How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

181 results for

Orthostatic Sodium Retention

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

61. Latuda - lurasidone

effects, or non-compliance, hence the need for additional treatments that are effective and well tolerated. Latuda Assessment report (EMA/113836/2014) Rev05.13 Page 9/147 2.2. Quality aspects 2.2.1. Introduction The finished product is presented as film-coated tablets available in three strengths designated as, 18.5 mg, 37 mg and 74 mg, corresponding to 18.6 mg, 37.2 mg and 74 g mg of lurasidone base. Other ingredients are mannitol, pregelatinised starch, croscarmellose sodium, hypromellose, magnesium

2014 European Medicines Agency - EPARs

62. Vokanamet - canagliflozin / metformin

RH Relative Humidity RLG Radioluminography RRT Relative retention time RSD Relative standard deviation RTG/RT G renal threshold for glucose RTT(s) renal tubular tumor(s) S9 exogenous mammalian metabolic activation system SAP statistical analysis plan SBP systolic blood pressure SCE Summary of Clinical Efficacy SD standard deviation SE standard error Sec Section SEM standard error of the mean SGLT1 sodium-glucose co-transporter-1 SGLT2 sodium-glucose co-transporter -2 SMIT1 sodium/myo-inositol co (...) hSGLT2 human SGLT2 hSGLT4 human sodium glucose co-transporter-4 hSGLT6 human sodium glucose co-transporter-6 hSMIT1 human sodium/myo-inositol co-transporter-1 IAS Integrated Analysis of Safety IC50 inhibiting concentration at 50% ICH International Conference on Harmonisation IPC In-process control IR Infrared ISE Integrated Summary of Efficacy ISS Integrated Summary of Safety J&JPRD Johnson & Johnson Pharmaceutical Research & Development, LLC JNJ- 28431754 Canagliflozin JRD Janssen Research

2014 European Medicines Agency - EPARs

63. Pharmacological treatment of bipolar disorder in primary care

, slowing, dystonia Anticholinergic reactions: constipation, dry mouth, blurred vision, urinary retention Other: sedation, increased appetite, sexual dysfunction, gastrointestinal upset, peripheral oedema, nausea, cerebrovascular events such as stroke and TIA (especially in older patients), orthostatic hypotension, tachycardia Jaundice, neuroleptic malignant syndrome, seizures, tardive dyskinesia, electrocardiogram changes (increased QT interval), SIADH, temperature irregularity, blood dyscrasias (...) -converting enzyme inhibitors, non-steroidal anti-inflammatory drugs) and sodium depletion (eg, gastrointestinal disturbance) There can be a delay of 6–8 weeks for an antidepressant effect Lithium toxicity: signs include loss of balance, increasing diarrhoea, vomiting, anorexia, weakness, ataxia, blurred vision, tinnitus, polyuria, coarse tremor, muscle twitching, irritability and agitation. Drowsiness, psychosis, disorientation, seizures, coma and renal failure may also occur. Valproate GIT: nausea

2010 Clinical Practice Guidelines Portal

64. Guidelines on Diagnosis and Management of Syncope

and pathophysiology . . . . . . . . . . . . . . 2635 1.2.1 Placing syncope in the larger framework of transient loss of consciousness (real or apparent) . . . . . . . . 2635 1.2.2 Classi?cation and pathophysiology of syncope . . . . 2636 1.2.2.1 Re?ex syncope (neurally mediated syncope) . . . 2637 1.2.2.2 Orthostatic hypotension and orthostatic intolerance syndromes . . . . . . . . . . . . . . . . . 2637 1.2.2.3 Cardiac syncope (cardiovascular) . . . . . . . . . . 2639 1.3 Epidemiology (...) . . . . . . . . . . . . . . . . . . . . . . . . . . 2645 2.2.1 Carotid sinus massage . . . . . . . . . . . . . . . . . . . 2645 2.2.2 Orthostatic challenge . . . . . . . . . . . . . . . . . . . . 2647 2.2.2.1 Active standing . . . . . . . . . . . . . . . . . . . . . . 2647 2.2.2.2 Tilt testing . . . . . . . . . . . . . . . . . . . . . . . . . 2647 2.2.3 Electrocardiographic monitoring (non-invasive and invasive) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2649 2.2.3.1 In-hospital monitoring . . . . . . . . . . . . . . . . . 2649

2009 European Society of Cardiology

65. Depression

is present on more days than not for at least 2 years. In contrast, subsyndromal depression is an acute mood disorder that is less severe (some, but not all, diagnostic symptoms present) than major depression. Possible Medical Causes of Depressive Symptoms in People With Cancer Uncontrolled pain.[ ][ ] Metabolic abnormalities: Hypercalcemia. Sodium/potassium imbalance. Anemia. Vitamin B12 or folate deficiency. Fever. Endocrine abnormalities: Hyperthyroidism or hypothyroidism. Adrenal insufficiency

2012 PDQ - NCI's Comprehensive Cancer Database

66. Gastrointestinal Complications

day that any patient starts taking drugs associated with constipation: Stool softeners (e.g., docusate sodium, one to two capsules per day). For opioid-related constipation, stool softeners may be used in combination with a stimulant laxative. Bulk-producing agents are not recommended in a regimen used to counteract the bowel effects of opioids. Two tablets of a senna preparation twice daily. One bisacodyl tablet at bedtime. Milk of magnesia, 30 to 45 mL, if a bowel movement is not achieved in 24 (...) hours after other methods are instituted. If the amount of stool is still inadequate, increase stool softeners up to six capsules per day or a senna preparation (e.g., Senokot) gradually to a maximum of eight tablets (four tablets twice a day); bisacodyl may be increased gradually to three tablets. If the amount of stool is still inadequate, a glycerin or bisacodyl suppository or enema (phosphate/biphosphate, oil retention, or tap water) is used with caution, especially in patients with neutropenia

2012 PDQ - NCI's Comprehensive Cancer Database

67. Sleep Disorders

include the following:[ ];[ ][ ] Pain. Anxiety. Night sweats/hot flashes (refer to the PDQ summary on for more information). GI disturbances (e.g., incontinence, diarrhea, constipation, or nausea). GU disturbances (e.g., incontinence, retention, or GU irritation). Respiratory disturbances. Fatigue. Sustained use of the following can cause insomnia: Sedatives and hypnotics (e.g., glutethimide, benzodiazepines, pentobarbital, chloral hydrate, secobarbital sodium, and amobarbital sodium). Anticonvulsants (...) . [ ][ ] Second-generation antidepressant trazodone (Desyrel) 25–100 mg Risk of orthostatic hypotension and falls. [ ] mirtazapine (Remeron) 7.5–45 mg If depression not a concern, 7.5–15 mg best for sleep, hot flashes, increased appetite, and less morning sedation. Risk of falls. [ ][ ] Antipsychotic quetiapine (Seroquel) 25–100 mg Risk of weight gain, metabolic syndrome, abnormal/involuntary movements; possible cardiovascular effects (e.g., prolonged QT interval). Generally not a preferred agent due to side

2012 PDQ - NCI's Comprehensive Cancer Database

68. Abilify Maintena (aripiprazole)

. Psychiatr Serv. 2012;63:87-90; 3) Schooler NR. Relapse and rehospitalization: comparing oral and depot antipsychotics. J Clin Psychiatry. 2003;64(Suppl 16):14-7. 4 1) Peuskens J, Olivares JM, Pecenak J et al. Treatment retention with risperidone long-acting injection: 24-month results from the Electronic Schizophrenia Treatment Adherence Registry (e-STAR) in six countries. Curr Med Res Opin. 2010;26:501-9, 2) Masand PS, Roca M, Turner MS et al. Partial adherence to antipsychotic medication impacts (...) systematic review and meta-analysis of randomised long- term trials. Schizophr Res. 2011;127:83-92. Abilify Maintena EMA/737723/2013 Page 9/70 The powder vial contains the following excipients: carmellose sodium, mannitol, sodium dihydrogen phosphate monohydrate, and sodium hydroxide. The solvent vial contains water for injections. The list of excipients is described in section 6.1 of the SmPC. 2.2.2. Active Substance Aripiprazole monohydrate is a white to off-white crystal. It is not hygroscopic

2013 European Medicines Agency - EPARs

69. Invokana - canagliflozin

Humidity RLG radioluminography ROW rest of world RRT Relative retention time RSD Relative standard deviation RTG/RT G renal threshold for glucose RTT(s) renal tubular tumor(s) S9 exogenous mammalian metabolic activation system SAP statistical analysis plan SBP systolic blood pressure SCE Summary of Clinical Efficacy SD standard deviation SE standard error Sec section SEM standard error of the mean SGLT1 sodium-glucose co-transporter-1 SGLT2 sodium-glucose co-transporter -2 SMIT1 sodium/myo-inositol co (...) SGLT1 hSGLT2 human SGLT2 hSGLT4 human sodium glucose co-transporter-4 hSGLT6 human sodium glucose co-transporter-6 hSMIT1 human sodium/myo-inositol co-transporter-1 IAS Integrated Analysis of Safety IC50 inhibiting concentration at 50% ICH International Conference on Harmonisation IPC In-process control IR Infrared ISE Integrated Summary of Efficacy ISS Integrated Summary of Safety J&JPRD Johnson & Johnson Pharmaceutical Research & Development, LLC JNJ- 28431754 Canagliflozin JRD Janssen Research

2013 European Medicines Agency - EPARs

70. Assistive Devices to Improve Independence (Follow-up)

mobility, orthostatic hypotension (systolic blood pressure [SBP] < 20 mm Hg), balance disorders, and vasovagal syncope. Depression, confusion, dementia, and other cognitive deficits also contribute to falls. Cognitive impairment, depressive symptoms, and orthostatic hypotension most contribute to gait dysfunction. Slower performance on the Timed Up-and-Go Test (TUG), a mobility task, is independently associated with poorer performance on measures of global cognition, executive function, memory (...) , female sex, cognitive impairment, poor self-rated health, low BMD, osteoporosis, inactivity, sedative use, alcohol use, and orthostatic hypotension. Extrinsic risk factors include adverse effects of medications, polypharmacy, and environmental hazards. Psychotropics, neuroleptics, tricyclic antidepressants, benzodiazepines, analgesics, sedatives, skeletal muscle relaxants, cardiac drugs (diuretics, antiarrhythmics), vasodilators, and antihistamines may contribute to falls. Results of studies suggest

2014 eMedicine.com

71. Altitude-Related Disorders (Follow-up)

to displace the CSF. Conversely, those with lesser CSF to brain volume ratio have limited space for compensation of brain swelling and are prone to AMS. The role of fluid retention in the pathogenesis of AMS remains uncertain. Secretion of antidiuretic hormone and atrial natriuretic factor is altered in AMS and may contribute to vasogenic edema. More recently, hypoxia-induced alterations in oxidative stress and free radical metabolism have been implicated in the pathophysiology of AMS. [ ] Treatment (...) of the pathogenesis of HAPE is shown below. This image shows the pathophysiology of high-altitude pulmonary edema (HAPE) following ascent to high altitude. Factors leading to a low partial pressure of oxygen (PO2), such as exercise, sleep, or a low ventilatory response to hypoxia, increase the likelihood of developing HAPE. Alterations in the sympathetic nervous system are also believed to contribute to the development of HAPE. Recent evidence suggests that a defect in sodium transport across the alveolar

2014 eMedicine.com

72. Rehabilitation of Persons With Spinal Cord Injuries (Follow-up)

. Clinical problems result from inappropriately low or high sympathetic responses, the former during the acute phase and the latter in the subacute and chronic phases. Problems are most common in those with injuries to level T6 and above, as such levels isolate the sympathetic outflow to the splanchnic vascular bed. Resting blood pressure is low with higher cord injury, which is asymptomatic. Orthostatic blood pressure changes can cause weakness, light-headedness, and fainting. Management includes (...) gradual mobilization, liberal sodium intake, use of compression hose, and an abdominal binder. [ , ] Fludrocortisone acetate (0.1 mg PO qd) can expand intravascular volume and therefore is helpful. Midodrine (titrated upward daily from a dosage of 5 mg PO bid/tid) may be helpful. Midodrine can cause supine hypertension and presumably may exacerbate any tendency toward autonomic hyperreflexia (AH). Bradycardia is common soon after injury and usually resolves after several weeks. Tracheal suctioning can

2014 eMedicine Surgery

73. Assistive Devices to Improve Independence (Overview)

mobility, orthostatic hypotension (systolic blood pressure [SBP] < 20 mm Hg), balance disorders, and vasovagal syncope. Depression, confusion, dementia, and other cognitive deficits also contribute to falls. Cognitive impairment, depressive symptoms, and orthostatic hypotension most contribute to gait dysfunction. Slower performance on the Timed Up-and-Go Test (TUG), a mobility task, is independently associated with poorer performance on measures of global cognition, executive function, memory (...) , female sex, cognitive impairment, poor self-rated health, low BMD, osteoporosis, inactivity, sedative use, alcohol use, and orthostatic hypotension. Extrinsic risk factors include adverse effects of medications, polypharmacy, and environmental hazards. Psychotropics, neuroleptics, tricyclic antidepressants, benzodiazepines, analgesics, sedatives, skeletal muscle relaxants, cardiac drugs (diuretics, antiarrhythmics), vasodilators, and antihistamines may contribute to falls. Results of studies suggest

2014 eMedicine.com

74. Rehabilitation of Persons With Spinal Cord Injuries (Overview)

. Clinical problems result from inappropriately low or high sympathetic responses, the former during the acute phase and the latter in the subacute and chronic phases. Problems are most common in those with injuries to level T6 and above, as such levels isolate the sympathetic outflow to the splanchnic vascular bed. Resting blood pressure is low with higher cord injury, which is asymptomatic. Orthostatic blood pressure changes can cause weakness, light-headedness, and fainting. Management includes (...) gradual mobilization, liberal sodium intake, use of compression hose, and an abdominal binder. [ , ] Fludrocortisone acetate (0.1 mg PO qd) can expand intravascular volume and therefore is helpful. Midodrine (titrated upward daily from a dosage of 5 mg PO bid/tid) may be helpful. Midodrine can cause supine hypertension and presumably may exacerbate any tendency toward autonomic hyperreflexia (AH). Bradycardia is common soon after injury and usually resolves after several weeks. Tracheal suctioning can

2014 eMedicine Surgery

75. Rehabilitation of Persons With Spinal Cord Injuries (Diagnosis)

. Clinical problems result from inappropriately low or high sympathetic responses, the former during the acute phase and the latter in the subacute and chronic phases. Problems are most common in those with injuries to level T6 and above, as such levels isolate the sympathetic outflow to the splanchnic vascular bed. Resting blood pressure is low with higher cord injury, which is asymptomatic. Orthostatic blood pressure changes can cause weakness, light-headedness, and fainting. Management includes (...) gradual mobilization, liberal sodium intake, use of compression hose, and an abdominal binder. [ , ] Fludrocortisone acetate (0.1 mg PO qd) can expand intravascular volume and therefore is helpful. Midodrine (titrated upward daily from a dosage of 5 mg PO bid/tid) may be helpful. Midodrine can cause supine hypertension and presumably may exacerbate any tendency toward autonomic hyperreflexia (AH). Bradycardia is common soon after injury and usually resolves after several weeks. Tracheal suctioning can

2014 eMedicine Surgery

76. Cauda Equina Syndrome (Follow-up)

therapy. Methylprednisolone should be administered. It treatment must be started within 8 hours of injury. No evidence exists of any benefit if it is started more than 8 hours after injury; on the contrary, late treatment may have detrimental effects. Administration of ganglioside GM1 sodium salt beginning within 72 hours of injury may be beneficial; the dose is 100 mg IV qd for 18-32 days. Tirilazad mesylate (a nonglucocorticoid 21-aminosteroid) has been proven to be of benefit in animals (...) are to maximize the medical, physical, psychological, educational, vocational, and social function of the patient. To maximize medical function, ensure adequate prevention and treatment of possible medical complications already discussed, especially deep venous thrombosis, bladder and bowel problems, and decubitus ulcers Physical therapy Perform range of motion and strengthening exercises, sitting balance, transfer training, and tilt table as tolerated (because of tendency to orthostatic hypotension). Tilt

2014 eMedicine Surgery

77. Lower Gastrointestinal Bleeding: Surgical Perspective (Follow-up)

, and urine output. Orthostatic hypotension (ie, a blood pressure fall of >10 mm Hg) is usually indicative of blood loss of more than 1000 mL. Next: Resuscitation and Initial Assessment The 2016 American Academy of Family Physicians (AAFP) guidelines recommend the following for the initial evaluation, risk stratifcation, and hemodynamic resuscitation [ ] : Obtain a focused history, physical examination, and laboratory studies at time of patient presentation (to determine bleeding severity and potential (...) postural changes with dyspnea, tachypnea, and tachycardia. An orthostatic drop in systolic blood pressure of more than 10 mm Hg or an increase in heart rate of more than 10 beats per minute is indicative of at least 15% of blood volume loss. Severe postural dizziness with a postural pulse increase of at least 30 beats per minute is a sensitive and specific indicator of acute blood loss of more than 630 mL. [ ] A hematocrit level of less than 18% or a decrease of about 6% is indicative of significant

2014 eMedicine Surgery

78. Migraine Headache: Pediatric Perspective (Diagnosis)

Postdrome Premonitory Migraine with aura (previously known as classic migraine) and migraine without aura (previously known as common migraine) each have a premonitory phase, or prodrome, which may precede the headache phase by up to 24 hours. During this phase, the following features may occur: Irritability Elation or sadness Talkativeness or social withdrawal Increased or decreased appetite Food craving or anorexia Water retention Sleep disturbances These premonitions are often more pronounced (...) , nystagmus, gait unsteadiness, limb incoordination, and dysarthria. Genetic abnormalities have been identified; CACNA1A gene mutations (coding for calcium channel) on chromosome 19 in FHM1; mutations in the ATP1A2 gene (coding for a K/Na-ATPase) on chromosome 1 in FHM2; and mutations in the SCN1A gene (coding for a sodium channel) on chromosome 2 in FHM3. [ ] Consider structural lesions, vasculitis, cerebral hemorrhage, brain tumor, mitochondrial myopathy, encephalopathy, and lactic acidosis

2014 eMedicine.com

79. Multiple System Atrophy (Diagnosis)

Orthostatic Hypotension in MSA Class Drug Description or Mechanism Corticosteroids Fludrocortisone (Florinef) Mineralocorticoid; sodium retention, primarily in extravascular compartment, causes tissue edema to venous capacitance bed in lower extremity. With this edema, venous bed accommodates decreased volume of blood in an upright posture (high doses, late effect); increases sensitivity to norepinephrine (even with small doses) Sympathomimetic amines Midodrine Alpha1-adrenoreceptor agonist acts directly (...) .) Table 5. Clinicopathologic Correlations Clinical Symptom Pathologic Findings and Location of Damage or Cell Loss Orthostatic hypotension Primary preganglionic damage of intermediolateral cell columns Urinary incontinence (not retention) Preganglionic cell loss in spinal cord (intermediolateral cell columns), related to detrusor hyperreflexia caused mainly by loss of inhibitory input to pontine micturition center (rather than to external urethral sphincter denervation alone) Urinary retention caused

2014 eMedicine.com

80. Gynecologic Pain (Diagnosis)

improvement in patients with IC who were treated with amitriptyline. [ ] Corticosteroids are not widely used because of adverse effects such as fluid retention and osteoporosis. However, a study reported improved pain control and overall satisfaction with oral prednisone in a cohort of women with severe refractory IC. [ ] Pentosan polysulfate sodium (PPS) (Elmiron) is claimed to restore the depletion in the glycosaminoglycan (GAG) layer. A double-blind placebo-controlled trial revealed subjective (...) a reproductive age woman presents with pelivic pain and a positive pregnancy test. An unruptured ectopic pregnancy produces localized pain due to dilatation of the fallopian tube. Once the ectopic pregnancy is ruptured, the pain tends to be generalized due to peritoneal irritation. Symptoms of rectal urgency due to a mass in the pouch of Douglas may also be present. Syncope, dizziness, and orthostatic changes in blood pressure are sensitive signs of hypovolemia in these patients. Abdominal examination

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>