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Osteomyelitis in Sickle Cell Anemia

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1. Chronic Active Parietal Osteomyelitis Due to Salmonella typhi in a Patient with Sickle Cell Anemia (PubMed)

Chronic Active Parietal Osteomyelitis Due to Salmonella typhi in a Patient with Sickle Cell Anemia 28685705 2018 10 05 2018 11 13 1308-5263 34 4 2017 12 01 Turkish journal of haematology : official journal of Turkish Society of Haematology Turk J Haematol Chronic Active Parietal Osteomyelitis Due to Salmonella typhi in a Patient with Sickle Cell Anemia. 358-359 10.4274/tjh.2017.0094 Antar Ahmad A Almoosa Specialist Hospital, Department of Internal Medicine, Division of Hematology-Oncology, Al (...) 9606065 1300-7777 IM Anemia, Sickle Cell complications diagnostic imaging microbiology Chronic Disease Female Humans Magnetic Resonance Imaging Middle Aged Osteomyelitis complications diagnostic imaging microbiology Salmonella typhi isolation & purification 2017 7 8 6 0 2018 10 6 6 0 2017 7 8 6 0 ppublish 28685705 10.4274/tjh.2017.0094 PMC5774349 Int J Infect Dis. 2010 Jan;14(1):e2-e12 19497774 Medicine (Baltimore). 1971 Mar;50(2):97-112 4944120 Br J Haematol. 2005 May;129(4):482-90 15877730 J Infect

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2017 Turkish Journal of Hematology

2. Osteomyelitis in Sickle Cell Anemia

Osteomyelitis in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Osteomyelitis (...) in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Aka: Osteomyelitis in Sickle Cell Anemia From Related Chapters II. Pathophysiology Infection of infarcted bone, especially long bones (multiple sites in same bone may be involved) III. Causes Most common organism in Staphylococcal Aureus (<25% of cases) IV. Signs duration directly correlates with likelihood of (risk increases 80% each day of fever) Extremity swelling likelihood increases 8.4 fold Bone pain likelihood increases 20% each day

2018 FP Notebook

3. Osteomyelitis in Sickle Cell Anemia

Osteomyelitis in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Osteomyelitis (...) in Sickle Cell Anemia Osteomyelitis in Sickle Cell Anemia Aka: Osteomyelitis in Sickle Cell Anemia From Related Chapters II. Pathophysiology Infection of infarcted bone, especially long bones (multiple sites in same bone may be involved) III. Causes Most common organism in Staphylococcal Aureus (<25% of cases) IV. Signs duration directly correlates with likelihood of (risk increases 80% each day of fever) Extremity swelling likelihood increases 8.4 fold Bone pain likelihood increases 20% each day

2016 FP Notebook

4. CRACKCAST E121 – Anemia, Polycythemia, and White Blood Cell Disorders

] List 4 intrinsic and 4 extrinsic causes of hemolytic anemia Refer to box 112.8 for intrinsic and extrinsic causes of hemolytic anemia Intrinsic Causes of Hemolytic Anemia Enzyme defect (pyruvate kinase deficiency, G6PD deficiency) Membrane defect (spherocytosis, elliptostomatocytosis, paroxysmal nocturnal hemoglobinuria) Hemoglobin defect (Thalassemias, hemoglobin M, unstable hemoglobin, sickle cell) Extrinsic Causes of Hemolytic Anemia Immunologic (allo or autoantibodies) Mechanical (...) will have specific RBC morphologies suggesting etiology (bite cells, sickle cells, spherocytes, spur cells, Howell-Jolly bodies, etc.) Intravascular – peripheral smear will predominantly show schistocytes (RBC fragments) [17] Which types of hemolytic anemia tend to be intravascular? Which are extravascular? Extravascular – enzyme/membrane/hemoglobin defects, autoimmune hemolysis, toxins, hypersplenism Intravascular – MAHA (DIC, TTP, HUS), transfusion reactions, sepsis, heat injury, paroxysmal nocturnal

2017 CandiEM

5. Sickle cell disease

Life-threatening infections are common in people with sickle cell disease, partly due to splenic dysfunction, which reduces the ability of the immune system to clear circulating antigens [ ]. The most common infections are pneumococcal sepsis, gram-negative sepsis, lower respiratory tract infections, urinary tract infections, and osteomyelitis. Children younger than 5 years of age are particularly at risk of pneumococcal infection. Acute osteomyelitis This is one of the most common infectious (...) complications in people with sickle cell disease, and it occurs in people of all ages and genotypes [ ]. It is most commonly caused by Salmonella species, Gram-negative enteric bacteria, and Staphylococcus aureus . Recurrent bone infarcts may lead to the formation of bone sequestra. These may become secondarily infected, causing osteomyelitis. There may be local warmth, swelling, tenderness, and fever (an identical presentation to acute painful crisis). Acute priapism This is a persistent painful erection

2017 NICE Clinical Knowledge Summaries

6. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

7. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine.com

8. Sickle Cell Anemia (Overview)

Sickle Cell Anemia (Overview) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29, 2019 (...) Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD causes

2014 eMedicine.com

9. Sickle Cell Anemia (Diagnosis)

Sickle Cell Anemia (Diagnosis) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29 (...) , 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD

2014 eMedicine Pediatrics

10. Sickle Cell Anemia (Overview)

Sickle Cell Anemia (Overview) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29, 2019 (...) Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD causes

2014 eMedicine Pediatrics

11. Sickle Cell Anemia (Treatment)

Sickle Cell Anemia (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

12. Anemia, Sickle Cell (Overview)

Anemia, Sickle Cell (Overview) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29 (...) , 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD

2014 eMedicine Emergency Medicine

13. Anemia, Sickle Cell (Follow-up)

Anemia, Sickle Cell (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Emergency Medicine

14. Sickle Cell Anemia (Diagnosis)

Sickle Cell Anemia (Diagnosis) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29 (...) , 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD

2014 eMedicine.com

15. Sickle Cell Anemia, Skeletal

collapse of bone and sclerosis. Nuclear imaging can also be used to detect early osteonecrosis (see the image below). This modality also plays a role in detecting osteomyelitis. Likewise, indium leukocyte scanning has an important role in diagnosing osteomyelitis. Skeletal sickle cell anemia. Bone scan of bone infarct shows an area of increased uptake in the distal femoral metaphysis corresponding to the infarct demonstrated on the previous plain radiograph. Plain radiography of the extremities (...) fusion of the epiphysis resulting in abnormal shortening of the involved bone (see the image below). Skeletal sickle cell anemia. Bone deformity. Image shows shortening of the second and third metacarpals and phalanges with partial or complete early fusion of the growth plates due to osteonecrosis in infancy. Osteomyelitis is now superimposed the third metacarpal. After multiple infarctions of the long bones, sclerosis may assume the appearance of a bone within a bone, reflecting the old cortex

2014 eMedicine Radiology

16. Anemia, Sickle Cell (Treatment)

Anemia, Sickle Cell (Treatment) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Emergency Medicine

17. Sickle Cell Anemia (Follow-up)

Sickle Cell Anemia (Follow-up) Sickle Cell Anemia Treatment & Management: Approach Considerations, Hydroxyurea Therapy, Transfusion Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LXRyZWF0bWVudA (...) == processing > Sickle Cell Anemia Treatment & Management Updated: Jan 29, 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Treatment Approach Considerations The National Institutes of Health advises that optimal care for patients with sickle cell disease (SCD), including preventive care, is best achieved through treatment in clinics that specialize in the care of SCD. All patients with SCD should have a principal

2014 eMedicine Pediatrics

18. Anemia, Sickle Cell (Diagnosis)

Anemia, Sickle Cell (Diagnosis) Sickle Cell Anemia: Practice Essentials, Background, Genetics Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjA1OTI2LW92ZXJ2aWV3 processing > Sickle Cell Anemia Updated: Jan 29 (...) , 2019 Author: Joseph E Maakaron, MD; Chief Editor: Emmanuel C Besa, MD Share Email Print Feedback Close Sections Sections Sickle Cell Anemia Overview Practice Essentials Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS) [ ] (see the image below). The most common form of SCD found in North America is homozygous HbS disease (HbSS), an autosomal recessive disorder first described by Herrick in 1910. SCD

2014 eMedicine Emergency Medicine

19. Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

) Sharing Statement: Plan to Share IPD: No Layout table for additional information Studies a U.S. FDA-regulated Drug Product: Yes Studies a U.S. FDA-regulated Device Product: No Keywords provided by Caterina Minniti, Montefiore Medical Center: Sickle cell disease sodium nitrite wound healing Ulcer Additional relevant MeSH terms: Layout table for MeSH terms Anemia, Sickle Cell Leg Ulcer Anemia, Hemolytic, Congenital Anemia, Hemolytic Anemia Hematologic Diseases Hemoglobinopathies Genetic Diseases, Inborn (...) Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Topical Sodium Nitrite in Sickle

2016 Clinical Trials

20. Moderate Dose Hydroxyurea for Secondary Stroke Prevention in Children With Sickle Cell Disease in Sub-Saharan Africa

therapy for secondary stroke prevention and prevention of other neurological events in children with SCA with an acute overt stroke. Condition or disease Intervention/treatment Phase Sickle Cell Disease Sickle Cell Anemia Stroke Drug: Moderate Dose Hydroxyurea Drug: Low Dose Hydroxyurea Phase 3 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 120 participants Allocation: Randomized Intervention Model: Single Group Assignment (...) for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Children ages 1 to 16 years of age with sickle cell anemia confirmed by hemoglobin electrophoresis evaluation or high performance liquid chromatography (HPLC); Informed consent from a parent or legal guardian and assent of participants; Children with presence of new stroke up to and including 30 days prior to signing the informed consent; Acceptance of HU therapy for at least three years. Exclusion Criteria: Children with history

2016 Clinical Trials

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