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Osteomyelitis

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1. Antibiotics for treating osteomyelitis in people with sickle cell disease. (Abstract)

Antibiotics for treating osteomyelitis in people with sickle cell disease. Osteomyelitis (both acute and chronic) is one of the most common infectious complications in people with sickle cell disease. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis (...) to independently extract data and assess trial quality by standard Cochrane methodologies, but no eligible randomised controlled trials were identified.This update was unable to find any randomised or quasi-randomised controlled trials on antibiotic treatment approaches for osteomyelitis in people with sickle cell disease.We were unable to identify any relevant trials on the efficacy and safety of the antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis. Randomised

2019 Cochrane

2. Osteomyelitis

Osteomyelitis Osteomyelitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Osteomyelitis Last reviewed: February 2019 Last updated: May 2018 Summary Suspect osteomyelitis in those with a history of open fracture, recent orthopaedic surgery, or a discharging sinus; in the immunocompromised patient; or in the unwell child. Plain radiographs provide a good initial imaging modality for screening acute and chronic (...) osteomyelitis. Magnetic resonance imaging and computed tomography (CT) may be used to determine diagnosis and treatment decisions. In some cases positron emission tomography/CT or single-photon emission computed tomography/CT may have a role. Diagnosis must be confirmed using deep microbiological samples via radiological guided biopsy or open surgery. In chronic osteomyelitis, surgery to remove the dead bone is the primary treatment modality. Antibiotics alone cannot achieve a cure. Giving empirical

2018 BMJ Best Practice

4. Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus.

Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus. Date of origin: 1995 Last review date: 2012 ACR Appropriateness Criteria ® 1 Suspected Osteomyelitis-Diabetic Patient American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus Variant 1: Soft-tissue swelling without neuropathic arthropathy or ulcer. Radiologic Procedure Rating Comments RRL* X-ray foot 9 Initial study. Radiographs (...) ? CT foot with IV contrast 1 ? FDG-PET/CT foot 1 ???? Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Suspected Osteomyelitis-Diabetic Patient Clinical Condition: Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus Variant 2: Soft-tissue swelling with neuropathic arthropathy without ulcer. Radiologic Procedure Rating Comments RRL* X-ray foot 9 Initial study. Radiographs

2019 American College of Radiology

5. Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults

Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults Quality Department Guidelines for Clinical Care Inpatient Vertebral Osteomyelitis Guideline Team Team Leader Carol E. Chenoweth, MD Infectious Diseases Team Members Benjamin S. Bassin, MD Emergency Medicine Megan R. Mack, MD Internal Medicine Mark E. Oppenlander, MD Neurosurgery Douglas J. Quint, MD Radiology F. Jacob Seagull, PhD Medical Education Consultant Rakesh D. Patel, MD Orthopaedic Surgery Initial Release August (...) results. The ultimate judgment regarding any specific clinical procedure or treatment must be made by the physician in light of the circumstances presented by the patient. Vertebral Osteomyelitis, Discitis, and Spinal Epidural Abscess in Adults Patient Population: Adult patients with suspected or confirmed vertebral osteomyelitis, discitis, paravertebral abscess, or spinal epidural abscess. (This guideline does not address vertebral osteomyelitis associated with hardware placed at a previous surgery

2018 University of Michigan Health System

6. Antibiotics for treating osteomyelitis in people with sickle cell disease. Full Text available with Trip Pro

Antibiotics for treating osteomyelitis in people with sickle cell disease. Osteomyelitis (both acute and chronic) is one of the most common infectious complications in people with sickle cell disease. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis (...) -randomised controlled trials.Each author intended to independently extract data and assess trial quality by standard Cochrane methodologies, but no eligible randomised controlled trials were identified.This update was unable to find any randomised or quasi-randomised controlled trials on antibiotic treatment approaches for osteomyelitis in people with sickle cell disease.We were unable to identify any relevant trials on the efficacy and safety of the antibiotic treatment approaches for people with sickle

2016 Cochrane

7. Fosfomycin (Fomicyt) - for the treatment of the following infections in adults and children including neonates: acute osteomyelitis; complicated urinary tract infections; nosocomial lower respiratory tract infections; bacterial meningitis; and bacteraemia

Fosfomycin (Fomicyt) - for the treatment of the following infections in adults and children including neonates: acute osteomyelitis; complicated urinary tract infections; nosocomial lower respiratory tract infections; bacterial meningitis; and bacteraemia Final Appraisal Recommendation Advice No: 3015 – October 2015 Fosfomycin (Fomicyt ® ) 40 mg/ml powder for solution for infusion Limited submission by Nordic Pharma UK Ltd Additional note(s): ? Fosfomycin (Fomicyt ® ) is appropriate (...) within NHS Wales for the treatment of the following infections in adults and children including neonates: acute osteomyelitis; complicated urinary tract infections; nosocomial lower respiratory tract infections; bacterial meningitis; and bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. Fosfomycin (Fomicyt ® ) should be used only when it is considered inappropriate to use antibacterial agents that are commonly recommended

2015 All Wales Medicines Strategy Group

8. 99mTc‐HMPAO‐leukocyte scintigraphy for diagnosis and therapy monitoring of skull base osteomyelitis Full Text available with Trip Pro

99mTc‐HMPAO‐leukocyte scintigraphy for diagnosis and therapy monitoring of skull base osteomyelitis Skull base osteomyelitis (SBO) is a rare but life-threatening disease observed in elderly diabetic patients, with high risk of recurrence and difficult therapeutic management. The diagnosis is ascertained from a set of clinical, biological, and imaging findings. CT and MRI allow initial diagnosis, but are not accurate to affirm healing at the end of therapy. 99mTc-HMPAO-Leucocyte Scintigraphy

2018 Laryngoscope investigative otolaryngology

9. What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers?

What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? View (...) / Open Date 2015-05 Contributor Format Metadata Abstract A: What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? A: Magnetic resonance imaging (MRI) has a higher sensitivity and specificity (90% and 79%) than plain radiography (54% and 68%) for diagnosing diabetic foot osteomyelitis. MRI performs somewhat better than any of several common tests—probe to bone (PTB), erythrocyte sedimentation rate (ESR) >70 mm/ hr, C-reactive protein (CRP) >14 mg/L, procalcitonin

2015 Clinical Inquiries

10. What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers?

What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? View (...) / Open Date 2015-05 Contributor Format Metadata Abstract A: What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? A: Magnetic resonance imaging (MRI) has a higher sensitivity and specificity (90% and 79%) than plain radiography (54% and 68%) for diagnosing diabetic foot osteomyelitis. MRI performs somewhat better than any of several common tests—probe to bone (PTB), erythrocyte sedimentation rate (ESR) >70 mm/ hr, C-reactive protein (CRP) >14 mg/L, procalcitonin

2015 Clinical Inquiries

11. Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century. Full Text available with Trip Pro

Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century. The systematic analysis of museum collections can provide important insights into the dental and skeletal pathology of wild mammals. Here we present a previously unreported type of dental defect and related skull pathology in five juvenile Baltic grey seals that had been collected in the course of a seal culling program (...) extended from the pulp into the periapical space, leading to apical periodontitis with extensive bone resorption. Further spreading of the inflammation into the surrounding bone regions had then caused suppurative osteomyelitis of the jaws. The postcanine teeth of the pathological individuals typically had dentin of normal thickness and, except for one specimen, did not exhibit pulp exposure. The condition may have been caused by a late onset of secondary and tertiary dentin formation that led to pulp

2019 PLoS ONE

12. Retrospective analysis of diabetic foot osteomyelitis management and outcome at a tertiary care hospital in the UK. Full Text available with Trip Pro

Retrospective analysis of diabetic foot osteomyelitis management and outcome at a tertiary care hospital in the UK. This study aimed to analyse retrospectively management and outcomes of the diabetic foot osteomyelitis (DFOM) multi-disciplinary team at St Thomas' Hospital, London.Patients admitted during 2015 with diagnosis of DFOM were included. Data were obtained from medical and microbiology records.275 patients were admitted for DF infection in 2015: 45.1% had OM (75% males). 40% were newly

2019 PLoS ONE

13. Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. Full Text available with Trip Pro

Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. Empiric antibiotic therapy for suspected hematogenous vertebral osteomyelitis (HVO) should be initiated immediately in seriously ill patients and may be required in those with negative microbiological results. The aim of this study was to inform the appropriate selection of empiric antibiotic regimens for the treatment of suspected HVO by analyzing antimicrobial susceptibility of isolated bacteria

2019 PLoS ONE

14. A rare case of acute transverse myelitis associated with Staphylococcus aureus bacteremia and osteomyelitis Full Text available with Trip Pro

A rare case of acute transverse myelitis associated with Staphylococcus aureus bacteremia and osteomyelitis Direct intramedullary infections are considered very rare. Only few reports of Staphylococcus aureus myelitis have been published.Our patient, a 79-year-old male, presented with a 2-day history of high-grade fever and high inflammatory markers and progressively developed tetraplegia during hospitalization. Lumbar puncture revealed cerebrospinal fluid pleocytosis and a spinal cord MRI (...) revealed transverse myelitis at the level of C3-C5 and possible osteomyelitis of C5-T1. Two blood cultures were positive for methicillin-sensitive S. aureus. Despite control of the infection, there was no neurologic improvement.The morbidity of infectious myelitis can be severe. Considering the rarity of S. aureus myelitis, experience gained from case reports is important. A brief review of the available literature is provided.

2017 Spinal cord series and cases

15. Clival Osteomyelitis Presenting as a Skull Base Mass Full Text available with Trip Pro

Clival Osteomyelitis Presenting as a Skull Base Mass Central skull base osteomyelitis is a rare, but potentially life-threatening disease entity often lacking otologic symptoms or external auditory canal pathology. We present a case of a man in his 70s who had developed cranial nerve deficits with radiographic evidence that was consistent with a tumor due to this uncommon entity. The radiologic findings and our experience are discussed to increase awareness in the otolaryngology community.

2017 Journal of neurological surgery reports

16. Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot)

Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot) Date of origin: 2016 ACR Appropriateness Criteria ® 1 Suspected Osteomyelitis/Septic Arthritis American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot) Variant 1: Suspected osteomyelitis, septic arthritis, or soft-tissue infection (excluding spine and diabetic foot (...) Criteria ® 2 Suspected Osteomyelitis/Septic Arthritis Clinical Condition: Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot) Variant 3: Soft-tissue or juxta-articular swelling with a history of puncture wound. Suspected foreign body. Negative radiographs. Radiologic Procedure Rating Comments RRL* US area of interest 8 This procedure is an alternative to CT and MRI. It is favored for radiolucent (wood, plastic) foreign body. O CT area of interest

2016 American College of Radiology

17. Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults

Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults Practice Guidelines Search Search Practice Guidelines Practice guidelines are systematically developed statements to assist practitioners and patients in making decisions about appropriate health care for specific clinical circumstances. Attributes of good guidelines include validity, reliability, reproducibility, clinical applicability, clinical flexibility, clarity, multidisciplinary

2015 Infectious Diseases Society of America

18. Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats. (Abstract)

Exebacase in Addition to Daptomycin Is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats. Bacteriophage-derived lysins are being developed as anti-infective agents. In an acute osteomyelitis methicillin-resistant Staphylococcus aureus (MRSA) model, rats receiving no treatment or treatment with daptomycin, exebacase (CF-301), or daptomycin plus exebacase had means of 5.13, 4.09, 4.65, and 3.57 log10 CFU/gram of bone, respectively

2019 Antimicrobial Agents and Chemotherapy

19. An open-label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis. Full Text available with Trip Pro

An open-label trial of cryopreserved human umbilical cord in the treatment of complex diabetic foot ulcers complicated by osteomyelitis. Clinical trials of potential new therapies for diabetic foot ulcers rarely enroll patients whose wounds extend to muscle, fascia, or bone with clinical and radiographic evidence of underlying osteomyelitis. An open-label, multicenter trial of cryopreserved human umbilical cord (TTAX01) was undertaken in 32 subjects presenting with such complex wounds (...) in 18 of 32 (56%) wounds, with 16 (50%) of these having confirmed closure in 16 weeks with a median of one-product application. Cases with biopsy confirmed osteomyelitis (n = 20) showed initial closure in 12 (60%) wounds and confirmed closure in 10 (50%) wounds. Four of the five ulcers presenting as recurrences experienced confirmed closure. Mean overall time to healing was 12.8 ± 4.3 weeks. Mean wound area reduction from baseline was 91% for all wounds. Of the 16 wounds without confirmed closure

2019 Wound Repair and Regeneration

20. COULD OZONE TREATMENT BE A PROMISING ALTERNATIVE FOR OSTEOMYELITIS? AN EXPERIMENTAL STUDY. Full Text available with Trip Pro

COULD OZONE TREATMENT BE A PROMISING ALTERNATIVE FOR OSTEOMYELITIS? AN EXPERIMENTAL STUDY. The aim of the present study was to investigate the biochemical and histopathological impact of ozone treatment in an experimental model of osteomyelitis in rats.A total of 24 adult male Sprague-Dawley rats (3 months old, each weighing 300 to 400 g) were randomly allocated into three groups. Group I (n=8) served as a control and received no interventions or medications. In Group II (n=8), osteomyelitis (...) was induced in the femur and no treatment was applied. Group III (n=8) received intraperitoneal ozone treatment for 3 weeks after the formation of osteomyelitis in the femur. Serum samples were taken to assess total antioxidant capacity (TAC), protein carbonyl content (PCO), and lactate dehydrogenase (LDH). Bone specimens obtained from the femur were histopathologically evaluated for inflammation, necrosis, osteomyelitis, and abscess formation.Serum TAC levels were notably higher (p<0.001), while LDH

2019 Acta ortopedica brasileira Controlled trial quality: uncertain

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