentation. Case Description  We hereby report a rare case of a suspected pacemaker endocarditis which in fact turned out to be a primary cardiac B cell lymphoma. The lymphoma was removed surgically. Conclusion  Sometimes we encounter the unexpected

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2018 The Thoracic and Cardiovascular Surgeon Reports

157. Large Unilateral Pleural Effusion with Pacemaker-associated Post-cardiac Injury Syndrome (PubMed)

Large Unilateral Pleural Effusion with Pacemaker-associated Post-cardiac Injury Syndrome Post-cardiac injury syndrome (PCIS) as a delayed complication of permanent pacemaker implantation has rarely been reported in the literature. A 67-year-old man who recently underwent a dual chamber permanent pacemaker implantation came to the hospital for increasing dyspnea and chest discomfort. A diagnosis of pericarditis was made, and the patient was discharged on ibuprofen therapy. He presented to our (...) . However, no conclusive evidence of cardiac chamber perforation was found on echocardiogram or CT scan. A pacemaker interrogation was normal. A repeat CT scan showed the resolution of pleural effusion, and the chest tube was discontinued. A possible explanation for the absence of predominant pericardial findings may be the previous use of non-steroidal anti-inflammatory therapy.

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2018 Cureus

158. Reprogramming to Prevent Progressive Pacemaker-induced Remodelling

Reprogramming to Prevent Progressive Pacemaker-induced Remodelling Reprogramming to Prevent Progressive Pacemaker-induced Remodelling - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Reprogramming to Prevent (...) Progressive Pacemaker-induced Remodelling (PPPR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03627585 Recruitment Status : Recruiting First Posted : August 13, 2018 Last Update Posted : November 29, 2018 See Sponsor

2018 Clinical Trials

159. Effects of Inspiratory Muscle and Endurance Training in Heart Failure Patients With Pacemaker

Effects of Inspiratory Muscle and Endurance Training in Heart Failure Patients With Pacemaker Effects of Inspiratory Muscle and Endurance Training in Heart Failure Patients With Pacemaker - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Effects of Inspiratory Muscle and Endurance Training in Heart Failure Patients With Pacemaker The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03501355 Recruitment Status : Completed First Posted : April 17, 2018 Last Update Posted : February 15, 2019 Sponsor: Gazi

2018 Clinical Trials

160. Evaluation of EMI in Patients With Micra Leadless Pacemaker

Evaluation of EMI in Patients With Micra Leadless Pacemaker Evaluation of EMI in Patients With Micra Leadless Pacemaker - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of EMI in Patients (...) With Micra Leadless Pacemaker The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03508128 Recruitment Status : Completed First Posted : April 25, 2018 Last Update Posted : August 21, 2018 Sponsor: Edward-Elmhurst Health System Information provided by (Responsible Party): Janet Gifford, Edward-Elmhurst Health

2018 Clinical Trials

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