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Otosclerosis

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2. Cochlear Implant Users with Otosclerosis: Are Hearing and Quality of Life Outcomes Worse than in Cochlear Implant Users without Otosclerosis? (Abstract)

Cochlear Implant Users with Otosclerosis: Are Hearing and Quality of Life Outcomes Worse than in Cochlear Implant Users without Otosclerosis? The otosclerotic process may influence the performance of the cochlear implant (CI). Difficulty in inserting the electrode array due to potential ossification of the cochlea, facial nerve stimulation, and instability of the results are potential challenges for the CI team.To evaluate hearing results and subjective outcomes of CI users with otosclerosis (...) months, and at the last follow-up.Subjects were 22 CI users with otosclerosis and 217 without otosclerosis. Both groups had a similar duration of deafness and age at CI implantation. Results did not significantly differ according to group: no significant intergroup difference was found regarding the frequency of complete electrode insertion, facial stimulation, reimplantation, or PTA4 scores at the last follow-up. Regarding speech perception, no significant intergroup difference was found on any test

2019 Audiology & Neuro-Otology

3. Effect of CO2 laser for the management of primary otosclerosis: A protocol for systematic review and meta-analysis. Full Text available with Trip Pro

Effect of CO2 laser for the management of primary otosclerosis: A protocol for systematic review and meta-analysis. This study will explore the effect and safety of CO2 laser (COL) for the management of patients with primary otosclerosis (PO).The following electronic databases will be searched from inception to the present: PUBMED, EMBASE, The Cochrane Library, Web of Science, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese

2020 Medicine

4. GPER-1 and sex-hormone levels in patients with otosclerosis. (Abstract)

GPER-1 and sex-hormone levels in patients with otosclerosis. Otosclerosis is a widespread disease but the etiopathogenesis is still not fully understood. Hormonal factors especially estrogens are accused in recent years. The study aimed to evaluate the levels of G-protein associated membrane estrogen receptor-1 (GPER-1) and sex-hormones in patients with otosclerosis.The study included 60 people (30 otosclerosis patients, 30 control group). Serum sex-hormone (estradiol, progesterone, prolactin (...) and total testosterone) and GPER-1 levels were measured in otosclerosis patients and compared with the normal population. For the otosclerosis group, air conduction and bone conduction thresholds and air-bone gaps were viewed from audiograms and the relationships between hearing and GPER-1 or sex-hormone levels were also investigated.Sex-hormone levels were not different between the groups. GPER-1 level was significantly lower in the otosclerosis group [3.1353 (0.76-8.21) ng/mL] than the control group

2020 American Journal of Otolaryngology

5. Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis. Full Text available with Trip Pro

Osteoprotegerin gene polymorphisms and otosclerosis: an additional genetic association study, multilocus interaction and meta-analysis. Otosclerosis (OTSC) is among the most common causes of a late-onset hearing loss in adults and is characterized by an abnormal bone growth in the otic capsule. Alteration in the osteoprotegerin (OPG) expression has been suggested in the implication of OTSC pathogenesis.A case-control association study of rs2228568, rs7844539, rs3102734 and rs2073618 single

2020 BMC Medical Genetics

6. Sensitivity of High-Resolution Computed Tomography in Otosclerosis Patients undergoing Primary Stapedotomy. (Abstract)

Sensitivity of High-Resolution Computed Tomography in Otosclerosis Patients undergoing Primary Stapedotomy. To determine the incidence of abnormal otospongiotic or otosclerotic findings on high-resolution computed tomography (HRCT) as read by local radiologists in patients with surgically-confirmed otosclerosis.Retrospective chart review.Tertiary-referral private otology-neurotology practice.Adults (>18 years old) with surgically-confirmed otosclerosis between 2012 and 2017 with a HRCT (...) performed preoperatively.Preoperative HRCT then stapedotomy.Positive identification and location of radiographic otosclerosis as reported by the local radiologist. We then correlated the CT with surgical location as documented at time of surgery. Audiometry, demographic data, intraoperative findings, and surgical technique were secondarily reviewed.Of the 708 stapes surgeries were performed during the study time frame. Preoperative HRCT scans were available for 68 primary stapedotomy surgeries performed

2020 Rhinology and Laryngology

7. Third‐generation bisphosphonates for cochlear otosclerosis stabilizes sensorineural hearing loss in long‐term follow‐up Full Text available with Trip Pro

Third‐generation bisphosphonates for cochlear otosclerosis stabilizes sensorineural hearing loss in long‐term follow‐up To assess long-term hearing outcomes in patients treated with third-generation bisphosphonates for otosclerosis-related progressive sensorineural hearing loss (SNHL).Retrospective case series review.We performed a retrospective case series review of patients with otosclerosis and progressive SNHL. Patients were treated with either risedronate or zoledronate after (...) a diagnosis of otosclerosis with a significant SNHL component. Bone conduction pure tone threshold averages (BC-PTAs) and word recognition scores (WRS) before and after bisphosphonate administration in long-term follow-up was analyzed. Significant change in BC-PTA was defined as greater than 10dB or between 4% and 18% in WRS based on binomial variance.Seven patients were identified and 14 ears met inclusion criteria. Three patients were female and the mean age was 48.3 ± 10.3 years. The mean duration

2017 Laryngoscope investigative otolaryngology

8. Tinnitus Severity Change Following Stapedotomy in Patients With Otosclerosis. (Abstract)

Tinnitus Severity Change Following Stapedotomy in Patients With Otosclerosis. To determine whether stapedotomy was effective in reducing tinnitus severity. In addition, the relationship between reduction in tinnitus and improvement in hearing after stapedotomy was analyzed.Prospective clinical study.Tertiary referral center.A group of 168 otosclerosis patients diagnosed with chronic tinnitus.Stapedotomy.The Tinnitus Functional Index questionnaire (TFI) was used to assess tinnitus severity

2019 Otology and Neurotology

9. Utility of Perilymph microRNA Sampling for Identification of Active Gene Expression Pathways in Otosclerosis. (Abstract)

Utility of Perilymph microRNA Sampling for Identification of Active Gene Expression Pathways in Otosclerosis. Profiling of microRNA (miRNA) within perilymph samples collected at the time of stapedectomy can be used to identify active gene expression pathways in otosclerosis as compared with controls.miRNAs are small non-coding RNAs that effect gene expression by post-transcription regulation and silencing. Perilymph sampling allows for a novel way to collect material actively involved (...) in the disease process.Perilymph was collected at time of stapedectomy, underwent a microarray analysis, and significantly expressed miRNAs were correlated to known bone morphology pathways using a cochlear transcriptome library. To determine miRNA related specifically to otosclerosis, cochlear implant controls were used for statistical analysis.A total of 321 significantly expressed miRNAs were identified within the four otosclerosis perilymph samples. miRNAs associated with 23 genes involved in bone

2019 Otology and Neurotology

10. Increased Maternal Serum Placental Growth Hormone Variant in Pregnancies Complicated by Otosclerosis. Full Text available with Trip Pro

Increased Maternal Serum Placental Growth Hormone Variant in Pregnancies Complicated by Otosclerosis. To investigate the potential role of maternal serum concentrations of placental growth hormone variant (GH-V), insulin-like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 in pregnancies complicated by otosclerosis.Otosclerosis cases (n = 22) and age, ethnicity-matched controls (n = 22) were selected in a nested case-control study. Maternal serum hormone concentrations (...) at 26 and 34 weeks of gestation were determined by enzyme-linked immunosorbent assay (ELISA).Concentrations of all measured hormones except IGFBP-1 were increased as gestation progressed. Maternal serum GH-V concentrations at 26 and 34 weeks of gestation were significantly increased in the otosclerosis group, when compared to the control group (2.53 ± 0.17 ng/ml vs. 1.78 ± 0.19 ng/ml, p = 0.036; 4.34 ± 0.31 ng/ml vs. 3.12 ± 0.18 ng/ml, p < 0.001, respectively). Maternal serum IGF-1 concentrations

2019 Clinical Otolaryngology

11. Failure to close the gap: Concomitant superior canal dehiscence in otosclerosis patients. (Abstract)

Failure to close the gap: Concomitant superior canal dehiscence in otosclerosis patients. Superior semicircular canal dehiscence (SSCD) causing conductive hearing loss with present reflexes is a known reason for stapes surgery failure. However, concomitant SSCD and otosclerosis occur rarely. We present a case series of SSCD diagnosed in positively identified otosclerosis patients.Retrospective review of clinical case series in two tertiary-referral neurotologic practices was performed. Clinical (...) histories, operative findings, audiograms, and computed tomography (CT) images were reviewed for patients diagnosed with both SSCD and otosclerosis. Patients with present stapedial reflexes were excluded. Comprehensive literature review was performed.Four cases were identified. Three reported improved hearing with partial or complete closure of the air-bone gap (ABG), including one patient with far-advanced otosclerosis. One patient had no improvement in pure tone average or ABG. One patient reported

2019 Laryngoscope

12. Diagnostic Protocol for Detecting Otosclerosis on High-Resolution Temporal Bone CT. (Abstract)

Diagnostic Protocol for Detecting Otosclerosis on High-Resolution Temporal Bone CT. To present a systematic checklist to improve diagnosing otosclerosis (OS) on high-resolution computed tomography (HRCT) of the temporal bones and review this protocol's efficacy in diagnosing OS on HRCT.A retrospective case series was performed at a University Referral Hospital in urban Chicago, Illinois. High-resolution computed tomographies of the temporal bone were reviewed including 17 ears in the test group

2019 Rhinology and Laryngology

13. Promontory osteoma mimicking otosclerosis: case report. (Abstract)

Promontory osteoma mimicking otosclerosis: case report. This case report presents a middle-ear osteoma mimicking otosclerosis that was located at the promontory. The osteoma was successfully excised using an endoscopic transcanal approach without any complication.A 21-year-old man presented with a 4-year history of progressive conductive hearing loss (47 dB with a 30-dB air-bone gap) with intermittent tinnitus of recent onset in his right ear. Endoscopic transcanal middle-ear exploration showed

2019 Journal of Laryngology & Otology

14. Our experience of stapes superstructure and incudostapedial joint preservation in otosclerosis surgery. (Abstract)

Our experience of stapes superstructure and incudostapedial joint preservation in otosclerosis surgery. 30793516 2019 03 15 1749-4486 2019 Feb 21 Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery Clin Otolaryngol Our experience of stapes superstructure and incudostapedial joint preservation in otosclerosis surgery. 10.1111/coa.13321 Patel Anant A Norfolk & Norwich University Hospitals, Norwich, UK (...) . Prinsley Peter P Norfolk & Norwich University Hospitals, Norwich, UK. James Paget University Hospitals, Norwich, UK. eng Letter 2019 02 21 England Clin Otolaryngol 101247023 1749-4478 conductive hearing loss otosclerosis stapedectomy stapes surgery 2018 09 29 2019 02 07 2019 02 15 2019 2 23 6 0 2019 2 23 6 0 2019 2 23 6 0 aheadofprint 30793516 10.1111/coa.13321

2019 Clinical Otolaryngology

15. Modified-Power-Piston: Short-Incudial-Process-Vibroplasty and Simultaneous Stapedotomy in Otosclerosis. Full Text available with Trip Pro

Modified-Power-Piston: Short-Incudial-Process-Vibroplasty and Simultaneous Stapedotomy in Otosclerosis. If mixed-hearing-loss (MHL) occurs in otosclerosis, hearing-aids (HA) in addition to conventional-stapedotomy (SDT) may be necessary. If otosclerosis progresses or technical or medical problems prevent use of HA, combining active-middle-ear-implants (AMEI) with SDT ("power-piston") may be considered. Previously, AMEI-coupling to the long-incudial-process was suggested. Here, a "modified-power (...) -19.7 dB-HL; p = 0.991). ABG-PTA improved from 28.8 to 10.4 and from 29.1 to 9.6 dB-HL for mPP and SDT, respectively (Δ -18.3 versus -19.5 dB-HL; p = 0.771).In otosclerosis with MHL and limited satisfaction with HA, mPP appeared as safe and effective as SDT and may be considered a treatment alternative in these patients.

2019 Otology and Neurotology

16. The Epidemiology of Otosclerosis in a British Cohort. Full Text available with Trip Pro

The Epidemiology of Otosclerosis in a British Cohort. To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017.Retrospective cohort study.Five UK ENT Departments.Patients with surgically confirmed otosclerosis.Questionnaire data documented family history of otosclerosis, age of onset, medical history, and information on associated risk factors for 657 patients. Pre and post-surgical pure-tone audiometry was collected for 154 of these patients.The age (...) of onset, incidence of bilateral disease, tinnitus and vertigo, a higher prevalence of women (65%) than men (35%) are similar to those reported previously for otosclerosis cohorts. No association with measles infection was detected. Patients with a family history (40%) have an earlier age of onset and a higher incidence of bilateral disease and vertigo than non-familial subjects. Pedigree analysis is consistent with an autosomal dominant inheritance with reduced penetrance being apparent in 44/91

2019 Otology and Neurotology

17. Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis. Full Text available with Trip Pro

Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis. Patients with otosclerosis more often complain about postoperative taste disturbance than patients with chronic otitis media, which seems paradoxical. We aim to investigate if and potentially why this seems to be the case, since the chorda tympani nerve (CTN) is thought to be severely traumatized less frequently during surgery in the former than in the latter.Prospective cohort study.Department (...) of Otorhinolaryngology at Hospital of Vastmanland, Vasteras, Sweden.Sixty-five adults undergoing primary middle ear surgery were included. Thirty-seven were operated on for chronic suppurative otitis media with or without cholesteatoma (CSOM) and 28 for otosclerosis.Middle ear surgery due to otosclerosis or CSOM. Subjective and objective taste measurements and quality of life (QoL) questionnaire.Taste was assessed using electrogustometry (EGM) and the filter paper disc (FPD) method before and up to 1 year after

2019 Otology and Neurotology

18. High-Resolution Computed Tomography of the Inner Ear: Effect of Otosclerosis on Cochlear Aqueduct Dimensions. (Abstract)

High-Resolution Computed Tomography of the Inner Ear: Effect of Otosclerosis on Cochlear Aqueduct Dimensions. The cochlear aqueduct is a bony duct connecting the scala tympani with the subarachnoid space. Given the pathophysiology of otosclerosis, including bone resorption and new bone deposition, we hypothesize that the cochlear aqueduct in otosclerotic ears is narrowed.A retrospective review of patients with otosclerosis who have undergone high-resolution computed tomography (HRCT (...) ) of the temporal bone was completed. The control cohort included 20 patients with the diagnosis of noise-induced hearing loss, without the diagnosis of otosclerosis. Uniform measurements of cochlear aqueduct dimensions were performed using the axial plane.The otosclerosis cohort included 25 males and 52 females with mean age of 52.2 ± 17.6 years. The control group included 10 males and 10 females with mean age of 64.0 ± 18.5 years. The mean cochlear aqueduct length, width mid canal, aperture base, aperture

2019 Rhinology and Laryngology

19. Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops. (Abstract)

Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops. Endolymphatic hydrops (EH) has been reported in ears with otosclerosis. The objective of this study was to investigate the clinical features of ears with otosclerosis and EH on magnetic resonance imaging (MRI) and identify predictors for the presence of EH.Retrospective study.University hospital.Forty-six ears from 37 patients with otosclerosis were included in the present study.The subjects were divided into three groups (...) vestibular EH (26.1%). Average thresholds in ears with significant EH were significantly higher at several frequencies, both on air and bone conduction, than those with no or mild EH. Significant EH was more frequently observed in ears with advanced stages on CT than in those without advanced stages. The values of blood flow in the area anterior to the oval window were higher in some ears with EH than in ears without EH.EH was frequently present in ears with otosclerosis, especially those with severe

2019 Otology and Neurotology

20. Involvement of the Internal Auditory Canal in Subjects With Cochlear Otosclerosis: A Less Acknowledged Third Window That Affects Surgical Outcome. (Abstract)

Involvement of the Internal Auditory Canal in Subjects With Cochlear Otosclerosis: A Less Acknowledged Third Window That Affects Surgical Outcome. To investigate the effects of cavitating lesions involving the internal auditory canal (IAC) in subjects with cochlear otosclerosis with regard to poststapedotomy hearing outcome.Retrospective study.Tertiary referral center.A retrospective chart review of 134 subjects with otosclerosis treated from January 2011 to June 2017 at Seoul National (...) University Bundang Hospital was conducted. Sixteen subjects (23 ears) with temporal bone computed tomography (TBCT)-confirmed cochlear otosclerosis who underwent stapedotomy were included in the study.Pure tone audiometry (PTA) (i.e., air and bone conduction; AC and BC, respectively) thresholds and air-bone gap (ABG), measured at 6 months postoperatively were compared between cochlear otosclerosis with and without IAC involvement (IAC group and non-IAC group, respectively).A total of 14 of 23 ears showed

2019 Otology and Neurotology

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