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Ortho-Tricyclen

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1. Ortho-Tricyclen

Ortho-Tricyclen Ortho-Tricyclen Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ortho-Tricyclen Ortho-Tricyclen Aka: Ortho-Tricyclen (...) , OrthoTricyclen , Ortho Tricyclen , Ortho Tri-Cyclen , Tri-Sprintec II. Preparations (Norgestimate / Ethinyl Estradiol) Ortho Tri-Cyclen (0.18 - 0.215 - 0.250 / 35) III. Components 0.5 to 1.0 (see preparations above) 35 ug IV. Effect Relative : 0.3 (low) : 35 (moderate) : 0.15 (low) V. Pill associated problems Indications to switch to (lower androgen) Increased Appetite (lower ) Break-through bleed days 1-9 (more ) Break-through bleed all of month (more ) provoked (lower ) too light (more , less ) Indications

2018 FP Notebook

2. Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives (PubMed)

Flavoenzyme-mediated reduction reactions and antitumor activity of nitrogen-containing tetracyclic ortho-quinone compounds and their nitrated derivatives Nitrogen-based tetracyclic ortho-quinones (naphtho[1'2':4.5]imidazo[1,2-a]pyridine-5,6-diones, NPDOs) and their nitro-substituted derivatives (nitro-(P)NPDOs) were obtained by condensation of substituted 2,3-dichloro-1,4-naphthoquinones with 2-amino-pyridine and -pyrimidine and nitration at an elevated temperature. The structural features

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2017 EXCLI journal

3. Evaluation of cutaneous rejuvenation associated with the use of ortho-silicic acid stabilized by hydrolyzed marine collagen. (PubMed)

Evaluation of cutaneous rejuvenation associated with the use of ortho-silicic acid stabilized by hydrolyzed marine collagen. Organic silicon plays an important role in dermal structure by promoting neocollagenesis. Thus, the supplementation of silicon in a highly bioavailable form can be used for skin rejuvenation.This study aimed to evaluate skin changes associated with the use of ortho-silicic acid stabilized by hydrolyzed collagen.Patients were randomized to receive 600 mg of ortho-silicic (...) evaluations. Objective images showed no statistical differences. No side effects, hypersensitivity, or systemic symptoms were observed in group 1. Treatment satisfaction in group 1 reached 80%.Ortho-silicic acid stabilized by hydrolyzed collagen in a daily dose of 600 mg showed positive results in skin rejuvenation according to clinical evaluation in firmness, hydration, and skin texture. Further studies with larger and representative samples should be conducted to confirm our results.© 2017 Wiley

2019 Journal of cosmetic dermatology

4. Ortho-Tricyclen

Ortho-Tricyclen Ortho-Tricyclen Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ortho-Tricyclen Ortho-Tricyclen Aka: Ortho-Tricyclen (...) , OrthoTricyclen , Ortho Tricyclen , Ortho Tri-Cyclen , Tri-Sprintec II. Preparations (Norgestimate / Ethinyl Estradiol) Ortho Tri-Cyclen (0.18 - 0.215 - 0.250 / 35) III. Components 0.5 to 1.0 (see preparations above) 35 ug IV. Effect Relative : 0.3 (low) : 35 (moderate) : 0.15 (low) V. Pill associated problems Indications to switch to (lower androgen) Increased Appetite (lower ) Break-through bleed days 1-9 (more ) Break-through bleed all of month (more ) provoked (lower ) too light (more , less ) Indications

2015 FP Notebook

5. Rhodium-catalyzed ortho-heteroarylation of phenols: directing group-enabled switching of the electronic bias for heteroaromatic coupling partner †Electronic supplementary information (ESI) available: Detailed information on experimental procedures, char (PubMed)

Rhodium-catalyzed ortho-heteroarylation of phenols: directing group-enabled switching of the electronic bias for heteroaromatic coupling partner †Electronic supplementary information (ESI) available: Detailed information on experimental procedures, char The directed oxidative C-H/C-H cross-coupling reactions between a functionalized arene and a heteroarene typically exhibit an electronic bias for the heteroaromatic coupling partner. Disclosed herein is a conception of directing group enabled (...) -switching of the electronic bias for coupling partner from the electron-deficient to electron-rich heteroarene, demonstrating that the modification of the directing group may match the latent reactivity of heteroarene substrates caused by the distinctly different electronic nature. In this work, we develop a Rh(iii)-catalyzed ortho-heteroarylation of phenols with greatly important electron-rich heteroarenes such as benzothiophene, benzofuran, thiophene, furan and pyrrole via two-fold C-H activation

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2018 Chemical Science

6. Effects of Ferric Oxyhydroxide on Anaerobic Microbial Dechlorination of Polychlorinated Biphenyls in Hudson and Grasse River Sediment Microcosms: Dechlorination Extent, Preferences, Ortho Removal, and Its Enhancement (PubMed)

Effects of Ferric Oxyhydroxide on Anaerobic Microbial Dechlorination of Polychlorinated Biphenyls in Hudson and Grasse River Sediment Microcosms: Dechlorination Extent, Preferences, Ortho Removal, and Its Enhancement Microbial reductive dechlorination of polychlorinated biphenyls (PCBs) has been observed in many PCB-impacted sediments. However, this biodegradation is relatively site-specific and can be affected by PCB compositions and sediment geochemical conditions. To better understand (...) longer lag time. The inhibitory effect in the Grasse sediment was mainly due to the loss of unflanked para dechlorination activity. Fe(II) analysis showed that dechlorination started prior to the consumption of Fe(III), which indicates PCB reduction and Fe(III) reduction were able to take place concurrently. Dehalococcoides 16S rRNA genes increased with the commencement of dechlorination in the Grasse sediment, but not in the completely inhibited Hudson sediment. Rare ortho dechlorination pathways

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2018 Frontiers in microbiology

7. Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8gc00008e (PubMed)

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8gc00008e The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (∼30-40 bar) catalyzed by ortho

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2018 Green Chemistry

8. Synthesis and evaluation of ortho-[18F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging (PubMed)

Synthesis and evaluation of ortho-[18F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging An 18F-tagged NSAID analog was prepared for use as a probe for COX-2 expression, which is associated with tumor development.The in vivo uptake of celecoxib was monitored with ortho-[18F]fluorocelecoxib using positron emission tomography (PET). The binding affinity of ortho-[18F]fluorocelecoxib to COX-1 and COX-2 enzymes were assessed using the competitor celecoxib.The IC50 values were 0.039 μM and 0.024 (...) μM, respectively. A selectivity index of 1.63 was obtained (COX-2 vs COX-1). COX-2 overexpressed cholangiocarcinoma (CCA) murine cells took up more ortho-[18F]fluorocelecoxib than that by usual CCA cells from 10 to 60 minutes post incubation. Competitive inhibition (blocking) of the tracer uptake of ortho-[18F]fluorocelecoxib in the presence of celecoxib by the COX-2 overexpressed CCA cells and the usual CCA cells gave the IC50 values of 0.5 μM and 46.5 μM, respectively. Based on the in vitro

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2018 Drug design, development and therapy

9. An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine (PubMed)

An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine ortho-Toluidine (OT) was listed as a Group 1 carcinogen by the International Agency for Research on Cancer in 2012 based on epidemiological observations of workers co-exposed to OT and aromatic amines. From 2014 to 2017, several cases of bladder cancer (BCa) secondary to occupational exposure, primarily to OT, were detected in Japan.To describe 10 cases of BCa in male Japanese workers (...) -exposed to para-toluidine, ortho-anisidine, aniline, 2,4-xylidine or ortho-chloroaniline. The age range at diagnosis was 41-71 years (mean 56). The duration of OT exposure was 7-28 years (mean 16.5). Disease latency was 16-28 years (mean 21.9). Eight patients were smokers. The main symptom at diagnosis was hematuria (70%).The characteristics of BCa cases were associated with a high surrogate level of OT exposure and a disease latency of more than 20 years from the initial OT exposure. The main route

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2018 Journal of occupational health

10. Achieving High Ortho Selectivity in Aniline C–H Borylations by Modifying Boron Substituents (PubMed)

Achieving High Ortho Selectivity in Aniline C–H Borylations by Modifying Boron Substituents High ortho selectivity for Ir-catalyzed C-H borylations (CHBs) of anilines results when B2eg2 (eg = ethylene glycolate) is used as the borylating reagent in lieu of B2pin2, which is known to give isomeric mixtures with anilines lacking a blocking group at the 4-position. With this modification, high selectivities and good yields are now possible for various anilines, including those with groups (...) at the 2- and 3-positions. Experiments indicate that ArylN(H)Beg species are generated prior to CHB and support the improved ortho selectivity relative to B2pin2 reactions arising from smaller Beg ligands on the Ir catalyst. The lowest-energy transition states (TSs) from density functional theory computational analyses have N-H···O hydrogen-bonding interactions between PhN(H)Beg and O atoms in Beg ligands. Ir-catalyzed CHB of PhN(H)Me with B2eg2 is also highly ortho-selective. 1H NMR experiments show

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2018 ACS Catalysis

11. Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives (PubMed)

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives (Z,Z')-1,1'-(4-ortho-Caboranyldimethyl)-bis(2-methoxyphenylethan-1-oxime) intermediate 3 was synthesized by a three-step reaction with a final treatment with base to give a new series of ortho-carboranyl biphenyloxime derivatives (4-8). Compounds 7 and 8 showed high solubility and the in vitro study results revealed high levels of accumulation in HeLa cells with higher cytotoxicity and boron uptake

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2018 Chemistry Central journal

12. Pyrene-Containing ortho-Oligo(phenylene)ethynylene Foldamer as a Ratiometric Probe Based on Circularly Polarized Luminescence (PubMed)

Pyrene-Containing ortho-Oligo(phenylene)ethynylene Foldamer as a Ratiometric Probe Based on Circularly Polarized Luminescence In this manuscript, we report the first synthesis of an organic monomolecular emitter, which behaves as a circularly polarized luminescence (CPL)-based ratiometric probe. The enantiopure helical ortho-oligo(phenylene)ethynylene ( o-OPE) core has been prepared by a new and efficient macrocyclization reaction. The combination of such o-OPE helical skeleton and a pyrene

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2018 The Journal of organic chemistry

13. Crystal structure and Hirshfeld surface analysis of (E)-N′-benzyl­idene-4-chloro­benzene­sulfono­hydrazide and of its (E)-4-chloro-N′-(ortho- and para-methyl­benzyl­idene)benzene­sulfono­hydrazide derivatives (PubMed)

Crystal structure and Hirshfeld surface analysis of (E)-N′-benzyl­idene-4-chloro­benzene­sulfono­hydrazide and of its (E)-4-chloro-N′-(ortho- and para-methyl­benzyl­idene)benzene­sulfono­hydrazide derivatives (E)-N'-Benzyl-idene-4-chloro-benzene-sulfono-hydrazide, C13H11ClN2O2S, (I), and its ortho- and para-methyl-substituted derivatives, C14H13ClN2O2S, namely (E)-4-chloro-N'-(2-methyl-benzyl-idene)benzene-sulfono-hydrazide, (II), and (E)-4-chloro-N'-(4-methyl-benzyl-idene)benzene (...) portions of the mol-ecules, S-N-N=C, are slightly twisted from planarity, with a torsion angle of 166.5 (3)° in (I), 165.4 (3)° in (II) and 157.9 (2)° in (III). The two aromatic rings present in the compounds are inclined to each other by 78.4 (2), 74.8 (2) and 76.9 (1)° in (I), (II) and (III), respectively. In the crystal structure of the parent compound (I), and of the ortho-methyl derivative (II), an N-H⋯O hydrogen bond links the mol-ecules into chains along [001], which are inter-connected by weak

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2018 Acta Crystallographica Section E: Crystallographic Communications

14. Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors (PubMed)

Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors In this work, design, synthesis, and screening of thiophene carboxamides 4-13 and 16-23 as dual vascular endothelial growth factor receptors (VEGFRs) and mitotic inhibitors was reported. All compounds were screened against two gastrointestinal solid cancer cells, HepG-2 and HCT-116 cell lines. The most active cytotoxic derivatives 5 and 21 displayed 2.3- and 1.7-fold

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2018 Journal of enzyme inhibition and medicinal chemistry

15. Carbon Nanotube Formic Acid Sensors Using a Nickel Bis(ortho-diiminosemiquinonate) Selector (PubMed)

Carbon Nanotube Formic Acid Sensors Using a Nickel Bis(ortho-diiminosemiquinonate) Selector Formic acid is corrosive, and a sensitive and selective sensor could be useful in industrial, medical, and environmental settings. We present a chemiresistor for detection of formic acid composed of single-walled carbon nanotubes (CNTs) and nickel bis( ortho-diiminosemiquinonate) (1), a planar metal complex that can act as a ditopic hydrogen-bonding selector. Formic acid is detected in concentrations

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2018 ACS Sensors

16. Mannich base-connected syntheses mediated by ortho-quinone methides (PubMed)

Mannich base-connected syntheses mediated by ortho-quinone methides This article provides an overview about specifically modified Mannich reactions where the process involves an ortho-quinone methide (o-QM) intermediate. The reactions are classified on the basis of the o-QM source followed by the reactant, e.g., the dienophile partner in cycloaddition reactions (C=C or C=N dienophiles) or by the formation of multicomponent Mannich adducts. Due to the important pharmacological activities

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2018 Beilstein journal of organic chemistry

17. Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients

Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients Vitamin D and Bone Homeostasis in Ortho Polytrauma Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Vitamin D and Bone Homeostasis (...) in Ortho Polytrauma Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03066817 Recruitment Status : Enrolling by invitation First Posted : February 28, 2017 Last Update Posted : September 5, 2018 Sponsor: New York City Health and Hospitals Corporation Collaborators: Foundation of Orthopedic

2017 Clinical Trials

18. Pain after ortho-plastic reconstruction of lower limb injuries: A snapshot study. (PubMed)

Pain after ortho-plastic reconstruction of lower limb injuries: A snapshot study. The incidence of pain after flap reconstruction of complex lower limb injury is poorly reported in the literature, and yet represents a significant source of morbidity in these patients. In our centre (Southmead Hospital, Bristol, England) patients who have had flap reconstruction for complex lower limb injury are followed up at a joint ortho-plastics lower limb clinic run weekly. The aim of this study (...) was to report the incidence of pain in such patients at follow-up in the specialist clinic. The impact of the experience of pain upon the quality of life, and the efficacy of analgesia was assessed these cases.This was a cross sectional snapshot study of a cohort of complex lower limb patients attending our lower limb ortho-plastics outpatient clinic between the dates of: 17/5/16 and 28/6/16. Any patient attending clinic with previous flap reconstruction for lower limb injury was asked to complete the BPI

2017 Injury

19. Validating the factor structure and testing measurement invariance of modified Short-Form McGill Pain Questionnaire (Ortho-SF-MPQ) for orthodontic pain assessment. (PubMed)

Validating the factor structure and testing measurement invariance of modified Short-Form McGill Pain Questionnaire (Ortho-SF-MPQ) for orthodontic pain assessment. To validate the factor structure of recently modified Short-Form McGill Pain Questionnaire (Ortho-SF-MPQ) to assess orthodontic pain; and to test its Measurement Invariance (MI) across gender.180 orthodontic patients were enrolled in this study. 0.016 inch Super-elastic NiTi arch wire was used in 0.022″ × 0.028″ slot pre-adjusted (...) edgewise appliance. After initial arch wire placement, pain was assessed at T1 (24 hours), T2 (day 3), and T3 (day 7) by using the Ortho-SF-MPQ which consists of seven sensory (pressure, sore, aching, tight, throbbing, pulling, miserable) and four affective (uncomfortable, strange, frustrating, annoying) descriptors. Confirmatory factor analysis (CFA) models were fitted for analysis. Multiple-groups CFA (MG-CFA) approach was used for MI testing.Data from 172 patients (85 male, 87 female) with mean age

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2017 Journal of Orthodontics

20. Evaluation of the ORTHO-LBNP System

Evaluation of the ORTHO-LBNP System Evaluation of the ORTHO-LBNP System - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Evaluation of the ORTHO-LBNP System (ORTHO-LBNP) The safety and scientific validity (...) vision, loss of peripheral vision, blackout and finally G-induced loss of consciousness (G-LOC). A motorized tilt table to generate orthostatic (ORTHO) stress combined with an automatically controlled lower body negative pressure (LBNP) chamber to extort pooling of blood in the lower extremities has been developed in order to obtain new knowledge on counteracting the above-mentioned effects and minimizing the risk of their occurrence. This will help optimize the selection procedures of candidates

2017 Clinical Trials

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