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Osteomyelitis in Sickle Cell Anemia

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1. Chronic Active Parietal Osteomyelitis Due to Salmonella typhi in a Patient with Sickle Cell Anemia Full Text available with Trip Pro

Chronic Active Parietal Osteomyelitis Due to Salmonella typhi in a Patient with Sickle Cell Anemia 28685705 2018 10 05 2018 11 13 1308-5263 34 4 2017 12 01 Turkish journal of haematology : official journal of Turkish Society of Haematology Turk J Haematol Chronic Active Parietal Osteomyelitis Due to Salmonella typhi in a Patient with Sickle Cell Anemia. 358-359 10.4274/tjh.2017.0094 Antar Ahmad A Almoosa Specialist Hospital, Department of Internal Medicine, Division of Hematology-Oncology, Al (...) 9606065 1300-7777 IM Anemia, Sickle Cell complications diagnostic imaging microbiology Chronic Disease Female Humans Magnetic Resonance Imaging Middle Aged Osteomyelitis complications diagnostic imaging microbiology Salmonella typhi isolation & purification 2017 7 8 6 0 2018 10 6 6 0 2017 7 8 6 0 ppublish 28685705 10.4274/tjh.2017.0094 PMC5774349 Int J Infect Dis. 2010 Jan;14(1):e2-e12 19497774 Medicine (Baltimore). 1971 Mar;50(2):97-112 4944120 Br J Haematol. 2005 May;129(4):482-90 15877730 J Infect

2017 Turkish Journal of Hematology

2. Jaw Osteomyelitis as a Complication of Sickle Cell Anaemia in Three Omani Patients: Case reports and literature review Full Text available with Trip Pro

Jaw Osteomyelitis as a Complication of Sickle Cell Anaemia in Three Omani Patients: Case reports and literature review Sickle cell anaemia (SCA) is a common haemoglobinopathy among people from the Middle East, the Afro-Caribbean region, the Mediterranean and East India. While osteomyelitis of the long bones is a well-documented complication of SCA, there are few documented cases of SCA patients presenting with jaw osteomyelitis. We report three SCA patients with chronic jaw osteomyelitis who (...) presented to the Department of Oral Health, Sultan Qaboos University Hospital, Muscat, Oman, between 2009 and 2013. Two of the patients had osteomyelitis of the mandible and the third had osteomyelitis of the maxilla. In addition, a brief review of the literature is presented focusing on the clinical presentation, diagnosis and management of jaw osteomyelitis among patients with SCA.

2017 Sultan Qaboos University medical journal

3. Osteomyelitis in Sickle Cell Anemia

Osteomyelitis in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Osteomyelitis (...) in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Aka: Osteomyelitis in Sickle Cell Anemia From Related Chapters II. Pathophysiology Infection of infarcted bone, especially long bones (multiple sites in same bone may be involved) III. Causes Most common organism in Staphylococcal Aureus (<25% of cases) IV. Signs duration directly correlates with likelihood of (risk increases 80% each day of fever) Extremity swelling likelihood increases 8.4 fold Bone pain likelihood increases 20% each day

2018 FP Notebook

4. Guidelines on autopsy practice: Autopsy in sickle cell disease and persons with sickle trait

are not clear. [Level of evidence: GPP.] 14 Examples of cause of death opinions/statements 1a. Acute cardio-respiratory failure 1b. Acute chest syndrome following painful crisis 1c. Sickle cell disease 1a. Anaemia 1b. Hepato-splenic sequestration 1c. Sickle cell disease 1a. Severe sepsis 1b. Pneumococcal bacteraemia 1c. Sickle cell disease 1a. Cardiopulmonary failure/cor pulmonale 1b. Chronic sickle pulmonary arteriopathy 1c. Sickle cell disease 1a. Subarachnoid haemorrhage 1b. Chronic sickle cerebral (...) 2000;342: 1855 1865. 11 De Castro LM, Jonassaint JC, Graham FL, Ashley-Koch A, Telen MJ. Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes. Am J Haematol 2008;83:19 25. 12 Gladwin MT. Cardiovascular complications and risk of death in sickle cell disease. Lancet 2016;387:2565 2574. 13 Inusa B, Casale M, Booth C, Lucas SB. Subarachnoid haemorrhage and cerebral vasculopathy in a child with sickle cell anaemia. BMJ Case Rep 2014; doi:10.1136

2017 Royal College of Pathologists

5. Crizanlizumab, Voxelotor, and L-Glutamine for Sickle Cell Disease: Effectiveness and Value

Crizanlizumab, Voxelotor, and L-Glutamine for Sickle Cell Disease: Effectiveness and Value ©Institute for Clinical and Economic Review, 2020 Crizanlizumab, Voxelotor, and L-Glutamine for Sickle Cell Disease: Effectiveness and Value Evidence Report March 12, 2020 Prepared for ©Institute for Clinical and Economic Review, 2020 Page ii Evidence Report – Crizanlizumab, Voxelotor, and L-Glutamine for SCD None of the above authors disclosed any conflicts of interest. How to cite this document: Bradt P (...) , Spackman E, Synnott PG, Chapman R, Beinfeld M, Rind DM, Pearson SD. Crizanlizumab, Voxelotor, and L-Glutamine for Sickle Cell Disease: Effectiveness and Value. Institute for Clinical and Economic Review, January 23, 2020. https://icer-review.org/material/sickle-cell-disease-draft-evidence-report/ DATE OF PUBLICATION: March 12, 2020 Pamela Bradt served as the lead author for the report. Patricia Synnott led the systematic review and authorship of the comparative clinical effectiveness section

2020 California Technology Assessment Forum

6. Vitamin D supplementation for sickle cell disease. Full Text available with Trip Pro

-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis). With increased catabolism and deficits in energy and nutrient intake, individuals with sickle cell disease suffer multiple macro- and micro-nutritional deficiencies, including vitamin D deficiency. Since vitamin D maintains calcium homeostasis and is essential for bone mineralisation, its deficiency may worsen musculoskeletal health problems encountered in sickle cell disease. Therefore, there is a need to review the effects (...) .Randomised controlled studies and quasi-randomised controlled studies (controlled clinical studies) comparing oral administration of any form of vitamin D supplementation to another type of vitamin D or placebo or no supplementation at any dose and for any duration, in people with sickle cell disease, of all ages, gender, and phenotypes including sickle cell anaemia, haemoglobin sickle cell disease and sickle beta-thalassaemia diseases.Two authors independently extracted the data and assessed the risk

2017 Cochrane

7. CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders

] List 4 intrinsic and 4 extrinsic causes of hemolytic anemia Refer to box 112.8 for intrinsic and extrinsic causes of hemolytic anemia Intrinsic Causes of Hemolytic Anemia Enzyme defect (pyruvate kinase deficiency, G6PD deficiency) Membrane defect (spherocytosis, elliptostomatocytosis, paroxysmal nocturnal hemoglobinuria) Hemoglobin defect (Thalassemias, hemoglobin M, unstable hemoglobin, sickle cell) Extrinsic Causes of Hemolytic Anemia Immunologic (allo or autoantibodies) Mechanical (...) will have specific RBC morphologies suggesting etiology (bite cells, sickle cells, spherocytes, spur cells, Howell-Jolly bodies, etc.) Intravascular – peripheral smear will predominantly show schistocytes (RBC fragments) [17] Which types of hemolytic anemia tend to be intravascular? Which are extravascular? Extravascular – enzyme/membrane/hemoglobin defects, autoimmune hemolysis, toxins, hypersplenism Intravascular – MAHA (DIC, TTP, HUS), transfusion reactions, sepsis, heat injury, paroxysmal nocturnal

2017 CandiEM

8. Osteomyelitis in Sickle Cell Anemia

Osteomyelitis in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Osteomyelitis (...) in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Aka: Osteomyelitis in Sickle Cell Anemia From Related Chapters II. Pathophysiology Infection of infarcted bone, especially long bones (multiple sites in same bone may be involved) III. Causes Most common organism in Staphylococcal Aureus (<25% of cases) IV. Signs duration directly correlates with likelihood of (risk increases 80% each day of fever) Extremity swelling likelihood increases 8.4 fold Bone pain likelihood increases 20% each day

2016 FP Notebook

9. Oral manifestations of sickle cell disease. (Abstract)

and heart, lung and skin disorders. Oral lesions are also very common and include aseptic pulp necrosis, mucosal damage due to anaemia, fungal infections due to numerous antibiotic therapies, dental eruption delays, bone pain and osteomyelitis of the maxilla, and oral neuropathies, including of the mental nerve of the chin. The oral care of sickle cell patients requires specific precautions such as good management of local anaesthetics, rigorous anti-infective prophylaxis as well as controlled (...) Oral manifestations of sickle cell disease. Sickle cell disease is one of the most common autosomal recessive genetic diseases. It gives rise to abnormally shaped red blood cells with altered function, the primary clinical features being haemolytic anaemia and vascular occlusion. Acute complications are frequent and variable and include chest syndrome, stroke, infection mainly due to asplenia, bone pain and priapism. Other chronic complications which can occur are bone necrosis, nephropathy

2019 British Dental Journal

10. Imaging of musculoskeletal manifestations in sickle cell disease patients Full Text available with Trip Pro

Imaging of musculoskeletal manifestations in sickle cell disease patients Sickle cell disease (SCD) is a hereditary red cell disorder with clinical manifestations secondary to sickling or crescent-shaped distortion of the red blood cells. Major clinical manifestations of SCD include haemolytic anaemia and vaso-occlusive phenomena resulting in ischaemic tissue injury and organ damage. Chronic sequelae of the anaemia and vaso-occlusive processes involving the musculoskeletal system include (...) complications related to extramedullary haematopoiesis, osteonecrosis, myonecrosis and osteomyelitis. Sickle cell bone disease is one of the commonest clinical presentations. Awareness and knowledge of the imaging features related to these complications are essential for early diagnosis and prompt management. In this article, the pathophysiology and key imaging findings related to these complications are reviewed.

2017 The British journal of radiology

11. Sickle cell disease

and spleen; and cause intense pain (known as sickle cell crisis), anaemia, infections, chest problems, and other complications of sickle cell disease. Sickle cell diseases can be life-threatening, particularly for young children. People with sickle cell disease have inherited the gene for sickle haemoglobin (Hb S) from one parent and a gene for an abnormal haemoglobin variant from the other parent. If the second abnormal gene is also for Hb S, the person has homozygous sickle cell disease (Hb SS (...) ), commonly called sickle cell anaemia. This is the most common and severe type of sickle cell disease. Sickle cell trait occurs when a person inherits a gene for normal haemoglobin (Hb A) from one parent and a gene for sickle cell haemoglobin from their other parent; their genotype is Hb AS. These people rarely have symptoms; however, they have a 50% chance of passing the sickle cell gene to their child. If both parents are carriers, there is a 1 in 4 chance that their child will be born with sickle cell

2016 NICE Clinical Knowledge Summaries

12. Sickle Cell Anemia (Overview)

Sickle Cell Anemia (Overview) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29, 2019 (...) Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD causes

2014 eMedicine.com

13. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

14. Sickle Cell Anemia, Skeletal

collapse of bone and sclerosis. Nuclear imaging can also be used to detect early osteonecrosis (see the image below). This modality also plays a role in detecting osteomyelitis. Likewise, indium leukocyte scanning has an important role in diagnosing osteomyelitis. Skeletal sickle cell anemia. Bone scan of bone infarct shows an area of increased uptake in the distal femoral metaphysis corresponding to the infarct demonstrated on the previous plain radiograph. Plain radiography of the extremities (...) fusion of the epiphysis resulting in abnormal shortening of the involved bone (see the image below). Skeletal sickle cell anemia. Bone deformity. Image shows shortening of the second and third metacarpals and phalanges with partial or complete early fusion of the growth plates due to osteonecrosis in infancy. Osteomyelitis is now superimposed the third metacarpal. After multiple infarctions of the long bones, sclerosis may assume the appearance of a bone within a bone, reflecting the old cortex

2014 eMedicine Radiology

15. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

16. Sickle Cell Anemia (Diagnosis)

Sickle Cell Anemia (Diagnosis) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29 (...) , 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD

2014 eMedicine.com

17. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

18. Sickle Cell Anemia (Overview)

Sickle Cell Anemia (Overview) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29, 2019 (...) Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD causes

2014 eMedicine Pediatrics

19. Anemia, Sickle Cell (Diagnosis)

Anemia, Sickle Cell (Diagnosis) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29 (...) , 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD

2014 eMedicine Emergency Medicine

20. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

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