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101. Hypoglycemic Effects of Intestinal Electrical Stimulation by Enhancing Nutrient-Stimulated Secretion of GLP-1 in Rats. (Abstract)

Hypoglycemic Effects of Intestinal Electrical Stimulation by Enhancing Nutrient-Stimulated Secretion of GLP-1 in Rats. To find out the best location for intestinal electrical stimulation (IES) to decrease hyperglycemia, and mechanisms involving intraluminal nutrients and plasma glucagon-like peptide-1 (GLP-1) MATERIALS AND METHODS: Eight rats had electrodes implanted at the duodenum and ileums for IES. The oral glucose tolerance test (OGTT) was performed with IES and sham-IES and with/without (...) the important role of intraluminal nutrients. (3) An increase in GLP-1 was noted in the OGTT with IES at the duodenum in comparison with sham-IES. Moreover, the blocking effect of exendin suggested the role of GLP-1 in the hypoglycemic effect of IES.The best stimulation location for IES to decrease hyperglycemia is in the duodenum. The hypoglycemic effect of IES is attributed to the enhancement in nutrient-stimulated release of GLP-1.

2018 Obesity Surgery

102. Therapeutic electrical stimulation of injured peripheral nerve tissue using implantable thin-film wireless nerve stimulators. (Abstract)

Therapeutic electrical stimulation of injured peripheral nerve tissue using implantable thin-film wireless nerve stimulators. OBJECTIVE Electrical stimulation of peripheral nerve tissue has been shown to accelerate axonal regeneration. Yet existing methods of applying electrical stimulation to injured peripheral nerves have presented significant barriers to clinical translation. In this study, the authors examined the use of a novel implantable wireless nerve stimulator capable (...) of simultaneously delivering therapeutic electrical stimulation of injured peripheral nerve tissue and providing postoperative serial assessment of functional recovery. METHODS Flexible wireless stimulators were fabricated and implanted into Lewis rats. Thin-film implants were used to deliver brief electrical stimulation (1 hour, 20 Hz) to sciatic nerves after nerve crush or nerve transection-and-repair injuries. RESULTS Electrical stimulation of injured nerves via implanted wireless stimulators significantly

2018 Journal of Neurosurgery

103. Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation

Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Efficacy of the Theta Burst Stimulation and Functional Electrical Stimulation in Stroke Rehabilitation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03555474 Recruitment Status : Completed First Posted : June 13, 2018 Last Update Posted : June 15, 2018

2018 Clinical Trials

104. Effects of Electric Cortical Stimulation (ECS) and Transcranial Direct Current Stimulation (tDCS) on Rats With a Traumatic Brain Injury Full Text available with Trip Pro

Effects of Electric Cortical Stimulation (ECS) and Transcranial Direct Current Stimulation (tDCS) on Rats With a Traumatic Brain Injury To evaluate the effects of electric cortical stimulation (ECS) and transcranial direct current stimulation (tDCS) on motor and cognitive function recovery and brain plasticity in focal traumatic brain injury (TBI) of rats model.Forty rats were pre-trained to perform a single pellet reaching task (SPRT), rotarod test (RRT), and Y-maze test for 14 days (...) , then a focal TBI was induced by a weight drop model on the motor cortex. All rats were randomly assigned to one of the three groups: anodal ECS (50 Hz and 194 μs) (ECS group), tDCS (0.1 mA, 50 Hz and 200 μs) (tDCS group), and no stimulation as a control group. Four-week stimulation, including rehabilitation, was started 3 days after the operation. SPRT, RRT, and Y-maze were measured from day 1 to day 28 after the TBI was induced. Histopathological and immunohistochemistry staining evaluations were

2018 Annals of rehabilitation medicine

105. Pelvic floor electrical stimulation for the treatment of urinary incontinence

Pelvic floor electrical stimulation for the treatment of urinary incontinence Pelvic floor electrical stimulation for the treatment of urinary incontinence Pelvic floor electrical stimulation for the treatment of urinary incontinence HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc.. Pelvic floor electrical stimulation for the treatment (...) of urinary incontinence. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' conclusions Purpose of Technology: Pelvic floor electrical stimulation (PFES) refers to the use of non-implanted electrodes, usually in the vagina or anus, to deliver variable rates of electrical current to the pelvic floor musculature. The mechanisms of action vary depending on the type of urinary incontinence. The goal of PFES is to improve the function of the pelvic floor musculature (PFM) in patients with stress

2016 Health Technology Assessment (HTA) Database.

106. Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures

Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc (...) .. Noninvasive electrical bone growth stimulators for acute, delayed union, and nonunion fractures. Lansdale: HAYES, Inc.. Directory Publication. 2016 Authors' conclusions Noninvasive electrical bone growth stimulators (EBGS) are external devices that deliver electrical energy to a fracture or bone fusion site. The goal is to induce osteogenesis, stimulate bone growth, and promote healing of fresh, delayed, or nonunion bone fractures and surgical joint fusions. Rationale: In 2010, there were 18.3 million

2016 Health Technology Assessment (HTA) Database.

107. Cardiac Resynchronization Therapy Using Quadripolar Versus Non‐Quadripolar Left Ventricular Leads Programmed to Biventricular Pacing With Single‐Site Left Ventricular Pacing: Impact on Survival and Heart Failure Hospitalization Full Text available with Trip Pro

Cardiac Resynchronization Therapy Using Quadripolar Versus Non‐Quadripolar Left Ventricular Leads Programmed to Biventricular Pacing With Single‐Site Left Ventricular Pacing: Impact on Survival and Heart Failure Hospitalization In cardiac resynchronization therapy (CRT), quadripolar (QUAD) left ventricular (LV) leads are less prone to postoperative complications than non-QUAD leads. Some studies have suggested better clinical outcomes.Clinical events were assessed in 847 patients after CRT (...) -pacing or CRT-defibrillation using either QUAD (n=287) or non-QUAD (n=560), programmed to single-site site LV pacing. Over a follow-up period of 3.2 years (median [interquartile range, 1.90-5.0]), QUAD was associated with a lower total mortality (adjusted hazard ratio [aHR]: 0.32, 95% confidence interval [CI], 0.20-0.52), cardiac mortality (aHR: 0.36, 95% CI, 0.20-0.65), and heart failure (HF) hospitalization (aHR: 0.62, 95% CI, 0.39-0.99), after adjustment for age, sex, New York Heart Association

2017 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

108. Left ventricular-only pacing in heart failure patients with normal atrioventricular conduction improves global function and left ventricular regional mechanics compared with biventricular pacing: an adaptive cardiac resynchronization therapy sub-study. Full Text available with Trip Pro

Left ventricular-only pacing in heart failure patients with normal atrioventricular conduction improves global function and left ventricular regional mechanics compared with biventricular pacing: an adaptive cardiac resynchronization therapy sub-study. Right ventricular (RV) pacing can impair left ventricular (LV) function. When timed with native RV activation, LV-only pacing may cause greater improvements in LV function than biventricular pacing. This study compared the chronic effects (...) of cardiac resynchronization therapy (CRT) on LV mechanics between biventricular pacing and LV-only pacing in patients with normal atrioventricular (AV) conduction.The Adaptive CRT (aCRT) algorithm provides LV-only pacing timed with native RV activation when the AV interval is normal (≤200 ms during sinus rhythm). We studied patients from the aCRT trial with normal AV conduction at their baseline visit and compared changes in cardiac function after 12 months of treatment with conventional biventricular

2017 European Journal of Heart Failure Controlled trial quality: uncertain

109. Functional Electrical Stimulation (FES) for treatment of foot drop in multiple sclerosis patients

Functional Electrical Stimulation (FES) for treatment of foot drop in multiple sclerosis patients Functional Electrical Stimulation (FES) for treatment of foot drop in multiple sclerosis patients Functional Electrical Stimulation (FES) for treatment of foot drop in multiple sclerosis patients HAYES, Inc. Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation HAYES, Inc (...) .. Functional Electrical Stimulation (FES) for treatment of foot drop in multiple sclerosis patients. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2015 Final publication URL The report may be purchased from: Indexing Status Subject indexing assigned by CRD MeSH Electric Stimulation; Gait Disorders, Neurologic; Humans; Multiple Sclerosis; Peroneal Neuropathies Language Published English Country of organisation United States English summary An English language summary is available. Address

2015 Health Technology Assessment (HTA) Database.

110. Atrial fibrillation incidence and impact of biventricular pacing on long-term outcome in patients with heart failure treated with cardiac resynchronization therapy. Full Text available with Trip Pro

Atrial fibrillation incidence and impact of biventricular pacing on long-term outcome in patients with heart failure treated with cardiac resynchronization therapy. In patients with cardiac resynchronization therapy (CRT), atrial fibrillation (AF) is associated with an unfavorable outcome and may cause loss of biventricular pacing (BivP). An effective delivery of BivP of more than 98% of all ventricular beats has been shown to be a major determinant of CRT-success.At a Swedish tertiary referral (...) center, data was retrospectively obtained from patient registers, medical records and preoperative electrocardiograms. Data regarding AF and BivP during the first year of follow-up was assessed from CRT-device interrogations. No intra-cardiac electrograms were studied. Kaplan-Meier curves and Cox-regression analyses adjusted for age, etiology of heart failure, left ventricular ejection fraction, left bundle branch block and NYHA class were performed to assess the impact of AF and BivP on the risk

2019 BMC Cardiovascular Disorders

112. Remote Monitoring of Implantable Cardioverter-Defibrillators, Cardiac Resynchronization Therapy, and Permanent Pacemakers

Remote Monitoring of Implantable Cardioverter-Defibrillators, Cardiac Resynchronization Therapy, and Permanent Pacemakers Public Comment: Held April 5 to 26, 2018. Remote Monitoring of Implantable Cardioverter- Defibrillators, Cardiac Resynchronization Therapy, and Permanent Pacemakers: Health Quality Ontario Recommendation FINAL RECOMMENDATION • Health Quality Ontario, under the guidance of the Ontario Health Technology Advisory Committee, recommends publicly funding remote monitoring (...) for patients with implantable cardioverter-defibrillators, cardiac resynchronization therapy devices with or without a defibrillator, and permanent pacemakers RATIONALE FOR THE RECOMMENDATION There was consensus among the Ontario Health Technology Advisory Committee members that using remote monitoring improves clinical outcomes without affecting patients’ safety, it is good value for money, and patients report positive experiences with using remote monitoring. 1 Remote Monitoring of Implantable

2018 Health Quality Ontario

113. The efficacy of vestibular electrical stimulation on patients with unilateral vestibular pathologies. Full Text available with Trip Pro

The efficacy of vestibular electrical stimulation on patients with unilateral vestibular pathologies. This study aims to investigate the efficacy of vestibular electrical stimulation (VES) in unilateral vestibular lesions including benign paroxysmal positional vertigo (BPPV).Between June 2007 and August 2007, a total of 19 patients diagnosed with BPPV were included in this study and they were randomized into two groups using the 1:1 method. Ten patients were administered medical treatment plus (...) VES (treatment group; 1 male, 9 females; mean age 55.8 years; range 27 to 74 years), whereas nine patients were only administered medicine (control group; 2 males, 6 females; mean age 54.9 years; range 34 to 73 years). Both groups received the same medical treatment throughout the study. Vestibular electrical stimulation was performed for 30 min long twice a day, three times a week; 12 sessions in total with 80 Hz high-frequency Transcutaneous Electrical Nerve Stimulation (TENS). Before and after

2017 Turkish journal of physical medicine and rehabilitation Controlled trial quality: uncertain

114. Ultrasonographic assessment of neuromuscular electrical stimulation efficacy on glenohumeral subluxation in patients with hemiplegia: a randomized-controlled study. Full Text available with Trip Pro

Ultrasonographic assessment of neuromuscular electrical stimulation efficacy on glenohumeral subluxation in patients with hemiplegia: a randomized-controlled study. This study aims to investigate the short-term effects of neuromuscular electrical stimulation (NMES) on glenohumeral subluxation (GHS) in stroke patients.This prospective, randomized-controlled study included 24 unilateral hemiplegic patients (10 males, 14 females; mean age 64.1±14.8 years; range 22 to 84 years) with GHS as assessed

2017 Turkish journal of physical medicine and rehabilitation Controlled trial quality: uncertain

115. Effects of periodic sensory perturbations during electrical stimulation on gait cycle period. Full Text available with Trip Pro

Effects of periodic sensory perturbations during electrical stimulation on gait cycle period. The spinal cord contains the neural circuitry needed to generate rhythmic walking motions, and afferent sensory feedbacks are involved in the control of locomotion. In this study, we examined the influence of periodic electrical stimulation on the change in gait cycle period during treadmill walking. 40 subjects walked on a treadmill while receiving periodic bursts of electrical stimulation at various (...) perturbation periods (-20, -40, -60, +20, +40 milliseconds from their initial gait cycle periods). Eleven subjects received electrical stimulation to the hamstring, and 29 received electrical stimulation to the calf. Each subject completed four trials; two trials were conducted using high amplitude stimulation causing a slight degree of joint motion, and the other two trials were conducted using reduced amplitude stimulation which did not cause observable motion. Through the trials, we sought to answer

2018 PLoS ONE

116. Effects of neuromuscular electrical stimulation on gait performance in chronic stroke with inadequate ankle control - A randomized controlled trial. Full Text available with Trip Pro

Effects of neuromuscular electrical stimulation on gait performance in chronic stroke with inadequate ankle control - A randomized controlled trial. Neuromuscular electrical stimulation (NMES) has been used to improve muscle strength and decrease spasticity of the ankle joint in stroke patients. However, it is unclear how NMES could influence dynamic spasticity of ankle plantarflexors and gait asymmetry during walking. The study aimed to evaluate the effects of applying NMES over ankle

2018 PLoS ONE Controlled trial quality: uncertain

117. Cell stimulation versus cell death induced by sequential treatments with pulsed electric fields and cold atmospheric pressure plasma. Full Text available with Trip Pro

Cell stimulation versus cell death induced by sequential treatments with pulsed electric fields and cold atmospheric pressure plasma. Pulsed electric fields (PEFs) and cold atmospheric pressure plasma (CAP) are currently both investigated for medical applications. The exposure of cells to PEFs can induce the formation of pores in cell membranes and consequently facilitate the uptake of molecules. In contrast, CAP mainly acts through reactive species that are generated in the liquid environment (...) to the respective treatments than non-tumorigenic WB-F344 cells. More cells were killed when plasma-treated medium was applied first in combination with treatments with 100-μs PEFs. For the reversed treatment order, i.e. application of PEFs first, the combination with 100-ns PEFs resulted in a stimulating effect for non-tumorigenic but not for tumorigenic cells. The results suggest that other mechanisms, besides simple pore formation, contributed to the mutually reinforcing effects of the two methods.

2018 PLoS ONE

118. Unilateral electrical stimulation of the heart 7 acupuncture point to prevent emergence agitation in children: A prospective, double-blinded, randomized clinical trial. Full Text available with Trip Pro

Unilateral electrical stimulation of the heart 7 acupuncture point to prevent emergence agitation in children: A prospective, double-blinded, randomized clinical trial. Emergence agitation (EA) is a frequent phenomenon in children recovering from general anaesthesia and increases the risk of self-injury. Previously, our group reported that stimulating the heart 7 (HT7) acupuncture point bilaterally using two neuromuscular transmission monitoring devices (NTMs) decreased the incidence of EA (...) . However, bilateral stimulation is a barrier to clinical use because two NTMs are needed for one patient.The objective of this study was to examine the efficacy of unilateral electrical stimulation of HT7 using an NTM to prevent EA in children.Prospective, double-blinded, randomized clinical trial.Kanagawa Children's Medical Centre, Yokohama, Japan.One hundred children (ages 18-96 months) with ASA-PS I or II, who were scheduled to undergo inguinal hernia repair or orchiopexy under sevoflurane

2018 PLoS ONE Controlled trial quality: predicted high

119. A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias. Full Text available with Trip Pro

A modified approach for programmed electrical stimulation in mice: Inducibility of ventricular arrhythmias. Electrophysiological studies in mice, the prevailing model organism in the field of basic cardiovascular research, are impeded by the low yield of programmed electrical stimulation (PES).To investigate a modified approach for ventricular arrhythmia (VA) induction and a novel scoring system in mice.A systematic review of literature on current methods for PES in mice searching the PubMed (...) raised both the occurrence and the duration of VA compared to conventional PES (0% vs 50%; novel VA score p = 0.0002). Particularly, coupling of >6 extrastimuli raised the induction of VA. Predominantly, premature ventricular complexes (n = 6) and ventricular tachycardia <1s (n = 4) were observed. Repeated PES after adrenergic stimulation using isoprenaline resulted in enhanced induction of ventricular tachycardia <1s in both protocols.Our findings suggest that the presented approach of modified PES

2018 PLoS ONE

120. Effects of pharyngeal electrical stimulation on swallowing performance. Full Text available with Trip Pro

Effects of pharyngeal electrical stimulation on swallowing performance. Pharyngeal electrical stimulation (PEStim) has been found to facilitate voluntary swallowing. This study investigated how PEStim contributed to modulation of swallowing function in 15 healthy humans. In the involuntary swallowing test, water was injected onto the pharynx at 0.05 ml/s and the onset latency of the first swallow was measured. In the voluntary swallowing test, subjects swallowed their own saliva as quickly

2018 PLoS ONE

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