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Osteomyelitis

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1. Antibiotics for treating osteomyelitis in people with sickle cell disease. (PubMed)

Antibiotics for treating osteomyelitis in people with sickle cell disease. Osteomyelitis (both acute and chronic) is one of the most common infectious complications in people with sickle cell disease. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis (...) to independently extract data and assess trial quality by standard Cochrane methodologies, but no eligible randomised controlled trials were identified.This update was unable to find any randomised or quasi-randomised controlled trials on antibiotic treatment approaches for osteomyelitis in people with sickle cell disease.We were unable to identify any relevant trials on the efficacy and safety of the antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis. Randomised

2019 Cochrane

3. Osteomyelitis

Osteomyelitis Osteomyelitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Osteomyelitis Last reviewed: February 2019 Last updated: May 2018 Summary Suspect osteomyelitis in those with a history of open fracture, recent orthopaedic surgery, or a discharging sinus; in the immunocompromised patient; or in the unwell child. Plain radiographs provide a good initial imaging modality for screening acute and chronic (...) osteomyelitis. Magnetic resonance imaging and computed tomography (CT) may be used to determine diagnosis and treatment decisions. In some cases positron emission tomography/CT or single-photon emission computed tomography/CT may have a role. Diagnosis must be confirmed using deep microbiological samples via radiological guided biopsy or open surgery. In chronic osteomyelitis, surgery to remove the dead bone is the primary treatment modality. Antibiotics alone cannot achieve a cure. Giving empirical

2018 BMJ Best Practice

4. Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above (...) to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This feasibility study established a potential design for an RCT of early switching from intravenous to oral antibiotics for children with acute osteomyelitis or septic arthritis. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , , , , , , & . Hans de Graaf 1, 2 , Priya Sukhtankar 1, 2 , Barbara Arch 3 , Nusreen Ahmad 1, 2, 4 , Amanda Lees 5 , Abigail

2017 NIHR HTA programme

5. Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus.

Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus. Date of origin: 1995 Last review date: 2012 ACR Appropriateness Criteria ® 1 Suspected Osteomyelitis-Diabetic Patient American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus Variant 1: Soft-tissue swelling without neuropathic arthropathy or ulcer. Radiologic Procedure Rating Comments RRL* X-ray foot 9 Initial study. Radiographs (...) ? CT foot with IV contrast 1 ? FDG-PET/CT foot 1 ???? Rating Scale: 1,2,3 Usually not appropriate; 4,5,6 May be appropriate; 7,8,9 Usually appropriate *Relative Radiation Level ACR Appropriateness Criteria ® 2 Suspected Osteomyelitis-Diabetic Patient Clinical Condition: Suspected Osteomyelitis of the Foot in Patients with Diabetes Mellitus Variant 2: Soft-tissue swelling with neuropathic arthropathy without ulcer. Radiologic Procedure Rating Comments RRL* X-ray foot 9 Initial study. Radiographs

2019 American College of Radiology

6. Antibiotics for treating osteomyelitis in people with sickle cell disease. (PubMed)

Antibiotics for treating osteomyelitis in people with sickle cell disease. Osteomyelitis (both acute and chronic) is one of the most common infectious complications in people with sickle cell disease. There is no standardized approach to antibiotic therapy and treatment is likely to vary from country to country. Thus, there is a need to identify the efficacy and safety of different antibiotic treatment approaches for people with sickle cell disease suffering from osteomyelitis (...) -randomised controlled trials.Each author intended to independently extract data and assess trial quality by standard Cochrane methodologies, but no eligible randomised controlled trials were identified.This update was unable to find any randomised or quasi-randomised controlled trials on antibiotic treatment approaches for osteomyelitis in people with sickle cell disease.We were unable to identify any relevant trials on the efficacy and safety of the antibiotic treatment approaches for people with sickle

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2016 Cochrane

7. Antibiotic-Loaded Collagen Sponges in Clinical Treatment of Chronic Osteomyelitis: A Systematic Review

Antibiotic-Loaded Collagen Sponges in Clinical Treatment of Chronic Osteomyelitis: A Systematic Review Chronic osteomyelitis is caused by bacterial infection of the bone and is a major problem in orthopaedic surgery. Treatment of chronic osteomyelitis requires surgical debridement accompanied by local and systemic administration of antibiotics. A widely established biodegradable local antibiotic carrier is antibiotic-loaded collagen sponges (fleeces). These sponges are commonly used (...) in the treatment of chronic osteomyelitis, but a systematic review of their clinical efficacy and assessment of the quality of evidence have not been conducted, to our knowledge.This systematic review, performed according to the PRISMA statement, examined the clinical efficacy of and quality of evidence regarding different antibiotic-loaded collagen sponges in the clinical treatment of chronic osteomyelitis. Clinical efficacy was defined as eradication of infection with bone and wound-healing. In addition

2019 EvidenceUpdates

8. Clinical characteristics and treatment of clavicular osteomyelitis: a systematic review with pooled analysis of 294 reported cases

Clinical characteristics and treatment of clavicular osteomyelitis: a systematic review with pooled analysis of 294 reported cases It is usually difficult to diagnose clavicular osteomyelitis (OM), and treatment is delayed because of its rarity. This study aimed to summarize clinical characteristics and treatment of this disease.We searched the PubMed and Embase databases to identify English studies that reported on clavicular OM from January 1980 through December 2016. Effective data were

2019 EvidenceUpdates

9. Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot)

Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot) Date of origin: 2016 ACR Appropriateness Criteria ® 1 Suspected Osteomyelitis/Septic Arthritis American College of Radiology ACR Appropriateness Criteria ® Clinical Condition: Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot) Variant 1: Suspected osteomyelitis, septic arthritis, or soft-tissue infection (excluding spine and diabetic foot (...) Criteria ® 2 Suspected Osteomyelitis/Septic Arthritis Clinical Condition: Suspected Osteomyelitis, Septic Arthritis, or Soft Tissue Infection (Excluding Spine and Diabetic Foot) Variant 3: Soft-tissue or juxta-articular swelling with a history of puncture wound. Suspected foreign body. Negative radiographs. Radiologic Procedure Rating Comments RRL* US area of interest 8 This procedure is an alternative to CT and MRI. It is favored for radiolucent (wood, plastic) foreign body. O CT area of interest

2016 American College of Radiology

10. 99mTc‐HMPAO‐leukocyte scintigraphy for diagnosis and therapy monitoring of skull base osteomyelitis (PubMed)

99mTc‐HMPAO‐leukocyte scintigraphy for diagnosis and therapy monitoring of skull base osteomyelitis Skull base osteomyelitis (SBO) is a rare but life-threatening disease observed in elderly diabetic patients, with high risk of recurrence and difficult therapeutic management. The diagnosis is ascertained from a set of clinical, biological, and imaging findings. CT and MRI allow initial diagnosis, but are not accurate to affirm healing at the end of therapy. 99mTc-HMPAO-Leucocyte Scintigraphy

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2018 Laryngoscope investigative otolaryngology

11. Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century. (PubMed)

Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century. The systematic analysis of museum collections can provide important insights into the dental and skeletal pathology of wild mammals. Here we present a previously unreported type of dental defect and related skull pathology in five juvenile Baltic grey seals that had been collected in the course of a seal culling program (...) extended from the pulp into the periapical space, leading to apical periodontitis with extensive bone resorption. Further spreading of the inflammation into the surrounding bone regions had then caused suppurative osteomyelitis of the jaws. The postcanine teeth of the pathological individuals typically had dentin of normal thickness and, except for one specimen, did not exhibit pulp exposure. The condition may have been caused by a late onset of secondary and tertiary dentin formation that led to pulp

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2019 PLoS ONE

12. Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. (PubMed)

Selection of an appropriate empiric antibiotic regimen in hematogenous vertebral osteomyelitis. Empiric antibiotic therapy for suspected hematogenous vertebral osteomyelitis (HVO) should be initiated immediately in seriously ill patients and may be required in those with negative microbiological results. The aim of this study was to inform the appropriate selection of empiric antibiotic regimens for the treatment of suspected HVO by analyzing antimicrobial susceptibility of isolated bacteria

2019 PLoS ONE

13. Retrospective analysis of diabetic foot osteomyelitis management and outcome at a tertiary care hospital in the UK. (PubMed)

Retrospective analysis of diabetic foot osteomyelitis management and outcome at a tertiary care hospital in the UK. This study aimed to analyse retrospectively management and outcomes of the diabetic foot osteomyelitis (DFOM) multi-disciplinary team at St Thomas' Hospital, London.Patients admitted during 2015 with diagnosis of DFOM were included. Data were obtained from medical and microbiology records.275 patients were admitted for DF infection in 2015: 45.1% had OM (75% males). 40% were newly

2019 PLoS ONE

14. The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review. (PubMed)

The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review. Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age. The clinical spectrum of CNO covers sometimes asymptomatic inflammation of single bones at the one end and chronically active or recurrent multifocal osteitis at the other.Despite the intense scientific

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2017 Molecular and cellular pediatrics

15. What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers?

What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? View (...) / Open Date 2015-05 Contributor Format Metadata Abstract A: What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? A: Magnetic resonance imaging (MRI) has a higher sensitivity and specificity (90% and 79%) than plain radiography (54% and 68%) for diagnosing diabetic foot osteomyelitis. MRI performs somewhat better than any of several common tests—probe to bone (PTB), erythrocyte sedimentation rate (ESR) >70 mm/ hr, C-reactive protein (CRP) >14 mg/L, procalcitonin

2015 Clinical Inquiries

16. A rare case of acute transverse myelitis associated with Staphylococcus aureus bacteremia and osteomyelitis (PubMed)

A rare case of acute transverse myelitis associated with Staphylococcus aureus bacteremia and osteomyelitis Direct intramedullary infections are considered very rare. Only few reports of Staphylococcus aureus myelitis have been published.Our patient, a 79-year-old male, presented with a 2-day history of high-grade fever and high inflammatory markers and progressively developed tetraplegia during hospitalization. Lumbar puncture revealed cerebrospinal fluid pleocytosis and a spinal cord MRI (...) revealed transverse myelitis at the level of C3-C5 and possible osteomyelitis of C5-T1. Two blood cultures were positive for methicillin-sensitive S. aureus. Despite control of the infection, there was no neurologic improvement.The morbidity of infectious myelitis can be severe. Considering the rarity of S. aureus myelitis, experience gained from case reports is important. A brief review of the available literature is provided.

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2017 Spinal cord series and cases

17. Clival Osteomyelitis Presenting as a Skull Base Mass (PubMed)

Clival Osteomyelitis Presenting as a Skull Base Mass Central skull base osteomyelitis is a rare, but potentially life-threatening disease entity often lacking otologic symptoms or external auditory canal pathology. We present a case of a man in his 70s who had developed cranial nerve deficits with radiographic evidence that was consistent with a tumor due to this uncommon entity. The radiologic findings and our experience are discussed to increase awareness in the otolaryngology community.

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2017 Journal of neurological surgery reports

18. What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers?

What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? Toggle navigation Shared more. Cited more. Safe forever. Toggle navigation View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace This Collection Browse Statistics What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? View (...) / Open Date 2015-05 Contributor Format Metadata Abstract A: What’s the best test for underlying osteomyelitis in patients with diabetic foot ulcers? A: Magnetic resonance imaging (MRI) has a higher sensitivity and specificity (90% and 79%) than plain radiography (54% and 68%) for diagnosing diabetic foot osteomyelitis. MRI performs somewhat better than any of several common tests—probe to bone (PTB), erythrocyte sedimentation rate (ESR) >70 mm/ hr, C-reactive protein (CRP) >14 mg/L, procalcitonin

2015 Clinical Inquiries

19. Diagnosing pelvic osteomyelitis in patients with decubitus ulcers: a systematic review

Diagnosing pelvic osteomyelitis in patients with decubitus ulcers: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

20. Clinical Application of Antimicrobial Bone Graft Substitute in Osteomyelitis Treatment: A Systematic Review of Different Bone Graft Substitutes Available in Clinical Treatment of Osteomyelitis. (PubMed)

Clinical Application of Antimicrobial Bone Graft Substitute in Osteomyelitis Treatment: A Systematic Review of Different Bone Graft Substitutes Available in Clinical Treatment of Osteomyelitis. Osteomyelitis is a common occurrence in orthopaedic surgery, which is caused by different bacteria. Treatment of osteomyelitis patients aims to eradicate infection by debridement surgery and local and systemic antibiotic therapy. Local treatment increases success rates and can be performed with different (...) antimicrobial bone graft substitutes. This review is performed to assess the level of evidence of synthetic bone graft substitutes in osteomyelitis treatment. According to the PRISMA statement for reporting systematic reviews, different types of clinical studies concerning treatment of osteomyelitis with bone graft substitutes are included. These studies are assessed on their methodological quality as level of evidence and bias and their clinical outcomes as eradication of infection. In the fifteen included

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2016 BioMed research international

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