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181. Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization? (PubMed)

Dual Activation of Phosphodiesterases 3 and 4 Regulates Basal Spontaneous Beating Rate of Cardiac Pacemaker Cells: Role of Compartmentalization? Spontaneous firing of sinoatrial (SA) node cells (SANCs) is regulated by cyclic adenosine monophosphate (cAMP)-mediated, protein kinase A (PKA)-dependent (cAMP/PKA) local subsarcolemmal Ca2+ releases (LCRs) from ryanodine receptors (RyR). The LCRs occur during diastolic depolarization (DD) and activate an inward Na+/Ca2+ exchange current

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2018 Frontiers in physiology

182. Takotsubo syndrome with severe bradycardia initiated by seizure: Is the implantation of a permanent pacemaker necessary? (PubMed)

Takotsubo syndrome with severe bradycardia initiated by seizure: Is the implantation of a permanent pacemaker necessary? Although arrhythmias are frequent in patients with Takotsubo syndrome (TTS), data on sick sinus syndrome remain elusive. Here, we report a case of TTS initiated by a seizure as a physical trigger that led to sinus arrest. The patient presented with cardiogenic shock and bradycardia which required intensive cardiovascular care. However, in the subacute phase of TTS, the sinus (...) function recovered significantly, and pacemaker implantation was deferred.© BMJ Publishing Group Limited 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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2018 BMJ case reports

183. Recurrent, late-onset pleural effusions in elderly patients receiving pacemaker therapy. (PubMed)

Recurrent, late-onset pleural effusions in elderly patients receiving pacemaker therapy. Late-onset pacemaker-related pleural effusions (PEs) are rare and are often misdiagnosed with other entities. Our study aimed to detail the clinical features and management of PEs long after pacemaker insertion.We conducted a review of 6 consecutive elderly patients with PEs, who had undergone a new pacemaker insertion from September 2014 to January 2017. Also, the clinical characteristics and therapeutic (...) courses of PEs were summarized.Two cases involved fluids after the first implantations, with pacing durations of 3 and 7 months. Two other cases developed PEs 3 or 4 months after the first replacement, with pacing durations of 6 and 11 years. Another 2 cases developed PEs 3 or 5 months following the second replacement, with total pacing durations of 16 and 18 years, respectively. The average interval was 4.17 months for the 6 cases from the time of the new pacemaker insertion to the occurrence of PEs

2018 Medicine

184. Predictors of Advanced Conduction Disturbances Requiring a Late (≥48 H) Permanent Pacemaker Following Transcatheter Aortic Valve Replacement. (PubMed)

Predictors of Advanced Conduction Disturbances Requiring a Late (≥48 H) Permanent Pacemaker Following Transcatheter Aortic Valve Replacement. This study sought to determine predictors of advanced conduction disturbances requiring late (≥48 h) permanent pacemaker replacement (PPM) after transcatheter aortic valve replacement (TAVR).Data of consecutive patients were identified by retrospective review of a TAVR database of a single center in Milan, Italy, between October 2007 and July 2015. We

2018 JACC. Cardiovascular interventions

185. Posterior Spinal Fusion in a Scoliotic Patient with Congenital Heart Block Treated with Pacemaker: An Intraoperative Technical Difficulty. (PubMed)

Posterior Spinal Fusion in a Scoliotic Patient with Congenital Heart Block Treated with Pacemaker: An Intraoperative Technical Difficulty. Case report.To describe the technical difficulties on performing posterior spinal fusion (PSF) on a pacemaker-dependent patient with complete congenital heart block and right thoracic scoliosis.Congenital complete heart block requires pacemaker implantation at birth through thoracotomy, which can result in scoliosis. Corrective surgery in this patient (...) was challenging. Height gain after corrective surgery may potentially cause lead dislodgement. The usage of monopolar electrocautery may interfere with the function of the implanted cardiac device.A 17-year-old boy was referred to our institution for the treatment of right thoracic scoliosis of 70°. He had underlying complete congenital heart block secondary to maternal systemic lupus erythematosus. Pacemaker was implanted through thoracotomy since birth and later changed for four times. PSF was performed

2018 Spine

186. Relation of Left Ventricular Fractional Shortening to Need for Permanent Pacemaker After Transcatheter Aortic Valve Implantation. (PubMed)

Relation of Left Ventricular Fractional Shortening to Need for Permanent Pacemaker After Transcatheter Aortic Valve Implantation. Transcatheter aortic valve implantation (TAVI) can potentially alter conduction system function due to the mechanical force applied to the conduction system by the proximal edge of the valve, particularly the CoreValve. Some reasons for post-TAVI advanced atrioventricular block have been identified. We investigated whether the degree of the motion of the basal left (...) ventricular (LV) walls impacted the development of advanced atrioventricular block post-TAVI. A total of 407 patients (82.1 ± 6.2 years) without prior permanent pacemakers (PPMs) underwent TAVI using CoreValve (70%) or Edwards-SAPIEN (30%) prosthetic devices. The LV fractional shortening (FS) of the basal segments was measured in each patient, and the association between FS and PPM requirement, or new-onset left bundle branch block (LBBB) was evaluated. During hospitalization, 64 patients (15.7%) required

2018 American Journal of Cardiology

187. Delayed pacemaker requirement after transcatheter aortic valve implantation with a new-generation balloon expandable valve: Should we monitor longer? (PubMed)

Delayed pacemaker requirement after transcatheter aortic valve implantation with a new-generation balloon expandable valve: Should we monitor longer? To analyze the timing of appearance of conduction abnormalities (CAs) after transcatheter aortic valve implantation (TAVI), to identify predictors of delayed CAs requiring pacemaker (PM) implantation and to provide guidance regarding the duration of telemetry monitoring.How long patients remain at risk of development of CAs requiring PM

2018 International journal of cardiology

188. Updated Performance of the Micra Transcatheter Pacemaker in the Real-World Setting: A Comparison to the Investigational Study and a Transvenous Historical Control. (PubMed)

Updated Performance of the Micra Transcatheter Pacemaker in the Real-World Setting: A Comparison to the Investigational Study and a Transvenous Historical Control. Early results of the Micra Investigational Device Exemption (IDE) study and Micra Post-Approval Registry (PAR) demonstrated excellent safety and efficacy performance; however, intermediate-term results across a large patient population in the real-world setting have not been evaluated.We report updated performance of the Micra (...) transcatheter pacemaker from a worldwide PAR and compare it with the IDE study as well as a transvenous historical control.The safety objective of the analysis was system- or procedure-related major complications through 12 months postimplantation. We compared the major complication rate with that of the 726 patients from the IDE and with a reference data set of 2667 patients with transvenous pacemakers by using a Fine-Gray competing risk model.The Micra device was successfully implanted in 1801 of 1817

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2018 Heart Rhythm

189. The Diagnosis and Treatment of Pacemaker-Associated Infection. (PubMed)

The Diagnosis and Treatment of Pacemaker-Associated Infection. Approximately 105 000 cardiac electronic devices are newly implanted in Germany each year. Germany has the highest implantation rate with respect to population of any European country. Infections in cardiac implants are serious complications, with an associated in-hospital mortality of 5-15%. It is thus very important to optimize the diagnostic and therapeutic strategies by which such infections can be detected early and treated

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2018 Deutsches Arzteblatt international

190. Cause of the “power-on reset” phenomenon other than electric magnetic interference in a patient with a pacemaker (PubMed)

Cause of the “power-on reset” phenomenon other than electric magnetic interference in a patient with a pacemaker A 67-year old male with a dual-chamber pacemaker visited for a regular check-up. An unfamiliar message emerged on the display just after placing the programmer wand. We could recognize that the pacemaker had already been in the safe back-up mode of DDI, and the programmer prompted a re-initialization request. We are so surprised because there was no indication of device (...) malfunction the day before in daily monitoring and a 12-lead electrocardiogram revealed normally working in the DDD mode just before checking the device. The pacemaker was immediately re-programmed to the former setting. This phenomenon has not recurred for 12 months.Copyright © 2018 Indian Heart Rhythm Society. Production and hosting by Elsevier B.V. All rights reserved.

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2018 Indian pacing and electrophysiology journal

191. The Composition and Structure of Biofilms Developed by Propionibacterium acnes Isolated from Cardiac Pacemaker Devices (PubMed)

The Composition and Structure of Biofilms Developed by Propionibacterium acnes Isolated from Cardiac Pacemaker Devices The present study aimed to understand the biofilm formation mechanism of Propionibacterium acnes by analyzing the components and structure of the biofilms. P. acnes strains were isolated from the surface of explanted cardiac pacemaker devices that exhibited no clinical signs of infection. Culture tests using a simple stamp culture method (pressing pacemakers against the surface (...) of agar plates) revealed frequent P. acnes colonization on the surface of cardiac pacemaker devices. P. acnes was isolated from 7/31 devices, and the isolates were categorized by multilocus sequence typing into five different sequence types (STs): ST4 (JK18.2), ST53 (JK17.1), ST69 (JK12.2 and JK13.1), ST124 (JK5.3), ST125 (JK6.2), and unknown ST (JK19.3). An in vitro biofilm formation assay using microtiter plates demonstrated that 5/7 isolates formed biofilms. Inhibitory effects of DNase I

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2018 Frontiers in microbiology

192. How to recognize silent atrial fibrillation in pacemakers and defibrillators—the value of atrial electrograms (PubMed)

How to recognize silent atrial fibrillation in pacemakers and defibrillators—the value of atrial electrograms Today's pacemakers and defibrillators include diagnostic tools for detecting and treating cardiac arrhythmias like silent atrial fibrillation as atrial high rate episodes (AHREs). This diagnostic capability is crucial to prevent the potential embolic complications this AHREs are related to. However, sometimes data retrieved from diagnostic counters may be misleading reflecting

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2018 Journal of thoracic disease

193. Takotsubo cardiomyopathy after pacemaker implantation (PubMed)

Takotsubo cardiomyopathy after pacemaker implantation 29721007 2018 11 14 1671-5411 15 3 2018 Mar Journal of geriatric cardiology : JGC J Geriatr Cardiol Takotsubo cardiomyopathy after pacemaker implantation. 246-248 10.11909/j.issn.1671-5411.2018.03.010 Wei Zhong-Hai ZH Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Dai Qing Q Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Wu Han H (...) Pacemaker Takotsubo cardiomyopathy Ventriculography 2018 5 4 6 0 2018 5 4 6 0 2018 5 4 6 1 ppublish 29721007 10.11909/j.issn.1671-5411.2018.03.010 jgc-15-03-246 PMC5919816 J Cardiol. 1991;21(2):203-14 1841907 Int J Cardiol. 2013 Jul 1;166(3):584-8 22192296 Heart Fail Clin. 2013 Apr;9(2):243-7, x 23562125 N Engl J Med. 2015 Sep 3;373(10 ):929-38 26332547 Circ J. 2002 Dec;66(12 ):1181-4 12499630 Eur Heart J. 2006 Jul;27(13):1523-9 16720686 Eur J Heart Fail. 2016 Jan;18(1):8-27 26548803 Chest. 2007 Sep;132

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2018 Journal of geriatric cardiology : JGC

194. A Case of Pacemaker Endocarditis Caused by Aerococcus urinae (PubMed)

A Case of Pacemaker Endocarditis Caused by Aerococcus urinae Aerococcus urinae has lately been acknowledged as a cause of infective endocarditis (IE) especially in older males with underlying urinary tract disorders. In this population, cardiac implanted electronical devices (CIED) are not uncommon, but despite the capacity of A. urinae to form biofilm in vitro, no cases of aerococcal CIED infections have been reported to date.An 84-year-old male with pacemaker was admitted with dysuria one (...) the tricuspid valve or one of the pacing cables. The pacemaker system was completely removed and demonstrated macroscopic signs of infection. A temporary system was implanted, and after 14 days of penicillin G treatment, a new system permanent system was implanted. Total treatment time was 40 days. Recovery was uneventful.This report demonstrates that A. urinae can cause CIED infection. In patients with A. urinae bacteremia and a CIED, this risk must be considered, especially if bacteremia reoccurs.

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2018 Case reports in infectious diseases

195. Intracardiac Abscess and Pacemaker Lead Infection Secondary to Hematogenous Dissemination of Methicillin-Sensitive Staphylococcus Aureus from a Prior Diabetic Foot Ulcer and Osteomyelitis (PubMed)

Intracardiac Abscess and Pacemaker Lead Infection Secondary to Hematogenous Dissemination of Methicillin-Sensitive Staphylococcus Aureus from a Prior Diabetic Foot Ulcer and Osteomyelitis BACKGROUND Intracardiac abscesses are an unusual occurrence in developed countries. With the increase in use of implantable cardiac devices, the increase use of and advancements in antibiotics, and the longevity of patients with cardiac devices, one may expect an increase in such infections; however, case (...) reports are rare. We are presenting a case in which hematogenous dissemination of methicillin-sensitive Staphylococcus aureus (MSSA) infection from a lower extremity diabetic ulcer propagated into an infected pacemaker lead and ultimately an intracardiac abscess of the right atrium. CASE REPORT A 77-year-old male with a history of MSSA diabetic foot infection complicated by osteomyelitis presented with fever, syncope, and wide complex tachycardia, and he was found to have an intracardiac abscess

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2018 The American journal of case reports

196. Successful percutaneous retrieval of unusually knotted temporary pacemaker lead (PubMed)

Successful percutaneous retrieval of unusually knotted temporary pacemaker lead Implantation of temporary pacemaker lead is commonly performed procedure and is usually safe, but can sometimes develop rare and serious complication like intracardiac lead knotting which may require challenging retrieval techniques. We report a case of successful percutaneous retrieval of unusually knotted right internal jugular venous temporary pacing lead via left femoral transvenous approach using snare over

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2018 Indian pacing and electrophysiology journal

197. Pacemaker implantation in a challenging anatomy: isolated persistent left superior vena cava and azygos continuation of interrupted inferior vena cava (PubMed)

Pacemaker implantation in a challenging anatomy: isolated persistent left superior vena cava and azygos continuation of interrupted inferior vena cava Isolated persistent left superior vena cava (SVC) in the absence of right SVC is a rare congenital variant of thoracic venous drainage with the left subclavian and jugular veins that drain into the right atrium through the coronary sinus. Inferior vena cava interruption with azygos continuation is another congenital anomaly resulting in venous (...) drainage of the lower extremities via a typically dilated azygos vein. Although both variants are generally asymptomatic and incidentally detected, these can have clinical implications in specific circumstances and in particular during device implantation. We report a case of pacemaker implantation in which both anatomical variants were present.

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2018 Clinical Case Reports

198. Increased healthcare utilization associated with complete atrioventricular block in pacemaker patients (PubMed)

Increased healthcare utilization associated with complete atrioventricular block in pacemaker patients The purpose of the current study is to characterize and quantify the impact of complete atrioventricular block (cAVB) on heart failure hospitalization (HFH) and healthcare utilization in pacemaker (PM) patients.Patients ≥ 18 years implanted with a dual-chamber PM from April 2008 to March 2014 were selected from the MarketScan® Commercial and Medicare Supplemental claims databases. Patients

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2018 Journal of Interventional Cardiac Electrophysiology

199. Transcatheter aortic valve implantation with a mechanically expandable prosthesis: a learning experience for permanent pacemaker implantation rate reduction (PubMed)

Transcatheter aortic valve implantation with a mechanically expandable prosthesis: a learning experience for permanent pacemaker implantation rate reduction Permanent pacemaker implantation (PPMI) after transcatheter aortic valve implantation (TAVI) remains an issue open for criticism. Aim of this study is to investigate a strategy to reduce PPMI rate after TAVI in general and more specifically after implantation of the LOTUS® prosthesis.Through our learning curve, we have developed

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2018 European Journal Of Medical Research

200. Right Ventricle Perforation Post Pacemaker Insertion Complicated with Cardiac Tamponade (PubMed)

Right Ventricle Perforation Post Pacemaker Insertion Complicated with Cardiac Tamponade Pacemaker-lead-associated right ventricular perforation is a life-threatening complication. Acute perforation usually presents within 24 hours. Patients with lead perforation are often asymptomatic but fatal complications like hemopericardium, leading to cardiac tamponade and death, are reported. Diagnosis is based on chest x-ray, computed tomography (CT) scan, and echocardiography. The management

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2018 Cureus

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